Each study has a usefulness score out of 100 (rubric version 4.0). Tap a score to see what makes it up.
Highest usefulness score first. Studies without a score come last.
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In past decades, most individuals with Down syndrome were usually not afforded adequate medical care.
Why it matters
This clinical review describes health conditions seen across the lifespan in Down syndrome and notes that adulthood is often marked by accelerated aging and the threat of Alzheimer disease in some people. It is descriptive and offers no treatment, cure or prevention.
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Health disparities in dementia care are amplified among aging multilingual communities relative to their monolingual English-speaking counterparts, as social determinants of health and significant gaps in culturally responsive practice can contribute to misdiagnosis, underdiagnosis, and delays in intervention.
Why it matters
This case report describes using culturally adapted language assessment with one Tagalog-English speaker, so it cannot show whether such approaches improve dementia outcomes generally. It argues that culturally responsive assessment may reduce misdiagnosis and underdiagnosis in multilingual communities.
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Importantly, delirium is not merely a transient cognitive fluctuation; it is independently associated with increased short- and long-term mortality, longer hospital stays, higher healthcare costs, and persistent cognitive impairment comparable to mild dementia[4,5].
Why it matters
This paper argues that delirium is under-recognised in hospital and is linked to mortality, longer stays, higher costs and persistent cognitive impairment, and that antipsychotics have not consistently improved outcomes. It is about improving delirium recognition and care, not about treating, curing or preventing Alzheimer's disease.
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Diet and specific nutritional factors, alone and in combination with other lifestyle approaches, have an important role in decreasing the risk for dementia.
Why it matters
This review says diet and nutrition may help lower dementia risk, but it notes that more research is needed and that the benefits of single-nutrient supplements are unclear. It reports that the LipiDiDiet trial suggested a multinutrient supplement may improve cognitive function and slow progression in people with prodromal Alzheimer's disease.
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MDD prevalence was consistently higher among women than men across all regions and age groups, ranging from 4.42%-5.11% in women versus 2.87%-3.41% in men.
Why it matters
This study estimated that major depressive disorder accounts for a mean global population-attributable fraction of 4.81% for dementia, with the highest fractions in sub-Saharan Africa and low-SDI regions. It identifies geographic and demographic variation in depression-associated dementia risk but does not test any treatment, cure, or prevention.
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This study aimed to determine the effectiveness of regular dental scaling by evaluating the association between the frequency of dental scaling and the risk of dementia in individuals with moderate to severe periodontal disease.
Why it matters
In a Korean national cohort, regular dental scaling in people with moderate to severe periodontitis was associated with a lower risk of dementia, with adjusted hazard ratios around 0.50-0.51 in landmark analyses. This is an observational association, so it does not prove that dental scaling prevents dementia.
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The prevalence of hypertension showed statistically significant spatial clustering (global Moran’s I=0.442, p<.001), with high-high clusters concentrated in rural eup-myeon areas and low-low clusters in urban dong areas.
Why it matters
This study is about hypertension prevalence at the subdistrict level, not Alzheimer's disease, so it does not provide information on treating, curing or preventing Alzheimer's. It found that hypertension prevalence clustered spatially and was associated with factors such as older adult proportion and obesity prevalence.
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BackgroundWhile transcranial alternating current stimulation (tACS) shows therapeutic promise for neurological and psychiatric disorders when applied repeatedly, its potential is constrained by multiple laboratory visits.
Why it matters
Twenty family caregivers were trained to give home-based transcranial alternating current stimulation to patients with mild cognitive impairment under remote supervision, and most were confident and willing to reuse the system, though most experienced daily life interference. Effects on quality of life and memory were mixed, with some reporting mild deterioration, so this is an early feasibility study of caregiver-delivered stimulation, not proof of benefit.
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Why it matters
This entry is only supplementary material with no summary or key findings provided. No information is available to describe what it means for treating, curing or preventing Alzheimer's disease.
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Participants reported routine screening for cognitive impairment only in the context of the Medicare annual wellness visit and generally avoided routine screening because of limited treatment options to support patients, such as poor access to geriatrics/neuropsychiatric services.
Why it matters
Primary care physicians said they generally avoid routine cognitive screening because of limited treatment options and poor access to specialist services, and they raised ethical concerns about automated screening. This is about implementation and ethics, not about treating, curing or preventing Alzheimer's disease.
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Among the 1,035 patients in our dataset, 176 (17%) had a dementia diagnosis.
Why it matters
This study examined whether including dementia diagnosis or cognitive impairment improves prediction of home care costs. It found these factors did not materially improve prediction beyond daily living measures, which concerns cost prediction rather than treating, curing or preventing Alzheimer's disease.
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Average county‐level ADRD prevalence was 11.06% across the pre‐expansion period and 7.15% post‐expansion.
Why it matters
This study looked at county-level dementia diagnosis rates around the 2020 Medicare telehealth expansion and found overall prevalence fell, likely because of the COVID-19 pandemic. It is about diagnosis and detection, not about treating, curing or preventing Alzheimer's disease.
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33/100
The consequences of Alzheimer’s Disease and Related Dementias (ADRD) are well documented, but beyond the individual, family, and health system costs are implications for communities that are not well-studied.
Why it matters
This study describes community rates of Alzheimer's disease and related dementias and the availability of caregiver support groups and adult day services in three states. It is about community services, not about treating, curing or preventing the disease.
