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Newest studies

Every summary in our library, newest first, as a dated timeline.

What "newest" means here

The most recent study in this library is dated 2026-11-01 (Paths of Aging Minds: Health Journeys of Older Adults with Mild Cognitive Impairment). This is our summary library, not a news wire — it is added to in batches, so the newest entry may not be the newest paper published anywhere.

Entries are sorted strictly by publication date, newest first. 26489 of the 27380 entries carry a full day-level date. 65 have no date recorded at all and are placed by publication year, at the start of that year; those are marked "no date recorded" below so you can see where the ordering is a best effort rather than a fact.

Prefer a reader? Subscribe to the Atom feed. Want them sorted by subject or by score instead? Browse the research library.

Showing 23,876–23,900 of 27,380 studies, newest first · page 956 of 1096.

December 2004 5

  1. 2004-12-01

    Challenging the cholinergic system in mild cognitive impairment: a pharmacological fMRI study

    ✓ Peer-reviewed Treatments NeuroImage

    Key finding: Significant increases in brain activation from BL were observed after prolonged exposure only. +1 more finding

    Full summary, score breakdown and related studies → Original source

  2. 2004-12-01

    Efficacy of donepezil in early-stage Alzheimer disease: a randomized placebo-controlled trial

    ✓ Peer-reviewed Treatments Archives of neurology

    Key finding: These data suggest significant treatment benefits of donepezil in early-stage Alzheimer disease, supporting the initiation of therapy early in the disease course to improve daily cognitive functioning. +2 more findings

    Full summary, score breakdown and related studies → Original source

  3. 2004-12-01

    APOE genotype, family history of dementia, and Alzheimer disease risk: a 6-year follow-up study

    ✓ Peer-reviewed Genetics Archives of neurology

    Key finding: Family history of dementia was associated with an increased risk of dementia and AD in this very old population, but only among APOE epsilon4 carriers. +4 more findings

    Full summary, score breakdown and related studies → Original source

  4. 2004-12-01

    ApoE isoform affects LTP in human targeted replacement mice

    ✓ Peer-reviewed Genetics Neuroreport

    Key finding: Inheritance of the epsilon4 allele for apolipoprotein E (apoE) increases the risk of Alzheimer disease and memory impairment, whereas epsilon2 decreases these risks compared with the most common epsilon3 allele, but the mechanism for these effects is unknown. +1 more finding

    Full summary, score breakdown and related studies → Original source

  5. 2004-12-01

    MCI conversion to dementia and the APOE genotype: a prediction study with FDG-PET

    ✓ Peer-reviewed Genetics Neurology

    Key finding: After 1 year, 8 of 37 patients with MCI converted to AD (22%). +2 more findings

    Full summary, score breakdown and related studies → Original source

November 2004 20

  1. 2004-11-25

    Caloric restriction attenuates Abeta-deposition in Alzheimer transgenic models

    ✓ Peer-reviewed Biomarkers Neurobiology of aging

    Key finding: These influences of CR on AD-transgenic mice are consistent with epidemiological reports that show that high caloric diets associate with the risk of AD, and suggest that dietary interventions in adult life might slow disease progression.

    Full summary, score breakdown and related studies → Original source

  2. 2004-11-24

    Simultaneous measurement of beta-amyloid(1-42), total tau, and phosphorylated tau (Thr181) in cerebrospinal fluid by the xMAP technology

    ✓ Peer-reviewed Mild cognitive impairment Clinical chemistry

    Key finding: The INNO-BIA AlzBio3 selectively and specifically measured Abeta((1-42)), T-TAU, and P-TAU((181P)) in the CSF.

    Full summary, score breakdown and related studies → Original source

  3. 2004-11-15

    Treatment of vascular dementia--evidence from clinical trials with cholinesterase inhibitors

    ✓ Peer-reviewed Treatments Journal of the neurological sciences

    Key finding: Controlled clinical trials with donepezil, galantamine and rivastigmine in VaD, as well as in patients with AD plus CVD, have demonstrated improvements in cognition, behavior and activities of daily living.

