Each study has a usefulness score out of 100 (rubric version 4.0). Tap a score to see what makes it up.
Highest usefulness score first. Studies without a score come last.
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Dementia incidence was 0.89 per 1000 person-years.
Why it matters
This study found that glycemic index showed an inverse J-shaped association with dementia risk and glycemic load showed a J-shaped pattern, with low-GI diets possibly protective and high-GL diets possibly increasing risk. It suggests that considering both carbohydrate quality and quantity may be important in dementia prevention, but it does not show that changing diet prevents dementia.
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Three themes were identified: (1) Struggling with conflicting emotions and social challenges - caregivers reported experiencing stress, physical exhaustion, and emotional strain due to constant availability and the challenges of managing behavioral changes, further intensified by isolation and shrinking social networks.
Why it matters
Family caregivers described stress, physical exhaustion, emotional strain, isolation, and difficulty balancing autonomy in care decisions with limited information. The study highlights the need for person- and family-centered care, improved coordination, trained staff, and supportive policies.
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38/100
Most dementia caregiver programs focus on a single caregiver, overlooking diverse caregiving networks that include family, friends, and relatives who provide care.
Why it matters
This scoping review of 10 family-centered dementia caregiving programs found that most programs focus on a single caregiver and that effectiveness was reported by the primary caregiver and measured at the individual level. It does not test any treatment for dementia itself, and suggests programs may benefit from identifying core components and measuring outcomes at the family level.
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Compared with sMCI-resilient subjects, cMCI individuals exhibited increased frontal delta power, reduced posterior alpha power, and an elevated delta/alpha ratio in the right temporal region, consistent with cortical dysfunction.
Why it matters
This study found that people with mild cognitive impairment who stayed stable despite high-risk biomarker profiles showed different EEG patterns, including stronger alpha-band connectivity and more efficient network organization, than those who progressed. These EEG markers may help identify who is at risk of dementia and guide early intervention, though the study does not test any treatment.
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38/100
Mild cognitive impairment and dementia are common symptoms in people with Parkinson's disease (PwPD) that impair the quality of life of those affected.
Why it matters
This call-to-action paper proposes a framework for preventing cognitive impairment in people with Parkinson's disease, covering lifestyle factors such as physical and social activity, diet, hearing loss, and cardiovascular factors. It recommends regular cognitive assessment, risk communication, and multidomain risk reduction, but does not report new trial results.
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Our findings suggest the LEAD intervention is feasible and demonstrates initial efficacy in promoting dementia-focused ACP.
Why it matters
In this feasibility study of 48 dyads, 64% completed a web-based advance care planning intervention, with increased decision-making self-efficacy and reduced relationship strain among care partners. It concerns planning for future care, not treating, curing or preventing Alzheimer's disease.
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Kening Jiang, Daniel D Callow, Adam P Spira; The Role of Sleep in Dementia Prevention: Building the Case for Causality, Sleep, , zsaf285, https://doi.org/1
Why it matters
This article argues for building the case that sleep plays a causal role in dementia prevention. It does not present new treatment or prevention results, but rather discusses the evidence needed to establish causality.
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This study found that awareness of home-based nursing, interest in home-based care for older people, and attitudes toward filial responsibility significantly influence the intention to work in home-based care.
Why it matters
In this survey of Macau nurses, 62.3% expressed interest in home-based care, but only 38.5% were willing to consider it as a career. Nurses in private hospitals and long-term care facilities were more likely to intend to work in home-based care than those in government hospitals.
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Breast cancer is the most common malignant tumor among women.
Why it matters
This review is about breast cancer prevention and treatment support, not Alzheimer's disease. It reports that saturated and trans fats may raise breast cancer risk while polyunsaturated fats, a high-protein diet, a Mediterranean diet and physical activity may be protective.
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38/100
Respondents (N=69) identified access to resources as the most important unmet need for caregivers (53%).
Why it matters
In this mixed methods survey of 69 respondents, caregivers named access to resources as their most important unmet need and reported barriers such as high costs and difficulty choosing technology. The study suggests better product design and user communication could speed adoption, but it did not test whether technology improves outcomes.
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The analysis yielded three categories and nine subcategories describing surrogate decision-making practices regarding end-of-life care for people with dementia: (a) typical circumstances of end-of-life care planning, (b) expected roles of key personnel and related challenges and (c) important considerations.
Why it matters
This qualitative study describes how decisions about end-of-life care are made for people with dementia in long-term care hospitals, and finds the process complex and challenging for staff. It does not test any treatment, cure or prevention.
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Frontotemporal dementia (FTD) refers to a group of neurodegenerative disorders characterized clinically by behavioral disturbances and pathologically by frontal and anterior temporal lobe neurodegeneration, resulting in brain atrophy.
Why it matters
No disease-modifying therapy currently exists for frontotemporal dementia, and compounds developed so far have been designed to target specific genetic mutations. Ongoing randomized clinical trials are evaluating new disease-modifying or symptomatic treatments and whether strategies should target specific mutations or common protein deposits, but these are still laying groundwork for future innovations.
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BackgroundScreening for cognitive function, using tests such as the Mini-Mental State Examination (MMSE) and Montreal Cognitive Assessment (MoCA), is the first step in detecting mild cognitive impairment (MCI) and dementia.
Why it matters
This study found that patients who met the mild cognitive impairment criteria on both the MMSE and MoCA had a 20.65-fold higher risk of incident Alzheimer's disease dementia than those with normal scores on both tests. Patients who met the criteria on only one test showed a risk similar to the normal group.
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We included 21 ACP RCTs. Trials included 103 outcome measures (39 primary and 64 secondary), of which 11% measured process, 14% measured action, 49% measured healthcare, and 26% measured quality of care.
