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MIND diet adherence and cognitive function in Alzheimer's disease: Mediating roles of neural oscillatory markers from resting‐state EEG
Shijing Wu, Lihua Chen, Yurou He, Juanli Liu, Zhangjing Deng, Yingxi Chen, Ze-Hu Sheng, Boyuan Xia et al.. Psychiatry and Clinical Neurosciences, 2025-11-19
Topic: Amyloid, tau and blood-test diagnosis
MIND scores were significantly lower in the AD group (P < 0.001). Higher MIND adherence was linked to better global cognition, lower dementia severity, fewer mood symptoms, and greater daily functioning (P < 0.05). Individuals in the lowest adherence tertile had 6.78 times higher odds of cognitive impairment compared to those in the highest tertile (OR = 6.78, 95% CI: 4.54-10.13, P < 0.001). EEG analyses revealed that greater MIND adherence was associated with increased alpha power, reduced occipital theta/beta and delta/alpha ratios, and stronger frontoparietal connectivity. Mediation analysis indicated that frontal and global alpha power partially mediated the associations between MIND diet adherence and dementia severity, mood symptoms, and functional status. High MIND adherence is associated with improved cognitive and functional outcomes in AD. EEG signatures may partially mediate these effects, highlighting the clinical potential of the MIND diet for early intervention and neurophysiological monitoring.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Wu, S., Chen, L., He, Y., Liu, J., Deng, Z., Chen, Y., et al. (2025). MIND diet adherence and cognitive function in Alzheimer's disease: Mediating roles of neural oscillatory markers from resting‐state EEG. Psychiatry and Clinical Neurosciences. https://doi.org/10.1111/pcn.13923
Vancouver
Wu S, Chen L, He Y, Liu J, Deng Z, Chen Y, et al. MIND diet adherence and cognitive function in Alzheimer's disease: Mediating roles of neural oscillatory markers from resting‐state EEG. Psychiatry and Clinical Neurosciences. 2025. doi:10.1111/pcn.13923. PMID: 41261525.
BibTeX
@article{wu2025-41261525,
author = {Wu, Shijing and Chen, Lihua and He, Yurou and Liu, Juanli and Deng, Zhangjing and Chen, Yingxi and Sheng, Ze-Hu and Xia, Boyuan and others},
title = {{MIND diet adherence and cognitive function in Alzheimer's disease: Mediating roles of neural oscillatory markers from resting‐state EEG}},
journal = {Psychiatry and Clinical Neurosciences},
year = {2025},
doi = {10.1111/pcn.13923},
pmid = {41261525},
url = {https://doi.org/10.1111/pcn.13923}
}
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Key findings
- MIND scores were significantly lower in the AD group (P < 0.001).
- Higher MIND adherence was linked to better global cognition, lower dementia severity, fewer mood symptoms, and greater daily functioning (P < 0.05).
- Individuals in the lowest adherence tertile had 6.78 times higher odds of cognitive impairment compared to those in the highest tertile (OR = 6.78, 95% CI: 4.54-10.13, P < 0.001).
- EEG analyses revealed that greater MIND adherence was associated with increased alpha power, reduced occipital theta/beta and delta/alpha ratios, and stronger frontoparietal connectivity.
- Mediation analysis indicated that frontal and global alpha power partially mediated the associations between MIND diet adherence and dementia severity, mood symptoms, and functional status.
Why it matters
In this study, higher MIND diet adherence was associated with better cognition, lower dementia severity, fewer mood symptoms and greater daily functioning in people with Alzheimer's disease. EEG markers partially mediated these associations, but the study cannot show that the diet causes these improvements.
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Study details
- Participants204
- Effect sizeOR = 6.78
- Evidence strengthLow
How this study scored 37/100
Published in a peer-reviewed journal. Scored zero for study design and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Psychiatry and Clinical Neurosciences) |
| Journal's citation record | 1 / 4 | Psychiatry and Clinical Neurosciences: journal h-index 120 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 4 / 5 | 2025 — within 3 year(s) of the newest study here |
| Sample size | 2 / 4 | 204 participants |
| Effect reported | 3 / 3 | Effect reported with a statistic (interval, p-value, ratio or similar) |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 1 / 7 | Cited 1 times (OpenAlex, 2026-10-10) |
| Citations per year | 0 / 5 | 0.3 citations a year over 3 year(s) since 2025 |
| Impact for its field and year | 1 / 6 | Cited 0.6× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 0 / 6 | No other study in this library cites it |
| Still being cited | 0 / 4 | Cited 1 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 1 / 4 | Last-listed author Yang Lü: h-index 19 (OpenAlex, whole career) |
| Institution's track record | 0 / 3 | Chongqing Medical University: institution h-index 359 (OpenAlex) |
| Multi-centre collaboration | 1 / 3 | OpenAlex lists 3 institution(s) in 1 country |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 41261525) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Total | 37 / 100 | — |
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