Each study has a usefulness score out of 100 (rubric version 4.0). Tap a score to see what makes it up.
Highest usefulness score first. Studies without a score come last.
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The CNN-BiLSTM-Attention model demonstrated relatively promising predictive performance (AUC: 0.7317), with moderately high sensitivity (0.6902) and a high negative predictive value (NPV) of 0.9414.
Why it matters
This study developed a model to predict mild cognitive impairment risk and found education was the most critical predictor, acting indirectly through factors like health insurance and social interaction. It is about predicting risk and identifying inequalities, not about treating, curing, or preventing Alzheimer's disease.
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We found that sleep disorders were associated with risk of Alzheimer’s disease (AD), amyotrophic lateral sclerosis, dementia, Parkinson’s disease (PD), and vascular dementia in three national biobanks (hazard ratios from 1.3 (PD) to 5.11 (dementia)).
Why it matters
Using health records from three national biobanks, this study found that sleep disorders were associated with higher risk of Alzheimer's disease, dementia, Parkinson's disease, and other neurodegenerative conditions, with risk appearing up to 15 years before diagnosis. It notes that poor sleep hygiene and sleep apnea have available treatments that could potentially reduce neurodegeneration risk, but this potential has not been confirmed as a way to prevent or cure Alzheimer's disease.
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We synthesized caregivers' multiple challenges under five themes - (1) lack of information and awareness limit perceived need for services, (2) cultural norms and values influence decision to seek services, (3) complex processes and long waiting times hinder ability to reach services, (4) financial constraints and high costs force alternate care arrangements, and (5) inability to meet expectations and lack of family support limit engagement with services.
Why it matters
This qualitative study grouped caregivers' challenges in accessing community dementia care into five themes, including lack of information, cultural norms, complex processes, costs, and limited family support. It calls for redesigning services to better meet the needs of people with dementia and their caregivers.
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Caregiving for persons living with dementia has long been conceived as a series of tasks that sustain the body.
Why it matters
This philosophical essay argues that dementia caregiving is not only body care but also mind care, describing the caregiving dyad as a kind of mental extension related to support of the self and the moral person. It is a theoretical discussion and does not present or test any treatment, cure, or prevention.
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Food choices profoundly impact population health and the environment.
Why it matters
This study is about the accuracy of food choice self-reports in a simulated online grocery store, not about Alzheimer's disease, so it provides no information on treating, curing or preventing Alzheimer's. It found that reporting accuracy improved with memory aids, but this concerns shopping surveys only.
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Harmonized neuropsychological assessment for neurocognitive disorders (NCDs) is an urgent priority in clinics.
Why it matters
This survey found that most clinicians have little or no experience using social cognitive tests, even though most agree these tests are relevant. It identifies practical barriers such as lack of measures, time, guidelines and training that currently prevent their use in memory clinics.
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The prevalence of dementia is growing worldwide due to the fast ageing of the population.
Why it matters
This paper proposes a deep learning and explainable artificial intelligence model for predicting and classifying dementia to support clinical decisions. It reports no tested treatment, cure, or prevention.
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A total of 8,062,333 subjects hospitalized with COPD exacerbation were included, of whom 574,005 (7.2%) had a diagnosis of delirium.
Why it matters
In this national inpatient sample of over 8 million COPD exacerbation hospitalizations, delirium was associated with higher odds of mortality and mechanical ventilation and with longer, costlier stays. The study describes worse outcomes associated with delirium and does not test any treatment, cure, or prevention for Alzheimer's disease.
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Thirty-seven participants had a CDR of 0, 61 had a CDR of 0.5, and 20 had a CDR ≥ 1.
Why it matters
This re-evaluation found that the AD8 screening tool may perform better with a cutoff value of 4 to discriminate between those with and without dementia, and that optimal cutoffs vary by purpose. It is about refining a screening tool and does not treat, cure or prevent Alzheimer's disease.
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44/100
Among 1,372,570 HH patients, 30% had diagnosed dementia.
Why it matters
Among home health care patients with diagnosed dementia, most had that diagnosis go undocumented, and these patients had longer stays and more hospital and emergency department use. This concerns record-keeping and care coordination, not treating, curing, or preventing Alzheimer's disease.
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The nationwide combined weighted PAF for the eight CMDs was 37% overall, with hypertension (9.6%), ischemic heart disease (6.7%), and chronic heart failure (5.7%) associated with the greatest attributable fractions of dementia cases.
Why it matters
This analysis estimated that eight cardiometabolic diseases together accounted for 37% of new dementia cases in US Medicare beneficiaries, with hypertension, ischemic heart disease, and chronic heart failure contributing the most, and the highest burden in the Southeastern United States. The authors state that if these eight conditions were mitigated, 37% of incident dementia cases could be eliminated, but this is an estimate of attributable burden, not proof that treating these conditions prevents dementia.
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The probability of reversion increased from 2% at baseline to a maximum of 8% by year 10 before gradual decline thereafter.
Why it matters
This analysis found that some people with mild cognitive impairment revert to normal cognition, but those who revert remain at increased risk of cognitive deterioration and of progressing back to mild cognitive impairment. It describes patterns of transition between cognitive states rather than testing any treatment.
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Mechanisms regulating human sleep and physiology have evolved in response to rhythmic variation in environmental variables driven by the Earth's rotation around its axis and the Sun.
Why it matters
This study of 70 people living with dementia found that higher bedroom temperature and less bright indoor daytime light were associated with more disrupted sleep and higher respiratory rate, beyond the effects of season. The authors say this sensitivity to indoor environmental variables implies that controlling indoor light and temperature can improve sleep.
