This page is alzhub.org's plain-English summary of a published study, not the paper itself. It is generated from the record we hold for this study, sourced and linked below — check the original for the full text and methods.

44/100

✓ Peer-reviewed alzhub usefulness score 44 out of 100. Inflammation and the immune system

Topic: Brain proteins, microglia and lab models

Background C-X-C motif chemokine ligand 10 (CXCL10) is implicated in HIV-associated neuroinflammation, yet its association with HIV-associated neurocognitive disorders (HAND) remains unclear. We conducted a meta-analysis to evaluate cerebrospinal fluid (CSF) CXCL10 differences between people living with HIV (PLWH) with and without HAND and to assess the odds of HAND in relation to high versus low CSF CXCL10 levels. Methods PubMed, Embase, and Web of Science were systematically searched. Observational studies reporting CSF CXCL10 levels in adult PLWH with and without HAND were included. Standardized mean difference (SMD) and odds ratio (OR) were pooled using random-effects models accounting for the potential influence of heterogeneity. Results Eleven studies involving 1,536 PLWH were included. Compared to those without HAND, PLWH with HAND had significantly higher CSF CXCL10 levels (SMD: 0.56, 95% CI: 0.17-0.96; p Conclusion Elevated CSF CXCL10 may be associated with HAND in PLWH, particularly among ART-naïve individuals and in more severe cognitive impairment. However, substantial heterogeneity and a wide PI suggest that the strength of this association varies across populations. CSF CXCL10 remains a promising but not definitive biomarker for HAND risk stratification.

Cite this study APA, Vancouver, BibTeX · download .bib or .ris

APA 7th

Gu, Q., Wang, S., Zhu, L., Sun, Q., & Zhang, Y. (2025). Association between cerebrospinal fluid CXCL10 and neurocognitive disorders in people living with HIV: a meta-analysis. AIDS research and therapy. https://doi.org/10.1186/s12981-025-00804-x

Vancouver

Gu Q, Wang S, Zhu L, Sun Q, Zhang Y. Association between cerebrospinal fluid CXCL10 and neurocognitive disorders in people living with HIV: a meta-analysis. AIDS research and therapy. 2025. doi:10.1186/s12981-025-00804-x. PMID: 41137028.

BibTeX

@article{gu2025-41137028,
  author  = {Gu, Q. and Wang, S. and Zhu, L. and Sun, Q. and Zhang, Y.},
  title   = {{Association between cerebrospinal fluid CXCL10 and neurocognitive disorders in people living with HIV: a meta-analysis}},
  journal = {AIDS research and therapy},
  year    = {2025},
  doi     = {10.1186/s12981-025-00804-x},
  pmid    = {41137028},
  url     = {https://doi.org/10.1186/s12981-025-00804-x}
}

Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. Check the citation against the original before you use it.

Key findings

We conducted a meta-analysis to evaluate cerebrospinal fluid (CSF) CXCL10 differences between people living with HIV (PLWH) with and without HAND and to assess the odds of HAND in relation to high versus low CSF CXCL10 levels.
Results Eleven studies involving 1,536 PLWH were included.
Compared to those without HAND, PLWH with HAND had significantly higher CSF CXCL10 levels (SMD: 0.56, 95% CI: 0.17-0.96; p Conclusion Elevated CSF CXCL10 may be associated with HAND in PLWH, particularly among ART-naïve individuals and in more severe cognitive impairment.
However, substantial heterogeneity and a wide PI suggest that the strength of this association varies across populations.

Why it matters

This meta-analysis of eleven studies with 1,536 people living with HIV looked at CXCL10, an inflammatory signaling molecule, in spinal fluid. People with HIV-associated neurocognitive disorders had significantly higher CXCL10 levels than those without. The authors call it a promising but not definitive marker for this HIV-related condition; the record does not address Alzheimer's itself.

Study details

Study designmeta-analysis
Evidence strengthHigh

How this study scored 44/100

Published in a peer-reviewed journal, and it is a meta-analysis pooling many studies. Scored zero for sample size, effect reported and studied in people because the record does not state it. We have no data on senior author's track record, so that was left out: it earned 42 of the 96 points we could judge it on, which is 44 out of 100.

Component	Points	Why
Journal tier	7 / 10	Tier 3 — peer-reviewed journal (AIDS research and therapy)
Journal's citation record	0 / 4	AIDS Research and Therapy: journal h-index 67 (OpenAlex, 2026-10-29)
Study design	12 / 12	A meta-analysis pooling many studies
Strength of evidence	5 / 5	Rated “high” in our summary
Peer-review validation	10 / 10	Peer-reviewed. Published as an article in a named peer-reviewed journal.
How recent	4 / 5	2025 — within 3 year(s) of the newest study here
Sample size	0 / 4	Participant count not stated — scores zero (not stated in the record — scored 0)
Effect reported	0 / 3	No effect size reported — scores zero (not stated in the record — scored 0)
Studied in people	0 / 3	Not stated whether this was studied in people — scores zero (not stated in the record — scored 0)
Randomised / blinded	0 / 2	A review of other studies — randomisation is not credited here
Times cited	0 / 7	Cited 0 times (OpenAlex, 2026-10-10)
Citations per year	0 / 5	0.0 citations a year over 3 year(s) since 2025
Impact for its field and year	0 / 6	Cited 0.0× the average for papers of its field and year (OpenAlex FWCI)
Cited by studies here	0 / 6	No other study in this library cites it
Still being cited	0 / 4	Cited 0 times in 2024–2026 (2026 still in progress; OpenAlex)
Senior author's track record	— / 4	Senior author's record not available — left out of this score
Institution's track record	0 / 3	Kangda College of Nanjing Medical University: institution h-index 60 (OpenAlex)
Multi-centre collaboration	0 / 3	OpenAlex lists 1 institution(s) in 0 countries — scores zero (affiliation lists can be incomplete)
Indexed in PubMed	2 / 2	Indexed in PubMed (PMID 41137028)
Free to read	2 / 2	Free to read
Points	42 / 96	Scored on 19 of 20 parts. We have no data for the rest, so they are left out: 42 of the 96 points we could judge it on is 44 out of 100.
Total	44 / 100	—

What each of these 20 components measures, and what this score is not →

Read the original

Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).

Related studies in Inflammation and the immune system

Also tagged “cerebral”

900 studies in the library carry the topic tag “cerebral”; these are this study's neighbours in a fixed, alphabetical-by-hash tour of them, not the closest in content. All 900 tagged studies.

Similar studies

More on Inflammation and the immune system

See all studies in Inflammation and the immune system →