    Full summary, score breakdown and related studies → Original source

  4. 2004-11-10

    Focal decline of cortical thickness in Alzheimer's disease identified by computational neuroanatomy

    ✓ Peer-reviewed Brain scans and imaging Cerebral cortex (New York, N.Y. : 1991)

    Key finding: We show significant cortical thickness decline in AD in temporal, orbitofrontal and parietal regions, with the most pronounced changes occurring in the allocortical region of the medial temporal lobes, outlining the parahippocampal gyrus, and representing a loss of >1.25 millimeters of cortical thickness. +1 more finding

    Full summary, score breakdown and related studies → Original source

  5. 2004-11-01

    The Relationship between Impaired Glucose Tolerance, Type 2 Diabetes, and Cognitive Function

    ✓ Peer-reviewed Risk genes beyond APOE Journal of Clinical and Experimental Neuropsychology

    Key finding: Some studies suggest that deficits in cognitive functions are associated with poorer glycemic control. +1 more finding

    Full summary, score breakdown and related studies → Original source

  6. 2004-11-01

    A modified beta-amyloid hypothesis: intraneuronal accumulation of the beta-amyloid peptide--the first step of a fatal cascade

    ✓ Peer-reviewed Down syndrome and Alzheimer's Journal of neurochemistry

    Key finding: Based on these results, a modified A beta hypothesis is formulated, that integrates biochemical, neuropathological and genetic observations with AD-typical neuron loss and plaque formation.

    Full summary, score breakdown and related studies → Original source

  7. 2004-11-01

    Abeta localization in abnormal endosomes: association with earliest Abeta elevations in AD and Down syndrome

    ✓ Peer-reviewed Down syndrome and Alzheimer's Neurobiology of aging

    Key finding: We found by ELISA and immunocytochemistry that the appearance of enlarged endosomes coincided with an initial rise in soluble Abeta40 and Abeta42 peptides, which preceded amyloid deposition. +2 more findings

    Full summary, score breakdown and related studies → Original source

  8. 2004-11-01

    Cerebrospinal anandamide levels are elevated in acute schizophrenia and are inversely correlated with psychotic symptoms

    ✓ Peer-reviewed Clinical safety Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology

    Key finding: We found that CSF anandamide levels are eight-fold higher in antipsychotic-naive first-episode paranoid schizophrenics (n = 47) than healthy controls (n = 84), dementia patients (n = 13) or affective disorder patients (n = 22). +2 more findings

    Full summary, score breakdown and related studies → Original source

  9. 2004-11-01

    Iron, brain ageing and neurodegenerative disorders

    ✓ Peer-reviewed Disease mechanisms Nature reviews. Neuroscience

    Key finding: Conditions such as neuroferritinopathy and Friedreich ataxia are associated with mutations in genes that encode proteins that are involved in iron metabolism, and as the brain ages, iron accumulates in regions that are affected by Alzheimer's disease and Parkinson's disease.

    Full summary, score breakdown and related studies → Original source

  10. 2004-11-01

    Synaptic targeting by Alzheimer's-related amyloid beta oligomers

    ✓ Peer-reviewed Disease mechanisms The Journal of neuroscience : the official journal of the Society for Neuroscience

    Key finding: The cognitive hallmark of early Alzheimer's disease (AD) is an extraordinary inability to form new memories.

    Full summary, score breakdown and related studies → Original source

  11. 2004-11-01

    Brain inflammation and Alzheimer's-like pathology in individuals exposed to severe air pollution

    ✓ Peer-reviewed Risk factors Toxicologic pathology

    Key finding: Dogs exposed to severe air pollution exhibit chronic inflammation and acceleration of Alzheimer's-like pathology, suggesting that the brain is adversely affected by pollutants. +3 more findings

    Full summary, score breakdown and related studies → Original source

  12. 2004-11-01

    Glutamate as a therapeutic target in psychiatric disorders

    ✓ Peer-reviewed Clinical trials Molecular psychiatry

    Key finding: Of these, the full agonists glycine and D-serine have both shown to induce significant, large effect size reductions in persistent negative and cognitive symptoms when added to traditional or newer atypical antipsychotics in double-blind, placebo-controlled clinical studies.

