Each study has a usefulness score out of 100 (rubric version 4.0). Tap a score to see what makes it up.
Highest usefulness score first. Studies without a score come last.
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Frailty increasingly is recognized as a factor that modifies the relationship between disease biomarkers, including neuropathology, and dementia expression.
Why it matters
This scoping review found five blood biomarkers linked to both frailty and cognition, suggesting shared aging pathways. It does not test any treatment or prevention, so it cannot show whether targeting these markers changes disease course.
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Endometriosis is a chronic, oestrogen-dependent inflammatory condition affecting approximately 10% of women of reproductive age, frequently associated with chronic pelvic pain, dysmenorrhoea and infertility, substantially impairing quality of life.
Why it matters
This review is about endometriosis, not Alzheimer's disease, and reports no findings on dementia treatment, cure, or prevention. It only notes that Mediterranean-style and low-inflammatory diets were associated with reduced pain and better gastrointestinal symptoms in endometriosis.
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In the whole sample, significant differences between ethnicities were found in demographic, SE, psychological, and health variables.
Why it matters
Among people living in the most deprived neighborhoods, Hispanic, African American, and non-Hispanic White individuals differed in education, income, insurance, social support, memory, and rates of conditions like diabetes, obesity, depression, and hypertension. These findings show that the health and social circumstances of disadvantaged neighborhoods are not the same across ethnic groups, which matters for targeting care.
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42/100
Parkinson's disease (PD) is a progressive neurodegenerative disorder with a growing global burden.
Why it matters
This review covers Parkinson's disease, not Alzheimer's disease, and reports no findings on treating, curing or preventing Alzheimer's. It notes that current Parkinson's drug therapies are limited to symptom management.
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Caregiver burden is a multidimensional phenomenon with significant effects on health and well-being.
Why it matters
This integrative review describes the many mental and physical health effects of informal dementia caregiving, including high rates of depression, anxiety, stress, and reduced quality of life. It summarizes existing evidence rather than testing a treatment or cure.
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All volumes showed the smallest in dementia, the intermediate in MCI, and the largest in healthy controls.
Why it matters
Smaller brain volumes were found in dementia compared with mild cognitive impairment and healthy controls, and higher neuropsychiatric symptom scores were associated with smaller hippocampal and gray matter volumes and larger cerebrospinal fluid volume. This cross-sectional study describes associations between brain structure and symptoms, not a treatment or cure.
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A total of 414 caregivers participated. They exhibited normal intensity of depression, anxiety, and stress symptomatology.
Why it matters
Caregivers in this study exhibited normal intensity of depression, anxiety, and stress symptoms, and greater time spent caregiving and less engagement in leisure or relaxation activities were associated with higher burden. Positive mental health was a robust factor associated with mental health issues among caregivers.
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Written by leaders of six established comprehensive dementia-care programs (including Care Ecosystem, MIND at Home, and BRI Care Consultation) that helped shape the CMS GUIDE model, this paper lays out a practical four-step roadmap for organizations trying to launch or sustain comprehensive dementia care programs like GUIDE.
Why it matters
Written by leaders of six established comprehensive dementia-care programs, this paper lays out a four-step roadmap for launching or sustaining programs like GUIDE. It is practical implementation guidance, not evidence that any specific approach improves dementia outcomes.
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42/100
Using LGBTQ+ Social Networks, Aging, and Policy Study Wave 3 data (N = 982), this study examines how caregiving for individuals with mild cognitive impairment, Alzheimer’s disease, and related dementias (MCI/ADRD) impacts everyday stressors, discrimination, and health outcomes among LGBTQ+ older adults in the Southern United States.
Why it matters
LGBTQ+ older adult caregivers of people with MCI or ADRD in the Southern U.S. were more likely to experience minority stress, suicidal ideation, cognitive problems, and high blood pressure than non-caregivers. The findings call for targeted supports for these caregivers but do not test any treatment, cure, or prevention.
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Multivariable linear regression analysis indicated that being married (β = 0.6, p-value = 0.02) and being a young adult (β = 0.52, p-value = 0.04) were significantly associated with better neurocognitive performance.
Why it matters
In people living with HIV/AIDS, being married and being a young adult were linked to better neurocognitive performance on the International HIV Dementia Scale. This study only examines the scale's properties as a screening tool and does not address treating, curing, or preventing dementia.
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The findings indicate that the deficiencies within these institutions are not merely technical but are significantly influenced by systemic disparities in power, resource allocation, and political stability.
Why it matters
This study compares local disaster risk reduction institutions in Mexico and Nicaragua, not Alzheimer's disease. It found that institutional weaknesses are shaped by power, resource allocation and political stability, and that a shift from compliance-driven reforms to integrated strategies is needed.
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Worldwide, over half of all individuals with dementia are undiagnosed.
Why it matters
This article discusses the importance of early detection of dementia and describes a public health center funded by the CDC to promote early detection strategies. It does not test a treatment or cure for Alzheimer's disease.
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Caregivers reported moderate to high well-being scores, with Environmental Mastery highest (M = 38.01, SD = 8.70) and Purpose in Life lowest (M = 33.14, SD = 6.72).
Why it matters
In this cross-sectional study, caregiver well-being was modestly linked to depressive symptoms, education, gender, and age, while the care recipient's cognitive status showed only weak links to anxiety. Education appeared as a consistent protective factor, but the authors note Bonferroni correction removed significance in separate models.
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A total of 85 patients were enrolled; 28 (32.9%) were classified as NECPAL-positive and 57 (67.1%) as NECPAL-negative.
