Each study has a usefulness score out of 100 (rubric version 4.0). Tap a score to see what makes it up.
Highest usefulness score first. Studies without a score come last.
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Among 51,202 admissions (mean/SD age = 82/7 years), any cognitive morbidity was present in 18,225 (35.6%, 95% CI 35.2-36.0%): delirium occurred in 24.0% (n = 12,289, of which 14.3% (n = 7332) had delirium only and 9.7% (n = 4957) had delirium + dementia) dementia only in 8.7%, (n = 4450), AMTS <8 in 2.9% (n = 1486).
Why it matters
This cross-sectional study found that cognitive morbidity was present in over a third of emergency hospital admissions, with delirium the most prevalent subtype across most specialties. It supports the need for hospital-wide delirium screening but does not test any treatment, cure or prevention for Alzheimer's disease.
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Older adults with schizophrenia face a significantly elevated risk of dementia.
Why it matters
This 12-year analysis in South Korea found that older adults with schizophrenia had a high and rising prevalence of dementia, with Alzheimer's disease the most common subtype, while incidence declined. It describes disease burden and treatment patterns and does not test any treatment, cure, or prevention.
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Current evidence suggests a potential for the Mediterranean diet to prevent cognitive decline, largely supported by observational studies, although randomized controlled trials show mixed results.
Why it matters
This review states that current evidence suggests a potential for the Mediterranean diet to prevent cognitive decline, based largely on observational studies. Randomized controlled trials show mixed results, so no firm conclusion can be drawn.
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The paper discusses according to prevailing diagnostic systems and algorithms, which cognitive domains that are relevant to investigate, which tests that may be relevant, what kind of norms have satisfactory quality, which cut-off scores do best balance sensitivity and specificity in a neurodiagnostic context, and what kind of conclusions and recommendations that can be drawn from neuropsychological findings.
Why it matters
This paper recommends comprehensive neuropsychological assessment using more than one test in each of five cognitive domains with culturally adapted norms as best practice for mild cognitive impairment. It concerns diagnosis and prognosis, not treatment, cure or prevention.
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We have enrolled 29 clinicians and 53 FCPs and aim to have 24 clinicians matched with 96 FCPs (N = 120) to complete the intervention.
Why it matters
This pilot randomized controlled trial protocol describes an intervention for caregivers of hospice patients living with dementia, with enrollment ongoing. If the pilot shows positive results, the plan is to test it in a multi-site, fully-powered RCT.
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Of 9872 individuals, 3563 (36%) died within 6 months.
Why it matters
This study found that GPT-4o could stratify 6-month mortality risk among patients with dementia using routinely generated documentation, with an area under the curve of 0.79. It suggests this could potentially facilitate hospice referral decisions, but the authors state that more prospective work is needed.
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Describe geographic variation from 2019 to 2023 in assisted living (AL) and memory care supply, and its correlation with county-level characteristics.
Why it matters
This descriptive study found low overall availability of assisted living and memory care, with decreases in supply in rural and socioeconomically disadvantaged counties from 2019 to 2023. It is about care supply and geography, not about treating, curing, or preventing Alzheimer's disease.
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MCI prevalence was comparable across groups (7.5%-8.0%), but progression to dementia varied (9.4% Black vs. 11.4% Other).
Why it matters
In the All of Us Research Program, perceived stress was the strongest predictor of mild cognitive impairment across groups, while predictors of progression to dementia varied by racial and ethnic group. The authors call for group-specific interventions such as stress mitigation and culturally tailored support, but the study identifies predictors rather than testing a treatment or prevention.
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Vascular dementia (VaD) represents the second-most common dementia type after Alzheimer's disease since it results from complications of cerebrovascular disease.
Why it matters
This review describes mechanisms of vascular dementia and notes that most new treatment approaches remain investigational. It concerns vascular dementia rather than Alzheimer's disease and reports no established treatment, cure or prevention.
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Meeting the care needs of people with dementia is a major public health and societal challenge.
Why it matters
This overview describes a planned study to survey the dementia care workforce and understand how training and composition affect care outcomes. It does not test any treatment, cure, or prevention for Alzheimer's disease.
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The risk of delirium admissions was elevated for the first 1-30 days of prescriptions [IRR 1.54 (95% CI 1.30-1.82) for men, 1.44 (1.22-1.70) for women] and whilst reducing over time for women [1.10 (0.94-1.29) for 91-365 days of prescriptions], it remained elevated for men [1.38 (1.17-1.64)].
Why it matters
This study found that adults without dementia had higher rates of hospital admission with delirium while taking overactive bladder anticholinergic medications, but not while taking mirabegron. The risk stayed raised longer for men and was greater in older men, suggesting alternative management options should be considered before prescribing anticholinergics.
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Recent work suggests that impairment in emotional processing, along with disinhibition, constitutes the necessary elements for CB in bvFTD.
Why it matters
This imaging study found structural and functional brain differences between behavioral variant frontotemporal dementia patients with and without criminal behavior, indicating disinhibition as the main driver. It addresses understanding of behavior and brain changes, not treatment, cure or prevention.
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< 0.0001) were significantly higher for the MCI cohort.
Why it matters
This retrospective cohort study found that the economic burden of mild cognitive impairment was more than double that for similar individuals without mild cognitive impairment or dementia. The authors state that timely diagnosis and intervention are key to delaying progression to Alzheimer's disease and reducing costs, but this is a cost study, not a treatment or cure.
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This study included 180 (65%) caregivers for the elderly with dementia and 98 (35%) without dementia.
