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Newest studies

Every summary in our library, newest first, as a dated timeline.

What "newest" means here

The most recent study in this library is dated 2026-11-01 (Paths of Aging Minds: Health Journeys of Older Adults with Mild Cognitive Impairment). This is our summary library, not a news wire — it is added to in batches, so the newest entry may not be the newest paper published anywhere.

Entries are sorted strictly by publication date, newest first. 26489 of the 27380 entries carry a full day-level date. 65 have no date recorded at all and are placed by publication year, at the start of that year; those are marked "no date recorded" below so you can see where the ordering is a best effort rather than a fact.

Prefer a reader? Subscribe to the Atom feed. Want them sorted by subject or by score instead? Browse the research library.

Showing 24,526–24,550 of 27,380 studies, newest first · page 982 of 1096.

April 2003 15

  1. 2003-04-01

    Presenilin 1 gene silencing by S-adenosylmethionine: a treatment for Alzheimer disease?

    ✓ Peer-reviewed Risk genes beyond APOE FEBS letters

    Key finding: Homocysteine accumulation, frequently observed in AD patients, may be a sign of a metabolic alteration in the S-adenosylmethionine (SAM) cycle, which generates the overexpression of genes controlled by methylation of their promoters, when the cytosine in CpG moieties becomes unmethylated. +2 more findings

    Full summary, score breakdown and related studies → Original source

  2. 2003-04-01

    Colocalization of tau and alpha-synuclein epitopes in Lewy bodies

    ✓ Peer-reviewed Lewy body dementia Journal of neuropathology and experimental neurology

    Key finding: Both direct immunochemical studies of partially purified LBs and indirect immunohistochemical studies have suggested that LBs may contain tau, but most of these studies were based upon a single tau antibody, and immunologic cross-reactivity was not completely excluded. +1 more finding

    Full summary, score breakdown and related studies → Original source

  3. 2003-04-01

    Characteristic developmental expression of amyloid beta40, 42 and 43 in patients with Down syndrome

    ✓ Peer-reviewed Down syndrome and Alzheimer's Brain & development

    Key finding: The immunoreactivity for each antibody was different in the degree of intensity and the chronological pattern of expression. +4 more findings

    Full summary, score breakdown and related studies → Original source

  4. 2003-04-01

    Nothing to say, something to sing: primary progressive dynamic aphasia

    ✓ Peer-reviewed Digital health tools Neurocase

    Key finding: The features of the language disorder indicated that the speech output pathway was disrupted at the early stage of generation of a new pre-verbal message. +2 more findings

    Full summary, score breakdown and related studies → Original source

  5. 2003-04-01

    Dementia associated with Parkinson's disease

    ✓ Peer-reviewed How common it is The Lancet. Neurology

    Key finding: Although there is some controversy with regard to the site and type of pathology involved, dementia is likely to be associated with the spread of pathology to other subcortical nuclei, the limbic system, and the cerebral cortex. +2 more findings

    Full summary, score breakdown and related studies → Original source

  6. 2003-04-01

    Prevalence of essential tremor in three elderly populations of central Spain

    ✓ Peer-reviewed Disparities Movement disorders : official journal of the Movement Disorder Society

    Key finding: Two hundred and four (79.7%) of the subjects with ET were detected through this screening and had not been diagnosed previously. +4 more findings

    Full summary, score breakdown and related studies → Original source

  7. 2003-04-01

    Caregiving and institutionalization of cognitively impaired older people: utilizing dynamic predictors of change

    ✓ Peer-reviewed Caregiving The Gerontologist

    Key finding: Although several results were consistent with prior findings, caregiving indicators (i.e., burden and self-rated health) and community-based service use were significant predictors of earlier placement.

    Full summary, score breakdown and related studies → Original source

  8. 2003-04-01

    Predictors of depression and life satisfaction among spousal caregivers in hospice: application of a stress process model

    ✓ Peer-reviewed Caregiving Journal of palliative medicine

    Key finding: Using a stress process model, risk factors (caregiving stressors, caregiver health, and negative social interactions) and protective factors (caregiving appraisals and social resources) were examined as predictors of family caregiver well-being (depression and life satisfaction).

