Each study has a usefulness score out of 100 (rubric version 4.0). Tap a score to see what makes it up.
Download bibliography of all 8,032 studies, highest score first: BibTeX (.bib) · RIS (.ris)
Highest usefulness score first. Studies without a score come last.
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There is enormous interest in designing training methods for reducing cognitive decline in healthy older adults.
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Driving simulator training offers the potential to enhance driving skills in older drivers.
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Evidence is accumulating which suggests that, in addition to leading to unprecedented rates of obesity, the current food environment is contributing to the development of cognitive impairment and dementia.
Why it matters
This review links the modern food environment, obesity and diets high in saturated fats and simple carbohydrates to cognitive impairment and dementia, and notes that many of these deficits involve inhibitory control over eating. Much of the supporting evidence comes from non-human animal research, so it does not yet show that changing diet prevents dementia in people.
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Only a minority of people with dementia receive a formal diagnosis despite a growing body of evidence highlighting the benefits of early diagnosis and intervention.
Why it matters
This review found that not enough has been done to address inequality in dementia service use for minority ethnic groups compared with the majority population. It reports no intervention with measurable outcomes, so it provides no evidence on treating, curing, or preventing Alzheimer's disease.
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The hippocampus, derived from medial regions of the telencephalon, constitutes a remarkable brain structure.
Why it matters
This review summarizes findings about how the hippocampus develops, including molecular signals that guide its formation. It is basic biology about brain development and does not test any treatment, cure, or prevention for Alzheimer's disease.
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The SHBM provides an empirically based conceptual framework for examining cross-cultural differences in dementia care-seeking among diverse groups.
Why it matters
This review found that minority ethnic older adults with dementia often had longer delays to diagnosis and more severe impairment at first evaluation, with barriers including lower acculturation, beliefs about memory loss, stigma and health system problems. It proposes a model to guide research and service planning rather than testing a treatment or cure.
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Neuropsychiatric symptoms such as agitation and delusions occur commonly in elderly patients with dementia and often cause significant distress.
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Based on the perceptions of bereaved family members, important opportunities exist to improve decision-making in feeding tube insertion.
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Ninety-four percent of hospices and 72% of PC programs had served at least one patient with a primary diagnosis of dementia within the past year.
Why it matters
This survey found that most hospices and many palliative care programs serve patients with dementia, and it identifies barriers such as lack of awareness and reimbursement policies. It does not test any treatment, cure, or prevention for Alzheimer's disease, and it suggests education and policy changes to improve palliative care.
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Patients with degenerative dementia often show language disorders, but little is known about their verbal (VC) and non-verbal communication (NVC).
Why it matters
This study described different patterns of verbal and non-verbal communication difficulties in patients with Alzheimer's disease, frontotemporal dementia, and dementia with Lewy bodies. It is about characterizing communication problems, not about treating, curing, or preventing Alzheimer's disease.
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Ethnic minority patients are seen on a regular basis in European dementia clinics.
Why it matters
This survey of European dementia centers found that most performed cognitive assessment with instruments validated only in Western cultures and that diagnostic evaluation of ethnic minority patients was considered challenging in 64% of centers. It describes clinical practice challenges and does not test any treatment, cure, or prevention.
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In this sample of older individuals, a higher dropout rate occurred in those assigned to the high-technology assessment techniques; however, once participants had completed baseline in all 3 arms, they continued participation through 1 month.
Why it matters
This pilot study tested whether home-based assessment methods are feasible for future Alzheimer prevention trials. It does not test any treatment and does not show whether any therapy prevents cognitive loss.
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This study aimed to validate the TICS and modified TICS (TICSm) in Korean elderly population and to compare MCI and dementia screening ability between TICS and TICSm.
Why it matters
This study tested whether telephone-based cognitive interviews can screen for mild cognitive impairment and dementia in Korean older adults. It does not test any treatment, cure, or prevention for Alzheimer's disease.
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Cognitive impairment (CI) is a common nonmotor complication of Parkinson's disease (PD), and is associated with significant disability for patients and burden for caregivers.
Why it matters
This review discusses that cognitive impairment in Parkinson's disease varies in which domains are affected and the timing of onset. It hypothesizes that the specific characteristics of cognitive impairment may provide clues to underlying pathological processes and help direct disease-specific treatments.
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Although automobiles remain the transportation of choice for many older adults, late-life cognitive impairment and dementia often impair the ability to drive safely.
