Cortical Gray Matter Proteins Associated With Cerebral Amyloid Angiopathy in Community-Dwelling Older Adults
Shahram Oveisgharan, Lei Yu, Jingyun Yang, Sonal Agrawal, Ricardo A. Vialle, Kátia de Paiva Lopes, Shinya Tasaki, Yanling Wang et al.. Neurology, 2025-08-22
Topic: Brain proteins, microglia and lab models
< 0.001). This study suggests 2 molecular pathways underlying CAA, with a larger effect size for the pathway including SFRP1 and APOE protein and C-terminally truncated Aβ before position 40. However, the study is an observational cross-sectional study that limits causal inference from the findings.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Oveisgharan, S., Yu, L., Yang, J., Agrawal, S., Vialle, R. A., Lopes, K. d. P., et al. (2025). Cortical Gray Matter Proteins Associated With Cerebral Amyloid Angiopathy in Community-Dwelling Older Adults. Neurology. https://doi.org/10.1212/wnl.0000000000214024
Vancouver
Oveisgharan S, Yu L, Yang J, Agrawal S, Vialle RA, Lopes KdP, et al. Cortical Gray Matter Proteins Associated With Cerebral Amyloid Angiopathy in Community-Dwelling Older Adults. Neurology. 2025. doi:10.1212/wnl.0000000000214024. PMID: 40845264.
BibTeX
@article{oveisgharan2025-40845264,
author = {Oveisgharan, Shahram and Yu, Lei and Yang, Jingyun and Agrawal, Sonal and Vialle, Ricardo A. and Lopes, Kátia de Paiva and Tasaki, Shinya and Wang, Yanling and others},
title = {{Cortical Gray Matter Proteins Associated With Cerebral Amyloid Angiopathy in Community-Dwelling Older Adults}},
journal = {Neurology},
year = {2025},
doi = {10.1212/wnl.0000000000214024},
pmid = {40845264},
url = {https://doi.org/10.1212/wnl.0000000000214024}
}
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Key findings
- This study suggests 2 molecular pathways underlying CAA, with a larger effect size for the pathway including SFRP1 and APOE protein and C-terminally truncated Aβ before position 40.
- However, the study is an observational cross-sectional study that limits causal inference from the findings.
Why it matters
This observational study suggests two molecular pathways involving proteins such as SFRP1 and APOE that are associated with cerebral amyloid angiopathy in older adults. Because it is cross-sectional, it cannot show cause and effect.
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Study details
- Study designcross-sectional
- Evidence strengthLow
How this study scored 50/100
Published in a leading specialty journal, and it is a snapshot of people at one point in time. Scored zero for sample size, effect reported, studied in people and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 9 / 10 | Tier 2 — leading specialty journal (Neurology) |
| Journal's citation record | 4 / 4 | Neurology: journal h-index 525 (OpenAlex, 2026-10-29) |
| Study design | 4 / 12 | A snapshot of people at one point in time |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 4 / 5 | 2025 — within 3 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 1 / 7 | Cited 3 times (OpenAlex, 2026-10-10) |
| Citations per year | 1 / 5 | 1.0 citations a year over 3 year(s) since 2025 |
| Impact for its field and year | 2 / 6 | Cited 1.7× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 0 / 6 | No other study in this library cites it |
| Still being cited | 1 / 4 | Cited 3 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 4 / 4 | Last-listed author David Alan Bennett: h-index 197 (OpenAlex, whole career) |
| Institution's track record | 3 / 3 | Harvard University: institution h-index 3,235 (OpenAlex) |
| Multi-centre collaboration | 2 / 3 | OpenAlex lists 8 institution(s) in 1 country |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 40845264) |
| Free to read | 2 / 2 | Free to read |
| Total | 50 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
- DOI: 10.1212/wnl.0000000000214024
- PubMed: 40845264
- Original source →
- Free full text: PubMed Central →
Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).
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Referenced by this study and also in the alzhub library, so you can read them here.
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Also tagged “precursor”
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