Each study has a usefulness score out of 100 (rubric version 4.0). Tap a score to see what makes it up.
Highest usefulness score first. Studies without a score come last.
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40/100
It is difficult to define what constitutes high-quality end-of-life care for people with dementia from the perspective of family carers.
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The prefrontal cortex and medial temporal lobe are particularly vulnerable to the effects of aging.
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For more than two decades, there have been extensive studies of experience-based neural plasticity exploring effective applications of brain plasticity for cognitive and motor development.
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Approaches to palliative care that were originally developed for people with cancer are now being adopted for people with dementia, as a response to many reports of poor-quality care for people with dementia at the end of life.
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40/100
These are not problems distinct to palliative care, but they may have different origins and explanations compared to other areas of health care.
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We propose that sleep disruption is a lever arm that influences how cognition emerges in development and then declines in response to Alzheimer disease in people with Down syndrome.
Why it matters
This article proposes that poor sleep may affect how cognition develops and declines in people with Down syndrome, and that addressing sleep problems might improve cognitive outcomes. It is a hypothesis paper, so the idea has not been tested as a treatment.
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Communication regarding care is rarely patient driven and more often professional caregiver or family driven.
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Idiopathic normal pressure hydrocephalus (INPH) is a syndrome of ventriculomegaly, gait impairment, cognitive decline and incontinence that occurs in an elderly population prone to many types of comorbidities.
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Regardless of the dementia stage, many nursing home residents develop serious clinical complications and symptoms in the last phase of life, posing major challenges to the provision of optimum end-of-life care.
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Our purpose was to determine whether the neurochemistry of the primary motor cortex measured with proton magnetic resonance spectroscopy, and its volume, were associated with gait performance while single and dual-tasking in mild cognitive impairment.
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40/100
The Niemann-Pick disease group is now divided into two distinct entities: (1) acid sphingomyelinase-deficient Niemann-Pick disease (ASM-deficient NPD) resulting from mutations in the SMPD1 gene and encompassing type A and type B as well as intermediate forms; (2) Niemann-Pick disease type C (NP-C) including also type D, resulting from mutations in either the NPC1 or the NPC2 gene.
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40/100
Microinfarctions are present in the aged and injured human brain.
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Palliative care (PC) has focused on patients with cancer within specialist services.
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The prevalence of age-related cognitive decline will increase due to graying of the global population.
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Accumulating evidence suggests that levels of inflammation, an immune response, increase with age throughout the body and the brain.
Why it matters
This review reports that inflammation in the body and brain increases with age and has been linked to cognitive decline and dementia risk in older adults. It suggests that health behaviors such as smoking, poor diet, and inactivity, and conditions like diabetes and hypertension, may increase inflammation, but it does not test any treatment.
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Dysphagia is a prevalent difficulty among aging adults.
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The hippocampus is classically involved in memory consolidation, spatial navigation and is involved in the stress response.
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Delirium in a non-selected population aged 65+ years is uncommon.
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This review describes recent discoveries in neurobiology of Down syndrome (DS) achieved with use of mouse genetic models and provides an overview of experimental approaches aimed at development of pharmacological restoration of cognitive function in people with this developmental disorder.
Why it matters
This review describes therapeutic strategies tested in mouse models of Down syndrome that may restore cognitive function, focusing on synaptic plasticity and amyloid processing. The findings are from animal models, so it is not yet known whether these strategies work in people.
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Compared with France, where the percentage of the elderly population has increased just twofold in the past 100 years, Japanese society is aging at an unprecedented rate.
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"Sundowning" in demented individuals, as distinct clinical phenomena, is still open to debate in terms of clear definition, etiology, operationalized parameters, validity of clinical construct, and interventions.
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This study shows that multistrategic memory training with the metamemory concept may improve memory ability and other cognitive functions which are not trained and that these improvements may be achieved by pure cognitive training effects.
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Additional research is warranted regarding the clinical decision-making processes that nurses use in assessing acute cognitive changes and in identifying strategies to improve delirium recognition.
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Personal attributes, environmental factors, and stimulus characteristics all contribute to the level and nature of engagement, with a secondary finding being that exposure to any stimulus elicits engagement in persons with dementia.
Why it matters
In nursing home residents with dementia, many different kinds of stimuli led to greater engagement than a control stimulus, and music increased how long people stayed engaged. This concerns engagement and activity, not treating, curing or preventing Alzheimer's disease.
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Frontotemporal dementia is commonly associated with parkinsonism in several sporadic (i.e., progressive supranuclear palsy, corticobasal degeneration) and familial neurodegenerative disorders (i.e., frontotemporal dementia associated with parkinsonism and MAPT or progranulin mutations in chromosome 17).
Why it matters
This paper describes the overlapping clinical features of frontotemporal dementia and parkinsonism and notes the difficulty of distinguishing these disorders before death. It reports no treatment, cure, or prevention.
From across this topic
10 of the 7,967 studies in this topic, picked by a fixed rule (a hash of each study's address), not by score or date; each page of this list shows a different 10. The same 10 appear here every time.
- Enhancing memory performance in older adults through socially engaging cognitive training
- The Geriatric Depression Scale and the Cornell Scale for Depression in Dementia. A validity study
- Defining end of life in dementia: A systematic review
- Home as mind: AI extenders and affective ecologies in dementia care
- Neuropsychological rehabilitation of memory deficits and activities of daily living in patients with Alzheimer's disease: a pilot study
- Exploring the effect of companion robots on emotional expression in older adults with dementia: a pilot randomized controlled trial
- The Oregon brain aging study: neuropathology accompanying healthy aging in the oldest old
- Dietary fat intake and the risk of incident dementia in the Rotterdam Study
- "Life's Essential 8" Cardiovascular Health and Dementia Risk, Cognition, and Neuroimaging Markers of Brain Health
- Short-Term Impacts of COVID-19 Public Health Regulation on Consumer Food Purchases: A Case Study From a Grocery Store in Montana