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Stroke risk profile, brain volume, and cognitive function: the Framingham Offspring Study
Seshadri S, Wolf PA, Beiser A, Elias MF, Au R, Kase CS, D'Agostino RB, DeCarli C.. Neurology, 2004-11-01
Topic: Risk, prevention and care in population studies
Background Mid-life stroke risk factors have been related to late-life cognitive impairment. This association may result not only from clinical strokes but also from subclinical brain injury, such as a global atrophy demonstrable on quantitative brain MRI. Methods The authors evaluated the community-based cohort of Framingham Offspring Study participants.
Key findings
- This association may result not only from clinical strokes but also from subclinical brain injury, such as a global atrophy demonstrable on quantitative brain MRI.
- Methods The authors evaluated the community-based cohort of Framingham Offspring Study participants.
- A total of 1,841 subjects (mean age, 62 years; 857 men, 984 women) who underwent quantitative MRI and cognitive testing between 1999 and 2001 and were free of clinical stroke and dementia constituted our study sample.
- The authors used age- and sex-adjusted linear regression models to relate previous (1991 to 1995) and recent (1998 to 2001) Framingham Stroke Risk Profile (FSRP) scores to the total cerebral brain volume ratio (TCBVr) on follow-up MRI, and further to relate the TCBVr with education-adjusted scores on neuropsychological tests administered at the time of imaging.
Why it matters
In 1,841 community-based participants free of clinical stroke and dementia, this study examined whether midlife stroke risk factors relate to late-life cognitive impairment and global brain atrophy on MRI. It reports associations and does not show that treating stroke risk factors prevents dementia.
Study details
- Participants1,841
- Evidence strengthModerate
How this study scored 57/100
Published in a leading specialty journal. Scored zero for study design, effect reported and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 9 / 10 | Tier 2 — leading specialty journal (Neurology) |
| Journal's citation record | 4 / 4 | Neurology: journal h-index 525 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 3 / 5 | Rated “moderate” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 1 / 5 | 2004 — older than 20 years, still counted |
| Sample size | 3 / 4 | 1,841 participants |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 5 / 7 | Cited 230 times (OpenAlex, 2026-10-10) |
| Citations per year | 3 / 5 | 9.6 citations a year over 24 year(s) since 2004 |
| Impact for its field and year | 3 / 6 | Cited 5.0× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 3 / 6 | Cited by 21 other studies in this library |
| Still being cited | 2 / 4 | Cited 19 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 4 / 4 | Last-listed author Charles S DeCarli: h-index 150 (OpenAlex, whole career) |
| Institution's track record | 1 / 3 | Boston University: institution h-index 1,456 (OpenAlex) |
| Multi-centre collaboration | 1 / 3 | OpenAlex lists 3 institution(s) in 1 country |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 15534241) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Total | 57 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
May need a subscription OpenAlex found no free copy of the full text (checked 6 Feb 1020), so the publisher may charge for it. The PubMed abstract is free.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record names 8 authors; APA and Vancouver show the first six, BibTeX and the downloads carry all of them. Check the citation against the original before you use it.
APA 7th
Seshadri, S., Wolf, P. A., Beiser, A., Elias, M. F., Au, R., Kase, C. S., et al. (2004). Stroke risk profile, brain volume, and cognitive function: the Framingham Offspring Study. Neurology. https://doi.org/10.1212/01.wnl.0000142968.22691.70
Vancouver
Seshadri S, Wolf PA, Beiser A, Elias MF, Au R, Kase CS, et al. Stroke risk profile, brain volume, and cognitive function: the Framingham Offspring Study. Neurology. 2004. doi:10.1212/01.wnl.0000142968.22691.70. PMID: 15534241.
BibTeX
@article{seshadri2004-15534241,
author = {Seshadri, S. and Wolf, P. A. and Beiser, A. and Elias, M. F. and Au, R. and Kase, C. S. and D'Agostino, R. B. and DeCarli, C.},
title = {{Stroke risk profile, brain volume, and cognitive function: the Framingham Offspring Study}},
journal = {Neurology},
year = {2004},
doi = {10.1212/01.wnl.0000142968.22691.70},
pmid = {15534241},
url = {https://doi.org/10.1212/01.wnl.0000142968.22691.70}
}
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