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Surprisingly, demographic normalisation worsened rather than improved diagnostic accuracy for detecting MCI with both MoCA and MMSE, reducing their effectiveness as diagnostic tools and confirming our hypothesis.
Why it matters
Adjusting MoCA and MMSE scores for age, sex and education actually made them slightly worse at detecting mild cognitive impairment, and results for early dementia were inconsistent. This concerns how screening tests are scored, not any treatment, cure or prevention of Alzheimer's disease.
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Current evidence suggests a potential for the Mediterranean diet to prevent cognitive decline, largely supported by observational studies, although randomized controlled trials show mixed results.
Why it matters
This review states that current evidence suggests a potential for the Mediterranean diet to prevent cognitive decline, based largely on observational studies. Randomized controlled trials show mixed results, so no firm conclusion can be drawn.
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The Mini-Mental State Examination (MMSE) is widely used in cognitive screening, including in primary care settings.
Why it matters
In 390 community-dwelling older adults, the MMSE distinguished dementia from no dementia with an AUC of 0.75, and at the conventional cutoff of 24 it had lower sensitivity but higher specificity than the optimal cutoff of 21. The authors warn that the MMSE can produce many false positives where dementia prevalence is low, such as primary care, so this is about interpreting a screening test, not about treating or preventing Alzheimer's disease.
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Voluntary assisted dying (VAD) is an end-of-life care option available to eligible Australians living with a terminal condition, though people living with dementia are typically ineligible to choose VAD as part of their end-of-life care.
Why it matters
In this online survey, 36 Australians living with dementia mostly wanted the option to access voluntary assisted dying themselves and through advance care directives. It reports their end-of-life care preferences, not any treatment, cure or prevention of Alzheimer's disease.
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33/100
Dementia is a progressive condition that affects cognitive and functional abilities.
Why it matters
This study uses sleep and physiological data to predict next-day agitation in people with dementia, which could help caregivers respond sooner. It addresses symptom management only and does not test any treatment, cure or prevention of Alzheimer's disease.
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The median proportion of in-hospital LTC certification applications was 30.5% (IQR 24.5%-36.1%).
Why it matters
This ecological study found that regions with a higher proportion of in-hospital long-term care certification applications had longer average hospital stays for older adults. The authors caution that the ecological design limits interpretation and that individual-level research is needed.
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BackgroundWith the growing demand for dementia-friendly care environments, existing smart room designs often lack systematic methods to translate user needs into functional solutions.
Why it matters
This study used a structured design method to prioritize user needs for smart living rooms in dementia nursing homes, with behavior recognition such as falls and wandering ranked highest. User satisfaction scores improved after the optimized designs were implemented, but this concerns care environments rather than treating or preventing the disease.
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Among 19 included studies, most used quantitative designs and secondary data.
Why it matters
This scoping review examined factors helping or hindering Annual Wellness Visits for detection and management of cognitive impairment among older adults. It addresses detection and implementation in primary care, not treating, curing, or preventing Alzheimer's disease.
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Data from the qualitative interviews will provide dyad preferences for intervention development.
Why it matters
This is a protocol for a mixed methods digital health study to support rural families at risk for Alzheimer's disease and related dementias by understanding intervention preferences and identifying modifiable protective and risk factors. The findings are expected to support community-based education and digital assessments, not to treat, cure, or prevent Alzheimer's disease directly.
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BackgroundPatients are enrolled into hospice for a variety of conditions.
Why it matters
This retrospective review found median hospice survival was 17.36 days overall, and 9.47% of enrollees survived at least 6 months. Survival of at least 6 months was more common for those enrolled for dementia.
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The unprecedented rise of artificial intelligence (AI) in recent times is unparalleled in history.AI 1 seemingly possesses cognitive abilities that hitherto only humans could boast of -reason, an inimitable, embodied, and finite existence. 47Nonetheless, the ubiquitous abilities of AI can help to enhance treatment and care for PLWDs in 48 enabling early diagnosis, continuous monitoring and personalized support.
Why it matters
This perspective discusses how AI might support early diagnosis, continuous monitoring, and personalized support for people living with dementia, alongside questions about personhood. It reports no treatment, cure, or prevention of Alzheimer's disease.
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The results of this study identified important relationships between cognitive features in the ADAS-Cog and provide a clear example of the value of data-driven machine learning approaches in the identification of markers that indicate disease progression in dementia.
Why it matters
Using ADNI data, this study identified cognitive features linked to dementia progression, with Delayed Word Recall emerging as a top marker in early stages and Orientation becoming more prominent later. The aim is to find cost-effective cognitive features for screening and monitoring progression, not to treat, cure, or prevent Alzheimer's disease.
From across this topic
10 of the 7,967 studies in this topic, picked by a fixed rule (a hash of each study's address), not by score or date; each page of this list shows a different 10. The same 10 appear here every time.
- Communicative intentions and liminal signs in interaction with people living with late-stage dementia
- The neuropsychological profile of vascular cognitive impairment in stroke and TIA patients
- Not only cardiovascular, but also coordinative exercise increases hippocampal volume in older adults
- Neuropsychiatric symptoms as risk factors for progression from CIND to dementia: the Cache County Study
- Association Between Metabolic Syndrome and Young-Onset Dementia
- Association of ambulatory blood pressure with ischemic brain injury
- Cognitive and neural plasticity in old age: A systematic review of evidence from executive functions cognitive training
- A case report of late-onset schizophrenia differentiated from a dementing disorder
- Management of psychiatric and neurological comorbidities in epilepsy
- Changing demography and the challenge of dementia in India