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Newest studies

Every summary in our library, newest first, as a dated timeline.

What "newest" means here

The most recent study in this library is dated 2026-11-01 (Paths of Aging Minds: Health Journeys of Older Adults with Mild Cognitive Impairment). This is our summary library, not a news wire — it is added to in batches, so the newest entry may not be the newest paper published anywhere.

Entries are sorted strictly by publication date, newest first. 26489 of the 27380 entries carry a full day-level date. 65 have no date recorded at all and are placed by publication year, at the start of that year; those are marked "no date recorded" below so you can see where the ordering is a best effort rather than a fact.

Prefer a reader? Subscribe to the Atom feed. Want them sorted by subject or by score instead? Browse the research library.

Showing 23,776–23,800 of 27,380 studies, newest first · page 952 of 1096.

February 2005 23

  1. 2005-02-01

    Extensive involvement of autophagy in Alzheimer disease: an immuno-electron microscopy study

    ✓ Peer-reviewed Brain tissue and pathology Journal of neuropathology and experimental neurology

    Key finding: Autophagy was evident in the perikarya of affected neurons, particularly in those with neurofibrillary pathology where it was associated with a relative depletion of mitochondria and other organelles. +1 more finding

    Full summary, score breakdown and related studies → Original source

  2. 2005-02-01

    Axonopathy and transport deficits early in the pathogenesis of Alzheimer's disease

    ✓ Peer-reviewed Risk genes beyond APOE Science (New York, N.Y.)

    Key finding: We identified axonal defects in mouse models of Alzheimer's disease that preceded known disease-related pathology by more than a year; we observed similar axonal defects in the early stages of Alzheimer's disease in humans.

    Full summary, score breakdown and related studies → Original source

  3. 2005-02-01

    Impaired insulin and insulin-like growth factor expression and signaling mechanisms in Alzheimer's disease--is this type 3 diabetes?

    ✓ Peer-reviewed Risk genes beyond APOE Journal of Alzheimer's disease : JAD

    Key finding: The neurodegeneration that occurs in sporadic Alzheimer's disease (AD) is consistently associated with a number of characteristic histopathological, molecular, and biochemical abnormalities, including cell loss, abundant neurofibrillary tangles and dystrophic neurites, amyloid-beta deposits, increased activation of pro-death genes and signaling pathways, impaired energy metabolism/mitochondrial function, and evidence of chronic oxidative stress. +2 more findings

    Full summary, score breakdown and related studies → Original source

  4. 2005-02-01

    Detection of a biomarker for Alzheimer's disease from synthetic and clinical samples using a nanoscale optical biosensor

    ✓ Peer-reviewed Tau biomarkers Journal of the American Chemical Society

    Key finding: A nanoscale optical biosensor based on localized surface plasmon resonance (LSPR) spectroscopy has been developed to monitor the interaction between the antigen, amyloid-beta derived diffusible ligands (ADDLs), and specific anti-ADDL antibodies. +3 more findings

    Full summary, score breakdown and related studies → Original source

  5. 2005-02-01

    Pharmacological treatment of neuropsychiatric symptoms of dementia: a review of the evidence

    ✓ Peer-reviewed Vascular contributions JAMA

    Key finding: Atypical antipsychotics are associated with an increased risk of stroke. +4 more findings

    Full summary, score breakdown and related studies → Original source

  6. 2005-02-01

    MR-based in vivo hippocampal volumetrics: 1. Review of methodologies currently employed

    ✓ Peer-reviewed Hippocampus size on brain scans Molecular psychiatry

    Key finding: Measurement of hippocampal volume has developed as a useful tool in the study of neuropsychiatric disorders. +4 more findings

    Full summary, score breakdown and related studies → Original source

  7. 2005-02-01

    MR-based in vivo hippocampal volumetrics: 2. Findings in neuropsychiatric disorders

    ✓ Peer-reviewed Hippocampus size on brain scans Molecular psychiatry

    Key finding: Significantly larger hippocampal volumes have been correlated with autism and children with fragile X syndrome.

