Each study has a usefulness score out of 100 (rubric version 4.0). Tap a score to see what makes it up.
Highest usefulness score first. Studies without a score come last.
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Mild Cognitive Impairment (MCI) is a transitional stage between normal age-related cognitive decline and the more severe cognitive loss seen in dementia.
Why it matters
This review describes eye tracking as a promising non-invasive method to examine cognitive functions related to eye movements for detecting mild cognitive impairment. It notes that no cure exists and current treatments only slow disease progression.
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The expansive challenges, issues and opportunities depicted by shifting climatic spheres as they exert hazardous consequences on humanity due to their emergence.
Why it matters
This paper is about extreme hydrologic events and climate change effects on environment and health, not about Alzheimer's disease. It provides no information relevant to treating, curing, or preventing Alzheimer's disease.
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39/100
The study involved 649 individuals in the CI group, 35,076 in the HA, 16,494 in the NR, and 1,280,788 in the NHL group.
Why it matters
This study found that cochlear implantation was associated with reduced incidence of dementia in individuals with severe to profound hearing loss, with the CI group showing a lower risk than the HA group and a similar risk to those with normal hearing. It suggests that auditory rehabilitation may play a role in reducing dementia risk.
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39/100
At baseline, the mean ZBI score was 24.5 ± 15.2 and correlated positively with caregiver CES-D and STAI scores and with patient neuropsychiatric symptoms (NPI-frequency × severity) and distress felt by the caregiver (NPI-distress).
Why it matters
In caregivers of patients diagnosed with mild cognitive impairment due to Alzheimer's disease, burden increased over a mean follow-up of 17.7 months, but no baseline characteristics predicted this increase. This concerns caregiver burden, not treating, curing or preventing the disease.
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90%) rated the app favorably, stating it was enjoyable and easy to complete unsupervised.
Why it matters
This study offers early support for the validity of the Ignite app tests for frontotemporal dementia, suggesting they measure intended cognitive processes and are well accepted in healthy controls. However, validation is ongoing, and further work is required before the app can be used as an endpoint in clinical trials.
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Onset-predictive biomarker tests (OPBTs) for genetic frontotemporal dementia (FTD) may predict symptom onset in coming years.
Why it matters
This article discusses the ethical considerations of disclosing onset-predictive biomarker test results for genetic frontotemporal dementia in research, covering actionability, autonomy and informed consent, psychological impact, and social impact. It addresses disclosure practices and does not report any treatment, cure or prevention for Alzheimer's disease.
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A total of 11 dyads participated in the study.
Why it matters
In just 11 Korean American dyads, sleep parameters of people with dementia were significantly correlated with those of their family caregivers, showing that wearable devices can measure sleep in both. This is a small feasibility study and does not test any treatment, cure, or prevention for Alzheimer's disease.
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Adults of 78.8 years on average, with low to middle socio-economic status, low education levels, and multiple comorbidities, have adverse well-being and support conditions, except for the spiritual component.
Why it matters
Elderly people with dementia in this study had significant nutritional and feeding problems, and their caregivers lacked adequate conditions to ensure quality care. The study concludes that these caregiver-patient pairs need a strategy to improve their healthcare experience.
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39/100
Dementia is a condition that affects a very large population, and an effective clinical diagnosis can lead to early intervention to delay progressive cognitive decline.
Why it matters
This study used quantum machine learning on EEG signals to classify healthy versus dementia, with a quantum neural network reaching 96.58% accuracy. It is a classification method, not a treatment, cure, or prevention.
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In this study, 122 individuals were divided into two groups.
Why it matters
In this randomized trial of 122 older patients undergoing hip or knee arthroplasty, cognitive training did not significantly reduce postoperative delirium compared with control. The authors note that delirium was only observed in patients with fewer training sessions, suggesting compliance may matter.
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Digital transformation in banking has significantly improved efficiency, including in the critical Letter of Credit (LC) examination area.
Why it matters
This paper is about artificial intelligence and optimization in the Letter of Credit examination process in banking and contains no information on Alzheimer's disease. It reports no findings relevant to treating, curing or preventing dementia.
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This study aimed to develop a conversion table for the Japanese version of the Montreal Cognitive Assessment (MoCA-J) to the Japanese version of the Mini-Mental State Examination (MMSE-J) to facilitate prediction of the MMSE-J score from the MoCA-J score.
Why it matters
This pilot study created a table to convert MoCA-J scores into MMSE-J scores in community-dwelling older Japanese adults without dementia. It is a cognitive screening tool and does not address treating, curing or preventing Alzheimer's disease.
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39/100
We showed that consumer wearables are a valid tool for long-term data collection in this vulnerable patient population.
Why it matters
Consumer wearables were found valid for long-term collection of movement intensity data in nursing home residents with dementia, but automatic classification of movement type was not yet ready for this mostly sedentary group. This concerns monitoring activity, not treating, curing or preventing Alzheimer's disease.
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Cerebral small vessel disease (CSVD) is one of the most common vascular diseases of the brain, primarily diagnosed using magnetic resonance imaging biomarkers.
Why it matters
This review discusses covert cerebral small vessel disease, which is common in older adults and increases the risk of stroke, cognitive decline, and vascular dementia. It states that management strategies for covert cerebral small vessel disease are poorly established and that limited scientific evidence exists, so more high-quality longitudinal studies are needed.
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Women carrying pathogenic/likely pathogenic (P/LP) variants in moderate- or high-penetrance genes have an increased risk of developing breast cancer.