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Research in animals and humans has shown that mastication maintains cognitive function in the hippocampus, a brain area important for learning and memory.
Why it matters
This review describes research in animals and humans suggesting that chewing maintains cognitive function in the hippocampus and that reduced chewing is a risk factor for dementia. Much of the evidence comes from animal studies, and it does not show that improving chewing prevents Alzheimer's disease in people.
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Among nursing home residents with advanced cognitive impairment admitted to acute care hospitals, for-profit ownership, larger hospital size, and greater ICU use was associated with increased rates of feeding tube insertion, even after adjusting for patient-level characteristics.
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It is widely known that exogenous formaldehyde exposure induces human cognitive impairment and animal memory loss; and recent studies show that formaldehyde at pathological levels induces Aβ deposition and misfolding of tau protein to form globular amyloid-like aggregates.
Why it matters
This study measured formaldehyde levels in urine from dementia patients, other patient groups, and healthy individuals and compared them with mini mental state examination scores. It reports a correlation only and does not test any treatment, cure, or prevention for Alzheimer's disease.
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41/100
The availability, accessibility and acceptability of services are critical factors in rural health service delivery.
Why it matters
This paper describes the development and evaluation of an interdisciplinary memory clinic intended to improve access to diagnosis and management of early stage dementia for older people in rural and remote Saskatchewan. It reports on service delivery and referral patterns, not on treating, curing, or preventing Alzheimer's disease.
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Time requirements for the medication administration process are substantial in LTC and are compounded when nurses are unfamiliar with residents.
Why it matters
This study measured how long nurses take to give medications in long-term care units, including dementia care units, but it did not test any treatment for Alzheimer's disease. It provides information about staffing and safety, not about curing or preventing Alzheimer's disease.
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Neuropsychiatric symptoms (NPS) are common in dementia, although little is known about their prevalence and treatment near the end of life.
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Research on the performance of patients with dementia on tests of effort is particularly limited.
Why it matters
This study examined how people with dementia performed on tests designed to measure effort. It is about test performance and specificity of effort indices, not about treating, curing or preventing Alzheimer's disease.
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Besides their diagnostic use, MRI and DTI will broaden our understanding of the pathophysiology of AD and the structural and functional basis of normal cognition.
Why it matters
This review describes MRI techniques for detecting Alzheimer's disease early, noting that hippocampus volume is the best established structural marker and is already used as a secondary endpoint in clinical trials. It is about imaging markers for detection and trial design, not about treating, curing or preventing the disease.
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The Arabic GDS is a useful measure to assess depression among community-dwelling older adults and primary care patients who do not have dementia.
Why it matters
This study validated an Arabic version of the 15-item Geriatric Depression Scale in older adults without dementia. It is a depression screening tool and has no direct implications for treating, curing, or preventing Alzheimer's disease.
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41/100
Despite the availability of different classes of drugs for the treatment of depressive and anxiety disorders, there are a number of clinically significant unmet needs, such as a high prevalence of treatment resistance, partial response, subsyndromal symptomatology, recurrence and relapse.
Why it matters
This review examines evidence on aripiprazole for depressive and anxiety disorders, not Alzheimer's disease. It provides no information on treating, curing, or preventing Alzheimer's disease.
From across this topic
10 of the 7,981 studies in this topic, picked by a fixed rule (a hash of each study's address), not by score or date; each page of this list shows a different 10. The same 10 appear here every time.
- Changes in everyday function in individuals with psychometrically defined mild cognitive impairment in the Advanced Cognitive Training for Independent and Vital Elderly Study
- Neighborhood disadvantage and subjective cognitive function among older Black women
- Perspectives on artificial intelligence-enabled socially assistive robots in long-term care: Experiences with LOVOT among people with dementia and family caregivers
- The Role of Quantitative EEG in the Diagnosis of Neuropsychiatric Disorders
- Cause-specific mortality in patients with severe psoriasis: a population-based cohort study in the U.K
- Current State of Self-Administered Brief Computerized Cognitive Assessments for Detection of Cognitive Disorders in Older Adults: A Systematic Review
- The economic cost of brain disorders in Europe
- The Effect of a Comprehensive Dementia Care Management Program on End-of-Life Care
- Effectiveness of interventions that assist caregivers to support people with dementia living in the community: a systematic review
- Nutritional challenges for the elderly