Why it matters
This cross-sectional study found that family caregivers of elderly people with dementia in Kuwait reported significantly higher burden and anxiety than caregivers of elderly people without dementia. It does not test any treatment, cure, or prevention for Alzheimer's disease.
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Residing in communities characterized by socioeconomic disadvantage may confer risk for neurodegenerative brain changes and future neuropathology.
Why it matters
In 388 middle- and older-aged adults without clinical dementia, higher community deprivation was associated with greater white matter hyperintensity volume, largely independent of blood pressure and other risk factors. This links social disadvantage to a marker of brain pathology but does not test any treatment, cure, or prevention.
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Significant improvements were observed after 1 month of VR intervention in both caregiver burden (Z=-3.095, P=.002, r=0.34) and neuropsychiatric symptoms (Z=-2.929, P=.003, r=0.32).
Why it matters
In this longitudinal observational study, a one-month immersive virtual reality reminiscence intervention improved neuropsychiatric symptoms and temporarily reduced caregiver burden, with some symptom improvements lasting up to two months. The authors say future studies with control groups are needed to validate these findings.
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45/100
/df = 2.81, P < 0.001). There were strong correlations between the C-QDRS and standardized neuropsychological tests, indicating that the C-QDRS exhibited concurrent validity (all P < 0.001).
Why it matters
This study found that the Chinese version of the Quick Dementia Rating System is a precise and effective tool for screening Alzheimer's disease and preclinical Alzheimer's disease. It is about improving screening accuracy, not about treating, curing, or preventing the disease.
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The ViT approach predicted dementia with 76.5% balanced accuracy, outperforming human-scored features (74.3%) and existing deep learning models (MiniVGG = 73.3%, MobileNetV2 = 72.3%, relevance factor variational autoencoder = 69.1%) on the TDRA dataset.
Why it matters
A vision transformer model predicted dementia from clock drawing test images with 76.5% balanced accuracy, slightly outperforming human scoring and other deep learning models. This automated approach could enable scalable remote screening, but it is a diagnostic tool and does not treat or prevent dementia.
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Of the 127 participants, one-third died during their stay.
Why it matters
Among 127 patients with dementia and very severe challenging behavior admitted to specialized units, one-third died during their stay, with the most aggressive patients having a ninefold increased mortality risk. It underlines the need for suitable terminal palliative care in this patient group.
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Artificial intelligence (AI) is revolutionizing the field of medical imaging, offering unprecedented capabilities in data analysis, image interpretation, and decision support.
Why it matters
This review describes how AI is being applied to transcranial Doppler and ultrasound imaging, such as detecting vasospasm and emboli, but notes that data standardization, algorithm interpretability, and clinical integration remain unresolved. It reports no treatment, cure, or prevention of Alzheimer's disease.
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Significant correlations emerged between higher MEDAS scores and BMI (r = −0.53, p < 0.01), FM% (r = −0.49, p < 0.01), VAT (r = −0.63, p < 0.01), and cIMT (r = −0.88, p < 0.01).
Why it matters
This study examined adherence to the Mediterranean diet and cardiovascular risk markers such as BMI, visceral fat, blood pressure and carotid intima-media thickness. It reports benefits for vascular health and cardiovascular disease prevention, but it does not address Alzheimer's disease.
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Ethnoracial identity was significantly associated with the likelihood of ACP engagement.
Why it matters
Non-Hispanic Black and Hispanic people with ADRD engaged in fewer advance care planning activities than non-Hispanic White counterparts. This is about care planning disparities, not about treating, curing, or preventing Alzheimer's disease.
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45/100
Representations of White-racialized older adults were 5-fold higher than those of other races in both years.
Why it matters
This study found that AI text-to-image generators kept producing ageist images over two years, mostly of White-racialized older adults, with no improvement in emotional representation despite neutral prompts. It is about bias in generated images and has no bearing on treating, curing or preventing Alzheimer's disease.
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We describe the complex care needs faced by families in dementia care and specialized multidisciplinary palliative care delivered through home visits as a feasible way to support advancing stages of dementia.
Why it matters
This preliminary longitudinal study of 47 participants found that multidisciplinary home-based palliative care significantly reduced palliative care concerns, while caregiver burden showed a slight increase at three months. The authors call for further longitudinal studies with robust methodology.
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45/100
NPs reported that the quality of dementia care in their practices is poorer than the overall care provided.
Why it matters
This cross-sectional survey found that nurse practitioners rated dementia care in their primary care practices as poorer than overall care, with significant gaps in structural capabilities and over a third reporting burnout. It describes problems in care delivery rather than testing any treatment, cure or prevention for Alzheimer's disease.
From across this topic
10 of the 7,967 studies in this topic, picked by a fixed rule (a hash of each study's address), not by score or date; each page of this list shows a different 10. The same 10 appear here every time.
- Classification of vascular dementia in the Cardiovascular Health Study Cognition Study
- Grief reactions in dementia carers: a systematic review
- Revised Diagnostic Criteria for Vascular Cognitive Impairment and Dementia—The VasCog-2-WSO Criteria
- Cognitive Dysfunction and Dementia in Type 2 Diabetes Mellitus: Insights into Mechanisms, Models, and Therapeutics
- Incontinence and troublesome behaviors predict institutionalization in dementia
- Communication skills training in a nursing home: effects of a brief intervention on residents and nursing aides
- Dysphagia: Evaluation and Collaborative Management
- Development and evaluation of a decision aid on mammography screening for women 75 years and older
- Increased fMRI responses during encoding in mild cognitive impairment
- Cerebral hypoperfusion and clinical onset of dementia: the Rotterdam Study