Each study has a usefulness score out of 100 (rubric version 4.0). Tap a score to see what makes it up.
Highest usefulness score first. Studies without a score come last.
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Our robust machine learning based analytical pipeline consists of segmentation, radiomic texture extraction, feature normalization and selection, and predictive-model generation.
Why it matters
This conference abstract describes a machine learning pipeline using radiomic features to predict POSTN expression status in glioblastoma patients and animal models. It does not report any treatment, cure, or prevention for Alzheimer's disease.
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Along with demographic changes, issues of age-related cognitive decline and impaired cognitive functioning have become more prevalent.
Why it matters
This study found that older adults in wealthier neighborhoods had somewhat higher cognitive test scores on average, but this difference largely disappeared once personal socioeconomic factors were considered. It found no systematic differences between neighborhoods in how fast cognition declined over the six years studied.
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37/100
Dementia mortality varied over 2-fold between DSPs (median rate ratio: 2.59).
Why it matters
This study found that dementia mortality varied over 2-fold between disease surveillance points in China, with significantly higher rates in the east compared with the north. It found that dementia mortality decreased by 15% in urban areas but increased by 24% in rural areas, and suggests that tailored preventive health strategies should be in place to narrow this inequality.
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We examined the real-world utilization and persistence of rapid acting insulin (RAI) in elderly patients with type 2 diabetes who added RAI to their drug (OAD) regimen.
Why it matters
This study examined how long elderly patients with type 2 diabetes continued rapid acting insulin and found persistence was very poor. It provides no information about treating, curing, or preventing Alzheimer's disease.
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The No coverage group had a 38% increase in the odds ratio of any use of antidementia medications (P = 0.0008) post-Part D relative to the No cap group.
Why it matters
This study found that use of cholinesterase inhibitors and memantine increased after Medicare Part D, with greater increases among beneficiaries who gained better drug coverage. It is about medication access and use, not about whether these drugs cure or prevent Alzheimer's disease.
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The design of the physical environment plays a major role in supporting the wayfinding abilities of people with dementia.
Why it matters
This review found that the design of the physical environment, especially the floor plan of a nursing home, plays a major role in supporting wayfinding for people with dementia. Additional features like signage, lighting, and colors can help but cannot compensate for an adverse architectural design.
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This study compared FDG-PET and clinical measurements in elderly subjects with memory disturbance to examine relationships between glucose metabolism and cognitive or functional scores.
Why it matters
Examines how cognitive, functional and FDG-PET imaging measures of decline relate to each other in Alzheimer's disease and mild cognitive impairment.
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37/100
The value and durability of this potential contribution, however, demands an improved discipline-wide knowledge base about the unique features associated with different dementia variants.
Why it matters
This overview describes cognition, language, and clinical features of several non-Alzheimer's dementias and suggests communication disorders may help distinguish subtypes. It concerns diagnosis and management, not treatment or prevention.
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The aim of this study was twofold: to compare the functional levels of elderly awaiting nursing home placement and nursing home residents, and to compare their nurses' physical and psychological workloads.
Why it matters
This Norwegian study found few statistically significant differences in functional levels between elderly people awaiting nursing home placement and nursing home residents. It indicates that those waiting for placement can be as frail as residents, which has implications for the support their carers need during the waiting period.
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Most family members contributed to a grocery list.
Why it matters
This study examined how families use grocery lists when shopping for food. It has no relevance to treating, curing, or preventing Alzheimer's disease.
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The number of people over the age of 60 years with lifelong developmental delays is predicted to double by 2030.
Why it matters
This review says exercise programs appear to have potential to improve overall health in adults with Down syndrome. It does not report a cure or prevention for Alzheimer disease.
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Based on efficacy and safety data, several drugs have been approved for symptomatic improvement of dementia of the Alzheimer type and one for the symptomatic improvement of dementia associated with Parkinson's disease.
Why it matters
This paper reviews regulatory requirements for measuring outcomes in dementia drug trials, not the results of a treatment study. It does not show whether any treatment works to treat, cure or prevent Alzheimer's disease.
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When diagnosis of dementia occurs earlier in the disease process, more time is available for treatment aimed at maintaining patient function and delaying decline, and for family education about the disease and its management.
Why it matters
This interview study of rural practitioners describes barriers to timely dementia diagnosis and treatment, including limited access to consultants and few community support and education resources. It concerns the diagnostic and care process, not any treatment, cure, or prevention for Alzheimer's disease.
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Assessment by a speech therapist, staffing ratios, advance directives, fiscal considerations, and specialized dementia units are potentially modifiable factors in nursing homes that may influence the practice of tube feeding in advanced cognitive impairment.
Why it matters
This descriptive study of 1,057 nursing homes found that having a full-time speech therapist, more licensed nurses and fewer nursing assistants were independently associated with greater use of tube feeding in severely cognitively impaired residents. It concerns care practices in advanced cognitive impairment and does not test any treatment, cure or prevention for Alzheimer's disease.
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The purpose of this study was to describe the recognition and management of delirium in hospitalized patients with and without dementia.
Why it matters
This small descriptive study looked at how delirium is recognized and managed in 20 hospitalized older patients with and without dementia. It does not test any treatment, cure, or prevention for Alzheimer's disease.
