Newest studies

Increased risk of chronic diseases and multimorbidity in middle-aged and elderly individuals with early vision, hearing, or dual sensory impairments: insights from prospective cohort studies and Mendelian randomization analysis

77/100 ✓ Peer-reviewed Risk factors BMC medicine

Key finding: The cohort study revealed that persistent HI significantly increased the risk of heart disease (P < 0.001, HR 1.63, 95% CI 1.31-2.03), stroke (P 0.004, HR 1.59, 95% CI 1.16-2.18), chronic lung disease (P 0.002, HR 1.53, 95% CI 1.17-1.99), and emotional, nervous, or psychiatric problems (P 0.016, HR 2.03, 95% CI 1.14-3.60). +4 more findings

• Risk Factors

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Impacts of tirzepatide on older patients with diminished β-cell function and dementia

43/100 ✓ Peer-reviewed Drug development Geriatrics & gerontology international

Key finding: Tirzepatide could control postprandial hyperglycemia even in cases with diminished β-cell function. +2 more findings

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18F-MK-6240 tau PET in patients at-risk for chronic traumatic encephalopathy

50/100 ✓ Peer-reviewed Brain scans and imaging Molecular neurodegeneration

Key finding: All six CTE stage III cases had Braak NFT stage III but no neuritic plaques. +4 more findings

• Brain Scans
• Clinical Trials
• Other Dementias

Full summary, score breakdown and related studies → Original source

Lecanemab for early Alzheimer's disease: Appropriate use recommendations from the French federation of memory clinics

45/100 ✓ Peer-reviewed Treatments The journal of prevention of Alzheimer's disease

Key finding: Lecanemab, a monoclonal antibody targeting β-amyloid protofibrils, has shown promising results in a Phase III clinical trial for the treatment of early stages of Alzheimer's disease (AD) and has been approved by the European Medicines Agency.

• Treatments
• Care Services
• Clinical Trials

Full summary, score breakdown and related studies → Original source

Unravelling the nexus of stroke and dementia: Deciphering the role of secondary neurodegeneration in orchestrating cognitive decline

32/100 ✓ Peer-reviewed Vascular contributions Neuroprotection/Neuroprotection (Chichester, England. Print)

Key finding: Even with this increased risk of PSCI and PSD in stroke survivors, understanding of how the stroke itself develops into these conditions remains incomplete. +1 more finding

• Risk Factors

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Prevalence and Risk Factors for Delirium on Arrival at the Emergency Room by Ambulance

53/100 ✓ Peer-reviewed Clinical safety Cureus

Key finding: Of the 20,660 patients who visited the ER, 1,486 patients who were transported by ambulance were included in this study. +4 more findings

• Risk Factors

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The Influence of a Specialized Dementia Ward on the Treatment of Alzheimer’s Disease Patients

36/100 ✓ Peer-reviewed Cognitive tests and assessment Journal of Personalized Medicine

Key finding: No statistically significant differences emerged between SDW and GW groups regarding baseline demographics, cognitive function, ADL, or neuropsychiatric symptoms. +4 more findings

• Treatments

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THE ROLE OF AI (ARTIFICIAL INTELLIGENCE) FOR ALZHEIMER: A SYSTEMATIC REVIEW

27/100 ✓ Peer-reviewed Digital health tools JITK (Jurnal Ilmu Pengetahuan dan Teknologi Komputer)

Key finding: Alzheimer's disease (AD) is the most common type of dementia and represents a significant global health problem due to its profound impact on patients' quality of life and the heavy burden it places on health care.

• Digital Tools

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Long-Term Exposure to PM 2.5 Constituents, Genetic Susceptibility, and Incident Dementia: A Prospective Cohort Study among 0.2 Million Older Adults

51/100 ✓ Peer-reviewed Disparities Environmental Science & Technology

Key finding: Our results showed that black carbon (BC), ammonium (NH 4 + ), organic matter (OM), and sulfate (SO 4 2– ) were positively associated with all-cause dementia, while BC and OM were linked to AD, with BC being the most influential.

• Genetics
• Risk Factors

Full summary, score breakdown and related studies → Original source

Interactive AI Technology for Dementia Caregivers: Needs and Implementation Evidence

53/100 ✓ Peer-reviewed Caregiving Journal of Technology in Human Services

Key finding: Our analyses of qualitative data findings revealed a demand for interactive agile AI solutions emphasizing emotional and social support.

• Digital Tools
• Caregiving

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Who’s On Your Team? Classifying Dementia Caregiving Networks and Associations With the Well-being of Caregivers and Care Recipients With Dementia

44/100 ✓ Peer-reviewed Caregiving The Journals of Gerontology Series B

Key finding: 3 network types were identified: "Siloed"-small networks, limited task sharing (29.8% of networks); "Small but Mighty"-small networks, high task sharing (23.0% of networks); and "Complex"-large networks, diverse membership, members who share and specialize in task assistance (47.2%). +2 more findings

• Caregiving

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The role of neuroimaging in Alzheimer’s disease: implications for the diagnosis, monitoring disease progression, and treatment

40/100 ✓ Peer-reviewed Brain scans and imaging Exploration of neuroscience

Key finding: It presents a significant challenge in terms of accurate diagnosis, disease progression monitoring, and the development of effective treatments. +2 more findings

• Brain Scans
• Treatments
• Diagnosis

Full summary, score breakdown and related studies → Original source

Adherence to the Mediterranean Diet and Obesity-Linked Cancer Risk in EPIC

65/100 ✓ Peer-reviewed Prevention and risk JAMA Network Open

Key finding: A total of 450 111 participants were included in the study (mean [SD] age, 51.1 [9.8] years; 70.8% women) and followed up during a median (IQR) time of 14.9 (4.1) years. +4 more findings