Why it matters
This small study of 85 critically ill patients found that about one-third were identified by the NECPAL tool as having palliative care needs, and these patients had a significantly higher ICU mortality rate. It suggests integration with ICU severity scores may improve early recognition of palliative care needs, but the authors state this warrants validation in larger multicentre studies.
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Global PSP prevalence ranges between 5-6.4 per 100,000, influenced by diagnostic criteria and healthcare infrastructure.
Why it matters
This global review describes how common progressive supranuclear palsy is, its symptoms, and how it varies by subtype and region. It is about PSP, not Alzheimer's disease, and does not report any treatment, cure, or prevention.
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Patients with DLB with anxiety had a significantly higher percentage of fluctuating cognition than those without anxiety.
Why it matters
This study found that anxiety in dementia with Lewy bodies is associated with fluctuating cognition and with regional cerebral blood flow in the right supramarginal gyrus. It does not test any treatment, so it does not show a cure or prevention.
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Cerebral small vessel disease (CSVD) is a major yet underappreciated driver of cognitive impairment and dementia, contributing to nearly half of all cases.
Why it matters
This hypothesis-driven review proposes that cerebral small vessel disease actively amplifies neurodegeneration through microvascular injury, blood-brain barrier breakdown, and glymphatic dysfunction, and it highlights possible diagnostic and therapeutic targets. These are proposed mechanisms and targets, not established treatments, cures, or prevention for Alzheimer's disease.
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The relative risk of dementia following cerebral hemorrhage ( relative risk(RR):3.02[1.17-7.78],P<0.001 ) was higher than that of cerebral infarction (RR: 2.07[1.47-2.96], P<0.001).
Why it matters
This study found that dementia risk was higher after cerebral hemorrhage than after cerebral infarction, but because infarction is more common it accounted for a larger share of dementia, with the two together explaining 1.31% of global dementia. It also identified a cerebrospinal fluid metabolite as a possible mediator, suggesting intervention targets for future prevention work.
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Interviews with 50 Dutch physicians and 47 American physicians and 3 nurse practitioners generated three themes of ethical considerations: (1) Respecting the autonomy of the person with dementia, (2) Rationality as the basis for decisions and subsequent actions, and (3) Minimizing burden and suffering.
Why it matters
This interview study identified ethical considerations among physicians in the United States and the Netherlands regarding advance care planning with people living with dementia, including tensions between autonomy and rationality. It addresses ethical decision-making in care planning and does not test any treatment, cure or prevention for Alzheimer's disease.
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Dementia diagnosis relies on assessing functional decline, yet widely used assessment tools are often developed in Euro-American contexts, limiting their cross-cultural validity.
Why it matters
This commentary argues that current tools for assessing functional decline in dementia are often developed in Euro-American contexts and may not work well across cultures. It proposes a framework to make these assessments more culturally inclusive so dementia is detected accurately in diverse populations.
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Fifty-nine patients fulfilled the inclusion criteria.
Why it matters
In 59 oldest-old patients with MCI, a model using the MMSE, clock test, and Lawton's Index predicted progression to dementia with an AUC of 0.945, while p-tau-181 and other blood biomarkers did not predict progression. The results highlight the strength of clinical variables for predicting MCI progression, not for treating or preventing it.
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Sleep, sedentary behaviour, and physical activity (PA) are important for brain health.
Why it matters
In this cohort, replacing sedentary behaviour with moderate-to-vigorous physical activity, light activity or sleep was linked to lower dementia risk. These findings come from an observational study and cannot show that changing behaviour directly prevents dementia.
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POD occurred in 43 patients (4.1%). Affected patients were older, in poorer preoperative health, and had longer anaesthesia and surgery times.
Why it matters
This retrospective cohort found that postoperative delirium occurred in 4.1% of adult surgical patients and that prolonged anaesthesia was a modifiable risk factor, with dementia associated with delirium on univariate analysis. It is about preventing delirium after surgery, not about treating, curing or preventing Alzheimer's disease.
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42/100
This study included 5899 older adults (65+) of whom 687 reported dysphagia (median age, 80 years; 62.2% female).
Why it matters
In this national study of 5899 older adults, frailty and low peak airflow were strongly associated with dysphagia, whereas dementia showed no significant association compared to normal cognition. It is about swallowing problems in older adults, not about treating, curing or preventing Alzheimer's disease.
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Dementia with Lewy bodies (DLB), the second common primary degenerative neurocognitive disorder after Alzheimer disease (AD), frequently presents concurrent co-pathologies that impact clinical presentation and progression.
Why it matters
This review discusses how common co-pathologies in dementia with Lewy bodies affect clinical presentation and progression. It suggests that clinical trials should account for these co-pathologies and that biomarkers may improve diagnostic accuracy, but it does not report new treatments or cures.
From across this topic
10 of the 7,967 studies in this topic, picked by a fixed rule (a hash of each study's address), not by score or date; each page of this list shows a different 10. The same 10 appear here every time.
- Synapse loss in dementias
- Longitudinal neuroimaging correlates of subjective memory impairment: 4-year prospective community study
- From Stroke to Dementia: a Comprehensive Review Exposing Tight Interactions Between Stroke and Amyloid-β Formation
- Discoveries in Down syndrome: moving basic science to clinical care
- Maltreatment Exposure, Brain Structure, and Fear Conditioning in Children and Adolescents
- Economic evaluation of a digital health intervention for preventing dementia in Canadians with mild cognitive impairment
- A vision transformer approach for fully automated and scalable dementia screening using clock drawing test images
- Nature, prevalence and factors associated with depression among the elderly in a rural south Indian community
- Structural and social determinants of dementia risk among adults racialized as Black: Results from a community‐based system dynamics approach
- Defining the Relationship Between Hypertension, Cognitive Decline, and Dementia: a Review