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EEG Microstate Differences Between Alzheimer’s Disease, Frontotemporal Dementia, and Healthy Controls Using 4 and 7 Clustering Classes with a Ratio Approach
Jinwon Chang. Medicina, 2025-10-25
Topic: Amyloid, tau and blood-test diagnosis
The four- and seven-class clustering solutions achieved high variance overlap with published microstate templates. In the four-class solution, temporal parameters of microstates B and D significantly differentiated controls from dementia groups, while in the seven-class solution, microstates C and G were the most informative. Ratio-normalized parameters improved group discrimination and were associated with MMSE scores. EEG microstates capture disease-related alterations in large-scale brain dynamics that differentiate patients with dementia from healthy individuals.
Key findings
- The four- and seven-class clustering solutions achieved high variance overlap with published microstate templates.
- In the four-class solution, temporal parameters of microstates B and D significantly differentiated controls from dementia groups, while in the seven-class solution, microstates C and G were the most informative.
- Ratio-normalized parameters improved group discrimination and were associated with MMSE scores.
- EEG microstates capture disease-related alterations in large-scale brain dynamics that differentiate patients with dementia from healthy individuals.
Why it matters
This study found that EEG microstate parameters differentiated patients with dementia from healthy controls and were associated with MMSE scores. Ratio-normalized parameters improved group discrimination.
Study details
- Evidence strengthLow
How this study scored 36/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported, studied in people and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Medicina) |
| Journal's citation record | 1 / 4 | Medicina: journal h-index 107 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 4 / 5 | 2025 — within 3 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 1 / 7 | Cited 4 times (OpenAlex, 2026-10-10) |
| Citations per year | 1 / 5 | 1.3 citations a year over 3 year(s) since 2025 |
| Impact for its field and year | 2 / 6 | Cited 2.5× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 0 / 6 | No other study in this library cites it |
| Still being cited | 1 / 4 | Cited 4 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 0 / 4 | Last-listed author Jinwon Chang: h-index 3 (OpenAlex, whole career) |
| Institution's track record | 3 / 3 | Harvard University: institution h-index 3,235 (OpenAlex) |
| Multi-centre collaboration | 1 / 3 | OpenAlex lists 3 institution(s) in 1 country |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 41303755) |
| Free to read | 2 / 2 | Free to read |
| Total | 36 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. Check the citation against the original before you use it.
APA 7th
Chang, J. (2025). EEG Microstate Differences Between Alzheimer’s Disease, Frontotemporal Dementia, and Healthy Controls Using 4 and 7 Clustering Classes with a Ratio Approach. Medicina. https://doi.org/10.3390/medicina61111917
Vancouver
Chang J. EEG Microstate Differences Between Alzheimer’s Disease, Frontotemporal Dementia, and Healthy Controls Using 4 and 7 Clustering Classes with a Ratio Approach. Medicina. 2025. doi:10.3390/medicina61111917. PMID: 41303755.
BibTeX
@article{chang2025-41303755,
author = {Chang, Jinwon},
title = {{EEG Microstate Differences Between Alzheimer’s Disease, Frontotemporal Dementia, and Healthy Controls Using 4 and 7 Clustering Classes with a Ratio Approach}},
journal = {Medicina},
year = {2025},
doi = {10.3390/medicina61111917},
pmid = {41303755},
url = {https://doi.org/10.3390/medicina61111917}
}
Studies this one cites
Referenced by this study and also in the alzhub library, so you can read them here.