    Full summary, score breakdown and related studies → Original source

  13. 2004-11-01

    Polyunsaturated fatty acids in the central nervous system: evolution of concepts and nutritional implications throughout life

    ✓ Peer-reviewed Brain scans and imaging Reproduction, nutrition, development

    Key finding: Studies on bottle-fed human infants have shown that adding DHA and AA to milk replacer-formulas can bring their concentrations in the infant blood lipids to values as high as those produced by breast-feeding and significantly improves mental development and maturation of visual function. +1 more finding

    Full summary, score breakdown and related studies → Original source

  14. 2004-11-01

    Cell biology of protein misfolding: the examples of Alzheimer's and Parkinson's diseases

    ✓ Peer-reviewed Risk genes beyond APOE Nature cell biology

    Key finding: The salutary intersection of fundamental cell biology with the study of disease is well illustrated by the emerging elucidation of neurodegenerative disorders. +2 more findings

    Full summary, score breakdown and related studies → Original source

  15. 2004-11-01

    Intranasal insulin improves memory in humans

    ✓ Peer-reviewed Tau biomarkers Psychoneuroendocrinology

    Key finding: To study changes in memory associated with a prolonged increase in brain insulin activity in humans, here we used the intranasal route of insulin administration known to provide direct access of the substance to the cerebrospinal fluid compartment. +4 more findings

    Full summary, score breakdown and related studies → Original source

  16. 2004-11-01

    Synaptic changes in Alzheimer's disease: increased amyloid-beta and gliosis in surviving terminals is accompanied by decreased PSD-95 fluorescence

    ✓ Peer-reviewed Biomarkers The American journal of pathology

    Key finding: The viability dye calcein AM was unchanged in AD terminals compared to controls, and the fraction of large synaptosome particles did not change, although a striking loss of large terminals was observed in some AD cases. +1 more finding

    Full summary, score breakdown and related studies → Original source

  17. 2004-11-01

    Vascular cognitive disorder: a new diagnostic category updating vascular cognitive impairment and vascular dementia

    ✓ Peer-reviewed Vascular contributions Journal of the neurological sciences

    Key finding: VCI may or may not exclude the host of "focal" circumscribed impairments of specialized functions such as language (aphasia), intentional gesture (apraxia), or categorical recognition (agnosia), among others, that may result from a stroke. +2 more findings

    Full summary, score breakdown and related studies → Original source

  18. 2004-11-01

    The human perirhinal cortex and semantic memory

    ✓ Peer-reviewed Hippocampus size on brain scans The European journal of neuroscience

    Key finding: Studies in macaque monkeys indicate that the perirhinal cortex in the temporal lobe participates in object memory. +3 more findings

    Full summary, score breakdown and related studies → Original source

  19. 2004-11-01

    A longitudinal study of hippocampal volume, cortisol levels, and cognition in older depressed subjects

    ✓ Peer-reviewed Hippocampus size on brain scans The American journal of psychiatry

    Key finding: Older depressed subjects have persisting cognitive impairments associated with hippocampal volume reduction, but the results do not support cortisol-mediated hippocampal neurotoxicity as the major etiological mechanism. +3 more findings

    Full summary, score breakdown and related studies → Original source

  20. 2004-11-01

    Cellular changes in the postmortem hippocampus in major depression

    ✓ Peer-reviewed Hippocampus size on brain scans Biological psychiatry

    Key finding: In MDD, the packing density of glia, pyramidal neurons, and granule cell neurons is significantly increased in all hippocampal subfields and the dentate gyrus, and pyramidal neuron soma size is significantly decreased as well. +4 more findings

    Full summary, score breakdown and related studies → Original source

Browse the library by subject, with the full score breakdown →