alzhub.org
Get help now — free helplines

You can call any of these for free. You do not need a diagnosis, an appointment, or a crisis to call — questions and plain exhaustion are reasons enough.

  • Alzheimer's Association 24/7 Helpline 800-272-3900 24 hours a day, 365 days a year Free, confidential support and information for people with dementia, caregivers, families and the public. Master's-level clinicians. Also Spanish.
  • 988 Suicide & Crisis Lifeline 988 24/7 Call or text 988, or chat at 988lifeline.org. For anyone in emotional distress or a mental-health crisis, including caregivers.
  • Alzheimer's Foundation of America (AFA) Helpline 866-232-8484 9:00 am - 9:00 pm ET, seven days a week Licensed social workers providing support, info and referrals. Also text message and web chat. Text: 646-586-5283

In a medical emergency, call 911. More numbers, and what each line does, on the help page.

Newest studies

Every summary in our library, newest first, as a dated timeline.

What "newest" means here

The most recent study in this library is dated 2026-11-01 (Paths of Aging Minds: Health Journeys of Older Adults with Mild Cognitive Impairment). This is our summary library, not a news wire — it is added to in batches, so the newest entry may not be the newest paper published anywhere.

Entries are sorted strictly by publication date, newest first. 26489 of the 27380 entries carry a full day-level date. 65 have no date recorded at all and are placed by publication year, at the start of that year; those are marked "no date recorded" below so you can see where the ordering is a best effort rather than a fact.

Prefer a reader? Subscribe to the Atom feed. Want them sorted by subject or by score instead? Browse the research library.

Showing 23,901–23,925 of 27,380 studies, newest first · page 957 of 1096.

November 2004 18

  1. 2004-11-01

    Hippocampal volume and depression: a meta-analysis of MRI studies

    ✓ Peer-reviewed Hippocampus size on brain scans The American journal of psychiatry

    Key finding: Hippocampal volume is reduced in patients with unipolar depression, maybe as a consequence of repeated periods of major depressive disorder. +1 more finding

    Full summary, score breakdown and related studies → Original source

  2. 2004-11-01

    Human immunodeficiency virus type 1 Nef protein mediates neural cell death: a neurotoxic role for IP-10

    ✓ Peer-reviewed Inflammation and the immune system Virology

    Key finding: Analysis of pro-inflammatory gene induction in astrocytes expressing Nef revealed increased IP-10 mRNA expression (4000-fold) that was Nef sequence dependent. +2 more findings

    Full summary, score breakdown and related studies → Original source

  3. 2004-11-01

    Stroke risk profile, brain volume, and cognitive function: the Framingham Offspring Study

    ✓ Peer-reviewed Brain tissue and pathology Neurology

    Key finding: Mid-life stroke risk factors have been related to late-life cognitive impairment. +3 more findings

    Full summary, score breakdown and related studies → Original source

  4. 2004-11-01

    Cognitive reserve and the neurobiology of cognitive aging

    ✓ Peer-reviewed Brain tissue and pathology Ageing research reviews

    Key finding: Intelligence, education and occupational level are believed to be major active components of cognitive reserve. +3 more findings

    Full summary, score breakdown and related studies → Original source

  5. 2004-11-01

    Distribution and signaling of TREM2/DAP12, the receptor system mutated in human polycystic lipomembraneous osteodysplasia with sclerosing leukoencephalopathy dementia

    ✓ Peer-reviewed TREM2 and immune genetics The European journal of neuroscience

    Key finding: In humans, however, loss-of-function mutations of TREM2/DAP12 leave myeloid cells unaffected but induce an autosomal recessive disease characterized, together with bone cysts, by a spectrum of pathological lesions in the cortex, thalamus and basal ganglia with clinical symptoms of progressive dementia (polycystic lipomembraneous osteodysplasia with sclerosing leukoencephalopathy). +3 more findings

    Full summary, score breakdown and related studies → Original source

  6. 2004-11-01

    Aging-related increase in oxidative stress correlates with developmental pattern of beta-secretase activity and beta-amyloid plaque formation in transgenic Tg2576 mice with Alzheimer-like pathology

    ✓ Peer-reviewed Risk genes beyond APOE International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience

