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42/100

✓ Peer-reviewed alzhub usefulness score 42 out of 100. Mild cognitive impairment

Topic: Risk, prevention and care in population studies

A total of 90 (38.96%) participants were healthy and 141 (61.04%) had MCI. Compared with the healthy group, MCI patients were more likely to have fewer years of education, inactivity and lower UA levels. UA levels were significantly lower in MCI patients than healthy individuals ( P < 0.05). After adjusting for these variables, we found that among MCI patients, lower UA levels were associated with worse cognitive function in the MMSE. Multivariate logistic regression models demonstrated that UA was a protective factor for MCI. Multivariate analysis comparing the high and low quartile group, which was the reference group, indicated that differences in cognition among groups were statistically significant. Lower UA levels were associated with worse cognitive function; therefore, controlling UA levels within a suitable range may slow the progression of cognitive disorders. Keywords: uric acid, mild cognition impairment, factors, differences between groups

Cite this study APA, Vancouver, BibTeX · download .bib or .ris

APA 7th

Xue, L., Xiao, X., Mao, X., Zhang, X., Liu, Y., & Wu, B. (2025). Blood Uric Acid in Mild Cognitive Impairment: A Cross-Sectional Study of Older Chinese Adults. Neuropsychiatric Disease and Treatment. https://doi.org/10.2147/ndt.s521296

Vancouver

Xue L, Xiao X, Mao X, Zhang X, Liu Y, Wu B. Blood Uric Acid in Mild Cognitive Impairment: A Cross-Sectional Study of Older Chinese Adults. Neuropsychiatric Disease and Treatment. 2025. doi:10.2147/ndt.s521296. PMID: 40607161.

BibTeX

@article{xue2025-40607161,
  author  = {Xue, Lingling and Xiao, Xifeng and Mao, Xin’e and Zhang, Xiaoli and Liu, Yongbing and Wu, Beibei},
  title   = {{Blood Uric Acid in Mild Cognitive Impairment: A Cross-Sectional Study of Older Chinese Adults}},
  journal = {Neuropsychiatric Disease and Treatment},
  year    = {2025},
  doi     = {10.2147/ndt.s521296},
  pmid    = {40607161},
  url     = {https://doi.org/10.2147/ndt.s521296}
}

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Key findings

A total of 90 (38.96%) participants were healthy and 141 (61.04%) had MCI.
Compared with the healthy group, MCI patients were more likely to have fewer years of education, inactivity and lower UA levels.
UA levels were significantly lower in MCI patients than healthy individuals ( P < 0.05).
After adjusting for these variables, we found that among MCI patients, lower UA levels were associated with worse cognitive function in the MMSE.
Multivariate logistic regression models demonstrated that UA was a protective factor for MCI.

Why it matters

In this cross-sectional study of older Chinese adults, lower blood uric acid levels were associated with worse cognitive function and uric acid appeared to be a protective factor for mild cognitive impairment. The authors suggest controlling uric acid within a suitable range may slow progression, but this is an association finding, not proof of a treatment.

Study details

Study designcross-sectional
Participants231
Effect size38.96%; 61.04%
Evidence strengthLow

How this study scored 42/100

Published in a peer-reviewed journal, and it is a snapshot of people at one point in time. Scored zero for randomised / blinded because the record does not state it.

Component	Points	Why
Journal tier	7 / 10	Tier 3 — peer-reviewed journal (Neuropsychiatric Disease and Treatment)
Journal's citation record	1 / 4	Neuropsychiatric Disease and Treatment: journal h-index 126 (OpenAlex, 2026-10-29)
Study design	4 / 12	A snapshot of people at one point in time
Strength of evidence	1 / 5	Rated “low” in our summary
Peer-review validation	10 / 10	Peer-reviewed. Published as an article in a named peer-reviewed journal.
How recent	4 / 5	2025 — within 3 year(s) of the newest study here
Sample size	2 / 4	231 participants
Effect reported	2 / 3	Effect reported as a number, without an interval or test
Studied in people	3 / 3	Studied in people (participant count stated)
Randomised / blinded	0 / 2	No randomisation or blinding stated — scores zero (not stated in the record — scored 0)
Times cited	1 / 7	Cited 1 times (OpenAlex, 2026-10-10)
Citations per year	0 / 5	0.3 citations a year over 3 year(s) since 2025
Impact for its field and year	1 / 6	Cited 0.6× the average for papers of its field and year (OpenAlex FWCI)
Cited by studies here	0 / 6	No other study in this library cites it
Still being cited	0 / 4	Cited 1 times in 2024–2026 (2026 still in progress; OpenAlex)
Senior author's track record	1 / 4	Last-listed author Beibei Wu: h-index 7 (OpenAlex, whole career)
Institution's track record	0 / 3	Yangzhou University: institution h-index 405 (OpenAlex)
Multi-centre collaboration	1 / 3	OpenAlex lists 2 institution(s) in 1 country
Indexed in PubMed	2 / 2	Indexed in PubMed (PMID 40607161)
Free to read	2 / 2	Free to read
Total	42 / 100	—

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Referenced by this study and also in the alzhub library, so you can read them here.

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