Each study has a usefulness score out of 100 (rubric version 4.0). Tap a score to see what makes it up.
Highest usefulness score first. Studies without a score come last.
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45/100
Preexisting physician attitudes, knowledge, and beliefs prevent emergency physicians from addressing PC needs for AD patients.
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45/100
The prevalence of obesity is growing and now includes at least one-third of the adult population in the United States.
Why it matters
This review discusses ways a high-fat diet and obesity may affect the brain and cognition, including insulin resistance, oxidative stress, inflammation, and vascular alterations. It states that long-term effects of obesity on the brain need further examination and does not test any treatment or prevention for Alzheimer's disease.
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Current evidence indicates that spaced-retrieval training is effective in enabling people with dementia to learn new information and behavioral strategies.
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We have previously shown that beta-band EEG activity is related to attentional modulation in the visual system of cats and humans.
Why it matters
This study examined EEG beta band activity in relation to attention and attentional deficits in elderly subjects. It concerns attention in normal aging and does not test treating, curing or preventing Alzheimer's disease.
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Community-based surveys were performed in seven rural areas in Japan to investigate the prevalence of dementia and illnesses causing dementia.
Why it matters
This preliminary population survey in Japan found that Alzheimer's disease was the most frequent illness causing dementia and reported a prevalence of dementia higher than in previous reports. It describes how common dementia is, not how to treat, cure, or prevent Alzheimer's disease.
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The aim of this study is to validate the Italian version of the Pittsburgh Sleep Quality Index (PSQI), comparing five different groups of individuals (healthy young and elderly, sleep apnoea syndrome patients, depressed patients, individuals with dementia) by both questionnaire scores and polysomnographic measures.
Why it matters
This study tested an Italian version of a sleep quality questionnaire in 50 people, including 10 with dementia, and found it reliably told 'good' from 'bad' sleepers. It is a tool for measuring sleep quality, not a treatment, cure or prevention for Alzheimer's disease.
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Brain oxidative processes play a major role in age-related cognitive decline, thus consumption of antioxidant-rich foods might help preserve cognition.
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45/100
The clinical hallmark of Alzheimer's disease (AD) is a gradual decline in cognitive function.
Why it matters
This paper describes how Alzheimer's typically begins with decline in episodic memory, which is already evident in mild cognitive impairment and can help predict progression to dementia, especially alongside Alzheimer's biomarkers. It notes recent reports that amyloid accumulation may also be associated with memory performance in cognitively normal people, but it presents no treatment or cure.
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VTM is emerging as an effective way to provide consultation and care to rural residents who may not have access to specialty services and can be integrated into current clinical settings.
Why it matters
This small program evaluated 15 rural patients with memory complaints using video-telemedicine and found that the format allowed the team to arrive at a working diagnosis and make treatment recommendations. It is about remote diagnosis and management, not about treating, curing, or preventing Alzheimer's disease itself.
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45/100
This aim of this study was to assess the clinical utility of the Montreal Cognitive Assessment (MoCA) as a screening instrument for cognitive impairment in patients referred to a memory clinic, alone and in combination with the Mini-Mental State Examination (MMSE).
Why it matters
This prospective study of 150 memory clinic referrals assessed whether the MoCA works as a screening tool for cognitive impairment, alone and combined with the MMSE. It is about improving detection of cognitive impairment, not about treating, curing or preventing Alzheimer's disease.
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Only a minority of subjects initiated ACP.
Why it matters
This study found that by 5 years of follow-up, only 39% of people with mild cognitive impairment or Alzheimer's disease who had no advance directives at first presentation had initiated advance care planning. It concerns planning for future care decisions, not the treatment, cure, or prevention of Alzheimer's disease.
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Older patients account for up to a quarter of all emergency department (ED) visits.
Why it matters
This review discusses evaluation and management of older patients in the emergency department, including delirium, dementia, falls and polypharmacy. It offers strategies for emergency care, not for treating, curing or preventing Alzheimer's disease.