    Full summary, score breakdown and related studies → Original source

  8. 2005-02-01

    Pain and agitation in long-term care residents with dementia: use of the Pittsburgh Agitation Scale

    ✓ Peer-reviewed End-of-life care International journal of palliative nursing

    Key finding: Study design descriptive correlational design. +1 more finding

    Full summary, score breakdown and related studies → Original source

  9. 2005-02-01

    Bone-marrow-derived cells contribute to the recruitment of microglial cells in response to beta-amyloid deposition in APP/PS1 double transgenic Alzheimer mice

    ✓ Peer-reviewed Inflammation and the immune system Neurobiology of disease

    Key finding: To investigate whether beta-amyloid (Abeta) associated microglia are derived from blood monocytes, we transplanted BM cells from enhanced green fluorescent protein expressing mice into young or old transgenic AD mice and determined the engraftment of BM-derived cells into the brain and their relative distribution near Abeta deposits. +3 more findings

    Full summary, score breakdown and related studies → Original source

  10. 2005-02-01

    Chemokine receptors in the central nervous system: role in brain inflammation and neurodegenerative diseases

    ✓ Peer-reviewed Inflammation and the immune system Brain research. Brain research reviews

    Key finding: Research over the last decade, however, has shown that chemokine receptors are not restricted to leukocytes. +3 more findings

    Full summary, score breakdown and related studies → Original source

  11. 2005-02-01

    The Caregiver Burden Inventory in evaluating the burden of caregivers of elderly demented patients: results from a multicenter study

    ✓ Peer-reviewed Cognitive tests and assessment Aging clinical and experimental research

    Key finding: The burden perceived by caregivers of patients with dementia is a fundamental prognostic aspect in the history of the disease. +3 more findings

    Full summary, score breakdown and related studies → Original source

  12. 2005-02-01

    A randomized, observer-blind, controlled trial of the traditional Chinese medicine Yi-Gan San for improvement of behavioral and psychological symptoms and activities of daily living in dementia patients

    ✓ Peer-reviewed Cognitive tests and assessment The Journal of clinical psychiatry

    Key finding: This randomized, observer-blind, controlled trial examined the efficacy and safety of the traditional Chinese herbal medicine Yi-Gan San (YGS, Yokukan-San in Japanese) in the improvement of behavioral and psychological symptoms of dementia (BPSD) and activities of daily living (ADL). +3 more findings

    Full summary, score breakdown and related studies → Original source

  13. 2005-02-01

    Prevention of isoproterenol-induced tau hyperphosphorylation by melatonin in the rat

    ✓ Peer-reviewed Tau biomarkers Sheng li xue bao : [Acta physiologica Sinica]

    Key finding: Until now, there is no effective cure to arrest this hyperphosphorylation. +3 more findings

    Full summary, score breakdown and related studies → Original source

  14. 2005-02-01

    Clearance of apoptotic neurons without inflammation by microglial triggering receptor expressed on myeloid cells-2

    ✓ Peer-reviewed TREM2 and immune genetics The Journal of experimental medicine

    Key finding: Triggering receptor expressed on myeloid cells-2 (TREM2) is a recently identified innate immune receptor. +3 more findings

    Full summary, score breakdown and related studies → Original source

  15. 2005-02-01

    Genetic modulation of senescent phenotypes in Homo sapiens

    ✓ Peer-reviewed Risk genes beyond APOE Cell

    Key finding: These can be divided into two classes--those that have their impacts upon multiple organs and tissues (segmental progeroid syndromes) and those that have their major impacts upon a single organ or tissue (unimodal progeroid syndromes). +3 more findings

    Full summary, score breakdown and related studies → Original source

  16. 2005-02-01

    Parkin mediates nonclassical, proteasomal-independent ubiquitination of synphilin-1: implications for Lewy body formation

    ✓ Peer-reviewed Lewy body dementia The Journal of neuroscience : the official journal of the Society for Neuroscience

    Key finding: Because we demonstrated previously that parkin interacts with and ubiquitinates synphilin-1, we initially expected synphilin-1 degradation to be enhanced in the presence of parkin. +3 more findings

