Newest studies

Sex, apolipoprotein E epsilon 4 status, and hippocampal volume in mild cognitive impairment

50/100 ✓ Peer-reviewed Genetics Archives of neurology

Key finding: The APOE*E4 genotype status appears to have a greater deleterious effect on gross hippocampal pathology and memory performance in women than in men. +3 more findings

• Genetics
• Brain Scans
• Early Stage

Full summary, score breakdown and related studies → Original source

Inhibition of glycosphingolipid biosynthesis reduces secretion of the beta-amyloid precursor protein and amyloid beta-peptide

41/100 ✓ Peer-reviewed Risk genes beyond APOE The Journal of biological chemistry

Key finding: Amyloid beta-peptides are generated by proteolytic processing of the beta-amyloid precursor protein by beta- and gamma-secretases. +3 more findings

• Brain Biology

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Genomic architecture of human 17q21 linked to frontotemporal dementia uncovers a highly homologous family of low-copy repeats in the tau region

43/100 ✓ Peer-reviewed Disease mechanisms Human molecular genetics

Key finding: Annotation demonstrated that MAPT is surrounded by three highly homologous low-copy repeats (LCRs) in a region of 1.7 Mb. +1 more finding

• Genetics
• Other Dementias

Full summary, score breakdown and related studies → Original source

The low density lipoprotein receptor regulates the level of central nervous system human and murine apolipoprotein E but does not modify amyloid plaque pathology in PDAPP mice

47/100 ✓ Peer-reviewed Genetics The Journal of biological chemistry

Key finding: We also found that LDLR knock-out (Ldlr-/-) mice had a significant, approximately 50% increase in the level of apoE in the cerebrospinal fluid and extracellular pools of the brain. +2 more findings

• Brain Biology
• Genetics

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Structural properties of Abeta protofibrils stabilized by a small molecule

36/100 ✓ Peer-reviewed Treatments Proceedings of the National Academy of Sciences of the United States of America

Key finding: The CLC-Abeta aggregates exhibit the same protection from hydrogen-deuterium exchange as do protofibrils isolated from a spontaneous Abeta fibril formation reaction: approximately 12 of the 39 Abeta(1-40) backbone amide protons are protected from exchange in the protofibril, compared with approximately twice that number in amyloid fibrils.

• Treatments

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Total homocysteine is associated with white matter hyperintensity volume: the Northern Manhattan Study

54/100 ✓ Peer-reviewed Disparities Stroke

Key finding: These cross-sectional data provide evidence that tHcy is a risk factor for white matter damage.

• Brain Scans

Full summary, score breakdown and related studies → Original source

Inhibition of glycogen synthase kinase-3 by lithium correlates with reduced tauopathy and degeneration in vivo

36/100 ✓ Peer-reviewed Drug development Proceedings of the National Academy of Sciences of the United States of America

Key finding: To investigate whether kinase inhibition can reduce tauopathy and the degeneration associated with it in vivo, transgenic mice overexpressing mutant human tau were treated with the glycogen synthase kinase-3 (GSK-3) inhibitor lithium chloride. +3 more findings

• Brain Biology

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Cerebrospinal fluid profile in frontotemporal dementia and Alzheimer's disease

52/100 ✓ Peer-reviewed Tau biomarkers Annals of neurology

Key finding: CSF levels of tau, Abeta1-42, and iP differed significantly in FTD compared with AD. +3 more findings

• Biomarkers
• Other Dementias

Full summary, score breakdown and related studies → Original source

Age- and region-dependent alterations in Abeta-degrading enzymes: implications for Abeta-induced disorders

36/100 ✓ Peer-reviewed Down syndrome and Alzheimer's Neurobiology of aging

Key finding: Emerging evidence suggests that the steady-state levels of Abeta are determined by the balance between production and degradation. +4 more findings

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Vagal nerve stimulation: a review of its applications and potential mechanisms that mediate its clinical effects

36/100 ✓ Peer-reviewed Risk factors Neuroscience and biobehavioral reviews

Key finding: It is concluded that although the precise mechanism of action of VNS is still unknown, the search for the mechanism has the potential to lend new insight into the neuropathology of depression.