    Full summary, score breakdown and related studies → Original source

  9. 2003-04-01

    Memantine in moderate-to-severe Alzheimer's disease

    ✓ Peer-reviewed Treatments The New England journal of medicine

    Key finding: Two hundred fifty-two patients (67 percent women; mean age, 76 years) from 32 U.S. centers were enrolled. +2 more findings

    Full summary, score breakdown and related studies → Original source

  10. 2003-04-01

    Are amyotrophic lateral sclerosis patients cognitively normal?

    ✓ Peer-reviewed Getting a diagnosis Neurology

    Key finding: This study suggests that frontal executive deficits are present in half of ALS patients, many of whom meet strict research criteria for FTLD. +1 more finding

    Full summary, score breakdown and related studies → Original source

  11. 2003-04-01

    Influenza vaccination and reduction in hospitalizations for cardiac disease and stroke among the elderly

    ✓ Peer-reviewed Getting a diagnosis The New England journal of medicine

    Key finding: There were 140,055 subjects in the 1998-1999 cohort and 146,328 in the 1999-2000 cohort, of which 55.5 percent and 59.7 percent, respectively, were immunized. +3 more findings

    Full summary, score breakdown and related studies → Original source

  12. 2003-04-01

    Long-term prognosis after lacunar infarction

    ✓ Peer-reviewed Prevention and risk The Lancet. Neurology

    Key finding: Lacunar infarcts, small deep infarcts that result from occlusion of a penetrating artery, account for about a quarter of all ischaemic strokes. +4 more findings

    Full summary, score breakdown and related studies → Original source

  13. 2003-04-01

    Reasons for seeking genetic susceptibility testing among first-degree relatives of people with Alzheimer disease

    ✓ Peer-reviewed Treatments Alzheimer disease and associated disorders

    Key finding: We examined (1) reasons endorsed as motivations for seeking testing, (2) demographic characteristics associated with these reasons, and (3) how these reasons related to the eventual decision to pursue testing. +1 more finding

    Full summary, score breakdown and related studies → Original source

  14. 2003-04-01

    Ginkgo for elderly people with dementia and age-associated memory impairment: a randomized clinical trial

    ✓ Peer-reviewed Treatments Journal of clinical epidemiology

    Key finding: We found no statistically significant differences in mean change of scores between Ginkgo and placebo. +2 more findings

    Full summary, score breakdown and related studies → Original source

  15. 2003-04-01

    Olfaction in neurodegenerative disorder

    ✓ Peer-reviewed Genetics Movement disorders : official journal of the Movement Disorder Society

    Key finding: In this review of PD, parkinsonian syndromes, essential tremor, AD, motor neurone disease (MND) and Huntington's chorea (HC) the following observations are made: 1). olfactory dysfunction is frequent and often severe in PD and AD; 2). normal smell identification in PD is rare and should prompt review of diagnosis unless the patient is female with tremor-dominant disease; 3). anosmia in suspected progressive supranuclear palsy and corticobasal degeneration is atypical and should likewise provoke diagnostic review; 4). hyposmia is an early feature of PD and AD and may precede motor and cognitive signs respectively; 5). subjects with anosmia and one ApoE-4 allele have an approximate 5-fold increased risk of later AD; 6). impaired smell sense is seen in some patients at 50% risk of parkinsonism; 7). smell testing in HC and MND where abnormality may be found, is not likely to be of clinical value; and 8). biopsy of olfactory nasal neurons shows non-specific changes in PD and AD and at present will not aid diagnosis.

