Newest studies
Every summary in our library, newest first, as a dated timeline.
Showing 23,751–23,775 of 27,380 studies, newest first · page 951 of 1096.
March 2005 17
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2005-03-01
Beyond the global score of the Zarit Burden Interview: useful dimensions for clinicians
43/100 ✓ Peer-reviewed Cognitive tests and assessment International journal of geriatric psychiatry
Key finding: The purpose of this study was to explore the structure of the Zarit Burden Interview (ZBI) for informal caregivers of patients suffering from AD or related disorders, and to examine the relations of the dimensions found with functional disabilities and other patient health indicators. +3 more findings
Full summary, score breakdown and related studies → Original source
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2005-03-01
Use of the QOL-AD for measuring quality of life in people with severe dementia--the LASER-AD study
46/100 ✓ Peer-reviewed Cognitive tests and assessment Age and ageing
Key finding: Health-related quality of life (HR-QOL) scales are particularly important in older people as global outcome measures for interventions. +3 more findings
Full summary, score breakdown and related studies → Original source
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2005-03-01
Dap12 and Trem2, molecules involved in innate immunity and neurodegeneration, are co-expressed in the CNS
41/100 ✓ Peer-reviewed TREM2 and immune genetics Neurobiology of disease
Key finding: Our group has recently established the molecular background of PLOSL by identifying mutations in DAP12 and TREM2 genes. +3 more findings
Full summary, score breakdown and related studies → Original source
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2005-03-01
Glia and their cytokines in progression of neurodegeneration
47/100 ✓ Peer-reviewed Risk genes beyond APOE Neurobiology of aging
Key finding: All of these conditions are associated with early and often dramatic activation of, and cytokine overexpression in, microglia and astrocytes, sometimes decades before pathological changes consistent with a diagnosis of Alzheimer's disease are apparent, as in patients with Down's syndrome or head injury. +3 more findings
Full summary, score breakdown and related studies → Original source
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2005-03-01
Tau and alpha-synuclein inclusions in a case of familial frontotemporal dementia and progressive aphasia
41/100 ✓ Peer-reviewed Down syndrome and Alzheimer's Journal of neuropathology and experimental neurology
Key finding: Recent studies have shown that neurofibrillary tangles are frequently accompanied by alpha-synuclein inclusions in sporadic and familial Alzheimer disease, in Down syndrome, in progressive supranuclear palsy, and Parkinsonism dementia complex of Guam. +1 more finding
Full summary, score breakdown and related studies → Original source
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2005-03-01
Learning and memory as a function of age in Down syndrome: a study using animal-based tasks
45/100 ✓ Peer-reviewed Down syndrome and Alzheimer's Progress in neuro-psychopharmacology & biological psychiatry
Key finding: When considering age as the only clinical variable to parallel the animal studies, age was significantly correlated with performance on object memory and marginally related to performance on reversal learning and spatial memory. +2 more findings
Full summary, score breakdown and related studies → Original source
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2005-03-01
Alzheimer disease and Down syndrome: factors in pathogenesis
43/100 ✓ Peer-reviewed Down syndrome and Alzheimer's Neurobiology of aging
Key finding: There is evidence to suggest that certain shared features exist in the pathogenesis of vascular disease and Alzheimer disease (AD) in the general population.
Full summary, score breakdown and related studies → Original source
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2005-03-01
Reduced hippocampal volumes and memory loss in patients with early- and late-onset depression
52/100 ✓ Peer-reviewed Risk factors The British journal of psychiatry : the journal of mental science
Key finding: Although reduced hippocampal volumes are most pronounced in late-onset depression, older people with early-onset disorders also display volume changes and memory loss. +2 more findings
Full summary, score breakdown and related studies → Original source
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2005-03-01
Normative estimates of cross-sectional and longitudinal brain volume decline in aging and AD
67/100 ✓ Peer-reviewed How common it is Neurology
Key finding: Nondemented individuals exhibit a slow rate of whole-brain atrophy from early in adulthood with white-matter loss beginning in middle age; in older adults, the onset of dementia of the Alzheimer type is associated with a markedly accelerated atrophy rate. +1 more finding
Full summary, score breakdown and related studies → Original source
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2005-03-01
Cardiovascular death in rheumatoid arthritis: a population-based study
57/100 ✓ Peer-reviewed How common it is Arthritis and rheumatism
Key finding: These results indicate that markers of systemic inflammation confer a statistically significant additional risk for cardiovascular death among patients with RA, even after controlling for traditional cardiovascular risk factors and comorbidities. +2 more findings
Full summary, score breakdown and related studies → Original source
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2005-03-01
Albumin, length of stay, and proton pump inhibitors: key factors in Clostridium difficile-associated disease in nursing home patients
40/100 ✓ Peer-reviewed Disparities Journal of the American Medical Directors Association
Key finding: These findings may facilitate the timely and efficient management of CDAD in nursing home patients. +1 more finding
Full summary, score breakdown and related studies → Original source
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2005-03-01
Dementia subtypes in China: prevalence in Beijing, Xian, Shanghai, and Chengdu
53/100 ✓ Peer-reviewed Disparities Archives of neurology
Key finding: Prevalence of dementia subtypes in China is comparable with that in Western countries.