Why it matters
This review is about hereditary breast cancer risk assessment and prevention, not Alzheimer's disease, so it provides no information on Alzheimer's treatment, cure or prevention. It discusses risk-reducing options such as lifestyle changes, chemoprevention, enhanced surveillance and risk-reducing surgery for women with certain gene variants.
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According to FINDRISC score, 38.1% of adults were at mild risk, 21.9% were at moderate risk, and 20.9% were at high risk.
Why it matters
This study examined sociodemographic, lifestyle and diet factors linked to diabetes risk in overweight and obese Turkish adults, and did not study Alzheimer's disease. It found that low educational level, being married, being employed, smoking and having other conditions increased diabetes risk, and that lower diet quality was also linked to higher risk.
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Artificial intelligence (AI) is driving transformative changes in the field of medicine, with its successful application relying on accurate data and rigorous quality standards.
Why it matters
This general review describes how artificial intelligence is being applied across medicine, including dementia prediction models and cognitive health monitoring. It reports no tested treatment, cure, or prevention for Alzheimer's disease.
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In the testing cohort, the super learner obtained a concordance statistic (95% confidence interval) of 0.822 (0.810, 0.835), higher than any of the individual ML models (Figure 1), and its predicted risk aligned with observed risk in calibration slope plots (Figure 2).
Why it matters
This study developed a machine learning model to help screen for cognitive impairment in primary care, and the model's predictions aligned with observed risk in testing. It is about improving detection of cognitive impairment, not about treating, curing, or preventing Alzheimer's disease.
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There were no between-group differences in traditional performance measures of motor, cognitive, or IADL function.
Why it matters
This study found that a virtual reality shopping task distinguished people with Parkinson's disease from healthy older adults, even though traditional measures did not. It is about Parkinson's disease and does not test any treatment, cure, or prevention for Alzheimer's disease.
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39/100
Skilled home health care (HHC) is a critical service for community-dwelling older adults with dementia, but the majority of evidence about its use and quality is based on Traditional Medicare (TM) beneficiaries.
Why it matters
In this nationally representative sample of 316,407 persons with dementia, Medicare Advantage enrollees were less likely to use skilled home health care services than traditional Medicare beneficiaries (26.2% vs 29.8%). It contains no findings on treating, curing, or preventing Alzheimer's disease itself.
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Unlike other research, in this study higher body mass index was also found to increase the chance of prodromal dementia and dementia.
Why it matters
In 66 adults with Down syndrome, a lower score on the POMA-Gait subscale and higher body mass index were independent predictors of prodromal dementia and dementia. The authors conclude that applying the POMA could help diagnose dementia early in these individuals, though this is an association study and does not show that gait problems cause dementia.
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To explore changes in performance, weaknesses, and utilization of the long-term care (LTC) system for older people with disabilities and dementia (OPWDD) in Zhejiang Province, China, thereby providing a reference for decision-making amid a progressively aging population.
Why it matters
This study evaluated the long-term care system for older people with disabilities and dementia in one Chinese province and found improvements in most performance indicators, though some declined. It is about care system performance, not about treating, curing, or preventing Alzheimer's disease.
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Brain PET adds value in diagnosing neurodegenerative disorders, especially frontotemporal dementia (FTD) due to its syndromic presentation that overlaps with a variety of other neurodegenerative and psychiatric disorders. 18F-FDG-PET has improved sensitivity and specificity compared with structural MR imaging, with optimal diagnostic results achieved when both techniques are utilized.
Why it matters
This review describes how brain PET, especially FDG-PET, helps diagnose frontotemporal dementia and how tau-PET and amyloid-PET are used mainly to distinguish it from Alzheimer disease, mostly in research settings. It is about diagnosis and does not treat, cure or prevent Alzheimer's disease.
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We found notable differences in socio‐demographic and clinical characteristics, and utilization patterns in the year prior to death between decedents with dementia who were hospitalized in the last 30 days of life vs. those who were not.
Why it matters
This study described characteristics of Medicare Advantage plan members with dementia who received high-intensity end-of-life care. It found those hospitalized in the last 30 days of life were slightly younger and more likely to be men and people of color, which concerns end-of-life care patterns rather than treating or curing dementia.
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Each year’s cognitive functions were linked to the prior year’s food insecurity values.
Why it matters
In this cohort, food insecurity was linked to a faster decline in executive function but not to memory decline. This is an observational association, so it cannot show that reducing food insecurity prevents or treats Alzheimer's disease.
From across this topic
10 of the 7,967 studies in this topic, picked by a fixed rule (a hash of each study's address), not by score or date; each page of this list shows a different 10. The same 10 appear here every time.
- A Web-Based Multidomain Lifestyle Intervention for Older Adults: The eMIND Randomized Controlled Trial
- Dementia in Down's syndrome
- Cerebral hemodynamics and incident depression: the Rotterdam Study
- Grey matter changes in cognitively impaired Parkinson's disease patients
- Exercise therapy, cardiorespiratory fitness and their effect on brain volumes: a randomised controlled trial in patients with schizophrenia and healthy controls
- Predicting MCI outcome with clinically available MRI and CSF biomarkers
- Priority setting partnership to identify the top 10 research priorities for the management of Parkinson's disease
- Validation of the V66.7 Code for Palliative Care Consultation in a Single Academic Medical Center
- Atrial fibrillation and dementia in a population-based study. The Rotterdam Study
- Parkinson disease: an update