Newest studies

Co‐localization of tau and TDP ‐43 after extracellular vesicle delivery to cells

35/100 ✓ Peer-reviewed Brain tissue and pathology FEBS Journal

Key finding: Perturbations in the metabolism of microtubule‐associated protein tau (tau) underlie the pathology of a broad array of dementias, including chronic traumatic encephalopathy, amyotrophic lateral sclerosis (ALS) with cognitive impairment (ALSci) and approximately half of the dementias associated with frontotemporal lobar degeneration. +1 more finding

• Other Dementias

Full summary, score breakdown and related studies → Original source

EEG spectral power differences in Alzheimer’s disease and frontotemporal dementia

33/100 ✓ Peer-reviewed Cognitive tests and assessment International Journal of Neuroscience

Key finding: Both patient groups showed significant deviations from HC, but with distinct patterns. +4 more findings

• Diagnosis

Full summary, score breakdown and related studies → Original source

Measuring Mindfulness: Differences in the 15-Item Five Facet Mindfulness Questionnaire in Black and White Dementia Caregivers

30/100 ✓ Peer-reviewed Disparities Clinical Gerontologist

Key finding: The FFMQ-15 may reflect different experiences of mindfulness among Black caregivers of PWD. +4 more findings

• Caregiving

Full summary, score breakdown and related studies → Original source

Explainable Machine Learning-Based Classification of Clinical Dementia Ratings Using a Tablet-Based Cognitive Assessment

35/100 ✓ Peer-reviewed Getting a diagnosis International Journal of Computational Intelligence Systems

Key finding: Among different ML models, the deep learning model demonstrated superior predictive performance, achieving an accuracy of 100% and 95.8% for training and testing, respectively. +1 more finding

• Diagnosis
• Digital Tools

Full summary, score breakdown and related studies → Original source

CSF α-Synuclein Seed Amplification Assays and Alzheimer Disease Biomarkers in Dementia With Lewy Bodies: Presentation and Progression

53/100 ✓ Peer-reviewed Tau biomarkers Neurology

Key finding: α-Synuclein (αSyn) seed amplification assays (SAAs) accurately detect αSyn pathology in dementia with Lewy bodies (DLB). +3 more findings

• Biomarkers
• Other Dementias

Full summary, score breakdown and related studies → Original source

High-sensitivity plasma proteomics reveals disease-specific signatures and predictive biomarkers of Alzheimer's disease phenotypes in a large mixed-dementia cohort

54/100 ✓ Peer-reviewed Biomarkers Molecular neurodegeneration

Key finding: We identified proteins associated with disease status and AD-related phenotypes (Clinical Dementia Rating®, CSF Aβ42/Aβ40, Amyloid-PET, and Tau-PET). +4 more findings

• Biomarkers
• Other Dementias

Full summary, score breakdown and related studies → Original source

Engineered butyrate-producing yeasts mitigate Alzheimer-associated phenotypes

39/100 ✓ Peer-reviewed Risk genes beyond APOE Signal Transduction and Targeted Therapy

Key finding: Alzheimer’s disease (AD) is the most prevalent neurodegenerative disease without effective treatments. 1 Extracellular amyloid plaques, neurofibrillary tangles, neuroinflammation, and neuronal loss are the characteristics of AD neuropathology. +3 more findings

• Brain Biology

Full summary, score breakdown and related studies → Original source

Challenging the Wine Component in Mediterranean Diet Scores: Cognitive Outcomes in Portuguese Adults at High Risk of Dementia

55/100 ✓ Peer-reviewed Cognitive tests and assessment Nutrients

Key finding: MEDAS-R was positively associated with better MMSE performance (p = 0.043) and showed a borderline association with the MoCA (p = 0.051), but not with the ACE-R score (p = 0.356). +4 more findings

• Lifestyle
• Clinical Trials

Full summary, score breakdown and related studies → Original source

Preclinical and Prodromal Frontotemporal Dementia: Challenges and Opportunities

34/100 ✓ Peer-reviewed Lewy body dementia International Journal of Translational Medicine

Key finding: Increasing evidence indicates that disease mechanisms begin decades before the appearance of clinical symptoms, highlighting the importance of identifying preclinical and prodromal stages.

• Early Stage
• Other Dementias
• Genetics

Full summary, score breakdown and related studies → Original source

A modified α-synuclein seed amplification assay in Lewy body dementia using Raman spectroscopy and machine learning analysis

36/100 ✓ Peer-reviewed Digital health tools Journal of Neuroscience Methods

Key finding: Despite the very limited sample size, these findings highlight the potential of this novel workflow and strongly warrant its validation in larger cohorts.

• Other Dementias
• Digital Tools

Full summary, score breakdown and related studies → Original source

Prevalence and causes of anemia among older adults in India: findings from wave 2 of the Harmonized Diagnostic Assessment of Dementia for the Longitudinal Aging Study in India (LASI-DAD)

58/100 ✓ Peer-reviewed Clinical safety International Journal for Equity in Health

Key finding: The overall national anemia prevalence was 49.92%. +3 more findings

• Diagnosis

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TDP-43 Regulates Rab4 Levels to Support Synaptic Vesicle Recycling and Neuromuscular Connectivity in Drosophila and Human ALS Models

38/100 ✓ Peer-reviewed Brain tissue and pathology International Journal of Molecular Sciences

Key finding: Together, these findings define a TDP-43/Rab4/futsch/MAP1B regulatory axis that couples endosomal dynamics to cytoskeletal assembly.

