Get help now — free helplines

You can call any of these for free. You do not need a diagnosis, an appointment, or a crisis to call — questions and plain exhaustion are reasons enough.

  • Alzheimer's Association 24/7 Helpline 800-272-3900 24 hours a day, 365 days a year Free, confidential support and information for people with dementia, caregivers, families and the public. Master's-level clinicians. Also Spanish.
  • 988 Suicide & Crisis Lifeline 988 24/7 Call or text 988, or chat at 988lifeline.org. For anyone in emotional distress or a mental-health crisis, including caregivers.
  • Alzheimer's Foundation of America (AFA) Helpline 866-232-8484 9:00 am - 9:00 pm ET, seven days a week Licensed social workers providing support, info and referrals. Also text message and web chat. Text: 646-586-5283

In a medical emergency, call 911. More numbers, and what each line does, on the help page.

Each study has a usefulness score out of 100 (rubric version 4.0). Tap a score to see what makes it up.

Highest usefulness score first. Studies without a score come last.

  1. Decreased numbers of progenitor cells but no response to antidepressant drugs in the hippocampus of elderly depressed patients

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Neuropharmacology 2010-02-09 Hippocampus size on brain scans

    Imaging studies have consistently documented hippocampal volume reductions in depression.

  2. Cognitive exercise and its role in cognitive function in older adults

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Current psychiatry reports 2010-02-01 Prevention trials

    Converging lines of research indicate that complex mental activity is associated with reduced dementia risk.

  3. Nutrition and the brain

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Clinics in geriatric medicine 2010-02-01 Prevention trials

    Severe nutritional deficiencies, such as protein energy malnutrition and deficiency of nicotinamide, vitamin B(12), folate, and thiamine, have long been recognized to cause severe confusion.

  4. Raising the standard: palliative care in nursing homes

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Health affairs (Project Hope) 2010-01-01 End-of-life care

    More than two-thirds of long-stay nursing home residents suffer from dementia.

  5. Hospice care in the nursing home setting: a review of the literature

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Journal of pain and symptom management 2009-09-01 End-of-life care

    The U.S. Medicare hospice benefit has expanded considerably into the nursing home (NH) setting in recent years.

  6. Cholinesterase inhibitor and N-methyl-D-aspartic acid receptor antagonist use in older adults with end-stage dementia: a survey of hospice medical directors

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Journal of palliative medicine 2009-09-01 End-of-life care

    The findings from this survey indicate that cholinesterase inhibitors and/or NMDA receptor antagonists are prescribed for a subset of patients with advanced dementia and that a proportion of hospice medical directors report clinical benefit from the ongoing use of these agents.

  7. Palliative Access Through Care at Home: experiences with an urban, geriatric home palliative care program

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Journal of the American Geriatrics Society 2009-08-21 End-of-life care

    The aging of the U.S. population has resulted in a large number of persons with multiple, chronic illnesses and gradual functional decline.

  8. Capturing the costs of end-of-life care: comparisons of multiple sclerosis, Parkinson's disease, and dementia

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Journal of pain and symptom management 2009-07-01 End-of-life care

    The need for end-of-life care is going to increase substantially in many countries in the coming decades.

  9. Modifiers of cognitive function and brain structure in middle-aged and elderly individuals with type 2 diabetes mellitus

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Brain research 2009-05-20 Hippocampus size on brain scans

    Cognitive deficits and hippocampal atrophy, features that are shared with aging and dementia, have been described in type 2 diabetes mellitus (T2DM).

  10. Defining the human hippocampus in cerebral magnetic resonance images--an overview of current segmentation protocols

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. NeuroImage 2009-05-15 Hippocampus size on brain scans

    Due to its crucial role for memory processes and its relevance in neurological and psychiatric disorders, the hippocampus has been the focus of neuroimaging research for several decades.

  11. The prevention of dementia

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. International journal of geriatric psychiatry 2009-05-01 Prevention trials

    It may be that risk and protective factors vary with age, however, in the absence of prophylactic treatment it seems likely that the maintenance of a healthy lifestyle may represent the best option with regard to the prevention of dementia.

