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Community Socioeconomic Disadvantage Relates to White Matter Hyperintensity Burden in Mid-to-Late Life Adults
Anna L. Marsland, Minjie Wu, Mia K. DeCataldo, Howard Jay Aizenstein, Jinghang Li, Tamer S. Ibrahim, Stephen B. Manuck, Peter J. Gianaros. Psychosomatic Medicine, 2025-11-19
Topic: Risk, prevention and care in population studies
Linear regression models showed that higher community deprivation on the ADI was associated with greater WMH volume, independently of age, sex, years of education, smoking, and time between study visits (beta=0.11, p =.028). This association was largely independent of blood pressure, cardiometabolic risk, and systemic inflammation. The present novel findings add to growing evidence that community disadvantage relates to preclinical neurodegenerative changes, which may contribute to accelerated brain and cognitive aging. Future work is warranted to better understand pathways that link residential environments to brain health and to identify targets for community and public policy interventions.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Marsland, A. L., Wu, M., DeCataldo, M. K., Aizenstein, H. J., Li, J., Ibrahim, T. S., et al. (2025). Community Socioeconomic Disadvantage Relates to White Matter Hyperintensity Burden in Mid-to-Late Life Adults. Psychosomatic Medicine. https://doi.org/10.1097/psy.0000000000001453
Vancouver
Marsland AL, Wu M, DeCataldo MK, Aizenstein HJ, Li J, Ibrahim TS, et al. Community Socioeconomic Disadvantage Relates to White Matter Hyperintensity Burden in Mid-to-Late Life Adults. Psychosomatic Medicine. 2025. doi:10.1097/psy.0000000000001453. PMID: 41257402.
BibTeX
@article{marsland2025-41257402,
author = {Marsland, Anna L. and Wu, Minjie and DeCataldo, Mia K. and Aizenstein, Howard Jay and Li, Jinghang and Ibrahim, Tamer S. and Manuck, Stephen B. and Gianaros, Peter J.},
title = {{Community Socioeconomic Disadvantage Relates to White Matter Hyperintensity Burden in Mid-to-Late Life Adults}},
journal = {Psychosomatic Medicine},
year = {2025},
doi = {10.1097/psy.0000000000001453},
pmid = {41257402},
url = {https://doi.org/10.1097/psy.0000000000001453}
}
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record names 8 authors; APA and Vancouver show the first six, BibTeX and the downloads carry all of them. Check the citation against the original before you use it.
Key findings
- Linear regression models showed that higher community deprivation on the ADI was associated with greater WMH volume, independently of age, sex, years of education, smoking, and time between study visits (beta=0.11, p =.028).
- This association was largely independent of blood pressure, cardiometabolic risk, and systemic inflammation.
- The present novel findings add to growing evidence that community disadvantage relates to preclinical neurodegenerative changes, which may contribute to accelerated brain and cognitive aging.
- Future work is warranted to better understand pathways that link residential environments to brain health and to identify targets for community and public policy interventions.
Why it matters
This study found that higher community deprivation on the Area Deprivation Index was associated with greater white matter hyperintensity volume, largely independent of blood pressure, cardiometabolic risk, and systemic inflammation. The authors call for future work to understand pathways linking residential environments to brain health, so no treatment, cure, or prevention is established.
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Study details
- Participants388
- Evidence strengthLow
How this study scored 41/100
Published in a peer-reviewed journal. Scored zero for study design, effect reported and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Psychosomatic Medicine) |
| Journal's citation record | 3 / 4 | Psychosomatic Medicine: journal h-index 293 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 4 / 5 | 2025 — within 3 year(s) of the newest study here |
| Sample size | 2 / 4 | 388 participants |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 1 / 7 | Cited 2 times (OpenAlex, 2026-10-10) |
| Citations per year | 0 / 5 | 0.7 citations a year over 3 year(s) since 2025 |
| Impact for its field and year | 2 / 6 | Cited 2.2× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 0 / 6 | No other study in this library cites it |
| Still being cited | 0 / 4 | Cited 2 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 3 / 4 | Last-listed author Peter J. Gianaros: h-index 67 (OpenAlex, whole career) |
| Institution's track record | 1 / 3 | University of Pittsburgh: institution h-index 1,470 (OpenAlex) |
| Multi-centre collaboration | 0 / 3 | OpenAlex lists 1 institution(s) in 1 country — scores zero (affiliation lists can be incomplete) |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 41257402) |
| Free to read | 2 / 2 | Free to read |
| Total | 41 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
- DOI: 10.1097/psy.0000000000001453
- PubMed: 41257402
- Original source →
- Free full text: Psychosomatic Medicine →
Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).
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