Newest studies
Every summary in our library, newest first, as a dated timeline.
Showing 26,251–26,275 of 27,380 studies, newest first · page 1051 of 1096.
January 1997 14
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1997-01-01
Limitations of the Mini-Mental State Examination in diagnosing dementia in general practice
51/100 ✓ Peer-reviewed Cognitive tests and assessment International journal of geriatric psychiatry
Key finding: The study population consisted of 533 elderly patients (aged 65 and older) judged by 36 GPs as suffering from 'minimal to severe' dementia. +3 more findings
Full summary, score breakdown and related studies → Original source
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1997-01-01
An inventory to assess activities of daily living for clinical trials in Alzheimer's disease. The Alzheimer's Disease Cooperative Study
47/100 ✓ Peer-reviewed Cognitive tests and assessment Alzheimer disease and associated disorders
Key finding: Evaluation of ADL is an important outcome measure in AD clinical trials. +3 more findings
Full summary, score breakdown and related studies → Original source
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1997-01-01
Increased low-level chromosome 21 mosaicism in older individuals with Down syndrome
39/100 ✓ Peer-reviewed Down syndrome and Alzheimer's American journal of medical genetics
Key finding: During a study of the familial aggregation of Down syndrome (DS) and Alzheimer disease (AD), we observed an increase in mosaicism for disomy 21 in older individuals with DS. +2 more findings
Full summary, score breakdown and related studies → Original source
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1997-01-01
Aberrant expression of the constitutive endothelial nitric oxide synthase gene in Alzheimer disease
38/100 ✓ Peer-reviewed Down syndrome and Alzheimer's Molecular and chemical neuropathology
Key finding: The results suggest that aberrant ceNOS translocation and gene regulation may have important roles in the pathogenesis of AD neuritic pathology.
Full summary, score breakdown and related studies → Original source
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1997-01-01
Prospective study of the prevalence of Alzheimer-type dementia in institutionalized individuals with Down syndrome
40/100 ✓ Peer-reviewed Down syndrome and Alzheimer's American journal of mental retardation : AJMR
Key finding: Progressive mental and physical deterioration was found for 56 of the residents. +4 more findings
Full summary, score breakdown and related studies → Original source
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1997-01-01
Very old women at highest risk of dementia and Alzheimer's disease: incidence data from the Kungsholmen Project, Stockholm
59/100 ✓ Peer-reviewed How common it is Neurology
Key finding: (1) The incidence of dementia increases with age, even in the oldest age groups; (2) women have a higher risk of developing dementia than men, especially at very old ages; (3) this pattern is mainly due to the age and gender distribution of Alzheimer's disease, rather than vascular dementia. +1 more finding
Full summary, score breakdown and related studies → Original source
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1997-01-01
Atherosclerosis, apolipoprotein E, and prevalence of dementia and Alzheimer's disease in the Rotterdam Study
62/100 ✓ Peer-reviewed How common it is Lancet (London, England)
Key finding: All indicators of atherosclerosis were associated with dementia (odds ratios ranging from 1.3 to 1.9) and its major subtypes Alzheimer's disease (odds ratios 1.3-1.8) and vascular dementia (odds ratios 1.9-3.2). +3 more findings
Full summary, score breakdown and related studies → Original source
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1997-01-01
Criteria for Alzheimer's disease and the nosology of dementia with Lewy bodies
43/100 ✓ Peer-reviewed Disparities Neurology
Key finding: The percentages of mixed LB disease and AD versus pure LB disease varied from 91% mixed and 9% pure to 34% mixed and 66% pure, depending upon which diagnostic criteria for AD were employed.
Full summary, score breakdown and related studies → Original source
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1997-01-01
Neuronal loss correlates with but exceeds neurofibrillary tangles in Alzheimer's disease
60/100 ✓ Peer-reviewed Caregiving Annals of neurology
Key finding: These data suggest that neuronal loss in association areas such as the superior temporal sulcus contributes directly to cognitive impairment in AD.
Full summary, score breakdown and related studies → Original source
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1997-01-01
Quantitative magnetic resonance imaging in geriatric depression and primary degenerative dementia
42/100 ✓ Peer-reviewed Brain scans and imaging Journal of affective disorders
Key finding: Compared to the controls, depressed patients showed a significantly lower whole brain volume and a significantly higher CSF volume, whereas volumes of the frontal and temporal lobes as well as the amygdala-hippocampus complex volumes were not significantly decreased. +2 more findings
Full summary, score breakdown and related studies → Original source
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1997-01-01
Development of cognitive instruments for use in clinical trials of antidementia drugs: additions to the Alzheimer's Disease Assessment Scale that broaden its scope. The Alzheimer's Disease Cooperative Study
41/100 ✓ Peer-reviewed Getting a diagnosis Alzheimer disease and associated disorders
Key finding: As part of an overall ADCS protocol to develop new instruments to be used in trials of treatments for Alzheimer's disease (AD), patients with mild to moderate AD and cognitively normal elderly were administered a battery of five tests at least three times over 1 year.
Full summary, score breakdown and related studies → Original source
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1997-01-01
Aging, memory, and mild cognitive impairment
47/100 ✓ Peer-reviewed Getting a diagnosis International psychogeriatrics
Key finding: Our results and similar data from other study groups indicate that diagnostic criteria can be defined for patients who are likely to convert to AD; the natural history of these patients is becoming apparent, and variables that predict ultimate conversion can be defined.
