Each study has a usefulness score out of 100 (rubric version 4.0). Tap a score to see what makes it up.
Highest usefulness score first. Studies without a score come last.
-
In known-group validity analysis, the EQ-HWB instruments performed similarly to the C-DEMQOL in terms of effect sizes across a range of variables and slightly better than the CarerQol on some variables.
Why it matters
This study tested how well the EQ Health and Wellbeing instruments performed in caregivers of persons living with dementia, finding they performed similarly to the C-DEMQOL and slightly better than the CarerQol on some variables. It is about measuring caregiver wellbeing, not about treating, curing or preventing Alzheimer's disease.
-
Individual cognitive profiles of patients with Parkinson's disease dementia (PDD) are highly heterogeneous, suggesting possible biological subtypes.
Why it matters
Among 75 Parkinson's disease patients who developed dementia, this study identified two cognitive subtypes: a memory-predominant group and a visuospatial-predominant group, with the visuospatial group having more GBA mutations and hallucinations. These subtypes were independent of comorbid Alzheimer's pathology, so this is about characterizing Parkinson's disease dementia, not treating or preventing Alzheimer's disease.
-
Participants possessed some knowledge about dementia but highlighted a need for better access to information about dementia.
Why it matters
This qualitative study found that participants had some knowledge of dementia risk factors but low knowledge of risk prediction, and held cautiously optimistic views about risk prediction tools while stressing the psychological impact of a high-risk result. It identifies barriers to dementia services and service improvement recommendations, but tested no treatment, cure, or prevention.
-
Regular opioid use was associated with a 20% higher risk of all-cause dementia and a 49% higher risk of vascular dementia (VD) compared with those not using analgesics.
Why it matters
Among UK Biobank participants with chronic non-cancer pain, regular opioid use was associated with a 20% higher risk of all-cause dementia and 49% higher risk of vascular dementia, with stronger risks for strong opioids, along with lower brain volumes and lower fluid intelligence. These are observational associations and do not prove that opioids cause dementia or that stopping them prevents it.
-
Among the 116 patients studied, 62.1% exhibited effective responses, 12.1% showed ineffectiveness, and 25.9% had uncertain outcomes with valproate therapy.
Why it matters
In this retrospective study of 116 patients, valproate was judged effective in 62.1% for behavioral and psychological symptoms of dementia, but it appeared less effective in aggression with psychotic symptoms. The authors call for randomized controlled trials to confirm these observations before any conclusions about treatment can be drawn.
-
Greater perceived control at study baseline was associated with reduced hazard of ADRD.
Why it matters
In the ACTIVE study, greater perceived control at baseline was linked to lower risk of Alzheimer's disease and related dementias, but perceived control did not change the relationship between the training intervention and time to diagnosis. Strengthening perceived control through individual or environmental interventions may lower dementia risk.
-
Out of 163 caregivers invited to participate, 104 (64%) participated.
Why it matters
In this cross-sectional survey of 104 caregivers, many were involved in dietary supplement use by the person with dementia, several were unaware of safety concerns, and nearly 50% of those who sought professional advice were not satisfied with the response. The authors note the small, heterogeneous sample, and the study does not test any treatment, cure or prevention for dementia.
-
42/100
The literature review scrutinized 1394 articles, selecting 14 through rigorous evaluation.
Why it matters
This scoping review proposes a framework for preventing urinary tract infections in older people living with dementia, based on 14 identified risk factors and ten preventive domains. It notes that some framework factors need further validation and that existing preventive studies had limitations such as small samples and inconsistent findings.
-
Lewy body dementia (LBD) encompasses neurodegenerative dementias characterized by cognitive fluctuations, visual hallucinations, and parkinsonism.
Why it matters
Existing animal and cellular models lack specificity in capturing LBD's unique pathogenic mechanisms, limiting the exploration of therapeutic avenues for LBD specifically. This review assesses widely used PD and AD models for their relevance to LBD and discusses potential modifications to advance understanding of LBD mechanisms.
