Each study has a usefulness score out of 100 (rubric version 4.0). Tap a score to see what makes it up.
Highest usefulness score first. Studies without a score come last.
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DLB patients had a higher prevalence of VH than AD patients (p < 0.01).
Why it matters
Visual hallucinations were more common in Lewy body dementia than Alzheimer's disease and were linked to lower cognitive scores in both, with attention most affected in Lewy body dementia and orientation most affected in Alzheimer's. Different cognitive domains may help distinguish these two dementias in patients with visual hallucinations, but this does not treat the condition.
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The implementation of a transmural model of early palliative care for patients with advanced dementia requires the coordination between clinicians in the tertiary care setting and community, together with health information technologists.
Why it matters
This is a study protocol describing the planned development and evaluation of an early palliative care model for advanced dementia. No results are reported, and it does not test any treatment, cure or prevention.
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Vascular dementia is a highly heterogeneous neurodegenerative disorder induced by a variety of factors.
Why it matters
There are currently no definitive treatments for the cognitive dysfunction associated with vascular dementia, though early detection and preventive measures have proven effective in reducing risk of onset and improving prognosis. This review suggests targeting the nitric oxide soluble guanylate cyclase-cyclic guanosine monophosphate pathway may offer a novel approach for treating vascular dementia.
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During the follow-up time (2008-2019), 312,075 cancer cases were identified.
Why it matters
This cohort study is about cancer risk and lifestyle risk score trajectories, not Alzheimer's disease, and reports no findings on dementia. It found that high lifestyle risk score trajectories were linked to higher risk of several cancers in men and similar trends in women.
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BackgroundAccurate classification of cognitive impairment in population studies is challenging.
Why it matters
This study compared a diagnostic algorithm with a clinical consensus panel for classifying cognitive impairment and found moderate to substantial agreement. It is about improving classification methods and does not address treating, curing, or preventing Alzheimer's disease.
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In the dementia scenario, 26.9% of participants preferred unlimited medical treatment.
Why it matters
In this cross-sectional survey, 26.9% of community-dwelling adults preferred unlimited medical treatment in a dementia scenario, and this preference was linked to pre-existing attitudes favoring life-sustaining treatment and religious beliefs. The authors say advance care planning should align with individuals' values and beliefs, and that raising awareness of quality-of-life considerations may shift preferences toward palliative care.
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Alzheimer's Disease (AD), the most prevalent dementia subtype, early detection is paramount for slowing disease progression because cures are not available.
Why it matters
This study explores using EEG microstates to standardize sensor configurations and proposes a new AI model to make dementia detection work regardless of the number of sensors. It aims to reduce costs and increase accessibility of AI-driven detection, not to treat, cure or prevent Alzheimer's disease.
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Accidental femur fractures in older adults are a public health concern with a considerably high rate of mortality and morbidity.
Why it matters
This review of 470 deaths from hip fractures caused by ground-level falls found that dementia was among the most common conditions contributing to death. It shows the importance of accurate death certification to inform stakeholders about risk factors and comorbidities that may improve management of hip fractures in an ageing population.
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This paper presents a systematic bibliometric analysis of the research landscape at the intersection of Alzheimer's disease and gerontechnology, identifying key contributors, research hotspots, and emerging trends.
Why it matters
This bibliometric analysis maps research trends in digital biomarkers for dementia in older adults, noting growing emphasis on assistive technologies and artificial intelligence for early diagnosis and gaps in long-term effectiveness and inclusivity. It is a landscape analysis only and does not test any treatment, cure or prevention.
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No significant differences were found between the in-person and remote groups in terms of age, education, or gender.
Why it matters
In this small pilot study, a cognitive stimulation program delivered online or in person kept cognitive profiles and daily activities stable, and patients and caregivers reported high satisfaction. The authors note that larger studies with long-term follow-up are needed to assess lasting effects on cognition, quality of life, and caregiver burden.
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Three main categories were created: (1) Impact of observed cognitive decline, (2) Impact of diagnosis on service engagement, and (3) Support and follow-up for family caregivers.
Why it matters
This qualitative study found that family caregivers who had received a dementia diagnosis for their family members were more proactive in seeking help and services and better informed about resources. It is about the impact of receiving a diagnosis on caregivers and does not treat, cure or prevent Alzheimer's disease.
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This study underscores the importance of vigilant monitoring for ARIA and other neurologic and psychiatric AEs associated with lecanemab in real-world clinical settings.
Why it matters
In an analysis of FDA adverse event reports, the strongest safety signals for lecanemab were amyloid-related imaging abnormalities, including microhemorrhages and brain edema or sulcal effusion, along with infusion-related reactions and headache. The authors stress the importance of vigilant monitoring for ARIA and other neurologic and psychiatric adverse events.
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The mean hippocampal volumes were significantly smaller in the DEM group compared to the MCI and healthy groups (P <0.0001).
Why it matters
People with dementia had significantly smaller hippocampal volumes than those with mild cognitive impairment or healthy participants, and smaller volume went with worse cognitive scores. This supports hippocampal measurement as a possible marker for diagnosis and monitoring, but it does not treat or prevent dementia.
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Minor neurocognitive disorders (NCDs) represent a transitional phase between normal cognitive aging and dementia, highlighting the importance of early interventions.
