Home › Research › Long-term cohort studies
Lung function and risk of incident dementia: A prospective cohort study of 431,834 individuals
Ma YH, Shen LX, Li YZ, Leng Y, Yang L, Chen SD, He XY, Zhang YR et al.. Brain, behavior, and immunity, 2023-02-14
Topic: Risk, prevention and care in population studies
Background Whether lung function prospectively affects cognitive brain health independent of their overlapping factors remains largely unknown. This study aimed to investigate the longitudinal association between decreased lung function and cognitive brain health and to explore underlying biological and brain structural mechanisms. Methods This population-based cohort included 43,1834 non-demented participants with spirometry from the UK Biobank.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Ma, Y. H., Shen, L. X., Li, Y. Z., Leng, Y., Yang, L., Chen, S. D., et al. (2023). Lung function and risk of incident dementia: A prospective cohort study of 431,834 individuals. Brain, behavior, and immunity. https://doi.org/10.1016/j.bbi.2023.02.009
Vancouver
Ma YH, Shen LX, Li YZ, Leng Y, Yang L, Chen SD, et al. Lung function and risk of incident dementia: A prospective cohort study of 431,834 individuals. Brain, behavior, and immunity. 2023. doi:10.1016/j.bbi.2023.02.009. PMID: 36796705.
BibTeX
@article{ma2023-36796705,
author = {Ma, Y. H. and Shen, L. X. and Li, Y. Z. and Leng, Y. and Yang, L. and Chen, S. D. and He, X. Y. and Zhang, Y. R. and others},
title = {{Lung function and risk of incident dementia: A prospective cohort study of 431,834 individuals}},
journal = {Brain, behavior, and immunity},
year = {2023},
doi = {10.1016/j.bbi.2023.02.009},
pmid = {36796705},
url = {https://doi.org/10.1016/j.bbi.2023.02.009}
}
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record's author list ends in “et al.”, so not every author is named. Check the citation against the original before you use it.
Key findings
- This study aimed to investigate the longitudinal association between decreased lung function and cognitive brain health and to explore underlying biological and brain structural mechanisms.
- Methods This population-based cohort included 43,1834 non-demented participants with spirometry from the UK Biobank.
- Cox proportional hazard models were fitted to estimate the risk of incident dementia for individuals with low lung function.
- Mediation models were regressed to explore the underlying mechanisms driven by inflammatory markers, oxygen-carrying indices, metabolites, and brain structures.
Why it matters
This large study examined whether people with lower lung function are more likely to develop dementia later on. It also explored possible biological and brain structure reasons for any link, which could help explain how lung health relates to brain health.
Study details
- Study designlongitudinal study
- Participants43
- Evidence strengthModerate
How this study scored 59/100
Published in a peer-reviewed journal, and it is a longitudinal study following the same people over time. Scored zero for effect reported and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Brain, behavior, and immunity) |
| Journal's citation record | 2 / 4 | Brain Behavior and Immunity: journal h-index 249 (OpenAlex, 2026-10-29) |
| Study design | 7 / 12 | A longitudinal study following the same people over time |
| Strength of evidence | 3 / 5 | Rated “moderate” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 3 / 5 | 2023 — within 6 year(s) of the newest study here |
| Sample size | 1 / 4 | 43 participants |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 4 / 7 | Cited 52 times (OpenAlex, 2026-10-10) |
| Citations per year | 3 / 5 | 10.4 citations a year over 5 year(s) since 2023 |
| Impact for its field and year | 4 / 6 | Cited 9.4× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 1 / 6 | Cited by 1 other studies in this library |
| Still being cited | 3 / 4 | Cited 50 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 1 / 4 | Last-listed author Jin-Tai Yu: h-index 7 (OpenAlex, whole career) |
| Institution's track record | 2 / 3 | University of Oxford: institution h-index 2,205 (OpenAlex) |
| Multi-centre collaboration | 3 / 3 | OpenAlex lists 11 institution(s) in 3 countries |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 36796705) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Total | 59 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
May need a subscription OpenAlex found no free copy of the full text (checked 6 Feb 1020), so the publisher may charge for it. The PubMed abstract is free.
Studies this one cites
Referenced by this study and also in the alzhub library, so you can read them here.
Later studies that cite this one
1 study in the alzhub library lists this one in its references.
Related studies in Long-term cohort studies
Also tagged “biobank”
1,084 studies in the library carry the topic tag “biobank”; these are this study's neighbours in a fixed, alphabetical-by-hash tour of them, not the closest in content. All 1,084 tagged studies.