-
Digital phenotyping based on physiological parameters and sensing technology may increase pain assessment objectivity in older adults with dementia.
Why it matters
Digital phenotyping based on physiological parameters and sensing technology may increase the objectivity of pain assessment in older adults with dementia. This technology must be designed with user involvement and validated, and it concerns improving pain relief and care rather than treating, curing, or preventing Alzheimer's disease.
-
42/100
Of 238 participants with informant data, 131 had dementia, 60 had CIND, and 47 had normal cognition.
Why it matters
The IQCODE, AD8, and GPCOGi questionnaires had high sensitivity but low specificity, meaning they may be useful for ruling out dementia but not for ruling it in. Friends performed significantly better overall on IQCODE and AD8, but there was little evidence of difference by informant type once fully adjusted.
-
52.7% of dementia caregivers in the United States experience financial toxicity.
Why it matters
In a nationally representative U.S. survey, 52.7% of dementia caregivers reported financial toxicity, with the highest risk among Black caregivers. This describes a financial burden of caregiving and does not address treating, curing, or preventing dementia.
-
Sensor-based surveillance technology (SST) is increasingly employed in the care of people with dementia (PwD) in hospitals, nursing homes, and home care.
Why it matters
This discussion paper examines the ethics of sensor-based surveillance for people with dementia, noting that evidence of safety benefit exists mainly for detecting falls or people leaving an area. It proposes best practice recommendations for clinical use, not a treatment or cure.
-
For 2018 and 2019, 3.5% and 5.4% received ACP visits, and 0.4% and 0.5% received CAACPS visits, similar to use reported elsewhere.
Why it matters
This study found that few Medicare Advantage beneficiaries with Alzheimer's disease and related dementias received advance care planning or cognitive assessment and care planning service visits. It does not test any treatment, cure, or prevention for Alzheimer's disease.
-
Dementia is a growing global health concern that significantly impacts the quality of life for millions of individuals and imposes substantial burdens on healthcare systems.
Why it matters
This study used EEG data and convolutional neural networks to identify brain lobe biomarkers for dementia detection, finding that the parietal lobe exhibited the most significant changes in both Alzheimer's disease and frontotemporal dementia. The approach achieved high classification accuracy for both conditions.
-
Several risk factors contribute to DACD, including hyperglycemia, hypoglycemia, blood sugar fluctuations, hyperinsulinemia, aging, and others.
Why it matters
This review summarizes risk factors, mechanisms, and potential drug treatments for cognitive dysfunction associated with diabetes, including modifiable factors like blood glucose control, physical activity, diet, smoking, and hypertension management. It does not report testing any treatment for Alzheimer's disease, so it offers background on prevention and management rather than a cure.
-
Of 138 (27%) eligible patients (46% female, age 61 ± 8 years, Mini-Mental State Examination [MMSE] 22 ± 6), 75 (54%) underwent genetic testing.
Why it matters
Among 138 eligible memory clinic patients, 75 (54%) underwent genetic testing for familial dementia, and those tested had better cognition, higher quality of life, and more often undetermined diagnoses. Decisions were driven by intuitive, value-based judgments rather than factual deliberation, so this study is about genetic testing decisions, not about treating, curing, or preventing Alzheimer's disease.
-
Sixteen of 30 cases with DLB pathology had no parkinsonism, which represented diverse nigral neurodegeneration.
Why it matters
This autopsy study found that the fourth Consortium pathological criteria for dementia with Lewy Bodies could be applied in a psychiatric cohort, and that many cases with DLB pathology had no parkinsonism. It concerns diagnosis and classification of dementia with Lewy Bodies, not treatment, cure or prevention of Alzheimer's disease.
-
121 SCU admissions involved 107 unique patients.
Why it matters
A hospital-based special care unit for dementia reduced later hospital readmissions for behaviour and was linked to fewer falls and less occupational violence on medical wards. This is a service model for managing behaviour in hospital, not a treatment that changes the underlying disease.