• Treatments

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Acetylcholinesterase inhibitors reduce brain and blood interleukin-1beta production

40/100 ✓ Peer-reviewed Drug development Annals of neurology

Key finding: Overproduction of interleukin-1 within the brain is associated with Alzheimer's disease and other neurological conditions. +2 more findings

• Treatments

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The stress system in the human brain in depression and neurodegeneration

36/100 ✓ Peer-reviewed Tau biomarkers Ageing research reviews

Key finding: ACTH release results in the release of corticosteroids from the adrenal that, subsequently, through mineralocorticoid and glucocorticoid receptors, exert negative feedback on, among other things, the hippocampus, the pituitary and the hypothalamus. +4 more findings

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Palliative care for end-stage dementia: a discussion of the implications for education of health care professionals

36/100 ✓ Peer-reviewed End-of-life care Nurse education today

Key finding: The increasing burden of chronic disease demands that palliative care clinicians address the needs of patients with non-malignant disease. +4 more findings

• End-of-Life Care

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Prediction of appropriate timing of palliative care for older adults with non-malignant life-threatening disease: a systematic review

64/100 ✓ Peer-reviewed End-of-life care Age and ageing

Key finding: Whilst palliative care is appropriate for elderly patients with chronic, non-malignant disease, few of these patients access such care compared with cancer patients. +1 more finding

• End-of-Life Care

Full summary, score breakdown and related studies → Original source

Prevalence of cognitive impairment: results from the MRC trial of assessment and management of older people in the community

60/100 ✓ Peer-reviewed Cognitive tests and assessment Age and ageing

Key finding: The Mini-Mental State Examination (MMSE) is recommended to test for cognitive impairment and to monitor medication response. +3 more findings

• Clinical Trials
• Diagnosis

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Motor signs predict poor outcomes in Alzheimer disease

57/100 ✓ Peer-reviewed Cognitive tests and assessment Neurology

Key finding: A total of 533 patients with AD at early stages (mean Folstein Mini-Mental State Examination [MMSE] 21/30 at entry) were recruited and followed semiannually for up to 13.1 years (mean 3) in five University-based AD centers in the United States and European Union. +3 more findings

• Diagnosis

Full summary, score breakdown and related studies → Original source

Correlation of cerebrospinal fluid levels of tau protein phosphorylated at threonine 231 with rates of hippocampal atrophy in Alzheimer disease

46/100 ✓ Peer-reviewed Tau biomarkers Archives of neurology

Key finding: The microtubule-associated tau protein abnormally phosphorylated at threonine 231 (p-tau231) has been investigated as a potential marker of Alzheimer disease. +3 more findings

• Biomarkers
• Brain Biology

Full summary, score breakdown and related studies → Original source

The genetic causes of basal ganglia calcification, dementia, and bone cysts: DAP12 and TREM2

49/100 ✓ Peer-reviewed TREM2 and immune genetics Neurology

Key finding: Polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL), or Nasu-Hakola disease, is a presenile dementia associated with loss of myelin, basal ganglia calcification, and bone cysts. +3 more findings

• Genetics

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Oxidative DNA damage in peripheral leukocytes of mild cognitive impairment and AD patients

43/100 ✓ Peer-reviewed Mild cognitive impairment Neurobiology of aging

Key finding: We performed this study by a comet assay analysis to evaluate the level of primary and oxidative DNA damage in two groups of MCI and AD patients, compared to healthy controls. +3 more findings

• Early Stage

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Alzheimer disease and mortality: a 15-year epidemiological study

56/100 ✓ Peer-reviewed Disparities Archives of neurology

Key finding: Alzheimer disease was responsible for 4.9% of the deaths in this elderly cohort.

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Simplifying detection of cognitive impairment: comparison of the Mini-Cog and Mini-Mental State Examination in a multiethnic sample

54/100 ✓ Peer-reviewed Disparities Journal of the American Geriatrics Society

Key finding: A registry of the University of Washington Alzheimer's Disease Research Center Satellite.

• Diagnosis
• Health Equity

Full summary, score breakdown and related studies → Original source

Nighttime insomnia treatment and education for Alzheimer's disease: a randomized, controlled trial

67/100 ✓ Peer-reviewed Caregiving Journal of the American Geriatrics Society

Key finding: A randomized, controlled trial.

• Clinical Trials
• Caregiving
• Treatments

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Environmental enrichment mitigates cognitive deficits in a mouse model of Alzheimer's disease

49/100 ✓ Peer-reviewed Caregiving The Journal of neuroscience : the official journal of the Society for Neuroscience

Key finding: Epidemiological studies suggest that individuals with greater education or more cognitively demanding occupations have diminished risk of developing dementia. +2 more findings

• Brain Biology

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Classification of vascular dementia in the Cardiovascular Health Study Cognition Study

52/100 ✓ Peer-reviewed Brain scans and imaging Neurology

Key finding: None of the clinical criteria for VaD identified the same group of subjects. +1 more finding

• Other Dementias
• Risk Factors

Full summary, score breakdown and related studies → Original source

Determinants of vascular dementia in the Cardiovascular Health Cognition Study

54/100 ✓ Peer-reviewed Brain scans and imaging Neurology

Key finding: Vascular disease in the brain is prevalent among incident dementia cases.

• Risk Factors
• Other Dementias

Full summary, score breakdown and related studies → Original source