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A 12-week app-based multidomain intervention ameliorates cognitive performance in patients with mild cognitive impairment: preliminary results of the MEMODIO_APP@CARE RCT
Gereon Nelles, T. Steinmann, D. Stein, V. Weil, A. Bicu, Carlo Polidori. European Psychiatry, 2025-04-01
Topic: Risk, prevention and care in population studies
For the interim analysis as of October 2024, the results of the MCI study arm are reported (n=42). Results In the MCI group, the mean age was 71 years, 20 out of 42 patients were female. The preliminary analysis on MCI patients (mean age: 71 y ±9,49 SD, 48% were female) showed statistically significant improvements in MoCA in the IG (-0.84±3.5 SoC vs. 1.96±2.7 IG, p=0.006). Quality of life, physical activity and activities of daily living at the time point of the interim evaluation were not significantly different from baseline, but the activity level measured by PAQ showed a non-significant improvement in the SoC group. Image: Image 2: Image 3: Conclusions In this RCT, a significant improvement in cognition was shown in MCI-patients using the MEMODIO app compared to those receiving SoC alone.
Key findings
- For the interim analysis as of October 2024, the results of the MCI study arm are reported (n=42).
- Results In the MCI group, the mean age was 71 years, 20 out of 42 patients were female.
- The preliminary analysis on MCI patients (mean age: 71 y ±9,49 SD, 48% were female) showed statistically significant improvements in MoCA in the IG (-0.84±3.5 SoC vs. 1.96±2.7 IG, p=0.006).
- Quality of life, physical activity and activities of daily living at the time point of the interim evaluation were not significantly different from baseline, but the activity level measured by PAQ showed a non-significant improvement in the SoC group.
- Image: Image 2: Image 3: Conclusions In this RCT, a significant improvement in cognition was shown in MCI-patients using the MEMODIO app compared to those receiving SoC alone.
Why it matters
In this preliminary interim analysis of 42 patients with mild cognitive impairment, those using the MEMODIO app showed significantly improved cognition compared to those receiving standard care alone. Quality of life, physical activity and daily living activities were not significantly different from baseline at this interim point.
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Study details
- Participants42
- Evidence strengthHigh
How this study scored 40/100
Published in a peer-reviewed journal. Scored zero for study design, effect reported and randomised / blinded because the record does not state it. We have no data on senior author's track record, so that was left out: it earned 38 of the 96 points we could judge it on, which is 40 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (European Psychiatry) |
| Journal's citation record | 1 / 4 | European Psychiatry: journal h-index 143 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 5 / 5 | Rated “high” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 4 / 5 | 2025 — within 3 year(s) of the newest study here |
| Sample size | 1 / 4 | 42 participants |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 1 / 7 | Cited 1 times (OpenAlex, 2026-10-10) |
| Citations per year | 0 / 5 | 0.3 citations a year over 3 year(s) since 2025 |
| Impact for its field and year | 1 / 6 | Cited 0.6× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 0 / 6 | No other study in this library cites it |
| Still being cited | 0 / 4 | Cited 1 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | 1 / 3 | Heidelberg University: institution h-index 1,344 (OpenAlex) |
| Multi-centre collaboration | 1 / 3 | OpenAlex lists 2 institution(s) in 1 country |
| Indexed in PubMed | 1 / 2 | Not in PubMed, but has a DOI |
| Free to read | 2 / 2 | Free to read |
| Points | 38 / 96 | Scored on 19 of 20 parts. We have no data for the rest, so they are left out: 38 of the 96 points we could judge it on is 40 out of 100. |
| Total | 40 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. Check the citation against the original before you use it.
APA 7th
Nelles, G., Steinmann, T., Stein, D., Weil, V., Bicu, A., & Polidori, C. (2025). A 12-week app-based multidomain intervention ameliorates cognitive performance in patients with mild cognitive impairment: preliminary results of the MEMODIO_APP@CARE RCT. European Psychiatry. https://doi.org/10.1192/j.eurpsy.2025.1445
Vancouver
Nelles G, Steinmann T, Stein D, Weil V, Bicu A, Polidori C. A 12-week app-based multidomain intervention ameliorates cognitive performance in patients with mild cognitive impairment: preliminary results of the MEMODIO_APP@CARE RCT. European Psychiatry. 2025. doi:10.1192/j.eurpsy.2025.1445.
BibTeX
@article{nelles2025-2bd19de5,
author = {Nelles, Gereon and Steinmann, T. and Stein, D. and Weil, V. and Bicu, A. and Polidori, Carlo},
title = {{A 12-week app-based multidomain intervention ameliorates cognitive performance in patients with mild cognitive impairment: preliminary results of the MEMODIO\_APP@CARE RCT}},
journal = {European Psychiatry},
year = {2025},
doi = {10.1192/j.eurpsy.2025.1445},
url = {https://doi.org/10.1192/j.eurpsy.2025.1445}
}