alzhub.org
Get help now — free helplines

You can call any of these for free. You do not need a diagnosis, an appointment, or a crisis to call — questions and plain exhaustion are reasons enough.

  • Alzheimer's Association 24/7 Helpline 800-272-3900 24 hours a day, 365 days a year Free, confidential support and information for people with dementia, caregivers, families and the public. Master's-level clinicians. Also Spanish.
  • 988 Suicide & Crisis Lifeline 988 24/7 Call or text 988, or chat at 988lifeline.org. For anyone in emotional distress or a mental-health crisis, including caregivers.
  • Alzheimer's Foundation of America (AFA) Helpline 866-232-8484 9:00 am - 9:00 pm ET, seven days a week Licensed social workers providing support, info and referrals. Also text message and web chat. Text: 646-586-5283

In a medical emergency, call 911. More numbers, and what each line does, on the help page.

Newest studies

Every summary in our library, newest first, as a dated timeline.

What "newest" means here

The most recent study in this library is dated 2026-11-01 (Paths of Aging Minds: Health Journeys of Older Adults with Mild Cognitive Impairment). This is our summary library, not a news wire — it is added to in batches, so the newest entry may not be the newest paper published anywhere.

Entries are sorted strictly by publication date, newest first. 26489 of the 27380 entries carry a full day-level date. 65 have no date recorded at all and are placed by publication year, at the start of that year; those are marked "no date recorded" below so you can see where the ordering is a best effort rather than a fact.

Prefer a reader? Subscribe to the Atom feed. Want them sorted by subject or by score instead? Browse the research library.

Showing 23,926–23,950 of 27,380 studies, newest first · page 958 of 1096.

October 2004 25

  1. 2004-10-06

    The Caenorhabditis elegans IMPAS gene, imp-2, is essential for development and is functionally distinct from related presenilins

    ✓ Peer-reviewed Drug development Proceedings of the National Academy of Sciences

    Key finding: These data suggest that IMPs are functionally distinct from related PSs and implicate IMPs as critical regulators of development that may potentially interact with the lipid-lipoprotein receptor-mediated pathway.

    Full summary, score breakdown and related studies → Original source

  2. 2004-10-04

    MARK/PAR1 kinase is a regulator of microtubule-dependent transport in axons

    ✓ Peer-reviewed Brain scans and imaging The Journal of cell biology

    Key finding: We report here a mechanism whereby microtubule associated proteins (MAPs) represent obstacles to motors which can be regulated by microtubule affinity regulating kinase (MARK)/Par-1, a family of kinases that is known for its involvement in establishing cell polarity and in phosphorylating tau protein during Alzheimer neurodegeneration. +4 more findings

    Full summary, score breakdown and related studies → Original source

  3. 2004-10-04

    The association between blood pressure, hypertension, and cerebral white matter lesions: cardiovascular determinants of dementia study

    ✓ Peer-reviewed Risk factors Hypertension (Dallas, Tex. : 1979)

    Key finding: Cerebral white matter lesions are frequently observed on magnetic resonance imaging (MRI) scans in elderly people and are associated with stroke and dementia. +4 more findings

    Full summary, score breakdown and related studies → Original source

  4. 2004-10 month only

    Apolipoprotein E as vascular risk factor in neurodegenerative dementia

    ✓ Peer-reviewed Genetics International journal of molecular medicine

    Key finding: Apolipoprotein E (ApoE) is the major lipid-carrier protein in the brain, and several studies provided evidence that ApoE epsilon4 allele can be considered a genetic risk factor for vascular diseases. +2 more findings

    Full summary, score breakdown and related studies → Original source

  5. 2004-10-01

    The National Alzheimer's Coordinating Center (NACC) Database: an Alzheimer disease database

    ✓ Peer-reviewed Long-term cohort studies Alzheimer disease and associated disorders

    Key finding: The challenge for NACC is to expand and adjust previously collected data elements into an integrated database that could be used for administrative as well as research purposes. +4 more findings

    Full summary, score breakdown and related studies → Original source

  6. 2004-10-01

    Vaccine adjuvants: current state and future trends

    ✓ Peer-reviewed How common it is Immunology and cell biology

    Key finding: Consequently, there is a major unmet need for safer and more effective adjuvants suitable for human use. +4 more findings

    Full summary, score breakdown and related studies → Original source

  7. 2004-10-01

    Monitoring visual status: why patients do or do not comply with practice guidelines

    ✓ Peer-reviewed Digital health tools Health services research

    Key finding: Having an exam reflects multiple factors.