Full summary, score breakdown and related studies → Original source
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1997-01-01
Protocols to demonstrate slowing of Alzheimer disease progression. Position paper from the International Working Group on Harmonization of Dementia Drug Guidelines. The Disease Progression Sub-Group
35/100 ✓ Peer-reviewed Treatments Alzheimer disease and associated disorders
Key finding: Two suggested clinical trial designs for assessing progression of Alzheimer disease are the randomized withdrawal design and the randomized start design. +2 more findings
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1997-01-01
Slowing the progression of Alzheimer disease: methodologic issues
34/100 ✓ Peer-reviewed Treatments Alzheimer disease and associated disorders
Key finding: The evidence to support a claim that a new drug will slow the progression of Alzheimer disease (AD) must derive from epistemologically valid research methods. +4 more findings
Full summary, score breakdown and related studies → Original source
December 1996 11
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1996-12-01
Visual hallucinations associated with Parkinson disease
45/100 ✓ Peer-reviewed Health systems and care delivery Archives of neurology
Key finding: The phenomena of visual hallucinations associated with PD, while not fully explained, are unique enough to be of interest to all neurologists and neuroscientists. +4 more findings
Full summary, score breakdown and related studies → Original source
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1996-12-01
Pick's disease: hyperphosphorylated tau protein segregates to the somatoaxonal compartment
40/100 ✓ Peer-reviewed Drug development Acta neuropathologica
Key finding: Our results indicate that tau proteins in Pick's disease and Alzheimer's disease share similar phosphorylated residues, with the exception of serine 262, which is phosphorylated in Alzheimer tangles but not in Pick bodies or neuritic profiles.
Full summary, score breakdown and related studies → Original source
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1996-12-01
Presymptomatic hippocampal atrophy in Alzheimer's disease. A longitudinal MRI study
55/100 ✓ Peer-reviewed Brain scans and imaging Brain : a journal of neurology
Key finding: Seven at risk members of a familial Alzheimer's disease pedigree associated with the amyloid precursor protein 717 valine to glycine mutation underwent serial MR scanning and neuropsychological assessments over 3 years. +3 more findings
Full summary, score breakdown and related studies → Original source
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1996-12-01
The profile of soluble amyloid beta protein in cultured cell media. Detection and quantification of amyloid beta protein and variants by immunoprecipitation-mass spectrometry
36/100 ✓ Peer-reviewed Risk genes beyond APOE The Journal of biological chemistry
Key finding: We used this method to examine the Abeta species in conditioned media of mouse neuroblastoma cells transfected with cDNAs encoding wild type or mutant human amyloid precursor protein. +4 more findings
Full summary, score breakdown and related studies → Original source
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1996-12-01
The cognitive effects of recombinant interleukin-2 (rIL-2) therapy: a controlled clinical trial using computerised assessments
71/100 ✓ Peer-reviewed Cognitive tests and assessment European journal of cancer (Oxford, England : 1990)
Key finding: It has been suggested that patients undergoing treatment with recombinant interleukin-2 (rIL-2) may develop cognitive impairment. +4 more findings
Full summary, score breakdown and related studies → Original source
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1996-12-01
Regionally specific pattern of neurochemical pathology in schizophrenia as assessed by multislice proton magnetic resonance spectroscopic imaging
36/100 ✓ Peer-reviewed Hippocampus size on brain scans The American journal of psychiatry
Key finding: NAA-relative signal intensity reductions in schizophrenia appear to be remarkably localized, involving primarily the hippocampal region and the dorsolateral prefrontal cortex, two regions implicated prominently in the pathophysiology of this disorder. +2 more findings
Full summary, score breakdown and related studies → Original source
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1996-12-01
Magnetic resonance imaging study of hippocampal volume in chronic, combat-related posttraumatic stress disorder
41/100 ✓ Peer-reviewed Hippocampus size on brain scans Biological psychiatry
Key finding: This study used quantitative volumetric magnetic resonance imaging techniques to explore the neuroanatomic correlates of chronic, combat-related posttraumatic stress disorder (PTSD) in seven Vietnam veterans with PTSD compared with seven nonPTSD combat veterans and eight normal nonveterans. +4 more findings
Full summary, score breakdown and related studies → Original source
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1996-12-01
Participation of presenilin 2 in apoptosis: enhanced basal activity conferred by an Alzheimer mutation
53/100 ✓ Peer-reviewed Risk genes beyond APOE Science (New York, N.Y.)
Key finding: Transfection of antisense PS2 conferred protection against apoptosis induced by trophic withdrawal in nerve growth factor-differentiated or amyloid precursor protein-expressing PC12 cells. +3 more findings
Full summary, score breakdown and related studies → Original source
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1996-12-01
Oxidative stress and the pathogenesis of Parkinson's disease
50/100 ✓ Peer-reviewed Lewy body dementia Neurology
Key finding: A loss of GSH is associated with incidental Lewy body disease and may represent the earliest biochemical marker of nigral cell loss. +1 more finding
Full summary, score breakdown and related studies → Original source
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1996-12-01
The role of magnetic resonance imaging in the diagnosis of Alzheimer disease in adults with Down syndrome
35/100 ✓ Peer-reviewed Down syndrome and Alzheimer's Archives of neurology
Key finding: Magnetic resonance imaging is potentially a valuable tool in the diagnosis of Alzheimer disease in adults with Down syndrome, particularly in individuals for whom standard intellectual assessments are not possible. +1 more finding
Full summary, score breakdown and related studies → Original source
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1996-12-01
Unusual clinical presentations of cortical-basal ganglionic degeneration
48/100 ✓ Peer-reviewed Digital health tools Annals of neurology
Key finding: It is therefore apparent that the histological changes of cortical-basal ganglionic degeneration result in a variety of clinical presentations depending on the topography of the lesions. +1 more finding
Full summary, score breakdown and related studies → Original source
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