Full summary, score breakdown and related studies → Original source
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2005-03-01
Measurement of health-related quality of life for people with dementia: development of a new instrument (DEMQOL) and an evaluation of current methodology
16/100 ⚠ Report — not peer-reviewed Caregiving Health technology assessment (Winchester, England)
Key finding: Further research with DEMQOL is needed to confirm these findings in an independent sample, evaluate responsiveness, investigate the feasibility of use in specific subgroups and in economic evaluation, and develop population norms. +1 more finding
Scored 40 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.
Full summary, score breakdown and related studies → Original source
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2005-03-01
Temporal lobe atrophy on MRI in Parkinson disease with dementia: a comparison with Alzheimer disease and dementia with Lewy bodies
51/100 ✓ Peer-reviewed Brain scans and imaging Neurology
Key finding: Alzheimer disease (AD) and, to a lesser extent, dementia with Lewy bodies (DLB) showed more pronounced MTA. +2 more findings
Full summary, score breakdown and related studies → Original source
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2005-03-01
DWI predicts future progression to Alzheimer disease in amnestic mild cognitive impairment
50/100 ✓ Peer-reviewed Brain scans and imaging Neurology
Key finding: Higher baseline hippocampal diffusivity was associated with a greater risk of progression to AD in aMCI (p = 0.002).
Full summary, score breakdown and related studies → Original source
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2005-03-01
Mild cognitive impairment is related to Alzheimer disease pathology and cerebral infarctions
58/100 ✓ Peer-reviewed Getting a diagnosis Neurology
Key finding: Nearly all persons had at least some AD pathology. +2 more findings
Full summary, score breakdown and related studies → Original source
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2005-03-01
A diet enriched with the omega-3 fatty acid docosahexaenoic acid reduces amyloid burden in an aged Alzheimer mouse model
55/100 ✓ Peer-reviewed Genetics The Journal of neuroscience : the official journal of the Society for Neuroscience
Key finding: Epidemiological studies suggest that increased intake of the omega-3 (n-3) polyunsaturated fatty acid (PUFA) docosahexaenoic acid (DHA) is associated with reduced risk of Alzheimer's disease (AD). +4 more findings
Full summary, score breakdown and related studies → Original source
February 2005 8
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2005-02-28
Deaths: preliminary data for 2003
36/100 ✓ Peer-reviewed Risk factors PubMed
Key finding: The age-adjusted death rate for the United States decreased from 845.3 deaths per 100,000 population in 2002 to 831.2 deaths per 100,000 population in 2003. +3 more findings
Full summary, score breakdown and related studies → Original source
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2005-02-24
Mechanisms, pathophysiology, and therapy of arterial stiffness
54/100 ✓ Peer-reviewed Prevention and risk Arteriosclerosis, thrombosis, and vascular biology
Key finding: Arterial stiffness is a growing epidemic associated with increased risk of cardiovascular events, dementia, and death.
Full summary, score breakdown and related studies → Original source
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2005-02-18
Quetiapine and rivastigmine and cognitive decline in Alzheimer's disease: randomised double blind placebo controlled trial
57/100 ✓ Peer-reviewed Treatments BMJ (Clinical research ed.)
Key finding: Neither quetiapine nor rivastigmine are effective in the treatment of agitation in people with dementia in institutional care. +3 more findings
Full summary, score breakdown and related studies → Original source
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2005-02-18
BACE1 cytoplasmic domain interacts with the copper chaperone for superoxide dismutase-1 and binds copper
43/100 ✓ Peer-reviewed Risk genes beyond APOE The Journal of biological chemistry
Key finding: The amyloid precursor protein binds copper and zinc in its extracellular domain, and the Abeta peptides also bind copper, zinc, and iron. +3 more findings
Full summary, score breakdown and related studies → Original source
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2005-02-17
Statins cause intracellular accumulation of amyloid precursor protein, beta-secretase-cleaved fragments, and amyloid beta-peptide via an isoprenoid-dependent mechanism
44/100 ✓ Peer-reviewed Risk genes beyond APOE The Journal of biological chemistry
Key finding: It has been reported that statins reduce the risk of developing the disorder, and a link between cholesterol and Alzheimer disease pathophysiology has been proposed. +3 more findings
Full summary, score breakdown and related studies → Original source
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2005-02-11
Nicastrin is critical for stability and trafficking but not association of other presenilin/gamma-secretase components
44/100 ✓ Peer-reviewed Risk genes beyond APOE The Journal of biological chemistry
Key finding: Presenilin 1 (PS1) is known to be essential for the stability, interaction, and trafficking of the other PS1/gamma-secretase components. +3 more findings
Full summary, score breakdown and related studies → Original source
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2005-02-04
Nanoparticle-based detection in cerebral spinal fluid of a soluble pathogenic biomarker for Alzheimer's disease
43/100 ✓ Peer-reviewed Tau biomarkers Proceedings of the National Academy of Sciences of the United States of America
Key finding: The recently developed ultrasensitive bio-barcode assay was used to measure the concentration of amyloid-beta-derived diffusible ligands (ADDLs), a potential soluble pathogenic Alzheimer's disease (AD) marker, in the cerebrospinal fluid (CSF) of 30 individuals. +3 more findings
Full summary, score breakdown and related studies → Original source
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2005-02-01
Prevention of Alzheimer's disease pathology by cannabinoids: neuroprotection mediated by blockade of microglial activation
36/100 ✓ Peer-reviewed Disease mechanisms The Journal of neuroscience : the official journal of the Society for Neuroscience
Key finding: In pharmacological experiments, we found that G-protein coupling and CB1 receptor protein expression are markedly decreased in AD brains. +1 more finding
Full summary, score breakdown and related studies → Original source
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