Each study has a usefulness score out of 100 (rubric version 4.0). Tap a score to see what makes it up.
Highest usefulness score first. Studies without a score come last.
-
The item-bank included 180 symptoms, most of which focus group nurses (n = 17) identified as occurring in advanced dementia.
Why it matters
This study developed and tested a 27-item tool that nurses can use to identify symptoms in people with advanced dementia. It is about measuring and managing symptoms at the end of life, not about treating, curing or preventing Alzheimer's disease itself.
-
Dementia and depression are two prevalent disorders that warrant significant attention due to their high prevalence and substantial contribution to the global burden of disease.
Why it matters
This review discusses shared mechanisms between dementia and depression, including HPA axis dysfunction and neuroinflammation, and explores physical exercise as a potential non-pharmacological intervention for both. It is a narrative review and does not present new experimental evidence on treating or preventing Alzheimer's disease.
-
The capability of xEEGNet to filter specific EEG bands, learns band specific topographies and use the right EEG spectral bands for disease classification demonstrates its interpretability.
Why it matters
This work presents xEEGNet, a compact and explainable neural network that classifies Alzheimer's and frontotemporal dementia versus controls from EEG data with far fewer parameters than a comparison model. It is a diagnostic classification tool and does not treat, cure, or prevent dementia.
-
A total of 200 physicians participated in the study.
Why it matters
This cross-sectional study found that only 44.2% of surveyed physicians reported referring patients with advanced dementia to home hospice care, and only 6% correctly answered all four knowledge questions on the topic. It found no significant differences between referring and non-referring physicians in training, knowledge level, or attitudes, and suggests targeted training and structured exposure during residency may improve timely referrals.
-
The presence of cognitive lapses in the post-COVID-19 period, particularly among younger individuals, suggests a potential genetic predisposition.
Why it matters
This case-control study found that lower cognitive performance after COVID-19 was associated with certain genetic copy number variations and viral infections in an Armenian population. The findings are observational and do not provide a treatment, cure, or prevention for Alzheimer's disease.
-
42/100
Black participants had 2.883 times higher odds of developing dementia compared to Whites, while Hispanic participants had 1.230 times higher odds (not statistically significant).
Why it matters
This study found that Black participants had higher odds of developing dementia compared to Whites, and that mid- and late-life risk and protective factors explained part of the cognitive gap. It suggests that addressing disparities in education, wealth, cardiovascular risks, depression, and hearing loss can reduce cognitive dysfunction, but it does not test a specific treatment or cure.
-
Recently, dementia research has primarily concentrated on using Magnetic Resonance Imaging (MRI) to develop learning models in processing and analyzing brain data.
Why it matters
This study developed a fog computing-based system using MMSE and MoCA mental test scores with an AdaBoost model, reporting 0.93 accuracy for predicting dementia progression. It is a screening and prediction tool and does not test any treatment, cure or prevention.
-
A total of 258 usernames posted on the forum since its inception.
Why it matters
This content analysis of an online forum for caregivers of people with both dementia and cancer found that most posts provided social support, most commonly informational support. It describes peer support use and does not test any treatment, cure, or prevention.
-
Community-based dementia screening using a questionnaire on risk factors, cognitive symptoms and the Mini-COG was feasible and acceptable in Brunei.
Why it matters
This pilot study screened older adults in Brunei for dementia risk factors and symptoms using a brief cognitive tool. It is a small cross-sectional pilot and does not test any treatment, cure, or prevention.
-
Dementia with Lewy bodies (DLB), a progressive neurodegenerative disease with heterogeneous clinical presentations, greatly impacts patients, caregivers, and society.
Why it matters
This paper discusses biological frameworks for dementia with Lewy bodies and how in vivo biomarkers are improving disease identification and diagnostic accuracy. It addresses implications for clinical trials and care, but does not report a treatment or cure.
-
Lower cognitive levels in lonely and socially isolated patients suggest that these factors may contribute to dementia progression.
Why it matters
This retrospective cohort study using natural language processing found that lonely patients had lower MoCA scores at diagnosis, and socially isolated patients had a faster rate of cognitive decline before diagnosis. The authors suggest social isolation and loneliness are promising targets for slowing cognitive decline, but the study is observational and does not test an intervention.
-
The PIF for the total NZ population following a 15% risk factor reduction was 14.6% (95% confidence interval: 7.7-21.1) Modeled projections demonstrated prevalence reduction over time, from 1.0% at 10 years to 4.2% at 30 years.
Why it matters
Modeling for New Zealand estimated that a 15% reduction in risk factors could lower dementia prevalence, with the benefit growing over a 30-year horizon and being larger for Māori and Pacific peoples. This supports prevention through risk factor reduction, but the projections are modeled rather than tested in a trial.
-
42/100
Gender has an impact on CR, but not through socio‐economic variables.
Why it matters
This study found that women with subjective cognitive decline had lower cognitive reserve scores than men, but gender itself did not predict progression to mild cognitive impairment. Cognitive reserve did influence progression risk, suggesting that building reserve might help, though no treatment is tested.
-
Of the 99 participants, 43 were classified into the low social interaction frequency group, and 37 were classified into the high loneliness level group.
Why it matters
Among 99 older adults with subjective cognitive decline and mild cognitive impairment, machine learning models identified factors linked to low social interaction frequency and high loneliness, with physical movement and sleep quality as key factors. The authors suggest this approach may contribute to preventing cognitive and physical decline in older adults at high risk of dementia, but the study itself only detects vulnerable groups.
-
This study constitutes both a scoping review and a concept analysis, as it systematically examines digital literacy across settings (home, assisted living facilities, and other long-term care facilities) in the context of persons with dementia and their caregivers.