-
Patients in this study were from the China Stroke Center Alliance database.
Why it matters
In this study of stroke patients, those with both heart failure and dementia had higher in-hospital mortality and more complications than those with heart failure alone or neither condition. The study examines outcomes after stroke and does not test any treatment, cure, or prevention for Alzheimer's disease.
-
Alzheimer’s disease and related dementias (ADRD) pose a substantial caregiving burden in the United States, yet efforts to improve caregiver well-being have seen mixed results.
Why it matters
An app-based intervention to prioritize caregiver respite significantly improved the positive aspects of caregiving over 20 weeks, with greater benefits for women, lower-income households, caregivers with a college degree, and those providing at least 80% of care. No differences were found for care recipient memory and behavior problems, caregiver age, or caregiver race, and the study did not measure effects on the disease itself.
-
The number of people living with dementia is expected to rise to 153 million cases globally by 2050.
Why it matters
This scoping review found no studies explicitly targeting dementia risk reduction in younger adults with lower socioeconomic status, though many multidomain interventions addressed related risk factors like diet and physical inactivity. It highlights a gap in prevention research rather than showing that any intervention prevents dementia.
-
42/100
Our findings revealed a significant impact of unfavorable medical and psychiatric histories on processing speed and visual episodic memory decline (Hazard Ratio (HR) = 1.34, 95% CI: 1.20–1.51, p = 6.06 × 10⁻7; HR = 1.50, 95% CI: 1.22–1.86, p = 1.62 × 10⁻4, respectively).
Why it matters
Unfavourable medical and psychiatric histories were linked to faster decline in processing speed and visual episodic memory, while higher education, socioeconomic status, and handgrip strength appeared protective and high BMI, hypertension, and depression were detrimental. The authors say this can inform targeted interventions to delay cognitive decline.
-
Stark differences across SES in service use by people with dementia may indicate different health needs and/or allude to pervasive health inequities.
Why it matters
Among 193,834 older people newly diagnosed with dementia in Quebec, rates of 15 of 23 health service use indicators differed by socioeconomic status, with those from the most deprived areas having more hospitalizations, emergency visits, and higher 1-year mortality. The study is about service use and inequities, not about treating, curing, or preventing Alzheimer's disease.
-
42/100
We find that sexual minority status and gender interact to shape gay men's caregiving approaches.
Why it matters
This study found that gay men caring for spouses with dementia combine a task-oriented approach with concern for the care receiver's personhood, and reframe negative experiences as sources of strength. It highlights how gender and sexual orientation intersect to shape spousal caregiving.
From across this topic
10 of the 7,967 studies in this topic, picked by a fixed rule (a hash of each study's address), not by score or date; each page of this list shows a different 10. The same 10 appear here every time.
- Cerebral blood flow changes in benign aging and cerebrovascular disease
- Place of death and end-of-life transitions experienced by very old people with differing cognitive status: retrospective analysis of a prospective population-based cohort aged 85 and over
- Assessing the Time for Living and Caring (TLC) Study: Mixed-Methods Feasibility Study of a Web-Based Caregiver Intervention to Improve Respite
- Identification of prevalent dementia in Medicare Advantage encounters, compared with rigorous cohort assessments
- Lewy body dementia promotion by air pollutants
- The Mini-Addenbrooke's Cognitive Examination: a new assessment tool for dementia
- DemTect: a new, sensitive cognitive screening test to support the diagnosis of mild cognitive impairment and early dementia
- Alcohol use disorder accelerates age-related cognitive decline
- Risks and Benefits of Screening for Dementia in Primary Care: The Indiana University Cognitive Health Outcomes Investigation of the Comparative Effectiveness of Dementia Screening (IU CHOICE)Trial
- Fast-food for thought: Retail food environments as resources for cognitive health and wellbeing among aging Americans?