Consensus meta-analysis of genome-wide association studies for Alzheimer's disease and related dementia
ADGC, Bonn, CHARGE, EADB, EADI, FinnGen, GERAD, GR@ACE/DEGESCO, PGC-ALZ. medRxiv : the preprint server for health sciences, 2025-10-23
Topic: Genetics and APOE
Plain-language summary
To better characterize the genetic architecture underlying Alzheimer's disease (AD) and related dementia (ADRD), we performed a meta-analysis of European ancestry genome-wide association studies in 128,681 cases or proxy cases of ADRD and 849,833 (proxy) controls. We identified 91 genetic loci associated with ADRD risk, including 16 which are novel, and 56 which are specifically detected in clinically diagnosed AD cases. We also provide a list of 18 loci (15 novel) requiring further external validation. A polygenic score combining the effect of the ADRD loci except APOE was primarily associated with AD rather than non-AD pathology. Individuals in the 10th decile of the score had a 2-fold increased risk to present with Braak neurofibrillary tangles stage above 5 and moderate/severe neuritic amyloid plaque pathology at death compared to individuals in the median score group.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
ADGC, Bonn, CHARGE, EADB, EADI, FinnGen, et al. (2025). Consensus meta-analysis of genome-wide association studies for Alzheimer's disease and related dementia. medRxiv : the preprint server for health sciences. https://doi.org/10.1101/2025.10.20.25338060
Vancouver
ADGC, Bonn, CHARGE, EADB, EADI, FinnGen, et al. Consensus meta-analysis of genome-wide association studies for Alzheimer's disease and related dementia. medRxiv : the preprint server for health sciences. 2025. doi:10.1101/2025.10.20.25338060. PMID: 41282675.
BibTeX
@article{adgc2025-41282675,
author = {ADGC and Bonn and CHARGE and EADB and EADI and FinnGen and GERAD and GR@ACE/DEGESCO and PGC-ALZ},
title = {{Consensus meta-analysis of genome-wide association studies for Alzheimer's disease and related dementia}},
journal = {medRxiv : the preprint server for health sciences},
year = {2025},
doi = {10.1101/2025.10.20.25338060},
pmid = {41282675},
url = {https://doi.org/10.1101/2025.10.20.25338060}
}
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record names 9 authors; APA and Vancouver show the first six, BibTeX and the downloads carry all of them. Check the citation against the original before you use it.
Key findings
- We identified 91 genetic loci associated with ADRD risk, including 16 which are novel, and 56 which are specifically detected in clinically diagnosed AD cases.
- A polygenic score combining the effect of the ADRD loci except APOE was primarily associated with AD rather than non-AD pathology.
- Individuals in the 10th decile of the score had a 2-fold increased risk to present with Braak neurofibrillary tangles stage above 5 and moderate/severe neuritic amyloid plaque pathology at death compared to individuals in the median score group.
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Study details
- Study designmeta-analysis
- Evidence strengthHigh
How this study scored 16/100
Preprint — not yet peer-reviewed. It scored 48 on the same rubric, but non-peer-reviewed sources are capped at 16, so it shows as 16. Scored zero for sample size, effect reported and studied in people because the record does not state it. We have no data on times cited, citations per year, impact for its field and year, cited by studies here, still being cited, senior author's track record, institution's track record, multicenter collaboration and free to read, so those were left out: it earned 29 of the 60 points we could judge it on, which is 48 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 2 / 10 | Tier 4 — not a peer-reviewed journal (medRxiv : the preprint server for health sciences) |
| Journal's citation record | 0 / 4 | Not a journal article, so the journal's record does not count |
| Study design | 12 / 12 | A meta-analysis pooling many studies |
| Strength of evidence | 5 / 5 | Rated “high” in our summary |
| Peer-review validation | 4 / 10 | Preprint — not yet peer-reviewed. Hosted on a preprint server. |
| How recent | 4 / 5 | 2025 — within 3 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomized / blinded | 0 / 2 | A review of other studies — randomization is not credited here |
| Times cited | — / 7 | No citation count (not found in OpenAlex) — left out of this score |
| Citations per year | — / 5 | No citation count or no year — left out of this score |
| Impact for its field and year | — / 6 | No field-weighted citation impact (OpenAlex has none yet) — left out of this score |
| Cited by studies here | — / 6 | Not yet checked against this library's citation graph — left out of this score |
| Still being cited | — / 4 | No yearly citation counts — left out of this score |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | — / 3 | No institution listed in OpenAlex — left out of this score |
| Multicenter collaboration | — / 3 | Institutions not listed — left out of this score |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 41282675) |
| Free to read | — / 2 | Access not recorded — left out of this score |
| Points | 29 / 60 | Scored on 11 of 20 parts. We have no data for the rest, so they are left out: 29 of the 60 points we could judge it on is 48 out of 100. |
| Total | 48 / 100 | Capped to 16 because this is not a peer-reviewed article. |
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