    Key finding: To reveal whether aging-associated increases in brain oxidative stress and inflammation may trigger onset or progression of beta-amyloid deposition, a transgenic mouse (Tg2576) that express the Swedish double mutation of human amyloid precursor protein (APP) was used as animal model to study the developmental pattern of markers of oxidative stress and APP processing. +3 more findings

    Full summary, score breakdown and related studies → Original source

  7. 2004-11-01

    The role of the hippocampus in the pathophysiology of major depression

    ✓ Peer-reviewed Lewy body dementia Journal of psychiatry & neuroscience : JPN

    Key finding: Converging lines of research suggest that the hippocampal complex (HC) may have a role in the pathophysiology of major depressive disorder (MDD). +1 more finding

    Full summary, score breakdown and related studies → Original source

  8. 2004-11-01

    Cloning of the gene containing mutations that cause PARK8-linked Parkinson's disease

    ✓ Peer-reviewed Lewy body dementia Neuron

    Key finding: The hallmark pathological features of PD are loss of dopaminergic neurons from the substantia nigra and neuronal intracellular Lewy body inclusions. +4 more findings

    Full summary, score breakdown and related studies → Original source

  9. 2004-11-01

    Mutations in LRRK2 cause autosomal-dominant parkinsonism with pleomorphic pathology

    ✓ Peer-reviewed Lewy body dementia Neuron

    Key finding: Hence, LRRK2 may be central to the pathogenesis of several major neurodegenerative disorders associated with parkinsonism.

    Full summary, score breakdown and related studies → Original source

  10. 2004-11-01

    Vascular risk factors, incidence of MCI, and rates of progression to dementia

    ✓ Peer-reviewed How common it is Neurology

    Key finding: In this population, among those who progressed to dementia, 60% progressed to AD and 33% to VaD. +1 more finding

    Full summary, score breakdown and related studies → Original source

  11. 2004-11-01

    Racial similarities and differences in predictors of mobility change over eighteen months

    ✓ Peer-reviewed Disparities Journal of general internal medicine

    Key finding: Improving transportation access and diabetes care may be important targets for enhancing mobility and reducing racial disparities in mobility.

    Full summary, score breakdown and related studies → Original source

  12. 2004-11-01

    Attenuated central nervous system infection in advanced HIV/AIDS with combination antiretroviral therapy

    ✓ Peer-reviewed Disparities Archives of neurology

    Key finding: In contrast to observations in individuals not treated with CART, we found no relationship between CSF markers and neurological status in this CART-using cohort with advanced HIV/AIDS. +1 more finding

    Full summary, score breakdown and related studies → Original source

  13. 2004-11-01

    The metabolic syndrome, inflammation, and risk of cognitive decline

    ✓ Peer-reviewed Disparities JAMA

    Key finding: These findings support the hypothesis that the metabolic syndrome contributes to cognitive impairment in elders, but primarily in those with high level of inflammation. +4 more findings

    Full summary, score breakdown and related studies → Original source

  14. 2004-11-01

    Vascular pathologies and cognition in a population-based cohort of elderly people

    ✓ Peer-reviewed Brain scans and imaging Journal of the neurological sciences

    Key finding: Analysis of pathological data from the first 209 accumulated brain donations showed that both Alzheimer-type pathologies (ATP) and vascular pathologies (including congophilic amyloid angiopathy (CAA)) were common in both demented and non-demented respondents. +2 more findings

    Full summary, score breakdown and related studies → Original source

  15. 2004-11-01

    A randomized, controlled, clinical trial of activity therapy for apathy in patients with dementia residing in long-term care

    ✓ Peer-reviewed Treatments International journal of geriatric psychiatry

    Key finding: Despite the substantial improvement in apathy scores during the course of the study, there was no clear advantage to the reminiscence-based intervention over the time and attention, one-on-one control intervention. +2 more findings

    Full summary, score breakdown and related studies → Original source

  16. 2004-11-01

    Effect of person-centered showering and the towel bath on bathing-associated aggression, agitation, and discomfort in nursing home residents with dementia: a randomized, controlled trial

    ✓ Peer-reviewed Treatments Journal of the American Geriatrics Society

    Key finding: The techniques evaluated were person-centered showering and the towel bath (a person-centered, in-bed bag-bath with no-rinse soap).