• Brain Biology

Full summary, score breakdown and related studies → Original source

Polymer-Engineered Aβ-Degrading Proteases via Photo-ATRP for Alzheimer's Disease Therapeutics

27/100 ✓ Peer-reviewed Drug development Eurasian journal of applied biotechnology

Key finding: BSA-polymer conjugates displayed enhanced resistance to proteolytic degradation. +4 more findings

• Treatments
• Brain Biology

Full summary, score breakdown and related studies → Original source

Predicting mild cognitive impairment in patients with Parkinson’s disease by integrating striatal MRI radiomics with clinical features

40/100 ✓ Peer-reviewed Mild cognitive impairment BMC Medical Imaging

Key finding: Age and years of education (YOE) were identified as independent clinical risk factors for PD-MCI. +4 more findings

• Early Stage
• Brain Scans

Full summary, score breakdown and related studies → Original source

Mild Cognitive Impairment and Sarcopenia: Effects of Resistance Exercise Training on Neuroinflammation, Cognitive Performance, and Structural Brain Changes

39/100 ✓ Peer-reviewed Mild cognitive impairment International Journal of Molecular Sciences

Key finding: Clinically, RET has demonstrated significant and sustained improvements in executive function, memory, and global cognition, with effects persisting for up to 18 months.

• Early Stage
• Brain Biology
• Lifestyle

Full summary, score breakdown and related studies → Original source

Predictors of Transition from Mild Cognitive Impairment to Normal Cognition and Dementia

41/100 ✓ Peer-reviewed Disparities Behavioral Sciences

Key finding: Patients in the rMCI group were significantly younger and had a higher level of education compared with those in the pMCI group. +2 more findings

• Early Stage
• Brain Scans

Full summary, score breakdown and related studies → Original source

End-of-Life Care for Older Adults With Dementia by Race and Ethnicity and Physicians’ Role

51/100 ✓ Peer-reviewed Disparities JAMA Health Forum

Key finding: Among 259 945 decedents with dementia (mean [SD] age, 85.8 [8.0] years; 60.4% female), 8.3% were non-Hispanic Black, 4.4% were Hispanic, and 87.3% were non-Hispanic White. +4 more findings

• Health Equity
• End-of-Life Care

Full summary, score breakdown and related studies → Original source

An Ultra-Brief Informant Questionnaire for Case Finding of Cognitive Impairment Across Diverse Literacy: Diagnostic Accuracy Study

32/100 ✓ Peer-reviewed Getting a diagnosis JMIR Aging

Key finding: This ultra-brief questionnaire enables rapid screening for cognitive impairment (in <1 min) by family members or as part of community geriatric assessments. +1 more finding

• Diagnosis

Full summary, score breakdown and related studies → Original source

The Multinutrient Fortasyn Connect Influences Gut Microbiota and Intestinal Function in Early Alzheimer's Disease

50/100 ✓ Peer-reviewed Disease mechanisms Aging and disease

Key finding: In patients, supplementation was associated with higher fecal abundance of Bifidobacterium and Christensenellaceae, reduced inflammatory markers (calprotectin and myeloperoxidase), and increased butyrate levels.

• Brain Biology
• Lifestyle

Full summary, score breakdown and related studies → Original source

Using retinal diagnostics as a biomarker for neurodegenerative diseases: protocol for a systematic review

71/100 ✓ Peer-reviewed Brain scans and imaging BMJ open

Key finding: A narrative synthesis approach will be used to analyse the results, with meta-analysis performed if there is sufficient data.

Full summary, score breakdown and related studies → Original source

Acupuncture modulates the microbiota-gut-brain axis: a novel therapeutic strategy for amnestic mild cognitive impairment

33/100 ✓ Peer-reviewed Mild cognitive impairment Frontiers in Neuroscience

Key finding: Amnestic mild cognitive impairment (aMCI) represents a critical prodromal stage of Alzheimer's disease (AD), yet effective therapeutic interventions to prevent or delay this conversion remain an unmet clinical need. +4 more findings

• Early Stage
• Treatments

Full summary, score breakdown and related studies → Original source

Predictive factors for dementia among older adults in South Korea: an interpretable machine learning analysis

46/100 ✓ Peer-reviewed Digital health tools Alzheimer s Research & Therapy

Key finding: Predictive performance was comparable across algorithms, with R² ranging from 0.201 to 0.361, highest in the MCI_All dataset. +4 more findings

• Digital Tools

Full summary, score breakdown and related studies → Original source

Dementia in older adults with schizophrenia: a 12-year analysis of prevalence, incidence, and treatment patterns in South Korea

45/100 ✓ Peer-reviewed How common it is Schizophrenia

Key finding: Older adults with schizophrenia face a significantly elevated risk of dementia. +2 more findings

• Risk Factors
• Treatments

Full summary, score breakdown and related studies → Original source

Healthy Brain Healthy Life: an innovative and culturally tailored approach to dementia prevention in minority ethnic communities

29/100 ✓ Peer-reviewed Disparities Research for All

Key finding: Despite having an increased risk of developing dementia, individuals from minority ethnic communities are largely overlooked by research and dementia services and are less likely to receive timely diagnosis and appropriate support.

• Health Equity
• Prevention

Full summary, score breakdown and related studies → Original source

Diagnostic Value of Serum p-tau217 in Alzheimer Disease: Equal to Plasma in Levels and Clinical Utility?

51/100 ✓ Peer-reviewed Biomarkers Clinical Chemistry

Key finding: High correlations between plasma and serum were observed for most assays (ρ > 0.8), though plasma often yielded higher concentrations. +4 more findings

• Biomarkers

Full summary, score breakdown and related studies → Original source