Newest studies
Every summary in our library, newest first, as a dated timeline.
Showing 23,276–23,300 of 27,380 studies, newest first · page 932 of 1096.
February 2006 16
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2006-02-01
Alzheimer precursor protein interaction with the Nogo-66 receptor reduces amyloid-beta plaque deposition
43/100 ✓ Peer-reviewed Risk genes beyond APOE The Journal of neuroscience : the official journal of the Society for Neuroscience
Key finding: As part of the disease process, an aberrant axonal sprouting response is known to occur near Abeta deposits. +3 more findings
Full summary, score breakdown and related studies → Original source
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2006-02-01
Locus ceruleus degeneration promotes Alzheimer pathogenesis in amyloid precursor protein 23 transgenic mice
47/100 ✓ Peer-reviewed Risk genes beyond APOE The Journal of neuroscience : the official journal of the Society for Neuroscience
Key finding: Although this has been known for several decades, the contribution of LC degeneration to AD pathogenesis remains unclear. +3 more findings
Full summary, score breakdown and related studies → Original source
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2006-02-01
Biological rhythm disturbances in mood disorders
40/100 ✓ Peer-reviewed Risk factors International clinical psychopharmacology
Key finding: The present flourishing of circadian biology has revealed the molecular basis of 24-h rhythmicity driven by 'clock' genes, as well as the importance of zeitgebers (synchronisers).
Full summary, score breakdown and related studies → Original source
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2006-02-01
Steroid-responsive encephalopathy associated with autoimmune thyroiditis
47/100 ✓ Peer-reviewed Risk factors Archives of neurology
Key finding: The clinical, laboratory, and radiologic findings associated with SREAT are more varied than previously reported. +4 more findings
Full summary, score breakdown and related studies → Original source
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2006-02-01
Role of genes and environments for explaining Alzheimer disease
64/100 ✓ Peer-reviewed How common it is Archives of general psychiatry
Key finding: In the largest twin study to date, we confirmed that heritability for AD is high and that the same genetic factors are influential for both men and women. +2 more findings
Full summary, score breakdown and related studies → Original source
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2006-02-01
Depressive symptoms and cognitive decline in late life: a prospective epidemiological study
54/100 ✓ Peer-reviewed Disparities Archives of general psychiatry
Key finding: Depressive symptoms are cross-sectionally associated with cognitive impairment but not subsequent cognitive decline. +4 more findings
Full summary, score breakdown and related studies → Original source
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2006-02-01
Caregivers' reasons for nursing home placement: clues for improving discussions with families prior to the transition
54/100 ✓ Peer-reviewed Caregiving The Gerontologist
Key finding: Caregivers' reasons for placement included (a) the need for more skilled care (65%); (b) the caregivers' health (49%); (c) the patients' dementia-related behaviors (46%); and (d) the need for more assistance (23%). +3 more findings
Full summary, score breakdown and related studies → Original source
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2006-02-01
Quality of life in dementia: more than just cognition. An analysis of associations with quality of life in dementia
50/100 ✓ Peer-reviewed Caregiving Journal of neurology, neurosurgery, and psychiatry
Key finding: These data suggest that quality of life in dementia is complex, and that simple proxy substitutions of discrete measures such as cognition or function are likely to miss important factors. +4 more findings
Full summary, score breakdown and related studies → Original source
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2006-02-01
Magnetic resonance imaging of iron deposition in neurological disorders
50/100 ✓ Peer-reviewed Brain scans and imaging Topics in magnetic resonance imaging : TMRI
Key finding: Iron deposition is associated with a reduction in the T2 relaxation time, leading to hypointensity on spin-echo and gradient-echo T2-weighted images. +1 more finding
Full summary, score breakdown and related studies → Original source
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2006-02-01
Small-world networks and functional connectivity in Alzheimer's disease
55/100 ✓ Peer-reviewed Brain scans and imaging Cerebral cortex (New York, N.Y. : 1991)
Key finding: For a wide range of thresholds, the characteristic path length L was significantly longer in the Alzheimer patients, whereas the cluster coefficient C showed no significant changes.
Full summary, score breakdown and related studies → Original source
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2006-02-01
Mortality after the hospitalization of a spouse
63/100 ✓ Peer-reviewed Getting a diagnosis The New England journal of medicine
Key finding: Among elderly people hospitalization of a spouse is associated with an increased risk of death, and the effect of the illness of a spouse varies among diagnoses. +3 more findings
Full summary, score breakdown and related studies → Original source
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2006-02-01
Non-degenerative mild cognitive impairment in elderly people and use of anticholinergic drugs: longitudinal cohort study
70/100 ✓ Peer-reviewed Getting a diagnosis BMJ (Clinical research ed.)
