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The spectrum of Alzheimer's disease
J S Novotny, M Čarná, I Lyburn, T Kuruvilla, G B Stokin. medRxiv : the preprint server for health sciences, 2025-11-19
Topic: Plasma and spinal-fluid biomarkers
Plain-language summary
While hippocampal (H) and inferior parietal lobule (IPL) atrophy are used routinely in Alzheimer's disease (AD) diagnostics, the role of enlarged choroid plexus (ChP) remains unclear. We here examined the AD Neuroimaging Initiative (ADNI) cohort (N=872) to investigate the contribution of enlarged ChP in predicting AD using MRI volumetry. Analyses revealed that no individual volumetric brain changes, nor their combination, can predict AD. Among AD patients, only ~ 19%, 12% and 5% exhibited changes in H, ChP or IPL volumes, while 45% showed no volumetric brain changes at all, not even longitudinally. Amyloid-b peptides, therefore, contribute to brain atrophy and neuronal loss at best only in a subset of amyloid PET-CT positive AD patients. These findings suggest that despite shared amyloidopathy, the observed brain volumetric phenotypes, together with their corresponding cognitive and CSF biomarker profiles, represent unique entities within the AD spectrum much like the synucleinopathies, tauopathies and TDP43-proteinopathies.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Novotny, J. S., Čarná, M., Lyburn, I., Kuruvilla, T., & Stokin, G. B. (2025). The spectrum of Alzheimer's disease. medRxiv : the preprint server for health sciences. https://doi.org/10.1101/2025.11.17.25340406
Vancouver
Novotny JS, Čarná M, Lyburn I, Kuruvilla T, Stokin GB. The spectrum of Alzheimer's disease. medRxiv : the preprint server for health sciences. 2025. doi:10.1101/2025.11.17.25340406. PMID: 41332870.
BibTeX
@article{novotny2025-41332870,
author = {Novotny, J S and Čarná, M and Lyburn, I and Kuruvilla, T and Stokin, G B},
title = {{The spectrum of Alzheimer's disease}},
journal = {medRxiv : the preprint server for health sciences},
year = {2025},
doi = {10.1101/2025.11.17.25340406},
pmid = {41332870},
url = {https://doi.org/10.1101/2025.11.17.25340406}
}
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Key findings
- Analyses revealed that no individual volumetric brain changes, nor their combination, can predict AD.
- These findings suggest that despite shared amyloidopathy, the observed brain volumetric phenotypes, together with their corresponding cognitive and CSF biomarker profiles, represent unique entities within the AD spectrum much like the synucleinopathies, tauopathies and TDP43-proteinopathies.
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Study details
- Participants872
- Evidence strengthModerate
How this study scored 16/100
Preprint — not yet peer-reviewed. It scored 33 on the same rubric, but non-peer-reviewed sources are capped at 16, so it shows as 16. Scored zero for study design, effect reported and randomized / blinded because the record does not state it. We have no data on times cited, citations per year, impact for its field and year, cited by studies here, still being cited, senior author's track record, institution's track record, multicenter collaboration and free to read, so those were left out: it earned 20 of the 60 points we could judge it on, which is 33 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 2 / 10 | Tier 4 — not a peer-reviewed journal (medRxiv : the preprint server for health sciences) |
| Journal's citation record | 0 / 4 | Not a journal article, so the journal's record does not count |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 3 / 5 | Rated “moderate” in our summary |
| Peer-review validation | 4 / 10 | Preprint — not yet peer-reviewed. Hosted on a preprint server. |
| How recent | 4 / 5 | 2025 — within 3 year(s) of the newest study here |
| Sample size | 2 / 4 | 872 participants |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomized / blinded | 0 / 2 | No randomization or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | — / 7 | No citation count (not found in OpenAlex) — left out of this score |
| Citations per year | — / 5 | No citation count or no year — left out of this score |
| Impact for its field and year | — / 6 | No field-weighted citation impact (OpenAlex has none yet) — left out of this score |
| Cited by studies here | — / 6 | Not yet checked against this library's citation graph — left out of this score |
| Still being cited | — / 4 | No yearly citation counts — left out of this score |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | — / 3 | No institution listed in OpenAlex — left out of this score |
| Multicenter collaboration | — / 3 | Institutions not listed — left out of this score |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 41332870) |
| Free to read | — / 2 | Access not recorded — left out of this score |
| Points | 20 / 60 | Scored on 11 of 20 parts. We have no data for the rest, so they are left out: 20 of the 60 points we could judge it on is 33 out of 100. |
| Total | 33 / 100 | Capped to 16 because this is not a peer-reviewed article. |
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