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Frontotemporal dementia (FTD) is a dementia syndrome characterized by peculiar behavioral changes arising from frontotemporal involvement and distinct from Alzheimer's disease (AD).
Why it matters
This study used FDG PET to compare patterns of cerebral glucose metabolism in 21 patients with frontotemporal dementia, 21 with Alzheimer's disease, and 21 normal controls. It is a diagnostic comparison of two dementias and does not test any treatment, cure, or prevention.
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These studies have shown that PPF 300 mg t.i.d. is safe and well tolerated when taken on an empty stomach 1 h before meals.
Why it matters
In phase II trials, propentofylline (PPF) 300 mg three times daily improved cognitive scores and brain glucose metabolism compared with placebo in people with mild to moderate vascular or Alzheimer-type dementia. These were early-phase studies, and the text notes PPF should be taken on an empty stomach one hour before meals because of food interactions.
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As part of a cross-national study of dementia epidemiology, two types of verbal fluency tasks were administered to three groups of subjects, varying in level of literacy and education, recruited from the rural district of Ballabgarh in northern India.
Why it matters
In this cross-national dementia epidemiology study, education had a greater effect on initial sound fluency than on category fluency, and the ability to segment speech into phonemic units was dependent on literacy. This concerns how literacy and education affect verbal fluency test performance, not treatment, cure, or prevention.
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Dementia is one of the commonest and most disabling late-life mental disorders.
Why it matters
This paper argues that more dementia research is needed in developing countries, where most older people live but little research has been done, and where age-specific prevalence rates may be relatively low. It does not test a dementia treatment or prevention, so it cannot show how to cure or prevent dementia.
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Thus, a region that is reacting to nursing home abuse might impose regulations or enforcement encouraging additional hospitalization of the frail, and a region that has an oversupply of nursing home beds might have younger and healthier residents who more often desire aggressive diagnosis and treatment.
Why it matters
This commentary discusses hospitalization rates of nursing home residents and notes that it cannot be known whether these rates were optimal for patients. It argues that judging good care requires knowing what could be accomplished under well described conditions and what options exist in each environment.
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Participants described AI tools as potentially helpful for obtaining information, monitoring patients, managing medications and appointments, providing companionship, and conducting logistical tasks.
Why it matters
This qualitative study gathered views from family caregivers and hospice staff on whether and how artificial intelligence could be used in end-of-life dementia care. It is about caregiving tools and acceptance, not treating, curing or preventing Alzheimer's disease.
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Among 5.98 million inhabitants, GP contacts and primary care costs showed limited variation (bCV 0.8% and 4.7%).
Why it matters
This study looked at how health services for dementia vary by area in Denmark, finding that antipsychotic prescribing in dementia varied between councils. It does not test any treatment, cure, or prevention for Alzheimer's disease.
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36/100
There are significant opportunities for speech-language pathologists (SLPs) to play important roles in the primary and secondary prevention of Alzheimer's disease and related dementias (ADRD) beyond current practices.
Why it matters
This tutorial states that 45% or more cases of dementia can be delayed or prevented by addressing modifiable risk factors across the lifespan, and encourages speech-language pathologists to promote brain health. It is educational guidance rather than new trial evidence of a treatment or cure.
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Neighborhood disadvantage in later life is associated with poorer cognition and increased vulnerability to dementia.
Why it matters
In this study of 1149 men, living in a more disadvantaged neighborhood was linked to poorer executive function and processing speed. Men with higher general cognitive ability at about age 20 showed a weaker link between neighborhood disadvantage and executive function, suggesting early-life cognitive resources may offer some protection.
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Six core themes were identified through the synthesis of data from 17 studies.
Why it matters
This synthesis of 17 studies found home-based end-of-life care for people with dementia remains a long and challenging journey, with system-level and family-level barriers. It does not test any treatment, cure or prevention.
From across this topic
9 of the 7,967 studies in this topic, picked by a fixed rule (a hash of each study's address), not by score or date; each page of this list shows a different 9. The same 9 appear here every time.
- Cluster‐Derived Psychosocial Phenotypes, Cognitive Outcomes, and AD Plasma Biomarkers of Black and Hispanic/Latino Older Adults Enrolled in HABS‐HD
- Cognitive Impairment Screening Test in Korea as a Screening Tool for Dementia: The Correlation Study of Subtest Scores With Korean Version of the Mini Mental State Examination 2nd Edition
- Diabetes in midlife and cognitive change over 20 years: a cohort study
- Exposure to antipsychotics and risk of stroke: self controlled case series study
- Acute hospital dementia care: results from a national audit
- Efficacy of a group-based 8-week multicomponent cognitive training on cognition, mood and activities of daily living among healthy older adults: A two-year follow-up of a randomized controlled trial
- Multimarker Cerebral Small Vessel Disease Score and Risk of Incident Dementia in the Framingham Heart Study
- Safety and efficacy of rotigotine in patients with frontotemporal dementia: a phase 2, double-blind, randomized, placebo-controlled, multicenter trial
- Primary Care Physician Perspectives on Artificial Intelligence for Dementia Screening: A Qualitative Study