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A factor analysis revealed 3 dimensions of burden: role strain, personal strain, and worry about performance.
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Community-dwelling elders' preferences for end-of-life care are not consistent with documentation in their medical records.
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We propose a nonparametric, probabilistic model for the automatic segmentation of medical images, given a training set of images and corresponding label maps.
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45/100
The prevalence of cognitive impairment is higher in rural compared with urban populations.
Why it matters
In Northern Portugal, cognitive impairment and dementia were more common in rural than urban older populations, and cerebrovascular disease was noted as relevant. This describes where dementia is more common and points to vascular factors, not to any treatment or cure.
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Many brain structures show a complex, non-linear pattern of maturation and age-related change.
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A high adherence to the Mediterranean diet has been associated with slower cognitive decline, with reduced risk of mild cognitive impairment conversion to Alzheimer's disease and with reduced risk of Alzheimer's disease.
Why it matters
This review reports that in two prospective cohorts of older Americans and French people, high adherence to the Mediterranean diet was associated with slower cognitive decline and reduced risk of mild cognitive impairment converting to Alzheimer's disease. The authors call for replication in other populations before the diet can be proposed as a preventive approach.
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Mild cognitive impairment (MCI), the earliest clinically detectable phase of the trajectory toward dementia and Alzheimer's disease (AD), led to the need for even earlier detection and prevention of AD.
Why it matters
This review of autopsy findings reports that most people with amnestic mild cognitive impairment appear to be on a path toward Alzheimer's disease, with neurofibrillary pathology in certain brain regions rather than amyloid plaques as the main basis for memory decline. It is a review of brain tissue findings and does not test any treatment.
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Menopause is associated with sharp declines in concentrations of circulating estrogens.
Why it matters
This review of clinical trials concluded that estrogen therapy does not improve dementia symptoms in women who already have Alzheimer's disease. It also found that hormone therapy started after about age 65 increases dementia risk.
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Subjects with limited health literacy expressed more uncertainty about their preferences for end-of-life care than did subjects with adequate literacy.
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Relationships between self-reported retrospective falls and cognitive measures (executive function, reaction time [RT], processing speed, working memory, visual attention) were examined in a population based sample of older adults (n = 658).
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The data suggest that instruments measuring delirium severity and psychomotor features provide important prognostic information and should be integrated into the assessment of delirium.
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Progressive and non-progressive patients are difficult to differentiate on the basis of current clinical diagnostic criteria for FTD but a combination of general cognitive, executive dysfunction and impaired ADL measures appear to be the most promising discriminators.
Why it matters
This study looked at whether progressive and non-progressive behavioral variant frontotemporal dementia can be told apart at first presentation, and found the groups were largely indistinguishable on presenting clinical features. It concerns frontotemporal dementia diagnosis and progression, not Alzheimer's treatment, cure or prevention.
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Mild Cognitive Impairment (MCI) involves subtle functional losses that may include decrements in driving skills.
From across this topic
10 of the 7,967 studies in this topic, picked by a fixed rule (a hash of each study's address), not by score or date; each page of this list shows a different 10. The same 10 appear here every time.
- Socially assistive robots in elderly care: a systematic review into effects and effectiveness
- Invisibility
- Midlife vascular risk factors and midlife cognitive status in relation to prevalence of mild cognitive impairment and dementia in later life: The Atherosclerosis Risk in Communities Study
- Geographic Variation in One-Year Recurrent Ischemic Stroke Rates for Elderly Medicare Beneficiaries in the USA
- Frontotemporal dementia
- The benefits associated with volunteering among seniors: a critical review and recommendations for future research
- Populations and Interventions for Palliative and End-of-Life Care: A Systematic Review
- Predictors of survival in a series of clinically diagnosed progressive supranuclear palsy patients
- Progression of mild cognitive impairment to dementia: a challenge to current thinking
- Evaluation of an educational program for long-term care nursing assistants