Each study has a usefulness score out of 100 (rubric version 4.0). Tap a score to see what makes it up.
Highest usefulness score first. Studies without a score come last.
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J-MINT demonstrates cost-effectiveness by reducing overall care costs while improving QALYs in individuals with MCI.
Why it matters
This modelling study projected that the J-MINT multimodal lifestyle program for older adults with mild cognitive impairment would save costs and gain quality-adjusted life-years over 35 years compared with usual care. These are simulated long-term projections, and the authors note that targeting APOE ε4 carriers or people who adhere well to exercise could yield even greater benefits.
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We found significant associations between ADRD risk and particulate matter <2.5 µm in diameter and nitrogen dioxide in women.
Why it matters
In an aging U.S. cohort, air pollution and mental and physical health factors were each linked to higher dementia risk, and together they were associated with more than double the incidence. The results suggest that reducing air pollution and improving mental and physical health could help mitigate dementia risk.
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At the between-person level, no associations were observed between sleep and cognition.
Why it matters
No associations were observed between sleep and cognition at the between-person level, but within-person deviations from usual sleep patterns were associated with poorer next-day cognitive performance. APOE ε4 and Alzheimer's biomarkers did not interact with these relationships.
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BackgroundEvidence on the effects of caregiver-assisted combined exercise and cognitive interventions for persons with dementia (PwD) is inconsistent.
Why it matters
In this small pilot study of 33 people with mild dementia, a home-based caregiver-assisted exercise and cognitive training program delivered by video was feasible and acceptable, and exploratory analyses suggested possible improvements in cognition and neuropsychiatric symptoms. These are preliminary findings from a small sample and need confirmation in larger trials.
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Recruitment strategies are tailored in collaboration with community organizations to align with each language group's preferences, including adjusting the blood draw and interview sequence and hosting group blood draws where participants completed the procedure together, fostering a sense of community and reducing anxiety.
Why it matters
This pilot study describes ways to recruit older Chinese, Vietnamese, and Korean Americans into Alzheimer's disease and related dementias research, such as community partnerships and culturally relevant incentives. It reports no treatment, cure, or prevention findings.
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The ANCOVA demonstrated no significant overall differences in BPSD severity related to SES measures.
Why it matters
This preliminary study found no significant overall differences in the severity of behavioral and psychological symptoms of dementia based on socioeconomic status. It is about caregiver and symptom experiences, not about treating, curing, or preventing Alzheimer's disease.
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These findings suggest that moving to an AL influences Medicare enrollment decisions; and, variation in switching exists between the type of AL (general vs memory care) and whether or not an individual has dementia.
Why it matters
This study found that Medicare beneficiaries moving to assisted living licensed for memory care switched health plans less often than those moving to general assisted living. It does not address treating, curing, or preventing Alzheimer's disease.
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These findings suggest that moving to an AL influences Medicare enrollment decisions; and, variation in switching exists between the type of AL (general vs memory care) and whether or not an individual has dementia.
Why it matters
This study found that Medicare beneficiaries moving to assisted living licensed for memory care switched health plans less often than those moving to general assisted living. It does not address treating, curing, or preventing Alzheimer's disease.
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Among the study population at large, there was a statistically significant association between ADI and ESS scores (β = 0.490, 95% CI [0.138, 0.842], p = 0.007).
Why it matters
This study examined the link between neighborhood deprivation and sleepiness in cognitively normal older adults with and without subjective cognitive decline. It does not test any treatment, cure, or prevention for Alzheimer's disease.
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Participants had age mean = 81.7, SD = 4.5, range=75-93; educational attainment mean = 14.6, SD = 4.0, range=7-22, 17.2% < 12; 86.2% were women.
Why it matters
In this small sample of very old Black/African American adults, MoCA scores were lower than MMSE scores, especially among those without a high school degree, and MoCA was associated with age and education while MMSE was not. The authors caution that results should be interpreted with caution due to the small sample, and the study addresses cognitive screening rather than treatment or prevention.
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In a cohort of 75 patients who completed Moneta's program (average age 73 ± 10, average MoCA score 20 ± 5), 59% had MCI and 33% had dementia.
Why it matters
In a cohort of 75 patients, an AI-powered telephone cognitive rehabilitation program was followed by improved cognitive function and self-reported quality of life. The study reports real-world outcomes but does not compare against a randomized control group, so it cannot prove the program caused the improvements.
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A greater number of needs (B=.42), polypharmacy (B=.33), and unmanaged symptoms (B=.31) significantly predicted higher triage priority (p<.001).
Why it matters
Among 655 nursing home residents with cognitive impairment, the most common palliative care needs were polypharmacy, missing goals-of-care documentation and functional decline, and most screened residents were referred for a palliative care consult. This describes palliative care needs in nursing homes, not a treatment or cure for Alzheimer's disease.
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Early detection of dementia is a key requirement for effective patient management.
Why it matters
This paper proposes a hybrid quantum-classical neural network for classifying dementia from MRI images and reports experiments on benchmark datasets. It is a technical classification method and does not show any treatment, cure, or prevention of Alzheimer's disease.
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Value-based healthcare (VBHC) is a concept in health economics that aims to improve patient care through needs-oriented treatment approaches while considering the costs incurred.
Why it matters
This study analyzed and modified the diagnostic workflow of an outpatient memory clinic using value-based healthcare criteria, finding improved quality of care but a financial disadvantage for the care provider. It concerns diagnostic process and reimbursement, not treatment, cure, or prevention.
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Overall, both machine learning techniques had an equivalent performance.
