Newest studies
Every summary in our library, newest first, as a dated timeline.
Showing 22,651–22,675 of 27,380 studies, newest first · page 907 of 1096.
April 2007 24
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2007-04-01
The 'natural' endpoint of dementia: death from cachexia or dehydration following palliative care?
43/100 ✓ Peer-reviewed End-of-life care International journal of geriatric psychiatry
Key finding: Patients who survive to the final phase of dementia are more likely to die from cachexia or dehydration than those who die before.
Full summary, score breakdown and related studies → Original source
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2007-04-01
Assessment of quality of life as outcome in dementia and MCI intervention trials: a systematic review
67/100 ✓ Peer-reviewed End-of-life care Alzheimer disease and associated disorders
Key finding: We found 117 pharmacologic and 108 nonpharmacologic RCTs.
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2007-04-01
Would we rather lose our life than lose our self? Lessons from the Dutch debate on euthanasia for patients with dementia
36/100 ✓ Peer-reviewed End-of-life care The American journal of bioethics : AJOB
Key finding: It is concluded that, in addition to a moral discussion on the limits of anticipatory choices, there is an urgent need to develop research into the patient's perspective with regard to medical treatment and care-giving in dementia, including end-of-life care.
Full summary, score breakdown and related studies → Original source
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2007-04-01
Using video images of dementia in advance care planning
48/100 ✓ Peer-reviewed End-of-life care Archives of internal medicine
Key finding: Watching the video significantly changed preferences for care, transcending apparent differences in preferences associated with race/ethnicity and educational level. +4 more findings
Full summary, score breakdown and related studies → Original source
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2007-04-01
A randomized, double-blind, placebo-controlled trial of donepezil hydrochloride (Aricept) for reducing the incidence of postoperative delirium after elective total hip replacement
76/100 ✓ Peer-reviewed Clinical safety International journal of geriatric psychiatry
Key finding: The experimental paradigm was feasible and acceptable. +2 more findings
Full summary, score breakdown and related studies → Original source
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2007-04-01
Role of the blood-brain barrier in the pathogenesis of Alzheimer's disease
45/100 ✓ Peer-reviewed Brain tissue and pathology Current Alzheimer research
Key finding: The blood-brain barrier (BBB) is critical for brain Abeta homeostasis and regulates Abeta transport via two main receptors, the low density lipoprotein receptor related protein 1 (LRP1) and the receptor for advanced glycation end products (RAGE). +3 more findings
Full summary, score breakdown and related studies → Original source
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2007-04-01
Relation of obesity to cognitive function: importance of central obesity and synergistic influence of concomitant hypertension. The Framingham Heart Study
45/100 ✓ Peer-reviewed Long-term cohort studies Current Alzheimer research
Key finding: Obesity has been related to the incidence of dementia but its impact on cognitive performance in persons without dementia is less clear. +3 more findings
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2007-04-01
Cerebrospinal fluid tau protein is increased in neurosyphilis: a discrimination from syphilis without nervous system involvement?
34/100 ✓ Peer-reviewed Tau biomarkers Sexually transmitted diseases
Key finding: The objective of this study was to investigate the levels of tau protein in neurosyphilis. +3 more findings
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2007-04-01
TREM2-transduced myeloid precursors mediate nervous tissue debris clearance and facilitate recovery in an animal model of multiple sclerosis
52/100 ✓ Peer-reviewed TREM2 and immune genetics PLoS medicine
Key finding: In multiple sclerosis, inflammation can successfully be prevented, while promoting repair is still a major challenge. +3 more findings
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2007-04-01
Dietary docosahexaenoic acid and docosapentaenoic acid ameliorate amyloid-beta and tau pathology via a mechanism involving presenilin 1 levels
47/100 ✓ Peer-reviewed Risk genes beyond APOE The Journal of neuroscience : the official journal of the Society for Neuroscience
Key finding: One environmental factor that is increasingly being recognized as contributing to brain aging is diet, which has evolved markedly over modern history. +3 more findings
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2007-04-01
Efficacy of cognitive rehabilitation in patients with mild cognitive impairment treated with cholinesterase inhibitors
62/100 ✓ Peer-reviewed Mild cognitive impairment International journal of geriatric psychiatry
Key finding: A long-term TNP in ChEIs-treated MCI subjects induces additional cognitive and mood benefits. +2 more findings
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2007-04-01
Accumulation of pathological tau species and memory loss in a conditional model of tauopathy
49/100 ✓ Peer-reviewed Lewy body dementia The Journal of neuroscience : the official journal of the Society for Neuroscience
