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40/100

✓ Peer-reviewed alzhub usefulness score 40 out of 100. Health systems and care delivery

Topic: Risk, prevention and care in population studies

The study population of 99,774 individuals had a mean age of 71.0 years and was 49.1% female, 73.9% White, and 17.8% Black, with 62.0% living in an urban setting. Compared with patients who missed zero adherence measures, those who missed one measure had 23%–33% increased odds of cognitive decline (any decline OR = 1.23; dementia OR = 1.33; Alzheimer's disease OR = 1.27; all P values <0.01). Patients who missed 2–3 measures had 37%–96% increased odds of cognitive decline (any decline OR = 1.37; dementia OR = 1.58; Alzheimer's disease OR = 1.96; all P values <0.01). Patients who missed ≥4 adherence measures had the greatest odds of cognitive decline (any decline OR = 1.64; dementia OR = 2.05; Alzheimer's disease OR = 2.48; all P values <0.01). Not achieving CMS Star Medication Adherence quality measures for diabetes, hypertension, and hyperlipidemia therapies was associated with increased risk of cognitive decline outcomes.

Cite this study APA, Vancouver, BibTeX · download .bib or .ris

APA 7th

Racsa, P. N., Booth, T. A., Chung, L. N., Dixon, S., & Poonawalla, I. B. (2023). Association of medication adherence quality measures for diabetes, hypertension, and hyperlipidemia with cognitive decline. Journal of Family Medicine and Primary Care. https://doi.org/10.4103/jfmpc.jfmpc_935_23

Vancouver

Racsa PN, Booth TA, Chung LN, Dixon S, Poonawalla IB. Association of medication adherence quality measures for diabetes, hypertension, and hyperlipidemia with cognitive decline. Journal of Family Medicine and Primary Care. 2023. doi:10.4103/jfmpc.jfmpc_935_23. PMID: 38186814.

BibTeX

@article{racsa2023-38186814,
  author  = {Racsa, Patrick N. and Booth, Tori A. and Chung, Linda N. and Dixon, Suzanne and Poonawalla, Insiya B.},
  title   = {{Association of medication adherence quality measures for diabetes, hypertension, and hyperlipidemia with cognitive decline}},
  journal = {Journal of Family Medicine and Primary Care},
  year    = {2023},
  doi     = {10.4103/jfmpc.jfmpc_935_23},
  pmid    = {38186814},
  url     = {https://doi.org/10.4103/jfmpc.jfmpc_935_23}
}

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Key findings

The study population of 99,774 individuals had a mean age of 71.0 years and was 49.1% female, 73.9% White, and 17.8% Black, with 62.0% living in an urban setting.
Compared with patients who missed zero adherence measures, those who missed one measure had 23%–33% increased odds of cognitive decline (any decline OR = 1.23; dementia OR = 1.33; Alzheimer's disease OR = 1.27; all P values <0.01).
Patients who missed 2–3 measures had 37%–96% increased odds of cognitive decline (any decline OR = 1.37; dementia OR = 1.58; Alzheimer's disease OR = 1.96; all P values <0.01).
Patients who missed ≥4 adherence measures had the greatest odds of cognitive decline (any decline OR = 1.64; dementia OR = 2.05; Alzheimer's disease OR = 2.48; all P values <0.01).
Not achieving CMS Star Medication Adherence quality measures for diabetes, hypertension, and hyperlipidemia therapies was associated with increased risk of cognitive decline outcomes.

Why it matters

This study found that not achieving CMS Star Medication Adherence quality measures for diabetes, hypertension, and hyperlipidemia therapies was associated with increased risk of cognitive decline outcomes. The odds of cognitive decline increased as more adherence measures were missed.

Study details

Participants99,774
Effect size49.1%; 73.9%; 17.8%
Evidence strengthLow

How this study scored 40/100

Published in a peer-reviewed journal. Scored zero for study design and randomised / blinded because the record does not state it.

Component	Points	Why
Journal tier	7 / 10	Tier 3 — peer-reviewed journal (Journal of Family Medicine and Primary Care)
Journal's citation record	1 / 4	Journal of Family Medicine and Primary Care: journal h-index 80 (OpenAlex, 2026-10-29)
Study design	0 / 12	No study design recorded — scores zero, not guessed (not stated in the record — scored 0)
Strength of evidence	1 / 5	Rated “low” in our summary
Peer-review validation	10 / 10	Peer-reviewed. Published as an article in a named peer-reviewed journal.
How recent	3 / 5	2023 — within 6 year(s) of the newest study here
Sample size	4 / 4	99,774 participants
Effect reported	2 / 3	Effect reported as a number, without an interval or test
Studied in people	3 / 3	Studied in people (participant count stated)
Randomised / blinded	0 / 2	No randomisation or blinding stated — scores zero (not stated in the record — scored 0)
Times cited	1 / 7	Cited 4 times (OpenAlex, 2026-10-10)
Citations per year	0 / 5	0.8 citations a year over 5 year(s) since 2023
Impact for its field and year	2 / 6	Cited 1.1× the average for papers of its field and year (OpenAlex FWCI)
Cited by studies here	0 / 6	No other study in this library cites it
Still being cited	1 / 4	Cited 4 times in 2024–2026 (2026 still in progress; OpenAlex)
Senior author's track record	1 / 4	Last-listed author Insiya B. Poonawalla: h-index 12 (OpenAlex, whole career)
Institution's track record	0 / 3	Humana (United States): institution h-index 77 (OpenAlex)
Multi-centre collaboration	0 / 3	OpenAlex lists 1 institution(s) in 1 country — scores zero (affiliation lists can be incomplete)
Indexed in PubMed	2 / 2	Indexed in PubMed (PMID 38186814)
Free to read	2 / 2	Free to read
Total	40 / 100	—

What each of these 20 components measures, and what this score is not →

Read the original

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