Why it matters
In this 6-month study of 100 older adults with minor neurocognitive disorders, the group that did computerized cognitive training showed no significant cognitive changes, while the non-intervention group declined in several areas. The training may help delay cognitive deterioration, but it did not produce significant improvement.
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38/100
It was found that individuals with Alzheimer’s disease (AD) have poorer balance and a higher risk of falls compared to healthy individuals.
Why it matters
In this small study of 18 people with Alzheimer's dementia and 18 healthy controls, those with Alzheimer's had poorer balance and a higher risk of falls, while fear of movement (kinesiophobia) was similar between the groups. The authors conclude that balance assessments should be included when developing rehabilitation protocols for people with Alzheimer's disease.
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BackgroundEarly mild cognitive impairment (EMCI) represents a prodromal stage of dementia, and early detection is crucial for delaying dementia progression.
Why it matters
This study compared structural and functional brain imaging features across cognitively normal, early mild cognitive impairment, late mild cognitive impairment and Alzheimer's disease groups. It describes imaging differences only and does not test any treatment, cure or prevention.
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LDCs were recruited within the planned timeframe.
Why it matters
This feasibility study found that an intervention for long-distance family caregivers of older adults with dementia was acceptable and was linked to significant decreases in caregiver burden, strains, and depression from pre- to immediate post-intervention. It addresses caregiver support, not treating, curing, or preventing Alzheimer's disease.
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BackgroundDementia impacts individuals, families, and society, necessitating effective prevention strategies.
Why it matters
This one-arm feasibility trial found that a community multi-domain intervention was feasible, with high continuation and acceptability, and cognitive function remained stable. Because there was no control group, the study cannot show that the intervention prevents dementia or improves cognition.
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Of 81 stroke survivors (mean age 61.9±13.9 years), 72.8% had ischemic stroke, and 27.2% had hemorrhagic stroke.
Why it matters
In a retrospective study of 81 Sudanese stroke survivors, post-stroke cognitive impairment was highly prevalent, and higher education and female sex were associated with better cognitive outcomes. This is observational and does not test any treatment, cure, or prevention for Alzheimer's disease.
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Participants' attitude toward Alzheimer's disease and related dementia scores were significantly associated with employment status, race/ethnicity (Hispanic), and instrumental activities of daily living.
Why it matters
This cross-sectional study found that negative attitudes toward Alzheimer's disease and dementia care among midlife women family caregivers were associated with being unemployed, Hispanic, and having low instrumental activities of daily living. It concerns caregiver attitudes and does not test any treatment, cure, or prevention for Alzheimer's disease.
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There is limited experience in combining interdisciplinary rehabilitation for persons with dementia and caregiver support.
Why it matters
Informal caregivers in this qualitative study felt strengthened by an interdisciplinary rehabilitation program and better prepared for an uncertain future, though participation also challenged everyday routines. They perceived the benefits as outweighing the strain.
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This is the first study in Africa using blood-based and retinal imaging biomarkers to examine pathological processes underlying dementia, and systematically map services available for people with dementia.
Why it matters
This study is mapping dementia prevalence, causes, and available services in rural Uganda using cognitive screening, retinal imaging, and blood-based biomarkers. It aims to identify barriers and opportunities to strengthen support for people with dementia and their families, but no results on treating or preventing dementia are reported yet.
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These disasters, along with other endogenous causes not addressed in this article, have significantly hindered the country’s progress toward key global objectives, including the SFDRR.
Why it matters
This article assesses Algeria's progress in implementing the Sendai Framework for disaster risk reduction, not Alzheimer's disease. It provides no information relevant to treating, curing, or preventing Alzheimer's disease.
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Social distance showed no significant differences in the normal aging and mild stage of dementia across all vignettes.
Why it matters
This study found that social distance towards people with dementia was higher at moderate and severe stages, especially for those with behavioral and psychological symptoms, and that factors like social capital and contact were associated with lower social distance. It does not test a treatment or prevention for Alzheimer's disease.
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The retention rate for MLIP-CE was 90.2% (37/41).
Why it matters
This feasibility study of a mobile-based multidomain lifestyle intervention in older adults with subjective cognitive decline found high retention and app usage, with significant improvement in health behaviors and Mini-Mental State Examination scores. As a small feasibility study, it supports further research but does not establish that the intervention prevents Alzheimer's disease.
From across this topic
10 of the 7,967 studies in this topic, picked by a fixed rule (a hash of each study's address), not by score or date; each page of this list shows a different 10. The same 10 appear here every time.
- Subjective cognitive decline and rates of incident Alzheimer's disease and non-Alzheimer's disease dementia
- Hearing aid effectiveness and probable dementia risk across 33 countries: A pooled analysis of seven cohorts
- Effect of Area-Level Socioeconomic Deprivation on Risk of Cognitive Dysfunction in Older Adults
- Sex differences in clinical phenotypes of behavioral variant frontotemporal dementia
- Lecanemab Treatment in a Specialty Memory Clinic
- Essential hypertension
- Estimating the survival of elderly patients diagnosed with dementia in Taiwan: A longitudinal study
- Epidemiology, Pathophysiology, and Prognosis of Heart Failure in Older Adults
- Trajectories of general and central obesity beyond middle age in relation to late‐life cognitive decline and dementia
- Vaccination as a new form of cardiovascular prevention: a European Society of Cardiology clinical consensus statement