Newest studies

Age-specific and sex-specific prevalence of cerebral β-amyloidosis, tauopathy, and neurodegeneration in cognitively unimpaired individuals aged 50-95 years: a cross-sectional study

53/100 ✓ Peer-reviewed Brain scans and imaging The Lancet. Neurology

Key finding: Dichotomising these biomarkers as normal or abnormal results in eight possible profiles. +1 more finding

Full summary, score breakdown and related studies → Original source

Comparison of CSF markers and semi-quantitative amyloid PET in Alzheimer's disease diagnosis and in cognitive impairment prognosis using the ADNI-2 database

59/100 ✓ Peer-reviewed Long-term cohort studies Alzheimer's research & therapy

Key finding: The relative performance of semi-quantitative amyloid positron emission tomography (PET) and cerebrospinal fluid (CSF) markers in diagnosing Alzheimer's disease (AD) and predicting the cognitive evolution of patients with mild cognitive impairment (MCI) is still debated. +3 more findings

• Diagnosis
• Biomarkers
• Brain Scans

Full summary, score breakdown and related studies → Original source

Neuropsychological Testing and Machine Learning Distinguish Alzheimer's Disease from Other Causes for Cognitive Impairment

48/100 ✓ Peer-reviewed Tau biomarkers Frontiers in aging neuroscience

Key finding: However, existing diagnostic methods are either invasive (lumbar punctures, PET) or inaccurate Magnetic Resonance Imaging (MRI). +3 more findings

• Brain Scans

Full summary, score breakdown and related studies → Original source

UK Biobank: opportunities for cardiovascular research

79/100 ✓ Peer-reviewed Genetics European Heart Journal

Key finding: The need for large sample sizes has led to collaborative efforts, such as the Prospective Studies Collaboration (an individual participant meta-analysis of data from 61 studies and more than a million participants11) that has demonstrated conclusively that a continuous increase in blood pressure corresponds with an increased risk of vascular death across all age groups (see Figure 1 that illustrates the importance of a large sample size (about 500 000 participants) for detecting this association).12 Sample size is also of particular importance in the current era of genome-wide association studies, where many investigations are aiming to detect either small effects from common variants or large effects from rare variants.13 Absolute risk of ischaemic heart disease mortality by usual systolic blood pressure and age at risk in 5000, 50 000, and 500 000 participants. +4 more findings

• Genetics
• Risk Factors

Full summary, score breakdown and related studies → Original source

Brain metabolism in health, aging, and neurodegeneration

38/100 ✓ Peer-reviewed Disease mechanisms The EMBO journal

Key finding: At the molecular level, bioenergetic challenges result in the activation of transcription factors that induce the expression of proteins that bolster the resistance of neurons to the kinds of metabolic, oxidative, excitotoxic, and proteotoxic stresses involved in the pathogenesis of brain disorders including stroke, and Alzheimer's and Parkinson's diseases. +1 more finding

• Brain Biology

Full summary, score breakdown and related studies → Original source

Specialty Palliative Care Consultations for Nursing Home Residents With Dementia

43/100 ✓ Peer-reviewed End-of-life care Journal of pain and symptom management

Key finding: Consultations appear to reduce acute care use and (potentially) burdensome transitions for dying residents with dementia.

• End-of-Life Care
• Care Services

Full summary, score breakdown and related studies → Original source

TREM2, Microglia, and Neurodegenerative Diseases

49/100 ✓ Peer-reviewed TREM2 and immune genetics Trends in molecular medicine

Key finding: The neuropathological hallmarks of the disease are extracellular amyloid-β (Aβ) plaques and intraneuronal hyperphosphorylated tau aggregates. +3 more findings

• Genetics
• Brain Biology

Full summary, score breakdown and related studies → Original source

Role of inflammatory and hemostatic biomarkers in Alzheimer's and vascular dementia - A pilot study from a tertiary center in Northern India

36/100 ✓ Peer-reviewed Biomarkers Asian journal of psychiatry

Key finding: Hemostatic biomarkers were higher in Vascular group compared to Alzheimer group whereas there was no difference in inflammatory biomarkers. +4 more findings

• Biomarkers
• Brain Scans
• Other Dementias

Full summary, score breakdown and related studies → Original source

Developing indicators of appropriate and inappropriate end-of-life care in people with Alzheimer's disease, cancer or chronic obstructive pulmonary disease for population-level administrative databases: A RAND/UCLA appropriateness study

38/100 ✓ Peer-reviewed Digital health tools Palliative medicine

Key finding: We developed a comprehensive set of quality indicators of appropriate and inappropriate end-of-life care in people with Alzheimer's disease, cancer or chronic obstructive pulmonary disease, to be used in population-level research.