    Full summary, score breakdown and related studies → Original source

  8. 2004-10-01

    Glutamate-mediated excitotoxicity and neurodegeneration in Alzheimer's disease

    ✓ Peer-reviewed Brain tissue and pathology Neurochemistry international

    Key finding: A growing body of evidence suggests that perturbations in systems using the excitatory amino acid L-glutamate (L-Glu) may underlie the pathogenic mechanisms of (e.g.) hypoxia-ischemia, epilepsy, and chronic neurodegenerative disorders such as Huntington's disease and AD.

    Full summary, score breakdown and related studies → Original source

  9. 2004-10-01

    BDNF and 5-HT: a dynamic duo in age-related neuronal plasticity and neurodegenerative disorders

    ✓ Peer-reviewed Risk factors Trends in neurosciences

    Key finding: Brain-derived neurotrophic factor (BDNF) and serotonin (5-hydroxytryptamine, 5-HT) are known to regulate synaptic plasticity, neurogenesis and neuronal survival in the adult brain. +4 more findings

    Full summary, score breakdown and related studies → Original source

  10. 2004-10-01

    The effects of exercise training on elderly persons with cognitive impairment and dementia: a meta-analysis

    ✓ Peer-reviewed Prevention trials Archives of physical medicine and rehabilitation

    Key finding: Exercise training increases fitness, physical function, cognitive function, and positive behavior in people with dementia and related cognitive impairments. +2 more findings

    Full summary, score breakdown and related studies → Original source

  11. 2004-10-01

    Acetylcholinesterase inhibitors: novel activities of old molecules

    ✓ Peer-reviewed Treatments Pharmacological research

    Key finding: The therapeutic approach for improving the cognitive function in patients with Alzheimer's disease (AD) is mainly based on the potentiation of central cholinergic activity and is achieved clinically by the use of acetylcholinesterase (AChE) inhibitors such as tacrine, donepezil, rivastigmine, galantamine and other drugs currently in clinical trials. +2 more findings

    Full summary, score breakdown and related studies → Original source

  12. 2004-10-01

    A unified approach for morphometric and functional data analysis in young, old, and demented adults using automated atlas-based head size normalization: reliability and validation against manual measurement of total intracranial volume

    ✓ Peer-reviewed Hippocampus size on brain scans NeuroImage

    Key finding: Atlas normalization, as commonly used by functional data analysis, provides an automated solution to the widely encountered problem of correcting for head size variation in regional and whole-brain morphometric analyses, so long as an age- and population-appropriate target atlas is used. +1 more finding

    Full summary, score breakdown and related studies → Original source

  13. 2004-10-01

    The delirium index, a measure of the severity of delirium: new findings on reliability, validity, and responsiveness

    ✓ Peer-reviewed Clinical safety Journal of the American Geriatrics Society

    Key finding: The DI appears to be a reliable, valid, and responsive measure of the severity of delirium, in patients with delirium, with or without dementia. +1 more finding

    Full summary, score breakdown and related studies → Original source

  14. 2004-10-01

    Mediterranean diet and cognitive decline

    ✓ Peer-reviewed Prevention trials Public health nutrition

    Key finding: Essential components of the Mediterranean diet--MUFA, cereals and wine--seem to be protective against cognitive decline. +1 more finding

    Full summary, score breakdown and related studies → Original source

  15. 2004-10-01

    U-box protein carboxyl terminus of Hsc70-interacting protein (CHIP) mediates poly-ubiquitylation preferentially on four-repeat Tau and is involved in neurodegeneration of tauopathy

    ✓ Peer-reviewed Disease mechanisms Journal of neurochemistry

    Key finding: Molecular studies of frontotemporal dementia with parkinsonism-17 demonstrated that increasing the ratio of tau with exon 10 insertion induced fibrillar tau accumulation. +1 more finding

