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43/100

✓ Peer-reviewed alzhub usefulness score 43 out of 100. Vascular contributions

Topic: Amyloid, tau and blood-test diagnosis

Amyloid status moderated associations between IIV-dispersion and WMH, such that higher IIV-dispersion was associated with greater WMH in Aß+ individuals whether WMH was examined as a continuous (B = 0.30, ß = 0.13, p = .006) or a dichotomous variable based on quartiles (odds ratio [OR] = 2.41, p < .001). Sensitivity analyses to adjust for the effects of individual mean cognition in the models modified findings such that greater IIV-dispersion was again associated with greater WMH in Aß+ individuals when WMH was examined dichotomously (OR = 2.13, p = .018) but the effect was attenuated for continuous WMH. Greater IIV-dispersion was associated with greater WMH among Aß+ individuals. IIV-dispersion may be an early marker of cerebrovascular changes in AD although future research is needed to further establish its incremental utility.

Key findings

Amyloid status moderated associations between IIV-dispersion and WMH, such that higher IIV-dispersion was associated with greater WMH in Aß+ individuals whether WMH was examined as a continuous (B = 0.30, ß = 0.13, p = .006) or a dichotomous variable based on quartiles (odds ratio [OR] = 2.41, p < .001).
Sensitivity analyses to adjust for the effects of individual mean cognition in the models modified findings such that greater IIV-dispersion was again associated with greater WMH in Aß+ individuals when WMH was examined dichotomously (OR = 2.13, p = .018) but the effect was attenuated for continuous WMH.
Greater IIV-dispersion was associated with greater WMH among Aß+ individuals.
IIV-dispersion may be an early marker of cerebrovascular changes in AD although future research is needed to further establish its incremental utility.

Why it matters

In amyloid positive older adults, greater variability in cognitive test performance was associated with greater white matter hyperintensities. The authors suggest this variability may be an early marker of cerebrovascular changes in Alzheimer's disease, but they state that future research is needed to establish its usefulness.

Study details

Participants819
Effect sizeOR = 2.13
Evidence strengthLow

How this study scored 43/100

Published in a peer-reviewed journal. Scored zero for study design and randomised / blinded because the record does not state it. We have no data on senior author's track record, so that was left out: it earned 41 of the 96 points we could judge it on, which is 43 out of 100.

Component	Points	Why
Journal tier	7 / 10	Tier 3 — peer-reviewed journal (The Clinical Neuropsychologist)
Journal's citation record	1 / 4	The Clinical Neuropsychologist: journal h-index 128 (OpenAlex, 2026-10-29)
Study design	0 / 12	No study design recorded — scores zero, not guessed (not stated in the record — scored 0)
Strength of evidence	1 / 5	Rated “low” in our summary
Peer-review validation	10 / 10	Peer-reviewed. Published as an article in a named peer-reviewed journal.
How recent	4 / 5	2025 — within 3 year(s) of the newest study here
Sample size	2 / 4	819 participants
Effect reported	3 / 3	Effect reported with a statistic (interval, p-value, ratio or similar)
Studied in people	3 / 3	Studied in people (participant count stated)
Randomised / blinded	0 / 2	No randomisation or blinding stated — scores zero (not stated in the record — scored 0)
Times cited	1 / 7	Cited 2 times (OpenAlex, 2026-10-10)
Citations per year	0 / 5	0.7 citations a year over 3 year(s) since 2025
Impact for its field and year	2 / 6	Cited 1.3× the average for papers of its field and year (OpenAlex FWCI)
Cited by studies here	0 / 6	No other study in this library cites it
Still being cited	0 / 4	Cited 2 times in 2024–2026 (2026 still in progress; OpenAlex)
Senior author's track record	— / 4	Senior author's record not available — left out of this score
Institution's track record	2 / 3	University of California San Diego: institution h-index 1,852 (OpenAlex)
Multi-centre collaboration	1 / 3	OpenAlex lists 3 institution(s) in 1 country
Indexed in PubMed	2 / 2	Indexed in PubMed (PMID 41138063)
Free to read	2 / 2	Free to read
Points	41 / 96	Scored on 19 of 20 parts. We have no data for the rest, so they are left out: 41 of the 96 points we could judge it on is 43 out of 100.
Total	43 / 100	—

What each of these 20 components measures, and what this score is not →

Read the original

Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).

Cite this study APA, Vancouver, BibTeX · download .bib or .ris

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APA 7th

Ross, D., Chang, F., Edwards, L., Thomas, K. R., Bangen, K. J., & Alzheimer’s Disease Neuroimaging Initiative. (2025). Cognitive dispersion is associated with white matter hyperintensities in amyloid positive older adults. The Clinical Neuropsychologist. https://doi.org/10.1080/13854046.2025.2570301

Vancouver

Ross D, Chang F, Edwards L, Thomas KR, Bangen KJ, Alzheimer’s Disease Neuroimaging Initiative. Cognitive dispersion is associated with white matter hyperintensities in amyloid positive older adults. The Clinical Neuropsychologist. 2025. doi:10.1080/13854046.2025.2570301. PMID: 41138063.

BibTeX

@article{ross2025-41138063,
  author  = {Ross, Daliah and Chang, Fini and Edwards, Lauren and Thomas, Kelsey R. and Bangen, Katherine J. and {Alzheimer’s Disease Neuroimaging Initiative}},
  title   = {{Cognitive dispersion is associated with white matter hyperintensities in amyloid positive older adults}},
  journal = {The Clinical Neuropsychologist},
  year    = {2025},
  doi     = {10.1080/13854046.2025.2570301},
  pmid    = {41138063},
  url     = {https://doi.org/10.1080/13854046.2025.2570301}
}

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