Why it matters
This review of 21 randomized trials found that only 23% of the outcome measures used to test advance care planning in dementia were highly pragmatic, and most of these measured healthcare use rather than what matters to patients and care partners. The authors conclude that new outcome measures capturing the lived experience of people with dementia and their care partners are needed for trials embedded in routine care.
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Cognitive decline and dementia represent escalating global health challenges with limited therapeutic options, highlighting the need for effective preventive strategies.
Why it matters
This review reports that observational and interventional studies consistently link greater adherence to the Mediterranean diet with slower cognitive decline, reduced incidence of mild cognitive impairment and lower risk of Alzheimer's disease. It describes possible biological mechanisms but does not establish that the diet prevents or treats Alzheimer's disease.
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The increasing number of natural and man-made disasters registered at the global level is causing a significant amount of damage.
Why it matters
This paper is about using serious games to plan evacuations in a road network during disasters, and has nothing to do with Alzheimer's disease. It offers no information on treating, curing or preventing Alzheimer's disease.
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This exploratory, interpretivist, pre-implementation qualitative study used semi-structured interviews with 15 participants—four people living with dementia and 11 carers—to identify their needs, preferences, and perspectives to inform the design and implementation of an in-home respite service.
Why it matters
This exploratory qualitative study with 15 participants aimed to identify the needs, preferences, and perspectives of people living with dementia and their carers to inform design of an in-home respite service. It is preliminary and reports no findings on treating, curing or preventing Alzheimer's disease.
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Cognitive decline in older adults has significant implications for autonomy and quality of life.
Why it matters
In this trial of 85 older adults, combining cognitive training with active transcranial direct current stimulation led to immediate and sustained improvements across cognitive tests, while the sham group showed gains only in specific memory tasks and the control group showed no significant changes. It does not show whether this combined approach prevents or treats Alzheimer's disease.
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The study included 2.35 million beneficiaries in 2019 and 1.85 million in 2021.
Why it matters
Among older adults with dementia, Black and Hispanic individuals and dual-eligible beneficiaries had higher probabilities of ambulatory care sensitive hospitalizations before the pandemic, and hospitalizations fell during the pandemic while dual-eligibles had increased mortality. This is about disparities in care and outcomes, not about treating or preventing dementia.
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The use of linguistic biomarkers for detecting cognitive decline and early stages of dementia has demonstrated great potential due to its low-cost and non-invasive nature, especially towards a large aging population.
Why it matters
In a new cohort of 52 Mandarin-speaking older adults, a feature panel of two syntactic features achieved the best discrimination between those with and without cognitive impairment in a story narrative task, with accuracy of 0.840 and AUC of 0.867. This demonstrates the potential of syntactic biomarkers for cost-effective cognitive impairment screening, not for treating, curing, or preventing Alzheimer's disease.
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Dementia is rising sharply in the Middle East and North Africa region (MENA), with cases projected to increase by 367% by 2050.
Why it matters
This review highlights that dementia cases in the Middle East and North Africa are projected to rise sharply, with research remaining fragmented and healthcare systems facing challenges like workforce shortages and economic burden. Addressing these gaps will require large-scale studies, policy reforms, and culturally adapted interventions.
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This study predicts how sociodemographic trends-smaller family sizes, increased longevity, and marital patterns-could affect family care for people with dementia through 2060.
Why it matters
This modeling study projects that future dementia cohorts will be more likely to have a living spouse, but racial disparities will persist, and more people will be exposed to family members with dementia. It addresses caregiving availability and risk, not treating, curing, or preventing Alzheimer's disease.
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In response to these challenges, the study recommends a paradigm shift in urban planning towards the adoption of future-oriented and participatory approaches.
Why it matters
This study is about socially inclusive infrastructure for disaster risk reduction in urban planning in the SADC region and contains no information on Alzheimer's disease. It reports no findings relevant to treating, curing or preventing dementia.
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In the ADNI dataset, MCI patients exhibited significant alterations in structural covariance edges, mainly involving the hippocampus, parahippocampal gyrus, and amygdala.
Why it matters
This study identified two subtypes of mild cognitive impairment based on structural covariance networks, with one subtype showing faster disease progression than the other. It describes heterogeneity in mild cognitive impairment and does not test any treatment, cure or prevention.
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38/100
The incidence of dementia, and specifically, Alzheimer's disease, is higher in women than men, even in middle age, making it possible to rule out lifespan differences between men and women as a contributing factor.
Why it matters
This review discusses studies linking a history of hypertensive disorders of pregnancy with Alzheimer's disease and vascular dementia, and presents potential mechanisms. It identifies gaps and opportunities for further research rather than a treatment, cure or prevention.
From across this topic
10 of the 7,967 studies in this topic, picked by a fixed rule (a hash of each study's address), not by score or date; each page of this list shows a different 10. The same 10 appear here every time.
- Physiological and functional consequences of caregiving for relatives with dementia
- Leisure-time physical activity at midlife and the risk of dementia and Alzheimer's disease
- Relationships Among Caregiver Burden, Psychological Flexibility Processes, and Depressive Symptoms in Family Caregivers of People with Dementia: Path Analyses
- Proton Pump Inhibitors: Review of Emerging Concerns
- The Oldest Old in the Last Year of Life: Population‐Based Findings from Cambridge City over‐75s Cohort Study Participants Aged 85 and Older at Death
- Diabetes, Prediabetes, and Brain Aging: The Role of Healthy Lifestyle
- Navigating Dementia and Delirium: Balancing Identity and Interests in Advance Directives
- Performance of Claims-based Dementia Algorithms in Medicare Fee-for-service and Medicare Advantage Populations
- Childhood Loneliness and Cognitive Decline and Dementia Risk in Middle-Aged and Older Adults
- Risk factors for postoperative delirium: An umbrella review of systematic reviews