Newest studies

Adenosine A2 receptor-mediated excitatory actions on the nervous system

36/100 ✓ Peer-reviewed Brain scans and imaging Progress in neurobiology

Key finding: The adenosine A2a receptor subtype, identified in the nervous system with ligand binding, functional studies or genetic molecular techniques, has been demonstrated in the striatum and other basal ganglia structures, in the hippocampus, in the cerebral cortex, in the nucleus tractus solitarius, in motor nerve terminals, in noradrenergic terminals in the vas deferens, in myenteric neurones of the ileum, in the retina and in the carotid body.

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Cytosolic phospholipase A2 (cPLA2) immunoreactivity is elevated in Alzheimer's disease brain

36/100 ✓ Peer-reviewed Biomarkers Neurobiology of disease

Key finding: In view of the presence of numerous inflammatory mediators and acute phase proteins in the Alzheimer's disease (AD) brain, localization of cPLA2 in AD brain was evaluated and compared to that observed in nonneurologically diseased controls. +1 more finding

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Sequence of Deposition of Heterogeneous Amyloid β-Peptides and APO E in Down Syndrome: Implications for Initial Events in Amyloid Plaque Formation

51/100 ✓ Peer-reviewed Down syndrome and Alzheimer's Neurobiology of Disease

Patients with trisomy 21 [Down syndrome (DS)] progressively develop amyloid beta-protein (A beta) deposits and then other features of Alzheimer's disease (AD), apparently due to increased gene dosage and thus expression of the beta-amyloid precursor protein.

• Brain Biology
• Down Syndrome

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Identification of famous faces and famous names in early Alzheimer's disease. Relationship to anterograde episodic and general semantic memory

48/100 ✓ Peer-reviewed Cognitive tests and assessment Brain : a journal of neurology

Key finding: Patients with DAT were impaired on all components of the remote memory tests, i.e. famous face recognition, identification and naming, and famous name recognition and identification. +3 more findings

• Diagnosis

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Transfer of beta-amyloid precursor protein gene using adenovirus vector causes mitochondrial abnormalities in cultured normal human muscle

42/100 ✓ Peer-reviewed Risk genes beyond APOE Proceedings of the National Academy of Sciences of the United States of America

Key finding: Other similarities between IBM muscle and AD brain phenotypes include paired helical filaments, hyperphosphorylated tau protein, apolipoprotein E, and mitochondrial abnormalities, including decreased cytochrome-c oxidase (COX) activity. +3 more findings

• Brain Biology
• Genetics

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Clinical, neuroimaging, and pathologic features of progressive nonfluent aphasia

59/100 ✓ Peer-reviewed Digital health tools Annals of neurology

Key finding: Longitudinal observations of 3 patients revealed progressively telegraphic speech and writing, followed by gradual deterioration of sentence comprehension, and finally, preterminal mutism and dementia. +2 more findings

• Brain Scans

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Long-term outcome of unilaterally transplanted parkinsonian patients. I. Clinical approach

48/100 ✓ Peer-reviewed Digital health tools Brain : a journal of neurology

Key finding: All these patients exhibited an increase in the fluorodopa uptake in the grafted putamen, which was most significant in the first and last patient of the series. +2 more findings

• Other Dementias

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Relationship of age, education, and occupation with dementia among a community-based sample of African Americans

44/100 ✓ Peer-reviewed Disparities Archives of neurology

Key finding: Education was independently associated with cognitive impairment and dementia among a representative community-based sample of African Americans and the association remains significant across a variety of sensitivity analyses designed to control for measurement and confounding biases. +4 more findings

• Health Equity

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1H-MRS, MRI-based hippocampal volumetry, and 99mTc-HMPAO-SPECT in normal aging, age-associated memory impairment, and probable Alzheimer's disease

42/100 ✓ Peer-reviewed Brain scans and imaging Journal of the American Geriatrics Society

Key finding: 1H-MRS showed significantly lower N-acetylasparatate concentration in DAT and AAMI compared with controls. +4 more findings

• Brain Scans

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Depressed mood and the incidence of Alzheimer's disease in the elderly living in the community

62/100 ✓ Peer-reviewed Getting a diagnosis Archives of general psychiatry

Key finding: In the 852 subjects without dementia, depressed mood was more common in individuals with greater cognitive impairment. +2 more findings

• Risk Factors

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Central auditory dysfunction, cognitive dysfunction, and dementia in older people

53/100 ✓ Peer-reviewed Prevention and risk Archives of otolaryngology--head & neck surgery

Key finding: Hearing loss significantly lowered performance on the verbal parts of the Mini-Mental State Examination. +1 more finding

• Diagnosis

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Genetic association between intronic polymorphism in presenilin-1 gene and late-onset Alzheimer's disease. Alzheimer's Disease Collaborative Group

