Each study has a usefulness score out of 100 (rubric version 4.0). Tap a score to see what makes it up.
Highest usefulness score first. Studies without a score come last.
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33/100
Modifiable risk factors associated with dementia were common in AA and NHW participants.
Why it matters
In African American participants, stroke or transient ischemic attack was linked to higher odds of dementia, while depression was linked to higher odds of dementia in both African American and non-Hispanic White participants. Depression was also linked to faster cognitive decline in impaired participants, suggesting risk factor modification may help reduce disparities.
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Being in the top 5% indicates that 95% of all other Medicare Advantage plans prescribed more Poly-ACH regimens than KPSC.
Why it matters
This report describes a decline in the concurrent prescribing of highly anticholinergic medications to older adults in one healthcare system. It does not address treating, curing, or preventing Alzheimer's disease.
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33/100
Limited research is available on the real-world experiences of patients with dementia with Lewy bodies (DLB).
Why it matters
This study found that patients with dementia with Lewy bodies had more clinical events, used more healthcare resources, and incurred higher healthcare costs compared with patients with other dementia types with psychosis. It concluded that understanding the clinical and economic impact of dementia with Lewy bodies and other dementia types with psychosis is important to improve care for patients with dementia.
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Adherence to ADRD medications was not associated with specialist availability but was related to individual and socioeconomic context factors in community‐dwelling older individuals with ADRD.
Why it matters
Among 54,194 Medicare beneficiaries with ADRD, adherence to ADRD medications was not significantly associated with specialist availability but was related to individual and socioeconomic context factors. The study is about factors influencing medication adherence, not about whether any treatment cures or prevents Alzheimer's disease.
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The case and death rates are, for example, significantly positively associated with early cases from the beginning of the epidemic, the average age, the population density and the number of people employed in elderly care.
Why it matters
This study is about COVID-19, not Alzheimer's disease, so it does not provide information on treating, curing or preventing Alzheimer's. It reports that COVID-19 case and death rates were associated with factors such as average age, population density and employment in elderly care.
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Experimental work regarding corrective actions on chromosomes and genes, and control of gene products is yielding promising results.
Why it matters
This article discusses experimental work on correcting chromosomes and genes and on controlling gene products in Down syndrome, and notes a small number of molecules being studied for effects on intellectual functioning. It presents these as promising directions, not as established treatments or cures.
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The increasing aging demographics never seen before is associated with the enormous challenge of dementia epidemics which urgently needs a paradigm shift in the approach to cognitive functions in health and disease.
Why it matters
This paper argues that maintaining a healthy lifestyle should be a medical priority and that early recognition of cognitive disturbances is mandatory. It emphasizes evaluating cognitive performance in older patients, especially those hospitalized for other reasons.
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OpenStreetMap provides a valuable crowd-sourced database of raw geospatial data for constructing models of urban street networks for scientific analysis.
Why it matters
This project built and shared street network models and measures for locations across the United States. It provides no information on treating, curing or preventing Alzheimer's disease.
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This review will describe the evidence for changing the hospital environment to improve nutrition of older people, with particular emphasis on the role of additional mealtime assistance.
Why it matters
This review describes evidence on changing the hospital environment to improve nutrition of older people, noting that volunteers can be trained to give additional mealtime assistance and can improve the quality of mealtime care, although evidence for improved dietary intake is mixed. It concludes that improving the nutrition of older patients in hospital is challenging.
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Multimorbidity results in use of multiple medications.
Why it matters
This article reviews medication reconciliation and education for older adults, noting that antipsychotics should be avoided as first-line treatment for behavior disturbances in dementia. It does not address treating, curing, or preventing Alzheimer's disease itself.
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The views of care home staff and relatives had similarities in general terms regarding the problems arising around expressions of sexuality in care homes: indicting that a light-hearted or non-physical connection between residents is deemed acceptable, but the moment it becomes a sexual relationship then decision making becomes more complicated.
Why it matters
This exploratory study examines the views of relatives and care home staff on new relationships and intimacy among residents with dementia. It provides no information on treating, curing or preventing Alzheimer's disease.
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Down syndrome (DS) is the most common genetic cause of cognitive deficits.
Why it matters
This article notes that researchers are exploring therapies, using mouse models and Alzheimer disease therapies, that may improve cognitive function in people with Down syndrome. It argues that no validated quality of life instruments exist for Down syndrome and that such instruments should be developed for therapeutic trials.
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33/100
Parkinson disease is a progressive neurologic disorder afflicting approximately 1 percent of Americans older than 60 years.
Why it matters
This update describes treatments for Parkinson disease, including carbidopa-levodopa, dopamine agonists, and deep brain stimulation, which reduce motor impairment. It concerns Parkinson disease and does not test any treatment, cure, or prevention for Alzheimer's disease.
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The Canadian population is aging. In Newfoundland and Labrador, nursing homes and supervised care facilities provide Long-Term Care (LTC).
Why it matters
This planning study compared long-term care clients in Newfoundland and Labrador and used a decision tree to estimate optimal placement across housing, supervised care, and nursing home care. It addresses long-term care bed planning, not treating, curing, or preventing Alzheimer's disease.
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Unintentional weight loss is associated with increased morbidity and mortality.
Why it matters
The paper describes weight loss, frailty, and nutrition problems in older people and notes that healthy dietary practices in later life can reduce illness and death. It does not report any specific effect on Alzheimer's disease.
