Newest studies

EARLY STAGES OF ALZHEIMERS DETECTION

39/100 ✓ Peer-reviewed Brain scans and imaging Zenodo (CERN European Organization for Nuclear Research)

Key finding: The model is trained to recognize subtle patterns in the brain—such as structural shrinkage, texture changes, and abnormalities—associated with Alzheimer’s progression. +2 more findings

• Brain Scans
• Diagnosis

Full summary, score breakdown and related studies → Original source

EARLY STAGES OF ALZHEIMERS DETECTION

28/100 ✓ Peer-reviewed Brain scans and imaging Zenodo (CERN European Organization for Nuclear Research)

Key finding: The model is trained to recognize subtle patterns in the brain—such as structural shrinkage, texture changes, and abnormalities—associated with Alzheimer’s progression. +2 more findings

• Brain Scans
• Diagnosis

Full summary, score breakdown and related studies → Original source

EARLY STAGES OF ALZHEIMERS DETECTION

28/100 ✓ Peer-reviewed Brain scans and imaging Zenodo (CERN European Organization for Nuclear Research)

Key finding: The model is trained to recognize subtle patterns in the brain—such as structural shrinkage, texture changes, and abnormalities—associated with Alzheimer’s progression. +2 more findings

• Brain Scans
• Diagnosis

Full summary, score breakdown and related studies → Original source

Polygenic risk score and cluster-based analysis suggests links between type 2 diabetes and vascular dementia in the KARE study

50/100 ✓ Peer-reviewed Genetics Nature communications

Key finding: We find that a higher overall polygenic risk score for type 2 diabetes is significantly associated with an increased risk of vascular dementia, but not Alzheimer's disease. +2 more findings

• Genetics
• Risk Factors
• Other Dementias

Full summary, score breakdown and related studies → Original source

Genetic drivers of progression in Alzheimer's disease are distinct from disease risk

16/100 ⚠ Preprint — not yet peer-reviewed Genetics medRxiv : the preprint server for health sciences

Key finding: Established AD risk factors, including APOE ε4 dosage and polygenic risk scores, were not associated with disease progression amyloid positive individuals who are actively declining. +4 more findings

• Genetics

Scored 57 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

Full summary, score breakdown and related studies → Original source

The spectrum of Alzheimer's disease

16/100 ⚠ Preprint — not yet peer-reviewed Tau biomarkers medRxiv : the preprint server for health sciences

Key finding: Analyses revealed that no individual volumetric brain changes, nor their combination, can predict AD. +1 more finding

• Biomarkers
• Brain Scans

Scored 33 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

Full summary, score breakdown and related studies → Original source

Needs of key stakeholders to make advance care plans and advance directives for people with dementia: a scoping review

28/100 ✓ Peer-reviewed End-of-life care Repository for Publications and Research Data (ETH Zurich)

Key finding: Dementia-specific ACP/AD require a relational, flexible and ethically grounded approach that evolves with the individual’s condition. +4 more findings

• End-of-Life Care

Full summary, score breakdown and related studies → Original source

Development and psychometric evaluation of a learning needs assessment tool for healthcare professionals in palliative dementia care: A cross-sectional study

39/100 ✓ Peer-reviewed End-of-life care International Journal of Nursing Studies Advances

Key finding: The 29-item needs assessment showed strong internal consistency, with a mean Cronbach’s alpha of .89 and McDonald’s omega of .90. +1 more finding

• End-of-Life Care

Full summary, score breakdown and related studies → Original source

MIND diet adherence and cognitive function in Alzheimer's disease: Mediating roles of neural oscillatory markers from resting‐state EEG

37/100 ✓ Peer-reviewed Prevention trials Psychiatry and Clinical Neurosciences

Key finding: MIND scores were significantly lower in the AD group (P < 0.001). +4 more findings

• Lifestyle

Full summary, score breakdown and related studies → Original source

The cGAS–STING Pathway in Dementia: An Emerging Mechanism of Neuroinflammation

38/100 ✓ Peer-reviewed Inflammation and the immune system Brain Sciences

Key finding: Recent advances underscore the pivotal role of neuroinflammation in dementia pathogenesis, particularly in Alzheimer's disease (AD). +4 more findings

• Brain Biology

Full summary, score breakdown and related studies → Original source

Cognitive Functioning of Older Women with Diverse Physical Fitness and Independence – Limitations of Dementia Screening in Primary Healthcare

29/100 ✓ Peer-reviewed Cognitive tests and assessment Medical Studies

Key finding: Wyniki i wnioski Wykazano różnice między grupami A i B w zakresie wszystkich zastosowanych testów przesiewowych (p<0,001). +4 more findings

• Diagnosis

Full summary, score breakdown and related studies → Original source

Delineation of the cognitive and neuropsychiatric features of Pisa syndrome in dementia with Lewy bodies

47/100 ✓ Peer-reviewed Cognitive tests and assessment Frontiers in Aging Neuroscience

Key finding: Our study reveals that PS in DLB is associated with specific deficits in attention and visuospatial/executive function, alongside more severe neuropsychiatric symptoms. +4 more findings

• Other Dementias
• Diagnosis

Full summary, score breakdown and related studies → Original source

Dysfunctional default mode and visual networks underlie cognitive deficits in dementia with Lewy bodies: a resting-state fMRI study

34/100 ✓ Peer-reviewed Cognitive tests and assessment Frontiers in Aging Neuroscience

Key finding: DLB is characterized by DMN and visual network dysfunction, disrupted local neural activity, and impaired global network integration. +2 more findings