Why it matters
This work used machine learning to detect Parkinson's disease and mild cognitive impairment, finding that combining DaT-SPECT with phosphorylated-tau-181 improved accuracy over DaT-SPECT alone. It concerns classification and diagnosis rather than treating, curing or preventing Alzheimer's disease.
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The 29-item needs assessment showed strong internal consistency, with a mean Cronbach’s alpha of .89 and McDonald’s omega of .90.
Why it matters
This study developed a 29-item questionnaire to assess what healthcare professionals still need to learn about palliative dementia care. It is a training and education tool and provides no treatment, cure or prevention for Alzheimer's disease.
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The Centers for Medicare & Medicaid Services' (CMS) Guiding an Improved Dementia Experience (GUIDE) Model represents a landmark opportunity to improve outcomes for persons with dementia and their caregivers and scale comprehensive dementia care through a structured service delivery and alternative payment approach.
Why it matters
This paper describes a four-step approach to adopting comprehensive dementia care based on six previously tested programs, under the CMS GUIDE Model. It focuses on care delivery, reimbursement, and implementation rather than treating, curing, or preventing Alzheimer's disease.
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Study 1 showed that each person's financial strain was associated with their own greater depressive symptoms.
Why it matters
In two studies of parent-child pairs coping with dementia, depression or recent delirium, greater financial strain was linked to more depressive symptoms in each person and between them. The authors call for attention to financial security in behavioural interventions, but this does not treat or prevent Alzheimer's disease.
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Dementia disproportionately affects Hispanic/Latino caregivers, and while some interventions exist, their consideration of intersectional factors remains unclear.
Why it matters
This review of interventions for Hispanic/Latino caregivers of people with dementia found that factors like occupation, gender identity, sexual orientation, religious beliefs, literacy, socioeconomic status, social capital, and disability were less studied. It identifies these factors as important for tailoring future caregiver interventions.
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After screening 3670 articles for eligibility, the review includes 12 studies.
Why it matters
This review of 12 studies found that artificial intelligence-based technologies are an emerging way to detect behavioral and psychological symptoms of dementia such as agitation and aggression. It tests no treatment, cure, or prevention, and the authors call for more research on effectiveness and quality of life.
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Alzheimer's Disease and Related Dementias (AD/ADRD) are progressive neurodegenerative conditions that impair memory, thought processes, and functioning.
Why it matters
This interview study of 25 family caregivers describes their mental health challenges and how their needs change across three stages of the caregiving journey. It offers a foundation for designing stage-sensitive mental health technologies, but it did not test whether any such intervention helps.
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Deep brain stimulation (DBS) is a well-established treatment for several neurological and neuropsychiatric conditions, including movement disorders such as Parkinson's disease, essential tremor, and dystonia, as well as Gilles de la Tourette's syndrome, epilepsy, and obsessive-compulsive disorder.
Why it matters
This review notes that deep brain stimulation is being explored for dementia among other conditions, but equitable access to the treatment has not kept pace with technological advances. Barriers to access remain a persistent global challenge influenced by socioeconomic, geographic, systemic, and policy-related factors.
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The validated nomogram enables individualized MCI risk stratification, supporting targeted community prevention strategies.
Why it matters
Using data from 7,702 Chinese adults aged 45 and older, researchers developed a model to predict mild cognitive impairment that includes air pollution, sociodemographic, and clinical factors. The model identified 13 factors associated with MCI, including age 75 and older, private medical insurance, mental disorders, male sex, and PM10 exposure.
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We identified two main themes (each with subthemes) that influence Latino dementia caregiver experiences with healthcare: (1) caregiving and understanding of dementia shaped by individual, family, and social factors (subthemes: Caregiver's own understanding of dementia; Lack of support and understanding from family; Latino cultural perspectives on dementia); and (2) navigating formal services amid gaps in cultural alignment and support (subthemes: Trial and error: education and resource gaps; Cultural tension with healthcare).
Why it matters
This qualitative study found that Latino dementia caregivers' understanding of dementia is shaped by culture and family dynamics, and that most faced challenges navigating healthcare and gaps in culturally concordant information and support. It calls for culturally centered education, resources, and support but did not test any intervention.
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The intervention group showed a significantly lower delirium incidence (34% versus 18%, p =0.010) and earlier detection of delirium after hospitalization (3.2 versus 2.2 days, p =0.035).
Why it matters
This retrospective case-control study found that an in-hospital IT system-based delirium management programme was associated with lower delirium incidence and earlier detection in medically hospitalised patients with dementia. Receiving the delirium management protocol and avoiding restraints were both associated with delirium presence.
From across this topic
10 of the 7,967 studies in this topic, picked by a fixed rule (a hash of each study's address), not by score or date; each page of this list shows a different 10. The same 10 appear here every time.
- Baseline Characteristics of Participants in the ASPREE (ASPirin in Reducing Events in the Elderly) Study
- Influence of the Mediterranean and Ketogenic Diets on Cognitive Status and Decline: A Narrative Review
- Forensic issues in Down syndrome fatalities
- Impaired Cognition and Brain Atrophy Decades After Hypertensive Pregnancy Disorders
- Comparative dementia risk with GLP1 receptor agonists, SGLT2 inhibitors, or DPP4 inhibitors: a population-based cohort study
- Multi-domain interventions for the prevention of dementia and cognitive decline
- Assessment of white matter tract damage in mild cognitive impairment and Alzheimer's disease
- The trajectory of gait speed preceding mild cognitive impairment
- Additional hospitalization costs associated with delirium among older adults: evidence from the Medicare Current Beneficiary Survey
- A Voxel-Based Morphometric Study of Ageing in 465 Normal Adult Human Brains