    Full summary, score breakdown and related studies → Original source

March 2003 10

  1. 2003-03-31

    The discovery of Alzheimer's disease

    ✓ Peer-reviewed Risk factors Dialogues in Clinical Neuroscience

    Key finding: On November 3, 1906, a clinical psychiatrist and neuroanatomist, Alois Alzheimer, reported "A peculiar severe disease process of the cerebral cortex" to the 37th Meeting of South-West German Psychiatrists in Tubingen, He described a 50-year-old woman whom he had followed from her admission for paranoia, progressive sleep and memory disturbance, aggression, and confusion, until her death 5 years later. +3 more findings

    Full summary, score breakdown and related studies → Original source

  2. 2003-03-26

    Silent Brain Infarcts and the Risk of Dementia and Cognitive Decline

    ✓ Peer-reviewed Vascular contributions New England Journal of Medicine

    Key finding: During 3697 person-years of follow-up (mean per person, 3.6 years), dementia developed in 30 of the 1015 participants. +4 more findings

    Full summary, score breakdown and related studies → Original source

  3. 2003-03-24

    Translational control of inducible nitric oxide synthase expression by arginine can explain the arginine paradox

    ✓ Peer-reviewed Inflammation and the immune system Proceedings of the National Academy of Sciences of the United States of America

    Key finding: The "arginine paradox" refers to the dependence of cellular NO production on exogenous L-arginine concentration despite the theoretical saturation of NOS enzymes with intracellular L-arginine. +3 more findings

    Full summary, score breakdown and related studies → Original source

  4. 2003-03-20

    Galantamine is an allosterically potentiating ligand of neuronal nicotinic but not of muscarinic acetylcholine receptors

    ✓ Peer-reviewed Treatments The Journal of pharmacology and experimental therapeutics

    Key finding: At concentrations >10 microM, galantamine acts as an nAChR inhibitor. +4 more findings

    Full summary, score breakdown and related studies → Original source

  5. 2003-03-17

    Neuropathology of human Alzheimer disease after immunization with amyloid-beta peptide: a case report

    ✓ Peer-reviewed Brain tissue and pathology Nature medicine

    Key finding: Immunization with Abeta in a transgenic mouse model of AD reduces both age-related accumulation of Abeta in the brain and associated cognitive impairment. +3 more findings

    Full summary, score breakdown and related studies → Original source

  6. 2003-03-16

    The role of presenilin cofactors in the gamma-secretase complex

    ✓ Peer-reviewed Risk genes beyond APOE Nature

    Key finding: Cleavage of betaAPP by FAD mutant presenilin results in the overproduction of highly amyloidogenic amyloid beta42 peptides. gamma-Secretase activity requires the formation of a stable, high-molecular-mass protein complex that, in addition to the endoproteolysed fragmented form of presenilin, contains essential cofactors including nicastrin, APH-1 (refs 15-18) and PEN-2 (refs 16, 19).

    Full summary, score breakdown and related studies → Original source

  7. 2003-03-12

    Insulin-degrading enzyme regulates the levels of insulin, amyloid β-protein, and the β-amyloid precursor protein intracellular domain in vivo

    ✓ Peer-reviewed Disease mechanisms Proceedings of the National Academy of Sciences

    Two substrates of insulin-degrading enzyme (IDE), amyloid beta-protein (Abeta) and insulin, are critically important in the pathogenesis of Alzheimer's disease (AD) and type 2 diabetes mellitus (DM2), respectively.

    Full summary, score breakdown and related studies → Original source

  8. 2003-03-03

    Adult mouse astrocytes degrade amyloid-β in vitro and in situ

    ✓ Peer-reviewed Disease mechanisms Nature Medicine

    Full summary, score breakdown and related studies → Original source

  9. 2003-03 month only

    Phospho-tau/total tau ratio in cerebrospinal fluid discriminates Creutzfeldt-Jakob disease from other dementias

    ✓ Peer-reviewed Tau biomarkers Molecular psychiatry

    Key finding: However, false negative results in autopsy-proven, sporadic CJD cases, as well as false positive results in several other disorders including AD and FTD showing high CSF tau protein levels, limit the potential of this marker. +2 more findings

    Full summary, score breakdown and related studies → Original source

  10. 2003-03-01

    Folate and homocysteine metabolism in neural plasticity and neurodegenerative disorders

    ✓ Peer-reviewed Disease mechanisms Trends in neurosciences

    Key finding: Folate is a cofactor in one-carbon metabolism, during which it promotes the remethylation of homocysteine -- a cytotoxic sulfur-containing amino acid that can induce DNA strand breakage, oxidative stress and apoptosis. +4 more findings

    Full summary, score breakdown and related studies → Original source

Browse the library by subject, with the full score breakdown →