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Effectiveness of a 6-year multidomain vascular care intervention to prevent dementia (preDIVA): a cluster-randomised controlled trial
Moll van Charante EP, Richard E, Eurelings LS, van Dalen JW, Ligthart SA, van Bussel EF, Hoevenaar-Blom MP, Vermeulen M et al.. Lancet (London, England), 2016-07-26
Topic: Risk, prevention and care in population studies
Background Cardiovascular risk factors are associated with an increased risk of dementia. Mean ALDS scores measured during follow-up did not differ between groups (85·7 [SD 6·8] in the intervention group and 85·7 [7·1] in the control group; adjusted mean difference -0·02, 95% CI -0·38 to 0·42; p=0·93). 309 (16%) of 1885 participants died in the intervention group, compared with 269 (16%) of 1634 participants in the control group (HR 0·98, 95% CI 0·80-1·18; p=0·81). Interpretation A nurse-led, multidomain intervention did not result in a reduced incidence of all-cause dementia in an unselected population of older people.
Key findings
- Background Cardiovascular risk factors are associated with an increased risk of dementia.
- Mean ALDS scores measured during follow-up did not differ between groups (85·7 [SD 6·8] in the intervention group and 85·7 [7·1] in the control group; adjusted mean difference -0·02, 95% CI -0·38 to 0·42; p=0·93). 309 (16%) of 1885 participants died in the intervention group, compared with 269 (16%) of 1634 participants in the control group (HR 0·98, 95% CI 0·80-1·18; p=0·81).
- Interpretation A nurse-led, multidomain intervention did not result in a reduced incidence of all-cause dementia in an unselected population of older people.
Why it matters
This randomised controlled trial found that a nurse-led, multidomain vascular care intervention did not reduce the incidence of all-cause dementia in an unselected population of older people. The intervention did not work for preventing dementia in this trial.
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Study details
- Study designrandomized controlled trial
- Participants3,526
- Evidence strengthHigh
How this study scored 79/100
Published in a top-tier journal, and it is a randomised controlled trial. Scored zero for effect reported because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 10 / 10 | Tier 1 — top-tier general journal (Lancet (London, England)) |
| Journal's citation record | 4 / 4 | The Lancet: journal h-index 1,205 (OpenAlex, 2026-10-29) |
| Study design | 11 / 12 | A randomised controlled trial |
| Strength of evidence | 5 / 5 | Rated “high” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 1 / 5 | 2016 — within 20 year(s) of the newest study here |
| Sample size | 3 / 4 | 3,526 participants |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomised / blinded | 1 / 2 | Randomised (as stated in the record) |
| Times cited | 6 / 7 | Cited 607 times (OpenAlex, 2026-10-10) |
| Citations per year | 5 / 5 | 50.6 citations a year over 12 year(s) since 2016 |
| Impact for its field and year | 6 / 6 | Cited 40.4× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 4 / 6 | Cited by 68 other studies in this library |
| Still being cited | 3 / 4 | Cited 165 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 3 / 4 | Last-listed author Willem A. van Gool: h-index 70 (OpenAlex, whole career) |
| Institution's track record | 1 / 3 | Radboud University Nijmegen: institution h-index 1,143 (OpenAlex) |
| Multi-centre collaboration | 1 / 3 | OpenAlex lists 3 institution(s) in 1 country |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 27474376) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Total | 79 / 100 | — |
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Read the original
- DOI: 10.1016/s0140-6736(16)30950-3
- PubMed: 27474376
- Original source →
- Free full text: Apollo (University of Cambridge) →
Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record's author list ends in “et al.”, so not every author is named. Check the citation against the original before you use it.
APA 7th
Moll van Charante, E. P., Richard, E., Eurelings, L. S., van Dalen, J. W., Ligthart, S. A., van Bussel, E. F., et al. (2016). Effectiveness of a 6-year multidomain vascular care intervention to prevent dementia (preDIVA): a cluster-randomised controlled trial. Lancet (London, England). https://doi.org/10.1016/s0140-6736(16)30950-3
Vancouver
Moll van Charante EP, Richard E, Eurelings LS, van Dalen JW, Ligthart SA, van Bussel EF, et al. Effectiveness of a 6-year multidomain vascular care intervention to prevent dementia (preDIVA): a cluster-randomised controlled trial. Lancet (London, England). 2016. doi:10.1016/s0140-6736(16)30950-3. PMID: 27474376.
BibTeX
@article{mollvancharante2016-27474376,
author = {Moll van Charante, E. P. and Richard, E. and Eurelings, L. S. and van Dalen, J. W. and Ligthart, S. A. and van Bussel, E. F. and Hoevenaar-Blom, M. P. and Vermeulen, M. and others},
title = {{Effectiveness of a 6-year multidomain vascular care intervention to prevent dementia (preDIVA): a cluster-randomised controlled trial}},
journal = {Lancet (London, England)},
year = {2016},
doi = {10.1016/s0140-6736(16)30950-3},
pmid = {27474376},
url = {https://doi.org/10.1016/s0140-6736(16)30950-3}
}
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