• Other Dementias

Full summary, score breakdown and related studies → Original source

Using machine learning for detection of Parkinson’s disease and mild cognitive impairment

39/100 ✓ Peer-reviewed Mild cognitive impairment PLoS ONE

Key finding: Overall, both machine learning techniques had an equivalent performance. +3 more findings

• Early Stage
• Other Dementias
• Digital Tools

Full summary, score breakdown and related studies → Original source

Physical Activity Over the Adult Life Course and Risk of Dementia in the Framingham Heart Study

62/100 ✓ Peer-reviewed How common it is JAMA Network Open

Key finding: This study included 1526 early adult-life (mean [SD] age, 36.7 [4.7] years; 821 [53.8%] female), 1943 midlife (mean [SD] age, 54.0 [5.8] years; 1010 [52.0%] female), and 885 late-life (mean [SD] age, 71.0 [4.5] years; 473 [53.4%] female) participants. +4 more findings

• Risk Factors
• Lifestyle

Full summary, score breakdown and related studies → Original source

β-Amyloid PET Signal Reduction in Prior ARIA-E Regions after Antiamyloid Therapy for Alzheimer Disease

38/100 ✓ Peer-reviewed Biomarkers American Journal of Neuroradiology

Key finding: In 4 of 5 patients treated with lecanemab or donanemab and who had moderate or severe ARIA-E, Aβ PET signal decreased significantly more in regions that had been involved with ARIA-E. +2 more findings

• Treatments
• Side Effects
• Brain Scans

Full summary, score breakdown and related studies → Original source

Community Socioeconomic Disadvantage Relates to White Matter Hyperintensity Burden in Mid-to-Late Life Adults

41/100 ✓ Peer-reviewed Risk factors Psychosomatic Medicine

Key finding: Linear regression models showed that higher community deprivation on the ADI was associated with greater WMH volume, independently of age, sex, years of education, smoking, and time between study visits (beta=0.11, p =.028). +3 more findings

• Risk Factors

Full summary, score breakdown and related studies → Original source

The Integration of Lifestyle Modification Advice and Diet and Physical Exercise Interventions: Cornerstones in the Management of Obesity with Incretin Mimetics

57/100 ✓ Peer-reviewed Prevention and risk Obesity Facts

Key finding: The introduction of incretin mimetics (IMs), including glucagon-like peptide-1 receptor agonists (GLP-1 RAs) such as liraglutide and semaglutide, as well as dual GLP-1/glucose-dependent insulinotropic polypeptide receptor co-agonists (GLP-1/GIP RAs) like tirzepatide, has revolutionized obesity treatment. +1 more finding

• Lifestyle
• Risk Factors
• Prevention

Full summary, score breakdown and related studies → Original source

Cognitive Age Delta as a Marker of Healthy and Pathological Cognitive Aging: The Role of Lifestyle, Cognitive Reserve, and Vascular Risk

40/100 ✓ Peer-reviewed Genetics Journal of Clinical Medicine

Key finding: CAD did not differ across biomarker groups (Kruskal–Wallis H(2) = 0.17, p = 0.91). +4 more findings

Full summary, score breakdown and related studies → Original source

Unfolded proteins and aggregates: The role of proteostasis in pseudoexfoliation pathology

43/100 ✓ Peer-reviewed Disease mechanisms Molecular vision

Key finding: Evidence indicates that chronic proteotoxic stress, arising from aging, oxidative damage, and environmental influences, disrupts the proteostasis network (PN). +4 more findings

Full summary, score breakdown and related studies → Original source

Sleep regularity as an important component of sleep hygiene: a systematic review

71/100 ✓ Peer-reviewed Risk factors Sleep medicine reviews

Key finding: Fifty-nine primary studies met all criteria. +4 more findings

• Risk Factors
• Lifestyle

Full summary, score breakdown and related studies → Original source

Real-world application of lecanemab in early-stage alzheimer's disease: a single-center prospective cohort analysis

70/100 ✓ Peer-reviewed Treatments Alzheimer's research & therapy

Key finding: The mean age was 66 years (65.53 ± 9.31), and 51 (67.1%) participants being female. +4 more findings

• Treatments
• Side Effects

Full summary, score breakdown and related studies → Original source

Spatial Multi-Omics Workflow and Analytical Guidelines for Alzheimer's Neuropathology

16/100 ⚠ Preprint — not yet peer-reviewed Genetics bioRxiv : the preprint server for biology

Key finding: Here, we present an end-to-end pipeline for the GeoMx Digital Spatial Profiler that simultaneously generates whole-transcriptome and 637-protein measurements from user-defined regions within the same tissue sections. +4 more findings

• Brain Biology
• Other Dementias

Scored 22 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

Full summary, score breakdown and related studies → Original source

Developing educational materials to aid in Alzheimer's blood biomarker disclosure

46/100 ✓ Peer-reviewed Biomarkers Alzheimer's & dementia (New York, N. Y.)

Key finding: Participants rated the materials highly regarding value and comprehension. +4 more findings

• Biomarkers

Full summary, score breakdown and related studies → Original source

Intercellular signaling and synaptic deconstruction uncovered by single-cell and spatial transcriptomics in an AD tauopathy model

41/100 ✓ Peer-reviewed Disease mechanisms Communications Biology

Key finding: Our findings reveal how tau hyperphosphorylation and aging alter ligand-receptor communication, transcription factor regulatory networks, and specific cellular networks. +2 more findings

• Brain Biology

Full summary, score breakdown and related studies → Original source