Newest studies

Statin‐Associated Adverse Cognitive Effects: Survey Results from 171 Patients

45/100 ✓ Peer-reviewed Drug development Pharmacotherapy The Journal of Human Pharmacology and Drug Therapy

Key finding: Patients completed a survey assessing statin-associated, cognitive-specific adverse drug reaction (ADR) characteristics, relation of the ADR to specific statin and dose (or potency), and time course of symptom onset and recovery. +4 more findings

• Treatments

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Treatment with a C5aR antagonist decreases pathology and enhances behavioral performance in murine models of Alzheimer's disease

47/100 ✓ Peer-reviewed Inflammation and the immune system Journal of immunology (Baltimore, Md. : 1950)

Key finding: Components of the complement system, known to produce a local inflammatory reaction, are associated with the plaques and tangles in AD brain, and thus a role for complement-mediated inflammation in the acceleration or progression of disease has been proposed. +3 more findings

• Brain Biology

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Role of synucleins in Alzheimer's disease

40/100 ✓ Peer-reviewed Disease mechanisms Neurotoxicity research

Key finding: Most of the studies in AD have been focused on investigating the role of Abeta and Tau; however, recent studies suggest that alpha-syn might also play a role in the pathogenesis of AD. +1 more finding

• Brain Biology

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Regulation of mitochondrial respiratory chain biogenesis by estrogens/estrogen receptors and physiological, pathological and pharmacological implications

36/100 ✓ Peer-reviewed Brain scans and imaging Biochimica et biophysica acta

Key finding: There has been increasing evidence pointing to the mitochondrial respiratory chain (MRC) as a novel and important target for the actions of 17beta-estradiol (E(2)) and estrogen receptors (ER) in a number of cell types and tissues that have high demands for mitochondrial energy metabolism. +3 more findings

• Brain Biology
• Policy

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β-Amyloid impairs axonal BDNF retrograde trafficking

36/100 ✓ Peer-reviewed Disease mechanisms Neurobiology of aging

Key finding: Alzheimer disease (AD) is characterized by early impairments in synaptic function that may result in part from neurotrophin signaling deficits. +1 more finding

• Brain Biology

Full summary, score breakdown and related studies → Original source

Are cholinesterase inhibitors effective in the management of the behavioral and psychological symptoms of dementia in Alzheimer's disease? A systematic review of randomized, placebo-controlled trials of donepezil, rivastigmine and galantamine

66/100 ✓ Peer-reviewed Treatments International psychogeriatrics

Key finding: 14 studies were identified that matched inclusion criteria. +4 more findings

• Treatments
• Clinical Trials

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Differential processing of amyloid-beta precursor protein directs human embryonic stem cell proliferation and differentiation into neuronal precursor cells

42/100 ✓ Peer-reviewed Down syndrome and Alzheimer's The Journal of biological chemistry

Key finding: We recently reported that this protein, normally associated with neurodegenerative conditions, is expressed by human embryonic stem cells (hESCs). +2 more findings

• Brain Biology

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Functional amyloids as natural storage of peptide hormones in pituitary secretory granules

41/100 ✓ Peer-reviewed Risk factors Science (New York, N.Y.)

Key finding: Amyloids are highly organized cross-beta-sheet-rich protein or peptide aggregates that are associated with pathological conditions including Alzheimer's disease and type II diabetes. +2 more findings

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Lithium Trial in Alzheimer's Disease

41/100 ✓ Peer-reviewed Drug development The Journal of Clinical Psychiatry

Key finding: No treatment effect on GSK-3 activity or CSF-based biomarker concentrations (P >. 05) was observed. +3 more findings

• Clinical Trials

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Cognitive function in early Parkinson's disease: a population-based study

50/100 ✓ Peer-reviewed Digital health tools European journal of neurology

Key finding: Cognitive dysfunction is common in untreated patients in early PD, affecting attention, psychomotor function, episodic memory, executive function and category fluency. +3 more findings

• Other Dementias

Full summary, score breakdown and related studies → Original source

Recommendations on the diagnosis and management of Niemann-Pick disease type C

36/100 ✓ Peer-reviewed Clinical safety Molecular genetics and metabolism

Key finding: In most countries, NP-C is managed through specialist centers, with non-specialist support provided locally. +4 more findings

• Treatments

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Molecular genetic analysis of Down syndrome

36/100 ✓ Peer-reviewed Down syndrome and Alzheimer's Human genetics

Key finding: Down syndrome (DS) is caused by trisomy of all or part of human chromosome 21 (HSA21) and is the most common genetic cause of significant intellectual disability. +2 more findings

• Down Syndrome
• Genetics

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Effects of voluntary and forced exercise on plaque deposition, hippocampal volume, and behavior in the Tg2576 mouse model of Alzheimer's disease