• Risk Factors
• Prevention
• Lifestyle

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Lecanemab autorizado para tratamiento del Alzhéimer en pacientes que tienen una o ninguna copia de ApoE4: una reacción adversa grave limita su uso

27/100 ✓ Peer-reviewed Treatments Panorama actual del medicamento

Key finding: La Agencia Europea de Medicamentos (EMA), tras realizar su comité CHMP una nueva evaluación de su dictamen inicial negativo en julio 2024, ha recomendado que se otorgue una autorización de comercialización limitada a pacientes de Alzheimer, que tienen una o ninguna copia de ApoE4, una determinada forma del gen de la proteína apolipoproteína E. +1 more finding

• Treatments

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DNA methylation patterns contribute to changes of cellular differentiation pathways in leukocytes with LOY from patients with Alzheimer´s disease

41/100 ✓ Peer-reviewed Genetics Cellular and Molecular Life Sciences

Key finding: In males, loss of chromosome Y (LOY) in leukocytes is strongly associated with AD. +4 more findings

• Genetics

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Heat-shock chaperone HSPB1 mitigates poly-glycine-induced neurodegeneration via restoration of autophagic flux

36/100 ✓ Peer-reviewed Biomarkers Autophagy

Key finding: Taken together, these findings highlight a mechanistic basis for the neuroprotective effects of HSPB1 and suggest its potential as a therapeutic target in treating poly-G-associated neurodegenerative diseases.

• Brain Biology

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Impact of Implantable Hearing Devices on Delirium Risk in Patients with Hearing Loss: A National Database Study

48/100 ✓ Peer-reviewed Clinical safety Otology & Neurotology

Key finding: The control cohort (n = 36.5 million) was 1:1 PSM for age and sex with the HL cohort (n = 1.77 million) in which 0.28% of patients developed delirium compared to 0.74% in the HL cohort (OR 2.66, 95% CI = 2.58-2.75). +4 more findings

• Risk Factors

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The Effect of Aerobic or Strength Training in Elderly with Cognitive Decline: The Fit4Alz Project

40/100 ✓ Peer-reviewed Prevention trials Journal of Sports Science and Medicine

Key finding: A repeated-measures ANCOVA revealed significant time-by-group interactions for physical performance measures, including the 2-minute step-in-place (p = 0.026), arm curl (p < 0.001), chair sit-and-reach (p < 0.001), back-scratch (p < 0.001), 8-foot up-and-go (p < 0.001), and 6-minute walk tests (p < 0.001). +4 more findings

• Diagnosis
• Lifestyle

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HIV-1 gp120 Interactions with Nicotine Modulate Mitochondrial Network Properties and Amyloid Release in Microglia

36/100 ✓ Peer-reviewed Inflammation and the immune system Neurochemical Research

Key finding: Human immunodeficiency virus (HIV) infections remain a significant public health burden globally with infected individuals at high risk for cognitive decline and memory loss even on combination antiretroviral therapy. +1 more finding

• Brain Biology

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Evaluation of cerebrospinal fluid levels of VAMP-2 and SNAP-25 in a dementia with Lewy bodies clinical cohort stratified by Alzheimer’s pathophysiological biomarkers

49/100 ✓ Peer-reviewed Cognitive tests and assessment Alzheimer s Research & Therapy

Key finding: Soluble N-ethylmaleimide-sensitive factor attachment proteins receptors (SNARE) proteins, such as VAMP-2 and SNAP-25, are implicated in α-synuclein pathophysiology and CSF levels of these proteins are associated with pathophysiological biomarkers and cognitive decline in Alzheimer’s disease (AD). +4 more findings

• Biomarkers
• Other Dementias

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Hippocampal mitophagy alterations in MAPT-associated frontotemporal dementia with parkinsonism

35/100 ✓ Peer-reviewed Lewy body dementia Acta Neuropathologica Communications

Key finding: We previously demonstrated a significant accumulation of pS65-Ub signals in autopsy brains of sporadic Lewy body disease and Alzheimer's disease cases, which strongly correlated with early tau pathology. +3 more findings

• Other Dementias
• Brain Biology

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Insights for dementia risk reduction among lower SES adults in OECD countries: scoping review of interventions targeting multiple common health risk factors

42/100 ✓ Peer-reviewed Risk factors International Journal for Equity in Health

Key finding: While several studies have demonstrated the feasibility of multidomain dementia risk reduction interventions in relatively older, educated and wealthy populations, we are not aware of any studies to date explicitly targeting younger adults (< 50 years) with lower socioeconomic status. +3 more findings

• Risk Factors
• Prevention
• Lifestyle

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Cognitive performance classification of older patients using machine learning and electronic medical records

49/100 ✓ Peer-reviewed Digital health tools Scientific Reports

Key finding: Dementia rates are projected to increase significantly by 2050, posing considerable challenges for healthcare systems worldwide. +2 more findings

• Digital Tools

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Antidepressant use and cognitive decline in patients with dementia: a national cohort study

66/100 ✓ Peer-reviewed How common it is BMC Medicine

Key finding: We included 18740 patients (10 205 women [54.5%]; mean [SD] age, 78.2[7.4] years), of which 4271 (22.8%) received at least one prescription for an antidepressant. +4 more findings

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Association between chronic illnesses in older adults and caregiver burden: a cross sectional study in the United States

46/100 ✓ Peer-reviewed Caregiving Aging & Mental Health

Key finding: Dementia was significantly associated with caregiver burden related to emotional difficulty (odds ratio [OR] = 2.04; 95% confidence interval [CI], 1.34-3.09) and physical difficulty (OR = 1.67, 95% CI, 1.01-2.78), but not financial difficulty. +2 more findings

• Caregiving

Full summary, score breakdown and related studies → Original source