Key finding: Neurofibrillary tangles (NFTs) are a pathological hallmark of Alzheimer's disease and other tauopathies, but recent studies in a conditional mouse model of tauopathy (rTg4510) have suggested that NFT formation can be dissociated from memory loss and neurodegeneration. +2 more findings
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2007-04-01
Neuropsychiatric and behavioral aspects of trisomy 21
37/100 ✓ Peer-reviewed Down syndrome and Alzheimer's Current psychiatry reports
Key finding: The well-known cheerful and friendly demeanor often creates a personality stereotype, with parents and observers commenting on the positive attributes. +4 more findings
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2007-04-01
Body mass index in midlife and risk of Alzheimer disease and vascular dementia
61/100 ✓ Peer-reviewed How common it is Current Alzheimer research
Key finding: Prior work has suggested that obesity and overweight as measured by body mass index (BMI) increases risk of dementia. +3 more findings
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2007-04-01
The association between genetic variants in SORL1 and Alzheimer disease in an urban, multiethnic, community-based cohort
58/100 ✓ Peer-reviewed Disparities Archives of neurology
Key finding: This study confirms the association between genetic variants in SORL1 and AD. +4 more findings
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2007-04-01
Brain structural alterations before mild cognitive impairment
52/100 ✓ Peer-reviewed Brain scans and imaging Neurology
Key finding: Structural brain changes in anatomic areas involved in higher cognitive processes precede clinical signs and symptoms in longitudinally followed normal subjects destined to develop mild cognitive impairment.
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2007-04-01
Sensitivity and specificity of dopamine transporter imaging with 123I-FP-CIT SPECT in dementia with Lewy bodies: a phase III, multicentre study
72/100 ✓ Peer-reviewed Getting a diagnosis The Lancet. Neurology
Key finding: A mean value of 85.7% was achieved for overall diagnostic accuracy, 82.4% for positive predictive value, and 87.5% for negative predictive value. +1 more finding
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2007-04-01
Effect of galantamine on verbal repetition in AD: a secondary analysis of the VISTA trial
61/100 ✓ Peer-reviewed Treatments Neurology
Key finding: Reduction of verbal repetition was set as a treatment goal in 44% (n = 57) of randomized patients. +2 more findings
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2007-04-01
A 24-week randomized, controlled trial of memantine in patients with moderate-to-severe Alzheimer disease
67/100 ✓ Peer-reviewed Treatments Alzheimer disease and associated disorders
Key finding: Prospectively defined analyses failed to demonstrate a statistically significant benefit of memantine treatment compared with placebo on the Severe Impairment Battery (SIB) at week 24 end point, although a significant advantage was observed for memantine at weeks 12 and 18. +4 more findings
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2007-04-01
Quetiapine for agitation or psychosis in patients with dementia and parkinsonism
70/100 ✓ Peer-reviewed Treatments Neurology
Key finding: Quetiapine was well-tolerated and did not worsen parkinsonism. +2 more findings
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2007-04-01
Association of increased cortical soluble abeta42 levels with diffuse plaques after severe brain injury in humans
41/100 ✓ Peer-reviewed Genetics Archives of neurology
Key finding: Selective increases in soluble Abeta(1-42) after TBI may predispose individuals with a brain injury to Alzheimer disease pathology. +3 more findings
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2007-04-01
Systemic inflammation, infection, ApoE alleles, and Alzheimer disease: a position paper
42/100 ✓ Peer-reviewed Genetics Current Alzheimer research
Key finding: Blood levels of CRP and IL-6 are also associated with higher risk of Alzheimer disease and cognitive decline during aging.
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2007-04-01
Course of cerebral amyloid angiopathy-related inflammation
53/100 ✓ Peer-reviewed Genetics Neurology
Key finding: Baseline MRI scans were characterized by asymmetric T2-hyperintense lesions extending to the subcortical white matter and occasionally the overlying gray matter, with signal properties suggesting vasogenic edema. +1 more finding
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2007-04-01
Relation of diabetes to mild cognitive impairment
69/100 ✓ Peer-reviewed Genetics Archives of neurology
Key finding: Diabetes is related to a higher risk of amnestic MCI in a population with a high prevalence of this disorder. +4 more findings
Full summary, score breakdown and related studies → Original source
March 2007 1
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2007-03-29
Curcumin labels amyloid pathology in vivo , disrupts existing plaques, and partially restores distorted neurites in an Alzheimer mouse model
52/100 ✓ Peer-reviewed Vascular contributions Journal of Neurochemistry
Key finding: Curcumin also led to a limited, but significant reversal of structural changes in dystrophic dendrites, including abnormal curvature and dystrophy size. +2 more findings
Full summary, score breakdown and related studies → Original source
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