Key finding: Elderly people taking anticholinergic drugs had significant deficits in cognitive functioning and were highly likely to be classified as mildly cognitively impaired, although not at increased risk for dementia. +3 more findings
Full summary, score breakdown and related studies → Original source
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2006-02-01
Ageing and the brain
46/100 ✓ Peer-reviewed Prevention and risk Postgraduate medical journal
Key finding: The brain shrinks with increasing age and there are changes at all levels from molecules to morphology. +4 more findings
Full summary, score breakdown and related studies → Original source
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2006-02-01
Adherence to continuous positive airway pressure treatment in patients with Alzheimer's disease and obstructive sleep apnea
50/100 ✓ Peer-reviewed Treatments The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry
Key finding: Patients wore CPAP for 4.8 hours per night. +1 more finding
Full summary, score breakdown and related studies → Original source
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2006-02-01
Effects of a gamma-secretase inhibitor in a randomized study of patients with Alzheimer disease
71/100 ✓ Peer-reviewed Treatments Neurology
Key finding: Abeta(1-40) in plasma decreased by 38.2%; in CSF, Abeta(1-40) decreased by 4.42 +/- 9.55% (p = not significant). +1 more finding
Full summary, score breakdown and related studies → Original source
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2006-02-01
Apolipoprotein E and dementia in Parkinson disease: a meta-analysis
56/100 ✓ Peer-reviewed Genetics Archives of neurology
Key finding: The APOE epsilon4 allele appears to be associated with a higher prevalence of dementia in PD.
Full summary, score breakdown and related studies → Original source
January 2006 9
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2006-01-31
Efficacy of rosiglitazone in a genetically defined population with mild-to-moderate Alzheimer's disease
72/100 ✓ Peer-reviewed Genetics The pharmacogenomics journal
Key finding: Primary end points at Week 24 were mean change from baseline in AD Assessment Scale-Cognitive (ADAS-Cog) and Clinician's Interview-Based Impression of Change Plus Caregiver Input global scores in the intention-to-treat population (N=511), and results were also stratified by apolipoprotein E (APOE) genotype (n=323). +4 more findings
Full summary, score breakdown and related studies → Original source
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2006-01-27
Pain in elderly people with severe dementia: a systematic review of behavioural pain assessment tools
67/100 ✓ Peer-reviewed Health systems and care delivery BMC geriatrics
Key finding: Based on the psychometric qualities and criteria regarding sensitivity and clinical utility, we conclude that PACSLAC and DOLOPLUS2 are the most appropriate scales currently available. +2 more findings
Full summary, score breakdown and related studies → Original source
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2006-01-25
The effectiveness of atypical antipsychotics for the treatment of aggression and psychosis in Alzheimer's disease
72/100 ✓ Peer-reviewed Vascular contributions The Cochrane database of systematic reviews
Key finding: Analysis included patients treated with an atypical antipsychotic, compared with placebo Main results Sixteen placebo controlled trials have been completed with atypical antipsychotics although only nine had sufficient data to contribute to a meta-analysis and only five have been published in full in peer reviewed journals. +4 more findings
Full summary, score breakdown and related studies → Original source
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2006-01-25
BDNF Val66Met allele is associated with reduced hippocampal volume in healthy subjects
36/100 ✓ Peer-reviewed Hippocampus size on brain scans Biological psychiatry
Key finding: In spite of a relatively small sample size, the presence of the met-BDNF allele was found associated with a reduced volume of the hippocampal formation in healthy volunteers and may represent a vulnerability factor for the development of disease processes associated with the dysfunction of this brain region. +2 more findings
Full summary, score breakdown and related studies → Original source
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2006-01-25
Donepezil for dementia due to Alzheimer's disease
83/100 ✓ Peer-reviewed Caregiving The Cochrane database of systematic reviews
Key finding: Selection criteria All unconfounded, double-blind, randomized controlled trials in which treatment with donepezil was compared with placebo for patients with mild, moderate or severe dementia due to Alzheimer's disease. +4 more findings
Full summary, score breakdown and related studies → Original source
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2006-01-25
Galantamine for Alzheimer's disease and mild cognitive impairment
72/100 ✓ Peer-reviewed Treatments The Cochrane database of systematic reviews
Key finding: Galantamine is a specific, competitive, and reversible acetylcholinesterase inhibitor. +3 more findings
Full summary, score breakdown and related studies → Original source
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2006-01-25
Cholinesterase inhibitors for Alzheimer's disease
72/100 ✓ Peer-reviewed Treatments The Cochrane database of systematic reviews
Key finding: Since the introduction of the first cholinesterase inhibitor (ChEI) in 1997, most clinicians and probably most patients would consider the cholinergic drugs, donepezil, galantamine and rivastigmine, to be the first line pharmacotherapy for mild to moderate Alzheimer's disease. +3 more findings
Full summary, score breakdown and related studies → Original source
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2006-01-24
Neuropsychological and behavioural correlates of CSF biomarkers in dementia
46/100 ✓ Peer-reviewed Tau biomarkers Neurochemistry international
Key finding: CSF tau and P-tau181 levels correlated significantly in all groups, whereas CSF Abeta42 correlated with tau and P-tau181 levels in healthy controls only. +2 more findings
Full summary, score breakdown and related studies → Original source
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2006-01-13
Risk factors for incident dementia in England and Wales: The Medical Research Council Cognitive Function and Ageing Study. A population-based nested case-control study
61/100 ✓ Peer-reviewed Disparities Age and ageing
Key finding: In this large multicentre and long-term population-based study, some well-known risk factors for dementia, of vascular and Alzheimer's type, are confirmed but not others. +2 more findings
Full summary, score breakdown and related studies → Original source
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