Each study has a usefulness score out of 100 (rubric version 4.0). Tap a score to see what makes it up.
Highest usefulness score first. Studies without a score come last.
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Of the 5200 participants (mean age = 71.0 years, 57.1% females), 302 (5.8%) were diagnosed with dementia.
Why it matters
This population-based study developed machine learning models using routinely available clinical information that showed excellent discrimination for detecting dementia in a rural older population in China. It is a detection tool only and does not test any treatment, cure or prevention.
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With the rising number of dementia cases, supporting family caregivers to maintain their well-being is crucial.
Why it matters
In this small feasibility study of 30 family caregivers, an online Acceptance and Commitment Therapy program was linked to significant improvements in depressive symptoms, stress, anxiety, and sense of competence. These are preliminary findings about caregiver well-being, not about treating, curing, or preventing Alzheimer's disease itself.
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Overall, the combined features model achieved a higher discrimination accuracy than models with single feature sets alone.
Why it matters
This study found that a multimodal model combining eye tracking and convolutional neural network analysis identified mild cognitive impairment with an average accuracy of 74.62% against healthy individuals including young adults, and 66.50% against elderly controls. It is about an auxiliary identification method and does not treat, cure or prevent Alzheimer's disease.
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The results showed that Age, Education, and, occasionally, Biological sex were significant predictors.
Why it matters
This study provides Italian norms for the MoCA 8.1, including the memory index score, with adjustments for age, education and sometimes biological sex. It is a standardisation for neuropsychological screening and does not test any treatment, cure or prevention.
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Our results showed that: (a) Behavioral data analysis: there were significant differences in accuracy and accuracy / reaction time between MCI and NC in tasks with memory load capacity of low load-four and high load-six, especially in tasks with memory load capacity of four.
Why it matters
This study found differences in brain network patterns and behavioral accuracy between people with mild cognitive impairment and normal controls during working memory tasks. The authors suggest that behavioral data and abnormal electrophysiological signals in the left prefrontal and right occipital lobes could be used for MCI diagnosis, but this is early diagnostic research and does not test any treatment.
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Among 195 participants, 33% had dementia after 3 years of follow-up.
Why it matters
In this study of 195 stroke patients, a high CT-based brain-frailty score was linked to a much higher risk of dementia at three years, and a combined model predicted dementia moderately well. The authors say CT-based brain-frailty may help identify highest-risk individuals for dementia prevention trials when cognitive testing isn't feasible.
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, respectively. standards in late life. https://doi.org/10.1289/EHP14723.
Why it matters
This study estimated the effects of hypothetical ambient PM2.5 interventions on dementia risk in the UK Biobank cohort. The available text does not report the study's results, so no conclusion about treating, curing or preventing Alzheimer's disease can be drawn from it.
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During a median follow-up of 14.1 years, 279 early-onset dementia cases and 3167 late-onset dementia cases were documented.
Why it matters
Middle-aged people with a cardiometabolic pattern of relatively high liver enzymes had higher risks of both early-onset and late-onset dementia, and a pattern of systemic inflammation was linked to higher late-onset dementia risk. These findings suggest that identifying such high-risk groups could help guide dementia prevention, regardless of APOE ε4 status.
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Early detection of abnormal neurodegeneration amidst normal cognitive aging is crucial.
Why it matters
In this cross-sectional study, individuals with subjective cognitive decline scored significantly lower on Stroop color-word tests and delayed recall memory compared with controls. It examines cognitive differences across aging and subjective cognitive decline but does not test any treatment, cure or prevention.
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BackgroundDementia is recognized as one of the prevalent neurocognitive disorders among older adults in Saudi Arabia, yet research efforts on its prevalence remains limited and fragmented, making it difficult to gain a full understanding of its epidemiology.
Why it matters
In a Saudi Arabian health system review, dementia was identified in 3.37% of participants aged 50 and older, with late-onset Alzheimer's disease the most prevalent subtype. The study describes prevalence and gender differences and may help early identification, but it reports no treatment or cure.
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The model showed excellent fit. Caregiver burden had a significant direct effect on anxiety (59.1% of the total effect), while indirect effects accounted for 40.9%.
Why it matters
This cross-sectional study found that caregiver burden had a significant direct effect on anxiety, with cognitive fusion as the only significant mediator, and that experiential avoidance mediated the relationship between burden and reduced values-driven actions. The authors suggest skills training targeting cognitive fusion and experiential avoidance, but the study does not address treating, curing, or preventing Alzheimer's disease.
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Our framework highlights individual-, system-, and community-level factors and resources influencing person-centered eating and swallowing care for PLWD.
Why it matters
This paper presents a conceptual framework of individual-, system- and community-level factors influencing person-centered eating and swallowing care for people living with dementia, and identifies areas at risk for inequitable care. It proposes future research areas rather than reporting a treatment, cure or prevention effect.
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In this study, we present a comprehensive pipeline to train and compare a broad spectrum of machine learning and deep learning brain clocks, integrating diverse preprocessing strategies and correction terms.
Why it matters
This study developed and compared machine learning and deep learning brain age models using MRI data, finding that accurate models can be achieved and may serve as biomarkers for neurodegenerative conditions. It is a methodological study and does not test any treatment, cure, or prevention for Alzheimer's disease.
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Dementia’s escalating incidence, coupled with its economic burden, highlights the need for architectural designs and forms that benefit people living with dementia.
Why it matters
This paper reviews architectural design strategies, such as visual cues, simplified layouts, safety features, and gardens, that aim to support autonomy, well-being, and safety for people with dementia. It concerns the built environment and quality of life, not treating, curing, or preventing the disease.
