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Disturbed fluctuations of resting state EEG synchronization in Alzheimer's disease
Stam CJ, Montez T, Jones BF, Rombouts SA, van der Made Y, Pijnenburg YA, Scheltens P.. Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology, 2004-10-28
Topic: Amyloid, tau and blood-test diagnosis
Objective We examined the hypothesis that cognitive dysfunction in Alzheimer's disease is associated with abnormal spontaneous fluctuations of EEG synchronization levels during an eyes-closed resting state. Methods EEGs were recorded during an eyes-closed resting state in Alzheimer patients (N=24; 9 males; mean age 76.3 years; SD 7.8; range 59-86) and non-demented subjects with subjective memory complaints (N=19; 9 males; mean age 76.1 years; SD 6.7; range: 67-89). The mean level of synchronization was determined in different frequency bands with the synchronization likelihood and fluctuations of the synchronization level were analysed with detrended fluctuation analysis (DFA). Results The mean level of EEG synchronization was lower in Alzheimer patients in the upper alpha (10-13Hz) and beta (13-30Hz) band. Spontaneous fluctuations of synchronization were diminished in Alzheimer patients in the lower alpha (8-10Hz) and beta bands. In patients as well as controls the synchronization fluctuations showed a scale-free pattern. Conclusions Alzheimer's disease is characterized both by a lower mean level of functional connectivity as well as by diminished fluctuations in the level of synchronization. The dynamics of these fluctuations in patients and controls was scale-free which might point to self-organized criticality of neural networks in the brain. Significance Impaired functional connectivity can manifest itself not only in decreased levels of synchronization but also in disturbed fluctuations of synchronization levels.
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APA 7th
Stam, C. J., Montez, T., Jones, B. F., Rombouts, S. A., van der Made, Y., Pijnenburg, Y. A., et al. (2005). Disturbed fluctuations of resting state EEG synchronization in Alzheimer's disease. Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology. https://doi.org/10.1016/j.clinph.2004.09.022
Vancouver
Stam CJ, Montez T, Jones BF, Rombouts SA, van der Made Y, Pijnenburg YA, et al. Disturbed fluctuations of resting state EEG synchronization in Alzheimer's disease. Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology. 2005. doi:10.1016/j.clinph.2004.09.022. PMID: 15721085.
BibTeX
@article{stam2005-15721085,
author = {Stam, C. J. and Montez, T. and Jones, B. F. and Rombouts, S. A. and van der Made, Y. and Pijnenburg, Y. A. and Scheltens, P.},
title = {{Disturbed fluctuations of resting state EEG synchronization in Alzheimer's disease}},
journal = {Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology},
year = {2005},
doi = {10.1016/j.clinph.2004.09.022},
pmid = {15721085},
url = {https://doi.org/10.1016/j.clinph.2004.09.022}
}
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record names 7 authors; APA and Vancouver show the first six, BibTeX and the downloads carry all of them. Check the citation against the original before you use it.
Key findings
- Objective We examined the hypothesis that cognitive dysfunction in Alzheimer's disease is associated with abnormal spontaneous fluctuations of EEG synchronization levels during an eyes-closed resting state.
- Results The mean level of EEG synchronization was lower in Alzheimer patients in the upper alpha (10-13Hz) and beta (13-30Hz) band.
Why it matters
This small EEG study found that people with Alzheimer disease had lower average synchronization in some frequency bands and diminished fluctuations of synchronization compared with people with subjective memory complaints. It describes a possible marker of brain network dysfunction, not a treatment, cure, or prevention.
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Study details
- Participants24
- Evidence strengthLow
How this study scored 48/100
Published in a peer-reviewed journal. Scored zero for study design, effect reported and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology) |
| Journal's citation record | 2 / 4 | Clinical Neurophysiology: journal h-index 247 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 1 / 5 | 2005 — older than 20 years, still counted |
| Sample size | 1 / 4 | 24 participants |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 5 / 7 | Cited 245 times (OpenAlex, 2026-10-10) |
| Citations per year | 3 / 5 | 10.7 citations a year over 23 year(s) since 2005 |
| Impact for its field and year | 3 / 6 | Cited 6.1× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 2 / 6 | Cited by 4 other studies in this library |
| Still being cited | 2 / 4 | Cited 20 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 4 / 4 | Last-listed author Philip Scheltens: h-index 181 (OpenAlex, whole career) |
| Institution's track record | 1 / 3 | Amsterdam UMC Location Vrije Universiteit Amsterdam: institution h-index 938 (OpenAlex) |
| Multi-centre collaboration | 1 / 3 | OpenAlex lists 2 institution(s) in 2 countries |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 15721085) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Total | 48 / 100 | — |
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Read the original
- DOI: 10.1016/j.clinph.2004.09.022
- PubMed: 15721085
- Original source →
- Free full text: Amsterdam UMC (VU Amsterdam) - Institutional Repository →
Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).
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