    Full summary, score breakdown and related studies → Original source

  17. 2004-11-01

    Impact of APOE in mild cognitive impairment

    ✓ Peer-reviewed Genetics Neurology

    Key finding: Approximately 40% of the subjects were APOE epsilon4 carriers. +1 more finding

    Full summary, score breakdown and related studies → Original source

  18. 2004-11-01

    Statin therapy and risk of dementia in the elderly: a community-based prospective cohort study

    ✓ Peer-reviewed Genetics Neurology

    Key finding: Employing time-dependent proportional hazards modeling, the authors found no significant association between statin use and incident dementia or probable AD. +1 more finding

    Full summary, score breakdown and related studies → Original source

October 2004 7

  1. 2004-10-28

    Disturbed fluctuations of resting state EEG synchronization in Alzheimer's disease

    ✓ Peer-reviewed Brain scans and imaging Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology

    Key finding: Alzheimer's disease is characterized both by a lower mean level of functional connectivity as well as by diminished fluctuations in the level of synchronization. +1 more finding

    Full summary, score breakdown and related studies → Original source

  2. 2004-10-27

    The spectrum of pathological involvement of the striatonigral and olivopontocerebellar systems in multiple system atrophy: clinicopathological correlations

    ✓ Peer-reviewed Lewy body dementia Brain : a journal of neurology

    Key finding: Multiple system atrophy (MSA) has varying clinical (MSA-P versus MSA-C) and pathological [striatonigral degeneration (SND) versus olivopontocerebellar atrophy (OPCA)] phenotypes. +4 more findings

    Full summary, score breakdown and related studies → Original source

  3. 2004-10-26

    Neuropsychological rehabilitation of memory deficits and activities of daily living in patients with Alzheimer's disease: a pilot study

    ✓ Peer-reviewed Prevention trials Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas

    Key finding: The results showed a statistically significant improvement in ADL measured by Functional Test (P = 0.04), and only a small improvement in memory and psychiatric symptoms. +1 more finding

    Full summary, score breakdown and related studies → Original source

  4. 2004-10-25

    Synapsin and synaptic vesicle protein expression during embryonic and post-natal lens fiber cell differentiation

    ✓ Peer-reviewed Down syndrome and Alzheimer's Molecular vision

    Key finding: The present findings demonstrate several fundamental parallels between lens and neuron vesicle trafficking cell biology and development, and suggest that more extensive AbetaPP related vesicle trafficking disease mechanisms may be shared by lens and brain. +3 more findings

    Full summary, score breakdown and related studies → Original source

  5. 2004-10-19

    Deconstructing Heart Failure Disease Management

    ✓ Peer-reviewed Health systems and care delivery Annals of Internal Medicine

    Key finding: DeMonte Jr., MD, Joshua Chodosh, MD, MSHS, Xinping Cui, PhD, Stefanie Vassar, MS, Naihua Duan, PhD, and Martin Lee, PhDReduced Health Care Costs Associated With Disease Management for Chronic Heart Failure: A Study Using Three Methods to Examine the Financial Impact of a Heart Failure Disease Management Program Among Medicare Advantage EnrolleesEffects of Nurse Management on the Quality of Heart Failure Care in Minority Communities A Randomized TrialJane E.

    Full summary, score breakdown and related studies → Original source

  6. 2004-10-13

    Identification of a new presenilin-dependent zeta-cleavage site within the transmembrane domain of amyloid precursor protein

    ✓ Peer-reviewed Risk genes beyond APOE The Journal of biological chemistry

    Key finding: To better understand the molecular events involved in gamma-secretase cleavage of APP, in this study we report the identification of a new intracellular long Abeta species containing residues 1-46 (Abeta46), which led to the identification of a novel zeta-cleavage site between the known gamma- and epsilon-cleavage sites within the transmembrane domain of APP. +3 more findings

    Full summary, score breakdown and related studies → Original source

  7. 2004-10-12

    Progressive posterior cortical dysfunction

    ✓ Peer-reviewed Risk factors Neurology

    Key finding: Neuropathologic etiologies of PPCD were Alzheimer disease (AD) (n = 13), AD plus Parkinson disease (n = 1), AD-Lewy body variant (n = 2), dementia with Lewy bodies plus progressive subcortical gliosis of Neumann (n = 1), corticobasal degeneration (n = 2), and prion-associated diseases: Creutzfeldt-Jakob disease (n = 1) and fatal familial insomnia (n = 1). +2 more findings

    Full summary, score breakdown and related studies → Original source

Browse the library by subject, with the full score breakdown →