    Full summary, score breakdown and related studies → Original source

  17. 2005-02-01

    Review of insulin and insulin-like growth factor expression, signaling, and malfunction in the central nervous system: relevance to Alzheimer's disease

    ✓ Peer-reviewed Risk factors Journal of Alzheimer's disease : JAD

    Key finding: The various experimental animal models generated by over-expression, mutation, or depletion of genes that are critical to the insulin or IGF signaling cascades are summarized, noting the degrees to which they reproduce the histopathological, biochemical, molecular, or behavioral abnormalities associated with AD. +1 more finding

    Full summary, score breakdown and related studies → Original source

  18. 2005-02-01

    Anti-Abeta antibody treatment promotes the rapid recovery of amyloid-associated neuritic dystrophy in PDAPP transgenic mice

    ✓ Peer-reviewed Brain scans and imaging The Journal of clinical investigation

    Key finding: Using multiphoton microscopy, we observed and monitored amyloid through cranial windows in PDAPP;Thy-1:YFP double-transgenic mice using the in vivo amyloid-imaging fluorophore methoxy-X04, and individual YFP-labeled dystrophic neurites by their inherent fluorescence. +3 more findings

    Full summary, score breakdown and related studies → Original source

  19. 2005-02-01

    A chart-based method for identification of delirium: validation compared with interviewer ratings using the confusion assessment method

    ✓ Peer-reviewed Getting a diagnosis Journal of the American Geriatrics Society

    Key finding: A chart-based instrument for delirium, which should be useful for patient safety and quality-improvement programs in older persons, was validated. +4 more findings

    Full summary, score breakdown and related studies → Original source

  20. 2005-02-01

    Sydney Multicenter Study of Parkinson's disease: non-L-dopa-responsive problems dominate at 15 years

    ✓ Peer-reviewed Getting a diagnosis Movement disorders : official journal of the Movement Disorder Society

    Key finding: The standardized mortality ratio is significantly elevated at 1.86 and is not significantly different between treatment arms. +1 more finding

    Full summary, score breakdown and related studies → Original source

  21. 2005-02-01

    High dietary fat induces NADPH oxidase-associated oxidative stress and inflammation in rat cerebral cortex

    ✓ Peer-reviewed Prevention and risk Experimental neurology

    Key finding: Epidemiological and experimental studies have suggested that high dietary intake of fats is associated with cognitive decline and a significantly increased risk of dementia. +3 more findings

    Full summary, score breakdown and related studies → Original source

  22. 2005-02-01

    Do statins reduce risk of incident dementia and Alzheimer disease? The Cache County Study

    ✓ Peer-reviewed Prevention and risk Archives of general psychiatry

    Key finding: Although statin use might be less frequent in those with prevalent dementia, we found no association between statin use and subsequent onset of dementia or AD. +2 more findings

    Full summary, score breakdown and related studies → Original source

  23. 2005-02-01

    fMRI evidence of compensatory mechanisms in older adults at genetic risk for Alzheimer disease

    ✓ Peer-reviewed Genetics Neurology

    Key finding: The results suggest that brain response differences are not due to poorer general memory abilities, differential atrophy, or brain response during control conditions, but instead appear to be directly influenced by APOE genotype. +3 more findings

    Full summary, score breakdown and related studies → Original source

January 2005 2

  1. 2005-01-26

    A National Study of the Location of Death for Older Persons with Dementia

    ✓ Peer-reviewed Health systems and care delivery Journal of the American Geriatrics Society

    Key finding: The majority of dementia-related deaths in the United States occurred in nursing homes (66.9%). +4 more findings

    Full summary, score breakdown and related studies → Original source

  2. 2005-01-25

    Adverse outcomes associated with inappropriate drug use in nursing homes

    ✓ Peer-reviewed Digital health tools The Annals of pharmacotherapy

    Key finding: Inappropriate drug use was common in our study cohort. +3 more findings

    Full summary, score breakdown and related studies → Original source

Browse the library by subject, with the full score breakdown →