  12. Dysphagia in patients with dementia: Alzheimer versus vascular

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Alzheimer disease and associated disorders 2009-04-01 Clinical safety

    Patients with dementia develop dysphagia some time during the clinical course of their disease.

  13. Surrogate decision makers' understanding of dementia patients' prior wishes for end-of-life care

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Journal of aging and health 2009-03-05 End-of-life care

    Most surrogates reported that patients had previously completed an advance directive (59%), discussed preferences for EOL care (56%), or done both (38%).

  14. Cognitive training for early-stage Alzheimer's disease and dementia

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Journal of gerontological nursing 2009-03-01 Prevention trials

    The purpose of this article is to critically review and synthesize the literature on the effects of nonpharmacological cognitive training on dementia symptoms in early-stage Alzheimer's disease (AD) and related dementia.

  15. Keeping In Touch Everyday (KITE) project: developing assistive technologies with people with dementia and their carers to promote independence

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. International psychogeriatrics 2009-02-05 Clinical safety

    Prototypes for two devices (armband and electronic notepad) were developed.

  16. MR tractography: a review of its clinical applications

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine 2009-01-01 Vascular contributions

    Magnetic resonance tractography based on diffusion-tensor imaging was first introduced to the medical imaging community a decade ago.

  17. Educating nursing home staff about the progression of dementia and the comfort care option: impact on family satisfaction with end-of-life care

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Journal of the American Medical Directors Association 2008-12-10 End-of-life care

    Although not significant, results as to the effectiveness of such an intervention to improve family satisfaction with end-of-life care are encouraging.

  18. Dying with dementia in long-term care

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. The Gerontologist 2008-12-01 End-of-life care

    We noted no differences between decedents with and without dementia in terms of pain, psychosocial status, family involvement, advance care planning, most life-prolonging interventions, and hospice use.

  19. Alcohol in moderation, cardioprotection, and neuroprotection: epidemiological considerations and mechanistic studies

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Alcoholism, clinical and experimental research 2008-11-19 Vascular contributions

    In contrast to many years of important research and clinical attention to the pathological effects of alcohol (ethanol) abuse, the past several decades have seen the publication of a number of peer-reviewed studies indicating the beneficial effects of light-moderate, nonbinge consumption of varied alcoholic beverages, as well as experimental demonstrations that moderate alcohol exposure can initiate typically cytoprotective mechanisms.

  20. Effects of prenatal alcohol exposure on hippocampal volume, verbal learning, and verbal and spatial recall in late childhood

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Journal of the International Neuropsychological Society : JINS 2008-11-01 Hippocampus size on brain scans

    Children with prenatal alcohol exposure (PAE) show deficits in verbal learning and spatial memory, as well as abnormal hippocampal development.

  21. Causes of death in elderly nursing home residents

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Journal of the American Medical Directors Association 2008-09-07 End-of-life care

    The single most common cause of death occurring within the nursing home was Alzheimer's, with most dying appropriately on hospice care.

  22. Hippocampus segmentation in MR images using atlas registration, voxel classification, and graph cuts

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. NeuroImage 2008-08-12 Hippocampus size on brain scans

    Since hippocampal volume has been found to be an early biomarker for Alzheimer's disease, there is large interest in automated methods to accurately, robustly, and reproducibly extract the hippocampus from MRI data.

  23. Pulmonary function, muscle strength and mortality in old age

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Mechanisms of ageing and development 2008-08-06 Clinical safety

    Numerous reports have linked extremity muscle strength with mortality but the mechanism underlying this association is not known.

  24. The role of reduced fitness to drive due to medical impairments in explaining crashes involving older drivers

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Traffic injury prevention 2008-08-01 Clinical safety

    Medical conditions overall, do impact the fitness to drive of older drivers; however, the crash risk tends to be only slightly to moderately increased.

  25. Content of advance directives for individuals with advanced dementia

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Journal of aging and health 2008-08-01 End-of-life care

    For advance directives to better reflect a person's wishes, discussions with individuals and families about advance directives should include a range of care issues in the settings of terminal illness, persistent vegetative state or end-stage illness.

From across this topic

10 of the 7,967 studies in this topic, picked by a fixed rule (a hash of each study's address), not by score or date; each page of this list shows a different 10. The same 10 appear here every time.

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