    Full summary, score breakdown and related studies → Original source

  16. 2004-10-01

    Transient cerebral ischemia induces site-specific hyperphosphorylation of tau protein

    ✓ Peer-reviewed Disease mechanisms Brain research

    Key finding: Our current study suggests that tau hyperphosphorylation may contribute to the brain damage induced by transient cerebral ischemia, and may be involved in the pathogenesis of neurodegenerative disorders in patients after stroke. +2 more findings

    Full summary, score breakdown and related studies → Original source

  17. 2004-10-01

    A focus on the synapse for neuroprotection in Alzheimer disease and other dementias

    ✓ Peer-reviewed Disease mechanisms Neurology

    Key finding: Synaptic dysfunction and failure are processes that occur early in Alzheimer disease (AD) and are important targets for protective treatments to slow AD progression and preserve cognitive and functional abilities. +4 more findings

    Full summary, score breakdown and related studies → Original source

  18. 2004-10-01

    Incidence of dementia in a community-dwelling Brazilian population

    ✓ Peer-reviewed Cognitive tests and assessment Alzheimer disease and associated disorders

    Key finding: In 1997, 1656 individuals aged 65 years or more, the majority being of very low educational level, were screened at their homes in Catanduva, Brazil, and dementia was diagnosed in 118 cases. +3 more findings

    Full summary, score breakdown and related studies → Original source

  19. 2004-10-01

    Amyloid beta-peptide(1-42) contributes to the oxidative stress and neurodegeneration found in Alzheimer disease brain

    ✓ Peer-reviewed Risk genes beyond APOE Brain pathology (Zurich, Switzerland)

    Key finding: Amyloid beta-peptide (1-42) has been shown to induce oxidative stress and neurotoxicity in vitro and in vivo. +3 more findings

    Full summary, score breakdown and related studies → Original source

  20. 2004-10-01

    Reduction of cortical TrkA but not p75(NTR) protein in early-stage Alzheimer's disease

    ✓ Peer-reviewed Mild cognitive impairment Annals of neurology

    Key finding: Degeneration of cholinergic nucleus basalis (NB) cortical projection neurons is associated with cognitive decline in late-stage Alzheimer's disease (AD). +2 more findings

    Full summary, score breakdown and related studies → Original source

  21. 2004-10-01

    High capacity and low cost detection of prion protein gene variant alleles by denaturing HPLC

    ✓ Peer-reviewed Down syndrome and Alzheimer's Journal of neuroscience methods

    Key finding: In the present study, we established the conditions for analysis of the PRNP open reading frame using denaturing high-performance liquid chromatography (DHPLC), whereby unpurified PCR products were subjected to denaturing and reannealing steps leading to heteroduplex formation. +4 more findings

    Full summary, score breakdown and related studies → Original source

  22. 2004-10-01

    Cholinesterase inhibitors: new roles and therapeutic alternatives

    ✓ Peer-reviewed Down syndrome and Alzheimer's Pharmacological research

    Key finding: Clinical results demonstrate examples of versatility of cholinergic enhancement.

    Full summary, score breakdown and related studies → Original source

  23. 2004-10-01

    Diabetes mellitus and risk of dementia in the Kungsholmen project: a 6-year follow-up study

    ✓ Peer-reviewed Risk factors Neurology

    Key finding: Diabetes mellitus increases the risk of dementia, and VaD in particular, in very old people. +3 more findings

    Full summary, score breakdown and related studies → Original source

  24. 2004-10-01

    Cerebral white matter lesions and the risk of dementia

    ✓ Peer-reviewed How common it is Archives of neurology

    Key finding: White matter lesions, especially in the periventricular region, increase the risk of dementia in elderly people. +1 more finding

    Full summary, score breakdown and related studies → Original source

  25. 2004-10-01

    Hyperinsulinemia and risk of Alzheimer disease

    ✓ Peer-reviewed How common it is Neurology

    Key finding: Hyperinsulinemia is associated with a higher risk of AD and decline in memory. +3 more findings

    Full summary, score breakdown and related studies → Original source

Browse the library by subject, with the full score breakdown →