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Statins show mixed results in CKD and ESRD, with limited benefits in reducing cardiovascular events in dialysis patients.
Why it matters
This review is about lipid management in chronic kidney disease and hemodialysis patients, not Alzheimer's disease, and reports no findings on dementia. It notes mixed results for statins and limited evidence for several other lipid-lowering therapies in this population.
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Among the atrophic brain regions in aMCI, VSTM performance correlated with the volume of the right prefrontal cortex (PFC) but not the medial temporal lobe (MTL), and this correlation was mainly present in patients with greater MTL atrophy.
Why it matters
In amnestic mild cognitive impairment, visual short-term memory correlated with right prefrontal cortex volume rather than medial temporal lobe volume, especially in those with greater medial temporal lobe atrophy. This suggests a possible compensatory role of the prefrontal cortex and potential targets for early intervention, but it does not test any treatment, cure or prevention.
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The average age for patient was 78.13 ± 10.25 and for caregivers was 54.64 ± 13.22 years.
Why it matters
In this cross-sectional study of palliative care patients, 76.8% of caregivers had moderate caregiver burden, and as patients' ability to perform daily activities decreased, caregiver burden increased. It recommends psychological and social support for caregivers of severely dependent patients, but does not address treating, curing or preventing Alzheimer's disease.
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Familial frontotemporal dementia (fFTD) is an autosomal dominant heritable form of FTD, onsetting in mid-life, characterized by behavioral and personality changes.
Why it matters
This qualitative study explored attitudes and approaches to reproductive decision-making among people at risk for familial frontotemporal dementia. It is about reproductive decision-making, not about treating, curing or preventing dementia.
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The Shifting Expectations narrative indicated that PwD's needs shifted to co-constructed needs with their family as PwD's independence declined.
Why it matters
This narrative study suggests that people with dementia can initiate and revise advance care planning throughout the disease trajectory when relational support from trusted key persons is available. It addresses care planning rather than treating, curing, or preventing Alzheimer's disease.
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The Sendai Framework for Disaster Risk Reduction 2015–2030 (SFDRR) is at its 10th anniversary amidst a rapidly changing climate, which, together with social vulnerabilities, have led to significant impacts on human health and well-being.
Why it matters
This article examines the Sendai Framework for Disaster Risk Reduction in relation to climate change and health, not Alzheimer's disease. It notes the framework's opportunities for addressing underlying disaster risk drivers but also challenges from differing national capacities and political interests.
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After matching for demographic and health variables, usage of ACP codes was associated with significantly fewer hospitalizations for Alzheimer's disease patients.
Why it matters
This study found that use of advance care planning billing codes was associated with significantly fewer hospitalizations for Alzheimer's disease patients and a 20% to 30% decrease in emergency department visits across all diseases. It concerns healthcare utilization, not treating, curing, or preventing Alzheimer's disease.
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The MMSE-2 demonstrated robust performance in differentiating participants across Clinical Dementia Rating (CDR) stages and CDR-Sum of Boxes scores.
Why it matters
The MMSE-2 was found to be a valid and reliable tool for detecting vascular mild cognitive impairment and vascular dementia in a Korean population. This is a screening tool and does not provide a treatment, cure, or prevention for Alzheimer's disease.
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Website goals were: providing ACP information and facilitating ACP conversations.
Why it matters
This usability study developed a website to support advance care planning for people with dementia and their family caregivers, and it was rated as usable by participants. It addresses care planning support and does not test any treatment, cure, or prevention for Alzheimer's disease.
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The demographic transition during the recent decades has resulted in an increase in older adults globally.
Why it matters
This narrative review summarizes evidence that multidomain lifestyle interventions targeting several risk factors, such as the FINGER trial, have been most effective for cognition and other outcomes and appear cost-effective. It supports the potential of such programs to reduce the economic and societal burden of dementia.
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All patients had a Needs Near the End-of-Life Care Screening (NEST-13) score ≥30, indicating a high level of EOL care need.
Why it matters
This cross-sectional study in Bangladesh found that all 301 patients with incurable illnesses, including dementia, had a high level of end-of-life care need, with high unmet needs in doctor-patient communication, goals of care, spiritual needs, and caregiving. It reveals an opportunity to improve person-centered end-of-life care, but does not test any treatment, cure, or prevention.
From across this topic
10 of the 7,967 studies in this topic, picked by a fixed rule (a hash of each study's address), not by score or date; each page of this list shows a different 10. The same 10 appear here every time.
- Factors associated with long-term institutionalization of older people with dementia: data from the Canadian Study of Health and Aging
- Differential effects of a multidomain intervention on cognitive decline in older adults with type 2 diabetes according to white matter hyperintensity status: A secondary analysis of the J‐ MIND ‐Diabetes
- Health care professionals' perspectives of advance care planning for people with dementia living in long-term care settings: A narrative review of the literature
- Long-term health conditions and their impact on people with sleep disturbances and dementia
- Exploring the Immediate and Long-Term Effects of Immersive Virtual Reality on Behavioral and Psychological Symptoms of Dementia and Caregiver Burden: Longitudinal Observational Study
- Greater risk of dementia when spouse has dementia? The Cache County study
- Global, regional, and national incidence, prevalence, and years lived with disability for 328 diseases and injuries for 195 countries, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016
- Effect of person-centered showering and the towel bath on bathing-associated aggression, agitation, and discomfort in nursing home residents with dementia: a randomized, controlled trial
- The prevalence of dementia and Alzheimer's disease in Shanghai, China: impact of age, gender, and education
- Neighborhood disadvantage and the incidence of dementia in US Black women