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BackgroundNeuropsychological (NP) assessment is crucial for diagnosing prodromal and Alzheimer's disease and related dementia (ADRD) syndromes.
Why it matters
This study used neuropsychological test errors and processes to identify distinct cognitive phenotypes in community-dwelling older adults and link them to brain imaging measures. It may improve how cognitive impairment is classified, but it does not test any treatment, cure, or prevention for Alzheimer's disease.
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The final analysis included 459,924 participants.
Why it matters
In this large study, frail participants had higher risks of progressing to stroke, dementia, and combined stroke-dementia, and genetic analysis linked predicted frailty to higher stroke-dementia risk. It suggests frailty status raises the risk of post-stroke dementia, with hypertension, diabetes, lung disease and visual impairment as notable contributors.
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Core cultural values, along with commonly held beliefs about dementia, influence the caregiving roles assumed by Hispanic/Latino caregivers.
Why it matters
This study describes attitudes and perspectives of Hispanic/Latino staff on participating in community-based dementia-support interventions, highlighting the value of research funding for immediate care needs and culturally appropriate terminology. It does not test a treatment or prevention for Alzheimer's disease.
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We interviewed 30 participants (9 PWD, 21 carepartners).
Why it matters
This qualitative study of 30 participants found that most patients with mild-to-moderate dementia and carepartners approach medical intervention decisions guided by their understanding of dementia prognosis, but risks of medical interventions are often unaddressed with the clinical team. It recommends clinicians provide dementia-related risks to facilitate decision-making and advance care planning.
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Unmet PC needs were highly prevalent (78.2%).
Why it matters
This one-year retrospective study found unmet palliative care needs were highly prevalent among patients with dementia at the end of life, and that frequent emergency department use was common. It does not test any treatment, cure or prevention.
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Of the 258 surveyed doctors, 74 (28.7%) practiced ACP.
Why it matters
This cross-sectional survey found that 28.7% of surveyed doctors in Japan practised advance care planning during the COVID-19 outbreak, with practice associated with doctor age 20-49 years, experience treating COVID-19 patients, patients' declining cognitive function, and difficulty preventing COVID-19 infection. It suggests advance care planning should be practised for older patients with dementia before COVID-19 infection worsens their symptoms.
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BackgroundCognitive impairment is common in older adults and negatively affects hearing aid use.
Why it matters
This feasibility study found that brief cognitive assessment can be implemented in hearing aid clinics, with some participants identified as having potential cognitive impairment and referred for further evaluation. It is about feasibility of screening in a clinical setting, not treatment, cure, or prevention.
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The ToAI framework followed a nine-step process: preparation, translation, native-speaker review, VIP team review, external panel review, pilot testing, proofreading, final formatting, and ongoing review and improvement.
Why it matters
This paper describes a framework for culturally adapting cognitive assessment tools for Vietnamese American older adults. It is about improving assessment methods and does not address treating, curing, or preventing Alzheimer's disease.
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Bisexual caregivers reported more stress, albeit better health than gay caregivers.
Why it matters
This study found that the health of sexual and gender minority dementia caregivers varies by sexual orientation and gender identity, with bisexual caregivers reporting more stress but better health than gay caregivers and transgender caregivers reporting worse health than cisgender caregivers. It does not test any treatment, but the authors say the findings can serve as targets for developing caregiver supports.
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Medicare beneficiaries who received an AWV were 13% to 21% more likely than those without an AWV to be diagnosed at MCI stage versus ADRD stage.
Why it matters
This study found that Medicare beneficiaries who received an annual wellness visit were 13% to 21% more likely to be diagnosed at the mild cognitive impairment stage rather than the dementia stage. Annual wellness visits reduced, but did not eliminate, racial and ethnic differences in early diagnosis.
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(n = 14) included NH administrators and other leaders, palliative care providers, telehealth representatives, dementia advocates, a care partner, and a PLWD.
Why it matters
Interviews with 14 key informants found that barriers to providing telehealth palliative care for people with dementia in nursing homes far outweighed the facilitators. It does not test any treatment, cure or prevention.
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We demonstrate that senolytic treatment is an effective therapeutic strategy to mitigate cognitive impairment by reducing neuroinflammation and associated metabolic disturbances.
Why it matters
In aged male mice, cognitive impairment was accompanied by markers of cellular senescence and inflammation in the hippocampus, and clearing senescent cells with dasatinib and quercetin reduced these markers and the cognitive differences. This is early animal research, so it does not yet show that senolytic drugs can treat or prevent Alzheimer's disease in people.
From across this topic
10 of the 7,967 studies in this topic, picked by a fixed rule (a hash of each study's address), not by score or date; each page of this list shows a different 10. The same 10 appear here every time.
- Timing of risk factors, prodromal features, and comorbidities of dementia from a large health claims case–control study
- Brain health services for the secondary prevention of cognitive impairment and dementia: Opportunities, challenges, and the business case for existing and future facilities
- HIV-associated cryptococcal meningitis
- The Link between Obstructive Sleep Apnea and Neurocognitive Impairment: An Official American Thoracic Society Workshop Report
- County‐level indicators of education quality and brain imaging markers of neurodegeneration and vascular injury among racially and ethnically diverse middle‐aged and older adults
- Computer-Based Cognitive Training in Aging
- Grocery lists: connecting family, household and grocery store
- Educational disparities in brain health and dementia across Latin America and the United States
- Documented head injury in early adulthood and risk of Alzheimer's disease and other dementias
- A Novel and Intelligent Home Monitoring System for Care Support of Elders with Cognitive Impairment