Each study has a usefulness score out of 100 (rubric version 4.0). Tap a score to see what makes it up.
Download bibliography of all 8,018 studies, highest score first: BibTeX (.bib) · RIS (.ris)
Highest usefulness score first. Studies without a score come last.
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The Rey Auditory Verbal Learning Test [RAVLT; Rey, A. (1941).
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Several studies have shown that pharmacological and cognitive treatments for Alzheimers's disease improve cognitive function for short periods, but fewer studies have evaluated the efficacy of those treatments for longer (2-year) periods.
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The present findings emphasize that patients with reduced hippocampal volumes show more executive dysfunctions than their counterparts.
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Caregivers had higher levels of 8 am, 5 pm, and 9 pm log cortisol as well as higher perceived stress than noncaregivers.
Why it matters
This small preliminary study compared stress, depression and cortisol in Hispanic and non-Hispanic white women who were dementia caregivers or not. It found caregivers had higher cortisol and perceived stress, but it is an early study of caregiver stress biology, not a treatment or prevention for Alzheimer's disease.
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These findings demonstrate a disruption in fornix integrity in patients with schizophrenia.
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All participants conveyed striking similarities of thought about normalization of cognitive symptoms until one critical event, usually relocation, precipitated family awareness that an elder's behavior was not the result of "normal aging."
Why it matters
This meta-synthesis found that lack of knowledge about Alzheimer's disease and physicians' failure to recognize it were major barriers to diagnosis in minority caregivers. It does not test any treatment, cure, or prevention for Alzheimer's disease.
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Despite variation and overlap of atrophy patterns, visual inspection of regional atrophy on MRI may aid in discriminating AD and FTLD.
Why it matters
In this study of pathologically confirmed young-onset dementias, visual inspection of MRI distinguished most dementia cases from controls but gave a correct specific diagnosis in only 58% of cases. It is about diagnosis using imaging, not about treating, curing or preventing Alzheimer's disease.
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Hippocampal atrophy has been related to mild cognitive impairment (MCI) and early Alzheimer disease (AD), but the diagnostic significance of cross-sectionally determined hippocampal volumes is still ambiguous.
Why it matters
In 18 people with mild cognitive impairment, left hippocampal volume was lower and hippocampal diffusivity was higher than in controls, and combining these measures related to poorer verbal memory. This is a small imaging study of brain structure and memory, not a test of any treatment, cure, or prevention.
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43/100
Mild cognitive impairment (MCI) describes a state of cognitive functioning that is below defined norms, yet falls short of dementia in severity.
Why it matters
There are currently no pharmacological treatments that can delay the long-term progression of mild cognitive impairment to dementia. Some evidence suggests acetylcholinesterase inhibitors may provide short-term symptomatic benefits, but they do not change the underlying course of the condition.
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Family caregivers experience both positive and negative reactions in caregiving situations.
Why it matters
This study explored an instrument to measure satisfaction among family caregivers of people with dementia living at home and found that burden and satisfaction can coexist. It is about the caregiver experience and does not test any treatment, cure, or prevention for Alzheimer's disease.
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The purpose of this study was to explore the structure of the Zarit Burden Interview (ZBI) for informal caregivers of patients suffering from AD or related disorders, and to examine the relations of the dimensions found with functional disabilities and other patient health indicators.
Why it matters
This study explored the structure of the Zarit Burden Interview and how its dimensions relate to patient disability and health in caregivers of people with Alzheimer's disease or related disorders. It is about measuring caregiver burden, not about treating, curing or preventing the disease.
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In nondemented older persons, executive function is independently associated with tasks of lower extremity function that require high attentional demand.
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Knowledge of cognitive performance earlier in life is essential in order to characterize precisely the extent to which these abilities have declined when an individual is diagnosed as having a dementing illness.
Why it matters
This paper concerns a French-language adaptation of the National Adult Reading Test to estimate a person's intellectual ability before dementia began. It is about assessment, not about treating, curing or preventing Alzheimer's disease.
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Neurological complications whether due to the uremic state or its treatment, contribute largely to the morbidity and mortality in patients with renal failure.
Why it matters
This review describes neurological complications of renal failure and its treatment, including dialysis dementia. It contains no information about treating, curing or preventing Alzheimer's disease.
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Scores from domains were summed and classified into 3 categories: 4 or less, minimal; 5-12, moderate; and more than 12, significant content.
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PTSD is not a necessary condition for small hippocampal size in trauma-exposed individuals.
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Older depressed subjects have persisting cognitive impairments associated with hippocampal volume reduction, but the results do not support cortisol-mediated hippocampal neurotoxicity as the major etiological mechanism.
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Epidemiologic evidence suggests that higher occupational attainment and education, as well as increased participation in intellectual, social, and physical aspects of daily life, are associated with slower cognitive decline in healthy elderly and may reduce the risk of incident Alzheimer's disease (AD).
Why it matters
This review discusses evidence that higher education, occupational attainment, and participation in intellectual, social, and physical activities are associated with slower cognitive decline and may reduce Alzheimer's disease risk. It hypothesizes that these life experiences provide a cognitive reserve that delays the onset of clinical dementia.
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Proactive interventions from a palliative care consultant within this subset of patients improved end-of-life care and decreased use of superfluous resources.
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43/100
Postoperative delirium is a serious complication.
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In patients with Parkinson's disease (PD) disturbances of mental state constitute some of the most difficult treatment challenges of advanced disease, often limiting effective treatment of motor symptoms and leading to increased disability and poor quality of life.
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43/100
Medication-free nonelderly depressed outpatients without alcohol dependence or adverse experiences in childhood had normal hippocampal volume.
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Participants with late-onset depression had bilateral hippocampal atrophy compared with those with early-onset depression and controls.
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Childhood abuse is linked to posttraumatic stress disorder (PTSD), which follows abuse survivors into adulthood.
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In this study we investigated impaired awareness of cognitive deficits in patients with mild cognitive impairment (MCI) and Alzheimer's disease (AD).
Why it matters
This study found no significant differences in the level of awareness of cognitive deficits between patients with mild cognitive impairment and Alzheimer's disease, with both groups showing impaired awareness. It is a descriptive study of insight and does not test any treatment, cure or prevention.
From across this topic
10 of the 7,967 studies in this topic, picked by a fixed rule (a hash of each study's address), not by score or date; each page of this list shows a different 10. The same 10 appear here every time.
- Brain clocks capture diversity and disparities in aging and dementia across geographically diverse populations
- Vascular depression consensus report - a critical update
- Identification of cognitively impaired patients at risk for development of Alzheimer’s disease dementia: an analysis of US Medicare claims data
- Improving Care Through Public Policy
- Incidence and risk factors of vascular dementia and Alzheimer's disease in a defined elderly Japanese population: the Hisayama Study
- Efficacy of flupirtine on cognitive function in patients with CJD: A double-blind study
- Vascular pathologies and cognition in a population-based cohort of elderly people
- Caregiver burden and quality of life associated with behavioral and psychological symptoms of Alzheimer's disease: A web-based cross-sectional survey study
- Hearing loss and cognition in the Baltimore Longitudinal Study of Aging
- Diet‐Driven Metabolite Patterns Link the MIND Diet to Dementia Biomarkers