54/100 ✓ Peer-reviewed Genetics Lancet (London, England)

Key finding: Homozygosity of the 1 allele in the PS-1 gene was associated with a doubling of the risk for late-onset Alzheimer's disease compared with the [12]/[22] genotype (odds ratio 1.97, 95% Cl 1.29-3.00). +1 more finding

• Genetics

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Neuroprotective strategy for Alzheimer disease: intranasal administration of a fatty neuropeptide

40/100 ✓ Peer-reviewed Disease mechanisms Proceedings of the National Academy of Sciences

Key finding: Furthermore, characteristic deficiencies in Alzheimer disease result from death of cholinergic neurons. +1 more finding

• Brain Biology

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[Progressive myoclonic epilepsy]

23/100 ✓ Peer-reviewed Risk factors Ugeskrift for laeger

Key finding: There is ethnic and geographic variation in the frequency of the syndrome. +4 more findings

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Vitamin E in Humans: Demand and Delivery

36/100 ✓ Peer-reviewed Prevention and risk Annual Review of Nutrition

Key finding: The cause of vitamin E deficiency, characterized by peripheral neuropathy and ataxia, is usually malabsorption-a result of fat malabsorption or genetic abnormalities in lipoprotein metabolism. +1 more finding

• Lifestyle

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A surface-based technique for warping three-dimensional images of the brain

36/100 ✓ Peer-reviewed Brain scans and imaging IEEE Transactions on Medical Imaging

Key finding: These sulci are sufficiently extended inside the brain to reflect subtle and distributed variations in neuroanatomy between subjects. +4 more findings

• Brain Scans

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A double-blind placebo-controlled study of clomipramine in depressed patients with Alzheimer's disease

73/100 ✓ Peer-reviewed Clinical trials The Journal of neuropsychiatry and clinical neurosciences

Key finding: Mood improved significantly on both clomipramine and placebo, but clomipramine was significantly more effective than placebo during the first 6-week treatment period. +2 more findings

• Clinical Trials

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Apolipoprotein E and Alzheimer's disease

38/100 ✓ Peer-reviewed Genetics Annual review of neuroscience

Key finding: The apolipoprotein E locus (APOE) is associated with variations in the age of onset and risk of Alzheimer's disease. +1 more finding

• Genetics

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The spectrum of behavioral changes in Alzheimer's disease

47/100 ✓ Peer-reviewed Clinical safety Neurology

Key finding: We investigated the range of behavioral abnormalities in patients with Alzheimer's disease (AD) compared with normal age-matched control subjects. +2 more findings

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Observed affect in nursing home residents with Alzheimer's disease

41/100 ✓ Peer-reviewed Health systems and care delivery The journals of gerontology. Series B, Psychological sciences and social sciences

Key finding: The 6-item Philadelphia Geriatric Center Affect Rating Scale was designed for the use of research and other staff in assessing positive affect (pleasure, interest, contentment) and negative affect (sadness, worry/anxiety, and anger) by direct observation of facial expression, body movement, and other cues that do not depend on self-report, among 253 demented and 43 nondemented residents. +4 more findings

• Care Services

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The Geriatric Depression Scale: a review of its development and utility

36/100 ✓ Peer-reviewed Health systems and care delivery International psychogeriatrics

Key finding: We conclude that the GDS is a relevant self-report for the assessment of depression in the elderly, given its advantage over other self-reports that are not as easily administered to this age group, its utility in the detection of depression, and its adequate psychometric properties.

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Oxidative stress in neurodegenerative diseases

36/100 ✓ Peer-reviewed Disease mechanisms Annual review of pharmacology and toxicology

Key finding: Growing data from experimental models and human brain studies suggest oxidative stress may play an important role in neuronal degeneration in diseases such as Parkinson's disease, Alzheimer's disease, and amyotrophic lateral sclerosis. +4 more findings

• Brain Biology

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The prevalence, associations and symptoms of depression amongst dementia sufferers

48/100 ✓ Peer-reviewed Risk factors Journal of affective disorders

Key finding: Major depression is more common and more severe in patients with vascular dementia. +2 more findings

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Pharmacology of nicotine: addiction and therapeutics

36/100 ✓ Peer-reviewed Risk factors Annual review of pharmacology and toxicology

Key finding: The metabolism of nicotine is now well characterized in humans. +4 more findings

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Amnesia induced in mice by centrally administered beta-amyloid peptides involves cholinergic dysfunction

36/100 ✓ Peer-reviewed Treatments Brain research

Key finding: Substantial evidences suggest that the increased cerebral deposition, and neurotoxic action of the beta-amyloid peptide, the major constituent of senile plaques, may represent the underlying cause of the cognitive deficits observed in Alzheimer's disease. +4 more findings

• Brain Biology
• Treatments

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