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Multi-infarct dementia (MID), thought to result from the cumulative effect of repeated episodes of cerebral infarction, represents a sizable proportion of the dementia cases in the population.
Why it matters
This report describes multi-infarct dementia, which is thought to result from repeated strokes, and notes that it may account for about 10% of dementia cases. It suggests that future studies need to define the condition precisely and clarify the timing between stroke and dementia to better understand cerebrovascular disease as a cause.
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33/100
To determine if impaired dichotic performance in patients with dementia of the Alzheimer type is due to the inability to divide attention or the inability to perceive degraded auditory stimuli, we measured performance on tasks of both dichotic and degraded monotic speech materials.
Why it matters
This study found that patients with Alzheimer-type dementia were more impaired on a dichotic speech test than on degraded monotic speech tests, concluding the difficulty reflects an inability to divide attention. It examines cognitive mechanisms and does not report any treatment, cure, or prevention.
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This study explored the ways in which food desert coverage was reported during the COVID-19 pandemic.
Why it matters
This analysis examines how food desert coverage was reported during COVID-19, not Alzheimer's disease, so it provides no information on treating, curing or preventing Alzheimer's. It identified themes of financial context, agriculture, community and vulnerability.
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This study explored the views and experiences of Australians living with dementia relating to voluntary assisted dying (VAD) as an end-of-life care option.
Why it matters
In interviews with 12 Australians living with dementia, participants wanted voluntary assisted dying as an end-of-life option to control their care and avoid a poor dying experience. It reports their views on end-of-life care, not a treatment or cure for Alzheimer's disease.
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How do clinicians distinguish early-stage dementia from the expected cognitive variability seen in ageing adults with Down syndrome?
Why it matters
This study found that adults with Down syndrome and probable dementia scored lower across all five adaptive domains compared to those without dementia, using carer-reported questionnaires. These findings point to a practical screening approach that can flag early decline in community settings.
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Incident dementia diagnoses increased in MA relative to traditional Medicare, despite an overall downward trend in diagnosis rates.
Why it matters
This study found that new dementia diagnoses in Medicare Advantage increased after Alzheimer's disease and related dementias were reintroduced into the risk adjustment model, with variation across plan types and insurers. It notes that larger increases may reflect coding practices rather than true disease prevalence, and it is not about treating, curing, or preventing Alzheimer's disease.
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This multisite initiative demonstrated that structured PPI is feasible in LMICs when supported by cultural adaptation, PPI coordinator roles, and tailored training for contributors and researchers.
Why it matters
This scoping review reports that structured patient and public involvement is feasible in low- and middle-income countries with cultural adaptation, coordinator roles and tailored training. It concerns research methods and contains no information on treating, curing or preventing Alzheimer's disease.
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To compare and rank the relative and additive effects of lifestyle components including exercise, diet, cognitive training, vascular management, and digital delivery on cognitive outcomes and dementia prevention in older adults without dementia.
Why it matters
This network meta-analysis aims to compare and rank the relative and additive effects of lifestyle components including exercise, diet, cognitive training, vascular management, and digital delivery on cognitive outcomes and dementia prevention in older adults without dementia. No results are reported in the provided text, so it offers no evidence yet about treating, curing, or preventing Alzheimer's disease.
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Compared with conventional activities, GDRT resulted in significantly greater reductions in overall BPSD (r = 0.56, p = .001) and caregiver burden (r = 0.44, p = .011).
Why it matters
In 44 nursing home residents, group digital reminiscence therapy on a large screen reduced behavioral and psychological symptoms of dementia and caregiver burden, and improved apathy and cognitive function, compared with usual activities. This is a small crossover study of a non-drug activity, so it addresses symptom management rather than curing or preventing Alzheimer's disease.
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In this update, we discuss the use of real-world data in the Haute Autorité de Santé assessment of economic evaluations, review how real-world evidence is supporting regulatory approvals in multiple myeloma, and consider lessons from the failed EVOKE trials of semaglutide in Alzheimer's disease for the broader application of target trial emulation.
Why it matters
This round-up discusses real-world evidence in health technology assessment and draws lessons from the failed EVOKE trials of semaglutide in Alzheimer's disease. It reports that those trials failed and offers no evidence of a treatment, cure or prevention.
From across this topic
10 of the 7,967 studies in this topic, picked by a fixed rule (a hash of each study's address), not by score or date; each page of this list shows a different 10. The same 10 appear here every time.
- Routine cognitive screening in a neurology practice: Effect on physician behavior
- Application of Upper Limb Multimodal Tasks Combined With fNIRS Technology in the Assessment of Mild Cognitive Impairment
- Long-term air pollution exposure and incident dementia: a systematic review and meta-analysis
- Diabetes is related to cerebral infarction but not to AD pathology in older persons
- Scaling of Small-Area Fair Market Rents: Evidence on Neighborhood Choices of Voucher Recipients
- Trends in Incident Dementia Diagnosis Before and After Medicare Risk Adjustment
- Informal care for people with dementia in Europe
- Vascular contributions to cognitive impairment and dementia including Alzheimer's disease
- Dose-response relationship between evening exercise and sleep
- Views of Family Caregivers on Advance Care Planning in Advanced Dementia Care in Hong Kong: A Qualitative Thematic Content Analysis Study