36/100 ✓ Peer-reviewed Hippocampus size on brain scans Neurobiology of disease

Key finding: However, levels of soluble Abeta-40 or Abeta-42 did not significantly differ among groups. +1 more finding

• Brain Biology
• Brain Scans
• Lifestyle

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Prevalence of depression among older Americans: the Aging, Demographics and Memory Study

53/100 ✓ Peer-reviewed Disparities International psychogeriatrics

Key finding: The finding of similar prevalence estimates for depression in men and women was not consistent with prior research that has shown a female predominance. +2 more findings

• Health Equity

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Omega-3 fatty acids and dementia

45/100 ✓ Peer-reviewed Prevention and risk Prostaglandins, leukotrienes, and essential fatty acids

Key finding: More than a dozen epidemiological studies have reported that reduced levels or intake of omega-3 fatty acids or fish consumption is associated with increased risk for age-related cognitive decline or dementia such as Alzheimer's disease (AD). +2 more findings

• Prevention
• Lifestyle
• Risk Factors

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Memantine in patients with Parkinson's disease dementia or dementia with Lewy bodies: a double-blind, placebo-controlled, multicentre trial

75/100 ✓ Peer-reviewed Treatments The Lancet. Neurology

Key finding: 72 patients with PDD or DLB were randomly assigned and started treatment: 34 with memantine and 38 with placebo. 56 (78%) completed the study. +1 more finding

• Clinical Trials
• Other Dementias
• Treatments

Full summary, score breakdown and related studies → Original source

Dystrophic (senescent) rather than activated microglial cells are associated with tau pathology and likely precede neurodegeneration in Alzheimer's disease

55/100 ✓ Peer-reviewed Inflammation and the immune system Acta neuropathologica

Key finding: Although several works suggest that chronic neuroinflammation caused by activated microglia contributes to neurofibrillary degeneration, anti-inflammatory drugs do not prevent or reverse neuronal tau pathology. +3 more findings

• Brain Biology

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Soluble fibrillar oligomer levels are elevated in Alzheimer's disease brain and correlate with cognitive dysfunction

45/100 ✓ Peer-reviewed Cognitive tests and assessment Neurobiology of disease

Key finding: Fibrillar plaque deposits are present in non-demented individuals and levels of soluble Abeta correlate better with cognitive dysfunction in AD and transgenic mouse models. +3 more findings

• Brain Biology

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Prevalence of functional disability in activities of daily living (ADL), instrumental activities of daily living (IADL) and associated factors, as predictors of morbidity and mortality

51/100 ✓ Peer-reviewed How common it is Archives of gerontology and geriatrics

Key finding: There is a significant association between age, gender and dependence, as well as between dependence and morbidity and mortality, so that dependence could be used as a predictor of both.

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Prevalence and prognostic value of CSF markers of Alzheimer's disease pathology in patients with subjective cognitive impairment or mild cognitive impairment in the DESCRIPA study: a prospective cohort study

67/100 ✓ Peer-reviewed How common it is The Lancet. Neurology

Key finding: The CSF AD profile was more common in patients with SCI (31 of 60 [52%]), naMCI (25 of 37 [68%]), and aMCI (56 of 71 [79%]) than in healthy controls (28 of 89 [31%]). +2 more findings

• Early Stage
• Biomarkers

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The cognitive impact of anticholinergics: a clinical review

40/100 ✓ Peer-reviewed Clinical safety Clinical interventions in aging

Key finding: Medications with anticholinergic activity negatively affect the cognitive performance of older adults.

• Side Effects

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Self administered cognitive screening test (TYM) for detection of Alzheimer's disease: cross sectional study

53/100 ✓ Peer-reviewed Cognitive tests and assessment BMJ (Clinical research ed.)

Key finding: Outpatient departments in three hospitals, including a memory clinic. +3 more findings

• Diagnosis

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Neurons in the white matter of the adult human neocortex

40/100 ✓ Peer-reviewed Brain scans and imaging Frontiers in neuroanatomy

Key finding: Interstitial neurons are most prominent in human brain, and only rudimentary in the brain of non-primate mammals. +4 more findings

• Brain Biology

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Transmission and spreading of tauopathy in transgenic mouse brain

58/100 ✓ Peer-reviewed Lewy body dementia Nature cell biology

Key finding: Tau mutations cause familial forms of frontotemporal dementia, establishing that tau protein dysfunction is sufficient to cause neurodegeneration and dementia. +4 more findings

• Brain Biology

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Automated MRI-based classification of primary progressive aphasia variants

49/100 ✓ Peer-reviewed Digital health tools NeuroImage

Key finding: Degeneration of language regions in the dominant hemisphere can result in primary progressive aphasia (PPA), a clinical syndrome characterized by progressive deficits in speech and/or language function. +3 more findings

• Brain Scans
• Other Dementias

Full summary, score breakdown and related studies → Original source