Impact of APOE in mild cognitive impairment
Farlow MR, He Y, Tekin S, Xu J, Lane R, Charles HC.. Neurology, 2004-11-01
Topic: Risk, prevention and care in population studies
Objective The authors aimed to use baseline data of an ongoing large, prospective study in subjects with mild cognitive impairment (MCI) to investigate the impact of APOE genotype on the symptom profile of the condition. Methods Cognitive assessments included the AD Assessment Scale cognitive subscale (ADAS-cog), the Mini-Mental State Examination (MMSE), and a cognitive battery for assessment of memory, attention, and executive function. Behavioral assessments included the Neuropsychiatric Inventory and Beck Depression Inventory. Activities of daily living were assessed by the AD Cooperative Study Activities of Daily Living (ADCS-ADL) scale. Hippocampal volumes were measured with MRI. Results A total of 494 of 1,018 study subjects provided APOE data. Approximately 40% of the subjects were APOE epsilon4 carriers. APOE epsilon4 carriers had lower MMSE (p = 0.01) and higher ADAS-cog (p Conclusion MCI subjects carrying the APOE epsilon4 allele showed distinct cognitive and imaging profiles, which appeared to resemble those of early Alzheimer patients. APOE epsilon4 genotype was associated with greater impairments in memory and functional activities as well as hippocampal atrophy.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Farlow, M. R., He, Y., Tekin, S., Xu, J., Lane, R., & Charles, H. C. (2004). Impact of APOE in mild cognitive impairment. Neurology. https://doi.org/10.1212/01.wnl.0000144279.21502.b7
Vancouver
Farlow MR, He Y, Tekin S, Xu J, Lane R, Charles HC. Impact of APOE in mild cognitive impairment. Neurology. 2004. doi:10.1212/01.wnl.0000144279.21502.b7. PMID: 15557508.
BibTeX
@article{farlow2004-15557508,
author = {Farlow, M. R. and He, Y. and Tekin, S. and Xu, J. and Lane, R. and Charles, H. C.},
title = {{Impact of APOE in mild cognitive impairment}},
journal = {Neurology},
year = {2004},
doi = {10.1212/01.wnl.0000144279.21502.b7},
pmid = {15557508},
url = {https://doi.org/10.1212/01.wnl.0000144279.21502.b7}
}
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Key findings
- Results A total of 494 of 1,018 study subjects provided APOE data.
- APOE epsilon4 genotype was associated with greater impairments in memory and functional activities as well as hippocampal atrophy.
Why it matters
Among 494 people with mild cognitive impairment, those carrying the APOE epsilon 4 allele had lower scores on cognitive tests and greater impairments in memory and daily activities, along with more hippocampal shrinkage. The authors note these carriers showed profiles resembling those of early Alzheimer's patients.
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Study details
- Participants494
- Evidence strengthLow
How this study scored 51/100
Published in a leading specialty journal. Scored zero for study design, effect reported and randomized / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 9 / 10 | Tier 2 — leading specialty journal (Neurology) |
| Journal's citation record | 4 / 4 | Neurology: journal h-index 525 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 1 / 5 | 2004 — older than 20 years, still counted |
| Sample size | 2 / 4 | 494 participants |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomized / blinded | 0 / 2 | No randomization or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 5 / 7 | Cited 199 times (OpenAlex, 2026-10-10) |
| Citations per year | 3 / 5 | 8.3 citations a year over 24 year(s) since 2004 |
| Impact for its field and year | 3 / 6 | Cited 6.4× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 2 / 6 | Cited by 8 other studies in this library |
| Still being cited | 1 / 4 | Cited 9 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 2 / 4 | Last-listed author H. Cecil Charles: h-index 46 (OpenAlex, whole career) |
| Institution's track record | 2 / 3 | Duke University: institution h-index 1,541 (OpenAlex) |
| Multicenter collaboration | 1 / 3 | OpenAlex lists 3 institution(s) in 1 country |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 15557508) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Total | 51 / 100 | — |
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