Why it matters
This scoping review and concept analysis of 22 empirical studies conceptualized digital literacy in dementia care, identifying antecedents, attributes and consequences such as technology acceptance and digital equity. It provides a foundation for designing technology-mediated interventions, but does not test any treatment, cure or prevention for dementia.
-
Most people with dementia (PwD) live with the support of their caregiver.
Why it matters
This qualitative study of 31 participants describes sleep experiences and challenges at home for people with dementia and their caregivers. It does not test any treatment, but the authors say the results may guide development of non-pharmacological interventions to support sleep and day structure.
-
Making early and informative diagnoses of mild cognitive impairment (MCI) is highly important for planning timely and appropriate interventions aimed at dementia risk reduction.
Why it matters
This study compared two sets of diagnostic criteria for MCI in 1021 older adults over 12 years and found both predicted dementia risk similarly, though the Neuropsychological criteria gave more consistent diagnoses. It also found that having both subjective memory complaints and objective impairment at baseline was linked to higher dementia risk, supporting comprehensive neuropsychological assessment for timely diagnosis.
-
78% of students agreed or strongly agreed that Time for Dementia had increased their knowledge of psychosocial issues, and 69% enjoyed the programme.
Why it matters
This cross-sectional study found that most students in a dementia education programme reported increased knowledge of psychosocial issues and enjoyed the programme. It addresses education and satisfaction, not treating, curing, or preventing Alzheimer's disease.
-
42/100
A total of 90 (38.96%) participants were healthy and 141 (61.04%) had MCI.
Why it matters
In this cross-sectional study of older Chinese adults, lower blood uric acid levels were associated with worse cognitive function and uric acid appeared to be a protective factor for mild cognitive impairment. The authors suggest controlling uric acid within a suitable range may slow progression, but this is an association finding, not proof of a treatment.
-
• Caregiver training helps dementia caregivers understand the disease and learn about caregiving skills. • Overall, about one in twelve informal dementia caregivers had taken any caregiving training. • Factors associated with the receipt of training included caregivers’ race, relationship, working status, and payer status, and care recipients’ level of assistance.
Why it matters
This study found that only 8.3% of informal dementia caregivers had received caregiver training, with receipt associated with caregivers' race, relationship, working status, and payer status, and care recipients' level of assistance. It identifies factors linked to training receipt but does not test any treatment, cure or prevention for Alzheimer's disease.
-
Caregivers in the control conditions reported significantly worsening sleep efficiency whereas in comparison, those in the active conditions reported improving sleep efficiency.
Why it matters
This randomised controlled trial found that caregivers in the control conditions reported worsening sleep efficiency while those using in-home assistive technology reported improving sleep efficiency. It is about supporting caregiver sleep, not about treating, curing or preventing Alzheimer's disease.
-
Dementia, particularly Alzheimer's Disease, continues to be a significant global health concern, driven by increasing prevalence as the population ages.
Why it matters
This review discusses how artificial intelligence is being applied to early detection, diagnosis, and management of dementia, including neuroimaging, biomarkers, and predictive modeling. It is a review of the field and does not report new trial results.
-
Participants sought to feel secure by following recommended practices, manage uncertainty, avoid crises, share burdens within families, and avoid poor end-of-life experiences.
Why it matters
This qualitative study found that even conscientious people planning for future dementia care struggled to access adequate support and clear information about disease progression and end-of-life decisions. It concerns planning and communication, not treating, curing or preventing Alzheimer's disease.
-
The MI group significantly improved in attention-executive functioning (p = 0.003) compared to ACI (Cohen's d: 0.47, 95% CI 0.13-0.79).
Why it matters
In this trial of people with subjective cognitive decline, a multidomain lifestyle intervention improved attention and executive function and reduced depressive symptoms and memory concerns, but it found no significant effects on brain structure or blood vessel outcomes. It does not show whether this intervention prevents progression to Alzheimer's disease.
-
Parkinson's disease (PD) exhibits a variety of symptoms, with approximately 25% of patients experiencing mild cognitive impairment and 45% developing dementia within ten years of diagnosis.
Why it matters
Using machine learning and Mendelian randomization, this study found genetic predisposition to be the dominant factor for dementia in Parkinson's disease, with comorbidities also influential, and suggested potential causal links with hypertension and type 2 diabetes. It proposes that managing blood pressure and glucose in Parkinson's patients may serve as a preventive strategy, but this was not tested in a trial.
From across this topic
10 of the 7,967 studies in this topic, picked by a fixed rule (a hash of each study's address), not by score or date; each page of this list shows a different 10. The same 10 appear here every time.
- Brain reserve and dementia: a systematic review
- A multimodal precision-prevention approach combining lifestyle intervention with metformin repurposing to prevent cognitive impairment and disability: the MET-FINGER randomised controlled trial protocol
- Daytime sleepiness is associated with dementia and cognitive decline in older Italian adults: a population-based study
- Ethical Aspects of Artificially Administered Nutrition and Hydration: An ASPEN Position Paper
- Development of an Evidence-Based Cognitive Training Application for Elderly Individuals with Cognitive Dysfunction
- NIH Primary and Secondary Prevention Research in Humans: a Portfolio Analysis of Study Designs Used in 2012-2019
- Fronto-temporal dementia: nosology, neuropsychology, and neuropathology
- Multilevel and Multidimensional Features of Socioeconomic Status and Cognitive Function in Older Adulthood: Findings from the IGNITE Study
- Diagnostic Accuracy of the Boston Criteria v2.0 in Memory Clinic Patients
- Shared Commitment and Distinct Innovations in Dementia Policy Development and Implementation in China, Japan, and South Korea