• End-of-Life Care

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Family and Other Unpaid Caregivers and Older Adults with and without Dementia and Disability

52/100 ✓ Peer-reviewed Caregiving Journal of the American Geriatrics Society

Key finding: Caregivers of care recipients without dementia or disability accounted for the largest absolute number of helpers. +1 more finding

• Caregiving

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Hearing Loss and Risk of Mild Cognitive Impairment and Dementia: Findings from the Singapore Longitudinal Ageing Study

59/100 ✓ Peer-reviewed Risk factors Dementia and geriatric cognitive disorders

Key finding: Hearing loss is independently associated with prevalent dementia and incident MCI or dementia. +2 more findings

• Risk Factors
• Early Stage
• Diagnosis

Full summary, score breakdown and related studies → Original source

TREM2-Ligand Interactions in Health and Disease

48/100 ✓ Peer-reviewed TREM2 and immune genetics Journal of molecular biology

Key finding: In recent years, the importance of TREM2 has been highlighted by the identification of coding variants that increase risk for Alzheimer's disease and other neurodegenerative diseases. +3 more findings

• Genetics

Full summary, score breakdown and related studies → Original source

Cognitive Impairment and Heart Failure: Systematic Review and Meta-Analysis

70/100 ✓ Peer-reviewed How common it is Journal of cardiac failure

Key finding: This review suggests a substantial proportion of patients with heart failure have concomitant cognitive problems. +3 more findings

• Risk Factors

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Primary motor cortex alterations in Alzheimer disease: A study in the 3xTg-AD model

34/100 ✓ Peer-reviewed Biomarkers Neurologia

Key finding: Patients with AD display signs and symptoms of functional impairment from early stages. +2 more findings

• Brain Biology

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Brain-predicted age in Down syndrome is associated with beta amyloid deposition and cognitive decline

48/100 ✓ Peer-reviewed Digital health tools Neurobiology of aging

Key finding: Mean brain-PAD in DS participants' was +2.49 years, significantly greater than controls (p < 0.001). +2 more findings

• Brain Scans
• Down Syndrome

Full summary, score breakdown and related studies → Original source

Resting-state network dysfunction in Alzheimer's disease: A systematic review and meta-analysis

83/100 ✓ Peer-reviewed Brain scans and imaging Alzheimer's & dementia (Amsterdam, Netherlands)

Key finding: Convergent evidence across the literature supports the use of resting-state connectivity as a biomarker of AD. +1 more finding

• Brain Scans

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What Older People Like to Play: Genre Preferences and Acceptance of Casual Games

48/100 ✓ Peer-reviewed Prevention trials JMIR serious games

Key finding: Overall, enjoyment and acceptance of casual game characteristics was high and significantly above the midpoint of the rating scale for all CVG genres. +4 more findings

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Plasma neurofilament light chain levels in Alzheimer's disease

49/100 ✓ Peer-reviewed Long-term cohort studies Neuroscience letters

Key finding: We examined whether plasma NFL might be a potential biomarker for the prodromal and dementia stages of AD. +3 more findings

• Biomarkers
• Early Stage

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Multimodal PET Imaging of Amyloid and Tau Pathology in Alzheimer Disease and Non-Alzheimer Disease Dementias

38/100 ✓ Peer-reviewed Biomarkers PET clinics

Key finding: Biomarkers of the molecular pathology underpinning dementia syndromes are increasingly recognized as crucial for diagnosis and development of disease-modifying treatments. +4 more findings

• Brain Scans
• Brain Biology

Full summary, score breakdown and related studies → Original source

Referring patients to hospice or palliative care

39/100 ✓ Peer-reviewed End-of-life care The Nurse practitioner

Key finding: NPs care for patients with chronic diseases such as heart failure, chronic obstructive pulmonary disease, cancer, and dementia. +2 more findings

• End-of-Life Care

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Neuropsychological measures that detect early impairment and decline in preclinical Alzheimer disease

64/100 ✓ Peer-reviewed Tau biomarkers Neurobiology of aging

Key finding: Identifying which neuropsychological measures detect early cognitive changes associated with Alzheimer disease (AD), brain pathology would be helpful clinically for the diagnosis of early AD and for the design of clinical trials. +2 more findings

• Biomarkers

Full summary, score breakdown and related studies → Original source

Toll-like receptor 4 in glial inflammatory responses to air pollution in vitro and in vivo

41/100 ✓ Peer-reviewed Risk factors Journal of neuroinflammation

Key finding: These results show TLR4 activation is integral in brain inflammatory responses to air pollution, and warrant further study of TLR4 in accelerated cognitive aging by air pollution. +3 more findings

• Brain Biology
• Risk Factors

Full summary, score breakdown and related studies → Original source

UB-311, a novel UBITh® amyloid β peptide vaccine for mild Alzheimer's disease

45/100 ✓ Peer-reviewed Cognitive tests and assessment Alzheimer's & dementia (New York, N. Y.)

Key finding: A novel amyloid β (Aβ) synthetic peptide vaccine (UB-311) has been evaluated in a first-in-human trial with patients of mild-to-moderate Alzheimer's disease. +3 more findings

• Prevention

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Prion-like Spreading in Tauopathies

38/100 ✓ Peer-reviewed Disease mechanisms Biological psychiatry

Key finding: A wealth of evidence has emerged within the last decade to suggest that the misfolded tau in tauopathies possesses prion-like features and that such features may explain the diverse characteristics of tauopathies. +2 more findings

• Brain Biology

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A review on neuroimaging-based classification studies and associated feature extraction methods for Alzheimer's disease and its prodromal stages

56/100 ✓ Peer-reviewed Mild cognitive impairment NeuroImage

Key finding: Neuroimaging has made it possible to measure pathological brain changes associated with Alzheimer's disease (AD) in vivo. +1 more finding

• Brain Scans
• Early Stage

Full summary, score breakdown and related studies → Original source